Gene info: ID 5173

Gene: PDYN

GENE ID: 5173

Synonyms: ADCA|PENKB|SCA23

Description: prodynorphin

Gene type: protein-coding

Location: 20p13

dbXrefs: Ensembl:ENSG00000101327 MIM:131340 Vega:OTTHUMG00000031683 UniprotKB:P01213

RefSeq: NG_028027.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 23

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.718e-1 (AD) 6.693e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OTOF	0.731
NIPAL1	0.707
ANKRD34B	0.702
TMEM159	0.692
KCNJ1	0.687
GPR6	0.685
DRD2	0.684
KL	0.681
TDRD9	0.678
IGSF22	0.671

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NXNL1	-0.412
PYGM	-0.411
ALDH1A1	-0.405
ASCL1	-0.4
MSX1	-0.39
CDKN2C	-0.35
CTSH	-0.345
RNF182	-0.34
ADAMTSL5	-0.339
ZIC2	-0.33

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C534222	1-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine	1-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine results in decreased degradation of PDYN protein modified form	18938155
C534222	1-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine	N-methylnaloxone inhibits the reaction [1-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine results in decreased degradation of PDYN protein modified form]	18938155
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PDYN mRNA"	25614096
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of PDYN protein]	15385614
C472365	3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine	"3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine inhibits the reaction [Levodopa results in increased expression of PDYN mRNA]"	19357321
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of PDYN mRNA	21983209
C502015	(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate	(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate inhibits the reaction [Levodopa results in increased expression of PDYN mRNA]	19357321
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of PDYN mRNA	12419474
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"4-iodo-2,5-dimethoxyphenylisopropylamine results in decreased expression of PDYN mRNA"	9526047
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C121465	6-methyl-2-(phenylethynyl)pyridine	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	19660528
D000082	Acetaminophen	Acetaminophen results in decreased expression of PDYN mRNA	26690555
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PDYN gene	27153756
D000638	Amiodarone	Amiodarone results in increased expression of PDYN mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PDYN mRNA	16483693
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of PDYN mRNA	11566502\|1868189
D003913	Dextroamphetamine	GRM1 protein affects the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]	11566502
D003913	Dextroamphetamine	Dextroamphetamine results in increased expression of PDYN mRNA	11532335\|1189708
D003913	Dextroamphetamine	LY 306740 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]	11897087
D003913	Dextroamphetamine	SL 327 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]	16459022
D003913	Dextroamphetamine	U 0126 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]	16459022
D003913	Dextroamphetamine	U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]	11532335
D000661	Amphetamine	ADORA2A protein affects the reaction [Amphetamine results in increased expression of PDYN mRNA]	12700712
D000661	Amphetamine	Amphetamine results in increased expression of PDYN mRNA	12700712
D000661	Amphetamine	Amphetamine results in increased expression of PDYN mRNA	14521997\|1503341
D000661	Amphetamine	Baclofen inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]	15033416\|1559234
D000661	Amphetamine	CTAP octapeptide inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]	14521997
D000661	Amphetamine	tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]	14521997
D001280	Atrazine	Atrazine results in increased expression of PDYN mRNA	27495953
D001418	Baclofen	Baclofen inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]	15033416\|1559234
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PDYN mRNA	22316170
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased secretion of PDYN protein alternative form	17670969
C006780	bisphenol A	bisphenol A affects the expression of PDYN mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased methylation of PDYN promoter	27312807
C006780	bisphenol A	bisphenol A results in increased expression of PDYN mRNA	25181051\|2618613
C047047	cabergoline	"cabergoline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PDYN mRNA]"	9930741
D002211	Capsaicin	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of PDYN protein]	15385614
D002211	Capsaicin	Capsaicin results in increased expression of PDYN mRNA	15385614
D002211	Capsaicin	Capsaicin results in increased expression of PDYN protein	15385614
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of PDYN mRNA	20682304
C098869	clasto-lactacystin beta-lactone	clasto-lactacystin beta-lactone results in decreased secretion of PDYN protein alternative form	17670969
D003042	Cocaine	Cocaine results in increased expression of PDYN mRNA	11427339
