Gene: ADA2

51816
ADGF|CECR1|IDGFL|PAN|SNEDS
adenosine deaminase 2
protein-coding
22q11.1
Ensembl:ENSG00000093072 MIM:607575 Vega:OTTHUMG00000030726 UniprotKB:Q9NZK5
NG_033943.1
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.507e-3 (AD)  4.559e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADA2 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ADA2 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of ADA2 mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ADA2 mRNA24449571
D001151ArsenicArsenic affects the methylation of ADA2 gene25304211
C118739entinostatentinostat results in decreased expression of ADA2 mRNA27188386
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ADA2 mRNA23086925
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ADA2 mRNA28001369
D009532NickelNickel results in increased expression of ADA2 mRNA25583101
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of ADA2 mRNA26272509
D015474IsotretinoinIsotretinoin results in increased expression of ADA2 mRNA20436886
D013849ThimerosalThimerosal results in decreased expression of ADA2 mRNA27188386
D014212TretinoinTretinoin results in decreased expression of ADA2 mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of ADA2 mRNA24935251|2718838
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ADA2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ADA2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ADA2 mRNA23179753|2438349
C111237vorinostatvorinostat results in decreased expression of ADA2 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004000adenosine deaminase activity-IBA21873635  
GO:0004000adenosine deaminase activity-IDA20147294  
GO:0004000adenosine deaminase activity-TAS-  
GO:0008083growth factor activity-IBA21873635  
GO:0008083growth factor activity-NAS10756095  
GO:0008201heparin binding-IEA-  
GO:0008270zinc ion binding-IDA20147294  
GO:0031685adenosine receptor binding-IDA20147294  
GO:0042803protein homodimerization activity-IPI20147294  
GO:0043394proteoglycan binding-IDA20147294  
GO ID GO Term Qualifier Evidence PubMed
GO:0006154adenosine catabolic process-IBA21873635  
GO:0006154adenosine catabolic process-IDA20147294  
GO:0007275multicellular organism development-NAS10756095  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0043103hypoxanthine salvage-IBA21873635  
GO:0043312neutrophil degranulation-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0046103inosine biosynthetic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA20147294  
GO:0005829cytosol-IBA21873635  
GO:0035578azurophil granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5683826Surfactant metabolismTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28321313Correlation study of adenosine deaminase and its isoenzymes in type 2 diabetes mellitus. (2017)Sapkota LBBMJ Open Diabetes Res Care
16128225The relation of the pleural thickening in tuberculosis pleurisy with the activity of adenosine deaminase. (2005 Jun)Uskul BMonaldi Arch Chest Dis