Gene: RTEL1

51750
C20orf41|DKCA4|DKCB5|NHL|PFBMFT3|RTEL
regulator of telomere elongation helicase 1
protein-coding
20q13.33
Ensembl:ENSG00000258366 MIM:608833 Vega:OTTHUMG00000032992 UniprotKB:Q9NZ71
NG_033901.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCDC570.94
SNAPC40.936
TUBGCP60.933
SFI10.925
PTCH20.919
RHOT20.915
POMT10.914
NEIL10.912
ATP13A10.907
DDX510.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.469
OR4F29-0.427
MTRNR2L9-0.391
MTRNR2L6-0.354
ZNF114-0.353
MTRNR2L10-0.344
PHEX-0.337
LRRIQ1-0.329
KLRC2-0.32
TMSB15A-0.318

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RTEL1 mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of RTEL1 mRNA]"19467301
D000082AcetaminophenAcetaminophen results in decreased expression of RTEL1 mRNA29067470
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of RTEL1 mRNA28522335
D001280AtrazineAtrazine results in increased expression of RTEL1 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of RTEL1 mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of RTEL1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RTEL1 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of RTEL1 mRNA28196854
C006780bisphenol Abisphenol A affects the expression of RTEL1 mRNA25181051
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of RTEL1 mRNA21878529
D003520CyclophosphamideCyclophosphamide results in increased expression of RTEL1 protein17475930
C014347decitabinedecitabine results in decreased expression of RTEL1 mRNA19194470
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of RTEL1 mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of RTEL1 gene22964155
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of RTEL1 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of RTEL1 mRNA19467301
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of RTEL1 mRNA27776689
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of RTEL1 mRNA26846883
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of RTEL1 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of RTEL1 mRNA26378955
D010416PentachlorophenolPentachlorophenol results in increased expression of RTEL1 mRNA23892564
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of RTEL1 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of RTEL1 mRNA26378955
C061133tamibarotenetamibarotene affects the expression of RTEL1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RTEL1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RTEL1 mRNA21215274
D014212TretinoinTretinoin results in decreased expression of RTEL1 mRNA15498508
D014520UrethaneUrethane results in decreased expression of RTEL1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased methylation of RTEL1 gene29154799
C025643vinclozolinvinclozolin results in increased expression of RTEL1 mRNA20566332

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0004003ATP-dependent DNA helicase activity-IBA21873635  
GO:0004003ATP-dependent DNA helicase activity-IMP18957201  
GO:0004003ATP-dependent DNA helicase activity-ISS24115439  
GO:0004003ATP-dependent DNA helicase activity-TAS-  
GO:0005515protein binding-IPI23959892  25620558  
GO:0005524ATP binding-IBA21873635  
GO:0005524ATP binding-IMP18957201  
GO:0046872metal ion binding-IEA-  
GO:00515394 iron, 4 sulfur cluster binding-IEA-  
GO:0070182DNA polymerase binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000723telomere maintenance-IMP23453664  
GO:0000723telomere maintenance-ISS-  
GO:0000732strand displacement-ISS-  
GO:0000732strand displacement-TAS-  
GO:0006281DNA repair-IEA-  
GO:0010569regulation of double-strand break repair via homologous recombination-IBA21873635  
GO:0010569regulation of double-strand break repair via homologous recombination-IMP18957201  
GO:0031297replication fork processing-ISS24115439  
GO:0032206positive regulation of telomere maintenance-ISS-  
GO:0032508DNA duplex unwinding-IBA21873635  
GO:0032508DNA duplex unwinding-ISS24115439  
GO:0043247telomere maintenance in response to DNA damage-ISS-  
GO:0045910negative regulation of DNA recombination-IBA21873635  
GO:0045910negative regulation of DNA recombination-ISS-  
GO:0090657telomeric loop disassembly-IBA21873635  
GO:0090657telomeric loop disassembly-IMP25620558  
GO:0090657telomeric loop disassembly-ISS-  
GO:1902990mitotic telomere maintenance via semi-conservative replication-ISS24115439  
GO:1904355positive regulation of telomere capping-IMP23959892  
GO:1904358positive regulation of telomere maintenance via telomere lengthening-IMP23959892  
GO:1904430negative regulation of t-circle formation-IBA21873635  
GO:1904430negative regulation of t-circle formation-IMP25620558  
GO:1904430negative regulation of t-circle formation-ISS24115439  
GO:1904430negative regulation of t-circle formation-TAS24115439  
GO:1904506negative regulation of telomere maintenance in response to DNA damage-ISS-  
GO:1904535positive regulation of telomeric loop disassembly-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric region-ISS-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-2564830Cytosolic iron-sulfur cluster assemblyIEA
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21742680Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. (2011 Sep 1)Lachance DHAm J Epidemiol
24231251Telomere length and risk of glioma. (2013 Dec)Walcott FCancer Epidemiol
20301779Dyskeratosis Congenita (1993)Savage SA-