D003042	Cocaine	Cocaine results in increased expression of PDYN mRNA	15009677\|1671032
D003042	Cocaine	Cocaine results in increased expression of PDYN protein	18538358
D003042	Cocaine	PDYN gene SNP affects the susceptibility to Cocaine	18923396
D003042	Cocaine	PDYN promoter polymorphism results in decreased susceptibility to Cocaine	11992566
D003042	Cocaine	PDYN promoter polymorphism results in increased susceptibility to Cocaine	16184603
D003042	Cocaine	Cocaine results in increased expression of PDYN mRNA	12786988
D003042	Cocaine	Cocaine promotes the reaction [DRD1 protein results in increased expression of PDYN protein]	15056714
D003042	Cocaine	Cocaine promotes the reaction [DRD3 protein results in decreased expression of PDYN protein]	15056714
D003042	Cocaine	Cocaine results in increased expression of PDYN mRNA	12742644\|1835596
D003042	Cocaine	Cocaine results in increased expression of PDYN protein	10943692\|1633903
D003042	Cocaine	[[Cocaine results in increased phosphorylation of and results in increased activity of MAPK1 protein] which results in increased expression of FOS protein] which affects the expression of PDYN protein	15056714
D003042	Cocaine	DRD3 protein inhibits the reaction [Cocaine results in increased expression of PDYN protein]	10943692
D003042	Cocaine	PDYN gene mutant form results in increased susceptibility to Cocaine	17532787
D003042	Cocaine	PDYN protein affects the reaction [Cocaine affects the expression of DRD2 protein]	17532787
D003042	Cocaine	PDYN protein affects the reaction [Cocaine results in increased activity of OPRM1 protein]	17532787
D003042	Cocaine	PDYN protein promotes the reaction [Cocaine results in increased abundance of Corticosterone]	17532787
D003042	Cocaine	RPS6KA3 gene mutant form inhibits the reaction [Cocaine results in increased expression of PDYN protein]	16339038
D003042	Cocaine	Cocaine affects the expression of PDYN mRNA	12128156\|1585771
D003042	Cocaine	Cocaine affects the expression of PDYN protein	14997015
D003042	Cocaine	Cocaine results in increased expression of PDYN mRNA	10971637\|1142733
D003042	Cocaine	Cocaine results in increased expression of PDYN mRNA	16339038
D003345	Corticosterone	PDYN protein promotes the reaction [Cocaine results in increased abundance of Corticosterone]	17532787
D003345	Corticosterone	Corticosterone inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	18687386
C529311	CTAP octapeptide	CTAP octapeptide inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]	14521997
C529311	CTAP octapeptide	CTAP octapeptide inhibits the reaction [Methamphetamine results in increased expression of PDYN mRNA]	20298714
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of PDYN mRNA	23914054
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of PDYN mRNA	23914054
C014347	decitabine	decitabine affects the expression of PDYN mRNA	23300844
D013759	Dronabinol	PDYN affects the susceptibility to Dronabinol	11717384
D013759	Dronabinol	Dronabinol results in increased expression of PDYN mRNA	12829401\|9244374
D003907	Dexamethasone	Dexamethasone results in decreased expression of PDYN mRNA	14618091
D003975	Diazepam	Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]	8417141
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PDYN mRNA	21266533
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PDYN mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of PDYN mRNA	23300844
D004041	Dietary Fats	Dietary Fats results in increased expression of PDYN mRNA	25016146
D007980	Levodopa	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of PDYN mRNA]	12373562
D007980	Levodopa	"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDYN mRNA]"	16950226
D007980	Levodopa	Levodopa results in increased expression of PDYN mRNA	11312565
D007980	Levodopa	[Levodopa co-treated with Oxidopamine] results in increased expression of PDYN mRNA	15207268
D007980	Levodopa	[Levodopa co-treated with Oxidopamine] results in increased expression of PDYN protein	19520364
D007980	Levodopa	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of PDYN mRNA]	16139809
D007980	Levodopa	"3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine inhibits the reaction [Levodopa results in increased expression of PDYN mRNA]"	19357321
D007980	Levodopa	(3-ethyl-2-methyl-quinolin-6-yl)-(4-methoxycyclohexyl)methanone methanesulfonate inhibits the reaction [Levodopa results in increased expression of PDYN mRNA]	19357321
D007980	Levodopa	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	19660528
D007980	Levodopa	8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Levodopa results in increased expression of PDYN mRNA]	19115412
D007980	Levodopa	Corticosterone inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	18687386
D007980	Levodopa	IEM 1460 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	20456008
D007980	Levodopa	[Levodopa co-treated with Oxidopamine] results in increased expression of PDYN mRNA	17219962\|1732943
D007980	Levodopa	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of PDYN mRNA]	17241287
D007980	Levodopa	Levodopa results in increased expression of PDYN mRNA	11739600\|1770484
D007980	Levodopa	Levodopa results in increased expression of PDYN protein alternative form	21984936\|9106744
D007980	Levodopa	[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA	15659429\|1868738
D007980	Levodopa	[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN protein	7477882
D007980	Levodopa	[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	15659429
C118739	entinostat	entinostat results in increased expression of PDYN mRNA	26272509\|2718838
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C078846	epoxomicin	epoxomicin inhibits the reaction [Potassium results in increased secretion of PDYN protein alternative form]	17670969
C078846	epoxomicin	epoxomicin results in decreased expression of and results in decreased secretion of PDYN protein alternative form	17670969
C078846	epoxomicin	epoxomicin results in decreased expression of PDYN protein alternative form	17670969
D000431	Ethanol	Ethanol results in decreased expression of PDYN mRNA	17934066
D000431	Ethanol	fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA]	17934066
D000431	Ethanol	PDYN gene SNP affects the susceptibility to Ethanol	18923396
D005283	Fentanyl	Fentanyl results in increased expression of PDYN protein	19200067
D005473	Fluoxetine	Fluoxetine affects the expression of PDYN protein	14997015
D005473	Fluoxetine	Fluoxetine results in decreased expression of PDYN mRNA	15936043
C010238	fomepizole	fomepizole inhibits the reaction [Ethanol results in decreased expression of PDYN mRNA]	17934066
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of PDYN mRNA	20068450
D005620	Freund's Adjuvant	PDYN protein affects the susceptibility to Freund's Adjuvant	20068450
D003932	Heroin	Heroin results in decreased expression of PDYN mRNA	16710320
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of PDYN mRNA	12419474
C110702	IEM 1460	IEM 1460 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	20456008
D007608	Kainic Acid	Diazepam inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]	8417141
D007608	Kainic Acid	Kainic Acid results in increased expression of PDYN mRNA	8417141
D007608	Kainic Acid	Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]	8417141
D007608	Kainic Acid	Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]	8417141
D019344	Lactic Acid	Lactic Acid results in increased expression of PDYN mRNA	24008352
C008261	lead acetate	lead acetate results in decreased expression of PDYN mRNA	11578147
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PDYN mRNA	12057914
C102280	LY 306740	LY 306740 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]	11897087
D008344	Maneb	[Paraquat co-treated with Maneb] results in decreased expression of PDYN	24376148
D008694	Methamphetamine	PDYN promoter polymorphism results in increased susceptibility to Methamphetamine	16529859
D008694	Methamphetamine	CTAP octapeptide inhibits the reaction [Methamphetamine results in increased expression of PDYN mRNA]	20298714
D008694	Methamphetamine	Methamphetamine results in increased expression of PDYN mRNA	20298714
D008731	Methoxychlor	Methoxychlor results in increased methylation of PDYN gene	23303685
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PDYN mRNA"	15661373
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDYN mRNA"	16950226
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PDYN mRNA"	9930741
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"cabergoline inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PDYN mRNA]"	9930741
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PDYN mRNA]"	16950226
D015632	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	"SK&F 82958 promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PDYN mRNA]"	9930741
D009020	Morphine	GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]	20359526
D009020	Morphine	Morphine results in increased expression of PDYN protein alternative form	20359526
D009020	Morphine	[Zymosan co-treated with Morphine] results in increased expression of PDYN mRNA	15979727
D009020	Morphine	Morphine results in decreased expression of PDYN mRNA	17401159
C027247	MR 2266	MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine Hydrobromide]	7768285
C003297	nandrolone decanoate	nandrolone decanoate results in increased expression of PDYN mRNA	19782718
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PDYN mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PDYN mRNA"	25554681
C041269	N-methylnaloxone	N-methylnaloxone inhibits the reaction [1-(2-((1-ethoxycarbonyloxyethoxycarbonylmethyl)carbamoyl)-3-phenylpropyldisulfanylmethyl)-3-methylsulfanylpropylamine results in decreased degradation of PDYN protein modified form]	18938155
D009638	Norepinephrine	[PDYN protein affects the activity of OPRK1 protein] which results in decreased secretion of Norepinephrine	2987744
D016627	Oxidopamine	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of PDYN mRNA]	12373562
D016627	Oxidopamine	Oxidopamine results in decreased expression of PDYN mRNA	12373562
D016627	Oxidopamine	[Levodopa co-treated with Oxidopamine] results in increased expression of PDYN mRNA	15207268
D016627	Oxidopamine	[Levodopa co-treated with Oxidopamine] results in increased expression of PDYN protein	19520364
D016627	Oxidopamine	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of PDYN mRNA]	16139809
