Gene: PER1

5187
PER|RIGUI|hPER
period circadian regulator 1
protein-coding
17p13.1
Ensembl:ENSG00000179094 MIM:602260 Vega:OTTHUMG00000178317 UniprotKB:O15534
NC_000017.11
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
11   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.490e-1 (AD)  6.571e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLXNB20.752
SAFB20.746
LTBP30.726
CLK30.726
USP360.725
NUMA10.725
GYS10.723
LRCH40.722
DVL20.721
ERF0.72

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.498
OR4F29-0.493
KLRC2-0.218
GSDMC-0.209
KRT72-0.209
GZMA-0.205
FBP2-0.205
LCE2A-0.204
RERGL-0.203
CETP-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PER1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PER1 mRNA"21354444|2890350
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of PER1 mRNA23792671
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PER1 mRNA28329830
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in increased expression of PER1 mRNA"20826375
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER1 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PER1 mRNA"21346803
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of PER1 mRNA28522335
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PER1 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of PER1 mRNA19191707
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of PER1 mRNA21882252
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of PER1 mRNA]21882252
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PER1 mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole affects the expression of PER1 mRNA"17020875
D000082AcetaminophenAcetaminophen results in increased expression of PER1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PER1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of PER1 mRNA28959563
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of PER1 mRNA19920212
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of PER1 mRNA"23195993
C103303alitretinoinalitretinoin results in increased expression of PER1 mRNA17069763
D000638AmiodaroneAmiodarone results in increased expression of PER1 mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PER1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PER1 mRNA24449571
D001151ArsenicArsenic results in decreased expression of PER1 mRNA19654921
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PER1 mRNA"18687144
D001280AtrazineAtrazine results in decreased expression of PER1 mRNA25929836
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER1 mRNA27858113
D019324beta-Naphthoflavonebeta-Naphthoflavone inhibits the reaction [CLOCK protein binds to PER1 promoter]20106950
D019324beta-Naphthoflavonebeta-Naphthoflavone inhibits the reaction [Colforsin results in increased expression of PER1 mRNA]23291558
D019324beta-Naphthoflavonebeta-Naphthoflavone promotes the reaction [AHR protein binds to PER1 promoter]20106950
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of PER1 mRNA20106950
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of PER1 protein20106950
D001564Benzo(a)pyrene[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of PER1 mRNA21882252
D001564Benzo(a)pyreneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of PER1 mRNA]21882252
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PER1 mRNA21569818|2261060
D004958EstradiolEstradiol results in increased expression of PER1 mRNA20826375
D004958EstradiolEstradiol results in increased expression of PER1 mRNA17761890
D004958EstradiolEstradiol results in increased expression of PER1 protein17761890
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of PER1 mRNA]17761890
C006780bisphenol Abisphenol A results in increased expression of PER1 mRNA20826375
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER1 mRNA"28433925
C006780bisphenol A[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PER1 promoter23359474
D002104CadmiumCadmium results in decreased expression of PER1 mRNA21694771
D019256Cadmium ChlorideCadmium Chloride affects the expression of PER123085516
D019256Cadmium ChlorideCadmium Chloride affects the expression of PER1 mRNA20107868|2144200
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PER1 mRNA17590544
D019256Cadmium ChlorideMelatonin affects the reaction [Cadmium Chloride affects the expression of PER1]23085516
D019256Cadmium ChlorideMelatonin inhibits the reaction [Cadmium Chloride affects the expression of PER1 mRNA]21442002
D019256Cadmium ChlorideMelatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER1 mRNA]17590544
D002392CatechinCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased expression of PER1 mRNA]21882252
D002737ChloropreneChloroprene results in increased expression of PER1 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PER1 mRNA27858113
D002922CiguatoxinsCiguatoxins affects the expression of PER1 mRNA18353800
D003042Cocaine[Cocaine co-treated with FOS protein mutant form] results in decreased expression of PER1 mRNA18355967
D003042CocaineCocaine promotes the reaction [NPAS2 protein binds to PER1 promoter]23776671
D003042CocaineCocaine results in increased expression of PER1 mRNA15994025|2377667
D003042CocaineCocaine results in increased expression of PER1 protein23776671
D003042CocaineCocaine affects the expression of PER1 mRNA20187946
D003042CocaineCocaine results in increased expression of PER1 mRNA27899881
D005576ColforsinAHR protein inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA]23291558
D005576Colforsinbeta-Naphthoflavone inhibits the reaction [Colforsin results in increased expression of PER1 mRNA]23291558
D005576Colforsin[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA23291558
D005576ColforsinColforsin results in increased expression of PER1 mRNA23291558
D016572CyclosporineCyclosporine results in increased expression of PER1 mRNA25562108
D003622DapsoneDapsone analog inhibits the reaction [Metribolone results in increased expression of PER1 mRNA]21440447
