Gene: PEG3

5178
PW1|ZKSCAN22|ZNF904|ZSCAN24
paternally expressed 3
protein-coding
19q13.43
Ensembl:ENSG00000198300 MIM:601483 Vega:OTTHUMG00000171954 UniprotKB:Q9GZU2
NG_012989.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.420e-2 (AD)  2.801e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15678121chr19:57352519PEG3Promoter1.644e-4Alcohol use disorders26763658
cg17663463chr19:57349709PEG3Promoter4.726e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRKACB0.959
CD2000.958
DNAJC60.954
TUSC30.946
KIF3A0.944
INPP5F0.944
REEP10.943
PNMA20.942
GPRASP20.942
ITFG10.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.539
RNF135-0.503
MAGEA12-0.498
OR4F5-0.489
RUNX3-0.487
EVC2-0.47
RHOD-0.468
OR4F29-0.468
CHST14-0.468
SYDE1-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of PEG3 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PEG3 mRNA"21394737
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of PEG3 mRNA"21920950
D000086AcetazolamideAcetazolamide results in increased expression of PEG3 mRNA19274763
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PEG3 gene27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PEG3 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PEG3 mRNA20106945|2163298
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PEG3 mRNA"26238291
C006780bisphenol Abisphenol A affects the methylation of PEG3 promoter27334623
C006780bisphenol Abisphenol A results in decreased methylation of PEG3 gene22131059|2269988
C006780bisphenol Abisphenol A results in increased expression of PEG3 mRNA25594700|2606340
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PEG3 mRNA17484886
D016572CyclosporineCyclosporine results in decreased expression of PEG3 mRNA21632981
D016572CyclosporineCyclosporine results in decreased expression of PEG3 mRNA19770486
C000944dicrotophosdicrotophos results in increased expression of PEG3 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of PEG3 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of PEG3 mRNA25016146
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of PEG3 mRNA21852083
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PEG3 mRNA24535843
D005557FormaldehydeFormaldehyde results in decreased expression of PEG3 mRNA27664576
D005839GentamicinsGentamicins results in decreased expression of PEG3 mRNA22061828
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of PEG3 mRNA25270620
D017313FenretinideFenretinide results in increased expression of PEG3 mRNA28973697
D007545IsoproterenolIsoproterenol results in increased expression of PEG3 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of PEG3 mRNA27440272
C410337K 7174K 7174 results in decreased expression of PEG3 mRNA24086573
D007854LeadLead affects the expression of PEG3 mRNA28903495
D007854LeadLead results in decreased methylation of PEG3 gene26115033
C045463leflunomideleflunomide results in increased expression of PEG3 mRNA28988120
D008731MethoxychlorMethoxychlor results in increased methylation of PEG3 gene21062904
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of PEG3 protein26558463
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PEG3 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of PEG3 protein26558463
C008493methylselenic acidmethylselenic acid affects the expression of PEG3 mRNA14617803
C523799MRK 003MRK 003 results in increased expression of PEG3 mRNA21169257
C523799MRK 003PEG3 results in increased susceptibility to MRK 00319903844
D009532NickelNickel results in decreased expression of PEG3 mRNA24768652|2558310
D000073878Palm OilPalm Oil results in decreased expression of PEG3 mRNA18042831
C016030pantogabpantogab results in increased expression of PEG3 mRNA17379144
C506614PD 0325901PD 0325901 results in decreased expression of PEG3 mRNA25119042
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of PEG3 mRNA28558994
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of PEG3 mRNA28558994
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PEG3 mRNA28558994
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PEG3 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PEG3 mRNA28558994
D010634PhenobarbitalPhenobarbital affects the expression of PEG3 mRNA23091169
C003121phosphinothricinphosphinothricin results in decreased expression of PEG3 mRNA25477793
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PEG3 mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of PEG3 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of PEG3 mRNA18301758|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of PEG3 mRNA]20059764
D010936Plant ExtractsPlant Extracts results in decreased expression of PEG3 mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of PEG3 mRNA23018184
C502851quinocetonequinocetone results in increased expression of PEG3 mRNA27046791
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of PEG3 mRNA21852083
D012293RifampinRifampin results in increased expression of PEG3 mRNA24552687
C009277sodium arsenatesodium arsenate results in increased expression of PEG3 mRNA21795629
D012969Sodium FluorideSodium Fluoride affects the methylation of PEG3 gene24030355
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PEG3 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEG3 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEG3 mRNA23142538
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PEG3 mRNA18691609|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of PEG3 gene23142538
D019284ThapsigarginThapsigargin results in increased expression of PEG3 protein24648495
C009495titanium dioxidetitanium dioxide results in increased expression of PEG3 mRNA23557971
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PEG3 mRNA29024780
D014415TunicamycinTunicamycin results in increased expression of PEG3 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of PEG3 mRNA19101580|2915479
D014635Valproic AcidValproic Acid results in increased methylation of PEG3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PEG3 gene25560391
C025643vinclozolinvinclozolin results in increased methylation of PEG3 gene19887539
C025643vinclozolinvinclozolin results in decreased expression of PEG3 mRNA18042343
D015032ZincZinc results in decreased expression of PEG3 mRNA16870260
C016837zinc chloridezinc chloride results in decreased expression of PEG3 mRNA16870260

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003676nucleic acid binding-IEA-  
GO:0003677DNA binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005776autophagosome-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27920589DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament. (2016)Fuemmeler BFGenet Epigenet
23116464Beckwith Wiedemann imprinting defect found in leucocyte but not buccal DNA in a child born small for gestational age. (2012 Nov 1)Murphy RBMC Med Genet
23609933Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. (2013 Jul)Vidal ACInt J Obes (Lond)
29698523Urine mercury levels correlate with DNA methylation of imprinting gene H19 in the sperm of reproductive-aged men. (2018)Lu ZPLoS One
22677950Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. (2012 Jul)Liu YEpigenetics