D016627	Oxidopamine	Oxidopamine results in decreased expression of PDYN mRNA	16139809
D016627	Oxidopamine	Oxidopamine results in decreased expression of PDYN mRNA	14622157
D016627	Oxidopamine	Oxidopamine results in increased expression of PDYN mRNA	14622157
D016627	Oxidopamine	6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	19660528
D016627	Oxidopamine	Corticosterone inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	18687386
D016627	Oxidopamine	IEM 1460 inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	20456008
D016627	Oxidopamine	[Levodopa co-treated with Oxidopamine] results in increased expression of PDYN mRNA	17219962\|1732943
D016627	Oxidopamine	Levodopa inhibits the reaction [Oxidopamine results in decreased expression of PDYN mRNA]	17241287
D016627	Oxidopamine	[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA	15659429\|1868738
D016627	Oxidopamine	[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN protein	7477882
D016627	Oxidopamine	Oxidopamine results in decreased expression of PDYN mRNA	15659429\|1724128
D016627	Oxidopamine	Oxidopamine results in increased expression of PDYN mRNA	12127155\|1469731
D016627	Oxidopamine	[TH co-treated with GCH1] inhibits the reaction [[Oxidopamine co-treated with Levodopa] results in increased expression of PDYN mRNA]	15659429
D017371	8-Hydroxy-2-(di-n-propylamino)tetralin	8-Hydroxy-2-(di-n-propylamino)tetralin inhibits the reaction [Levodopa results in increased expression of PDYN mRNA]	19115412
D010111	Oxymorphone	Oxymorphone results in increased expression of PDYN protein alternative form	16343768
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of PDYN mRNA	26272509
D010269	Paraquat	[Paraquat co-treated with Maneb] results in decreased expression of PDYN	24376148
D010424	Pentobarbital	Pentobarbital inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]	8417141
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of PDYN mRNA	15728792
C006253	pirinixic acid	pirinixic acid results in increased expression of PDYN mRNA	20813756
D011188	Potassium	epoxomicin inhibits the reaction [Potassium results in increased secretion of PDYN protein alternative form]	17670969
D011188	Potassium	Potassium results in increased secretion of PDYN protein alternative form	17670969
C045362	prochloraz	prochloraz results in increased expression of PDYN mRNA	29038839
D011374	Progesterone	Progesterone results in increased expression of PDYN mRNA	15650077
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of PDYN mRNA	16079270
D016713	Ritanserin	Ritanserin results in increased expression of PDYN mRNA	9526047
D012601	Scopolamine Hydrobromide	MR 2266 inhibits the reaction [PDYN protein modified form results in decreased susceptibility to Scopolamine Hydrobromide]	7768285
D012601	Scopolamine Hydrobromide	PDYN protein modified form results in decreased susceptibility to Scopolamine Hydrobromide	7768285
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in increased expression of PDYN mRNA	17540011
D012604	Scorpion Venoms	Scorpion Venoms results in increased hydrolysis of PDYN protein	25239630
C071262	SK&F 82958	"SK&F 82958 promotes the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PDYN mRNA]"	9930741
C424127	SL 327	SL 327 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]	16459022
C017947	sodium arsenite	sodium arsenite affects the methylation of PDYN gene	28589171
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PDYN mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PDYN mRNA	15703262
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of PDYN mRNA"	14622157
C009495	titanium dioxide	titanium dioxide results in increased expression of PDYN mRNA	23557971
D014147	Tramadol	Tramadol results in decreased expression of PDYN mRNA	17401159
D014212	Tretinoin	Tretinoin results in decreased expression of PDYN mRNA	20488242
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of PDYN mRNA	24935251\|2627250
C012589	trichostatin A	trichostatin A results in increased expression of PDYN mRNA	24204683
C092721	tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine	tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine inhibits the reaction [Amphetamine results in increased expression of PDYN mRNA]	14521997
C113580	U 0126	U 0126 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]	16459022
C045444	U 69593	U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA]	11532335
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of PDYN mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of PDYN mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid affects the expression of PDYN mRNA	17963808
D014635	Valproic Acid	Valproic Acid inhibits the reaction [Kainic Acid results in increased expression of PDYN mRNA]	8417141
C043425	vanoxerine	vanoxerine affects the expression of PDYN protein	14997015
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDYN mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of PDYN mRNA	26272509
D015054	Zymosan	[Zymosan co-treated with Morphine] results in increased expression of PDYN mRNA	15979727
D015054	Zymosan	Zymosan results in increased expression of PDYN mRNA	15979727

