Gene: CDK12

51755
CRK7|CRKR|CRKRS
cyclin dependent kinase 12
protein-coding
17q12
Ensembl:ENSG00000167258 MIM:615514 Vega:OTTHUMG00000133214 UniprotKB:Q9NYV4
NC_000017.11
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.503e-1 (AD)  2.938e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4794814chr17:39540599 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7503705chr17:39513451 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs11657899chr17:39470710 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRRC2C0.895
CCNT10.888
DCP1A0.88
CNOT10.879
MED10.875
DENND4A0.875
NUP1530.875
PHC30.874
HEATR10.873
PROSER10.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.452
OR4F29-0.435
NEU4-0.29
S100A1-0.268
APOA1-0.265
BTBD17-0.262
PLA2G5-0.252
HES5-0.252
KLRC2-0.251
C16orf74-0.243

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of CDK12 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CDK12 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK12 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK12 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK12 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CDK12 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of CDK12 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CDK12 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CDK12 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CDK12 mRNA16483693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CDK12 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDK12 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CDK12 mRNA"19150397|2001819
C006780bisphenol Abisphenol A affects the expression of CDK12 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CDK12 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of CDK12 mRNA25979313
D002737ChloropreneChloroprene results in increased expression of CDK12 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in increased expression of CDK12 mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of CDK12 mRNA21356183
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of CDK12 mRNA21356183
D003300CopperCopper results in increased expression of CDK12 mRNA21356183
D003300CopperCopper results in decreased expression of CDK12 mRNA18522721
D016572CyclosporineCyclosporine results in decreased expression of CDK12 mRNA25562108
D002945CisplatinCisplatin results in decreased expression of CDK12 mRNA27594783
D002945CisplatinCisplatin results in increased expression of CDK12 mRNA22023808
C000944dicrotophosdicrotophos results in increased expression of CDK12 mRNA28302478
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of CDK12 mRNA25236440
C029402diphenylcyclopropenonediphenylcyclopropenone results in decreased expression of CDK12 mRNA25236440
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK12 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CDK12 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDK12 mRNA17942748
C070081fulvestrantCDK12 affects the susceptibility to fulvestrant19651820
C010974glyphosateglyphosate results in increased expression of CDK12 mRNA26302742
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of CDK12 mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of CDK12 mRNA18951874
C492448ICG 001ICG 001 results in decreased expression of CDK12 mRNA26191083
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CDK12 mRNA21641980
D008727MethotrexateMethotrexate results in decreased expression of CDK12 mRNA24449571
C013598methoxyacetic acidmethoxyacetic acid affects the expression of CDK12 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of CDK12 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CDK12 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CDK12 mRNA"26251327
D010634PhenobarbitalPhenobarbital affects the expression of CDK12 mRNA19136022
C006253pirinixic acidpirinixic acid affects the expression of CDK12 mRNA19136022
C059514resveratrolresveratrol affects the phosphorylation of CDK12 protein25311616
D012822Silicon DioxideSilicon Dioxide results in increased expression of CDK12 mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of CDK12 mRNA19073995
C009277sodium arsenatesodium arsenate results in increased expression of CDK12 mRNA21795629
C017947sodium arsenitesodium arsenite results in increased expression of CDK12 mRNA25879800
D012999SomanSoman results in increased expression of CDK12 mRNA19281266
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of CDK12 mRNA21641980
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of CDK12 mRNA"26680231
D013629TamoxifenCDK12 affects the susceptibility to Tamoxifen19651820
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CDK12 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDK12 mRNA17942748
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CDK12 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of CDK12 mRNA28973697
D014520UrethaneUrethane results in increased expression of CDK12 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of CDK12 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CDK12 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CDK12 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CDK12 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of CDK12 mRNA17292431
D014638VanadatesVanadates results in decreased expression of CDK12 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CDK12 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of CDK12 mRNA22570695

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA11683387  
GO:0004693cyclin-dependent protein serine/threonine kinase activity-IBA21873635  
GO:0005515protein binding-IPI12841360  
GO:0005524ATP binding-IEA-  
GO:0008134transcription factor binding-IBA21873635  
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity-IBA21873635  
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity-IMP20952539  
GO:0019901protein kinase binding-IEA-  
GO:0030332cyclin binding-IBA21873635  
GO:0030332cyclin binding-IPI22012619  
GO:0044212transcription regulatory region DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006368transcription elongation from RNA polymerase II promoter-IBA21873635  
GO:0006397mRNA processing-IEA-  
GO:0006468protein phosphorylation-IBA21873635  
GO:0008380RNA splicing-ISS-  
GO:0032968positive regulation of transcription elongation from RNA polymerase II promoter-IBA21873635  
GO:0043405regulation of MAP kinase activity-IMP19651820  
GO:0043484regulation of RNA splicing-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IBA21873635  
GO:0046777protein autophosphorylation-IDA11683387  
GO:0051726regulation of cell cycle-IEA-  
GO:0070816phosphorylation of RNA polymerase II C-terminal domain-IBA21873635  
GO:0070816phosphorylation of RNA polymerase II C-terminal domain-IMP20952539  
GO:2000737negative regulation of stem cell differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000307cyclin-dependent protein kinase holoenzyme complex-IBA21873635  
GO:0000790nuclear chromatin-IBA21873635  
GO:0001650fibrillar center-IDA-  
GO:0002944cyclin K-CDK12 complex-IPI22012619  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005694chromosome-IBA21873635  
GO:0008024cyclin/CDK positive transcription elongation factor complex-IBA21873635  
GO:0016607nuclear speck-IDA11683387  
GO:0019908nuclear cyclin-dependent protein kinase holoenzyme complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal