Gene: ERAP1

51752
A-LAP|ALAP|APPILS|ARTS-1|ARTS1|ERAAP|ERAAP1|PILS-AP|PILSAP
endoplasmic reticulum aminopeptidase 1
protein-coding
5q15
Ensembl:ENSG00000164307 MIM:606832 Vega:OTTHUMG00000128721 UniprotKB:Q9NZ08
NG_027839.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
8.823e-2 (AD)  5.949e-1 (ND)   (Frontal_Cortex)
7.532e-2 (AD)  2.969e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs13160562chr5:96775667 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PBRM10.853
FAM208B0.845
CNOT10.837
ATF60.834
SYNRG0.83
FUBP10.827
NUP1530.826
SETX0.825
SPTLC10.825
PIKFYVE0.824

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.445
OR4F29-0.405
NANOGNB-0.261
PTGDR2-0.248
OR4F16-0.234
SPRR2A-0.225
S100A1-0.221
SPRR2D-0.22
TBX5-0.204
KLRC2-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ERAP1 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of ERAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of ERAP1 mRNA"27188386
D000393Air PollutantsAir Pollutants analog results in decreased expression of ERAP1 mRNA21757418
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ERAP1 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of ERAP1 protein16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ERAP1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of ERAP1 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ERAP1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ERAP1 mRNA20713471
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ERAP1 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ERAP1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ERAP1 mRNA26982218
C006780bisphenol Abisphenol A results in increased expression of ERAP1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of ERAP1 mRNA22079614
C018475butyraldehydebutyraldehyde results in decreased expression of ERAP1 mRNA26079696
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ERAP1 mRNA17484886
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ERAP1 mRNA24763279
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of ERAP1 mRNA26272509
D002994ClofibrateClofibrate results in decreased expression of ERAP1 mRNA22300585
C018021cobaltous chloridecobaltous chloride results in increased secretion of ERAP1 protein22079246
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ERAP1 mRNA20971185
D003520CyclophosphamideCyclophosphamide results in increased expression of ERAP1 mRNA27281708
D016572CyclosporineCyclosporine results in increased expression of ERAP1 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of ERAP1 mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ERAP1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ERAP1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ERAP1 mRNA27392435
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ERAP1 mRNA25380136
D004317DoxorubicinDoxorubicin results in decreased expression of ERAP1 mRNA16404146
C118739entinostatentinostat results in decreased expression of ERAP1 mRNA26272509
C118739entinostatentinostat results in increased expression of ERAP1 mRNA27188386
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
D005485FlutamideFlutamide results in decreased expression of ERAP1 mRNA24793618
D005839GentamicinsGentamicins results in increased expression of ERAP1 mRNA22061828
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of ERAP1 mRNA24763279
D017313FenretinideFenretinide results in increased expression of ERAP1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ERAP1 mRNA25613284
C081309irbesartanERAP1 gene polymorphism affects the susceptibility to irbesartan13678427
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ERAP1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ERAP1 mRNA24796395
C008261lead acetatelead acetate affects the expression of ERAP1 mRNA21147602
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with IFNG protein] results in increased secretion of ERAP1 protein"21531727
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ERAP1 mRNA26378955
C025340manganese chloridemanganese chloride results in increased expression of ERAP1 mRNA17467022
C042720mercuric bromidemercuric bromide results in decreased expression of ERAP1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of ERAP1 mRNA20353558
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ERAP1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ERAP1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of ERAP1 promoter"26251327
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ERAP1 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of ERAP1 mRNA20971185
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of ERAP1 mRNA26272509
D010416PentachlorophenolPentachlorophenol results in increased expression of ERAP1 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ERAP1 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ERAP1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of ERAP1 mRNA23811191
D059808PolyphenolsPolyphenols results in decreased expression of ERAP1 mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ERAP1 mRNA22714537
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ERAP1 mRNA27029645
C009277sodium arsenatesodium arsenate results in increased expression of ERAP1 mRNA21795629
C017947sodium arsenitesodium arsenite affects the expression of ERAP1 mRNA22058191
C017947sodium arsenitesodium arsenite results in decreased expression of ERAP1 mRNA28595984
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of ERAP1 mRNA26378955
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ERAP1 mRNA25613284
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ERAP1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of ERAP1 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] affects the expression of ERAP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ERAP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ERAP1 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of ERAP1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ERAP1 gene25560391
C111237vorinostatvorinostat results in decreased expression of ERAP1 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-EXP12436109  12436110  17088086  
GO:0004177aminopeptidase activity-IDA10220586  12748171  
GO:0005138interleukin-6 receptor binding-IPI12748171  
GO:0005151interleukin-1, type II receptor binding-TAS15691326  
GO:0005515protein binding-IPI18445477  
GO:0008235metalloexopeptidase activity-IDA10220586  
GO:0008270zinc ion binding-IBA21873635  
GO:0008270zinc ion binding-NAS10220586  
GO:0042277peptide binding-IBA21873635  
GO:0070006metalloaminopeptidase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-TAS15691326  
GO:0002250adaptive immune response-IEA-  
GO:0002474antigen processing and presentation of peptide antigen via MHC class I-TAS-  
GO:0006508proteolysis-IBA21873635  
GO:0006509membrane protein ectodomain proteolysis-IDA12748171  
GO:0008217regulation of blood pressure-NAS11056387  
GO:0008217regulation of blood pressure-TAS15691326  
GO:0009617response to bacterium-NAS16034137  
GO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class I-NAS12748171  
GO:0019885antigen processing and presentation of endogenous peptide antigen via MHC class I-TAS15691326  
GO:0043171peptide catabolic process-IBA21873635  
GO:0045088regulation of innate immune response-NAS12748171  
GO:0045444fat cell differentiation-NAS11056387  
GO:0045766positive regulation of angiogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA11056387  
GO:0005615extracellular space-HDA16502470  
GO:0005737cytoplasm-IBA21873635  
GO:0005783endoplasmic reticulum-NAS12748171  
GO:0005788endoplasmic reticulum lumen-TAS15691326  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005829cytosol-NAS10220586  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-NAS12748171  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHCTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23541940TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis. (2013 May)Yin XYJ Dermatol Sci
28400866Association of ERAP1, IL23R and PTGER4 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis. (2017)Ozen GOpen Rheumatol J