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001515	opioid peptide activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007218	neuropeptide signaling pathway	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007600	sensory perception	-	IBA	21873635
GO:0010469	regulation of signaling receptor activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	9047294
GO:0030425	dendrite	-	IBA	21873635
GO:0043025	neuronal cell body	-	IBA	21873635
GO:0043679	axon terminus	-	IBA	21873635

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-111885	Opioid Signalling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-202040	G-protein activation	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375276	Peptide ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23101464	Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states. (2013 Jun)	Karpyak VM	Int J Neuropsychopharmacol
16961766	The genetics of alcoholism: identifying specific genes through family studies. (2006 Sep)	Edenberg HJ	Addict Biol
20201854	Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. (2010 Feb)	Yuferov V	Ann N Y Acad Sci
24035285	Opioid system genes in alcoholism: a case-control study in Croatian population. (2013 Oct)	Cupic B	Neuropeptides
19183129	Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? (2009 Apr)	Hansell NK	Alcohol Clin Exp Res
21736916	Alcohol dependence, disinhibited behavior and variation in the prodynorphin gene. (2011 Sep)	Flory JD	Biol Psychol
28656735	An analysis of genetic association in opioid dependence susceptibility. (2018 Feb)	Nagaya D	J Clin Pharm Ther
19298317	An association of prodynorphin polymorphisms and opioid dependence in females in a Chinese population. (2009 Jul)	Clarke TK	Addict Biol
21521424	Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics. (2011 Jul)	Taqi MM	Addict Biol
16924269	Association of the kappa-opioid system with alcohol dependence. (2006 Nov)	Xuei X	Mol Psychiatry
25177835	A molecular prospective provides new insights into implication of PDYN and OPRK1 genes in alcohol dependence. (2014 Oct)	Faisal M	Comput Biol Med
16314761	A functional prodynorphin promoter polymorphism and opioid dependence. (2005 Dec)	Ray R	Psychiatr Genet
21338584	Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain. (2011 Apr 18)	Taqi MM	Brain Res
28336495	Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism. (2017 Jun 2)	D'Addario C	Prog Neuropsychopharmacol Biol Psychiatry
26029055	Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics. (2015)	Sarkisyan D	Front Cell Neurosci
27430399	Repeated nicotine exposure modulates prodynorphin and pronociceptin levels in the reward pathway. (2016 Sep 1)	Carboni L	Drug Alcohol Depend
18923396	A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. (2009 Apr)	Yuferov V	Neuropsychopharmacology
26502829	Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent. (2015 Oct 27)	Winham SJ	Sci Rep
22443215	Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction. (2012 Jun)	Clarke TK	Genes Brain Behav
17503481	The opioid system in alcohol and drug dependence: family-based association study. (2007 Oct 5)	Xuei X	Am J Med Genet B Neuropsychiatr Genet
23164614	Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice. (2013 Apr)	Zhang Y	Neuropharmacology
24816773	Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. (2014)	Cohen A	PLoS One
24231353	Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression. (2013 Dec)	Anderson SA	J Clin Invest