D003907DexamethasoneDexamethasone results in increased expression of PER1 mRNA15679045|2504701
D003907DexamethasoneDexamethasone results in increased expression of PER1 protein15679045
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PER1 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PER1 mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of PER1 mRNA22733784|2922923
D003907DexamethasoneDexamethasone results in increased expression of PER1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of PER1 mRNA]20032058
D003993Dibutyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PER1 promoter23359474
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of PER1 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PER1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PER1 mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of PER1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of PER1 mRNA25016146
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER1 mRNA"28433925
D004051Diethylhexyl Phthalate[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PER1 promoter23359474
C118739entinostatentinostat results in increased expression of PER1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PER1 mRNA"27188386
C062669epicatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER1 mRNA]29061316
C045651epigallocatechin gallate[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER1 mRNA]29061316
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of PER1 mRNA24412560
D000431EthanolPER1 protein promotes the reaction [Ethanol results in increased expression of CFD mRNA]24144995
D000431EthanolPER1 protein promotes the reaction [Ethanol results in increased expression of DGAT2 mRNA]24144995
D000431EthanolPER1 protein promotes the reaction [Ethanol results in increased expression of PPARG mRNA]24144995
D000431EthanolEthanol results in increased expression of PER1 mRNA29018328
D000431EthanolPER1 gene mutant form inhibits the reaction [Ethanol results in decreased expression of ACOX1 mRNA]24144995
D000431EthanolPER1 gene mutant form inhibits the reaction [Ethanol results in increased abundance of Triglycerides]24144995
D000431EthanolPER1 gene mutant form inhibits the reaction [Ethanol results in increased expression of CFD mRNA]24144995
D000431EthanolPER1 gene mutant form inhibits the reaction [Ethanol results in increased expression of DGAT2 mRNA]24144995
D000431EthanolPER1 gene mutant form inhibits the reaction [Ethanol results in increased expression of FASN mRNA]24144995
D000431EthanolPER1 gene mutant form inhibits the reaction [Ethanol results in increased expression of PPARG mRNA]24144995
D000431EthanolPER1 protein results in increased susceptibility to Ethanol24144995
D000431EthanolPER1 protein promotes the reaction [Ethanol results in increased abundance of Triglycerides]24144995
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PER1 mRNA17942748
D005283FentanylFentanyl results in decreased expression of PER1 mRNA15978007
D018120FinasterideFinasteride results in decreased expression of PER1 mRNA24136188
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of PER1 mRNA28329830
D005472FluorouracilFluorouracil results in decreased expression of PER1 mRNA18329632
D005473FluoxetineFluoxetine results in decreased expression of PER1 mRNA15994025
C069837fullerene C60fullerene C60 results in decreased expression of PER1 mRNA19167457
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of PER1 mRNA]17761890
D005707Gallic Acid[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER1 mRNA]29061316
C057580gallocatechol[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER1 mRNA]29061316
D006220HaloperidolHaloperidol results in increased expression of PER1 mRNA27746588
D006854HydrocortisoneHydrocortisone results in increased expression of PER1 mRNA21980503
D006861Hydrogen Peroxide[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] affects the reaction [Hydrogen Peroxide affects the expression of PER1 mRNA]29061316
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PER1 mRNA29061316
C492448ICG 001ICG 001 results in decreased expression of PER1 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PER1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PER1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PER1 mRNA16054899
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PER1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PER1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PER1 mRNA23086925
D007649KetamineKetamine results in increased expression of PER1 mRNA20080153
C008261lead acetatelead acetate results in decreased expression of PER1 mRNA21829687
C031895lead chromatelead chromate results in decreased expression of PER1 mRNA23584427
C025340manganese chloridemanganese chloride results in decreased expression of PER1 mRNA28511934
D008550MelatoninMelatonin affects the reaction [Cadmium Chloride affects the expression of PER1]23085516
D008550MelatoninMelatonin affects the reaction [Rotenone affects the expression of PER1 mRNA]25430725
D008550MelatoninMelatonin inhibits the reaction [Cadmium Chloride affects the expression of PER1 mRNA]21442002
D008550MelatoninMelatonin inhibits the reaction [Cadmium Chloride results in decreased expression of PER1 mRNA]17590544
D008694MethamphetamineMethamphetamine results in increased expression of PER1 mRNA26307267
D008694MethamphetamineMethamphetamine results in increased expression of PER1 mRNA19564919
D008727MethotrexateMethotrexate affects the expression of PER1 mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PER1 mRNA"26251327
D015741MetriboloneDapsone analog inhibits the reaction [Metribolone results in increased expression of PER1 mRNA]21440447
D015741MetriboloneMetribolone results in increased expression of PER1 mRNA21440447
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of PER1 mRNA]20096720
D015735MifepristoneMifepristone inhibits the reaction [Progesterone results in increased expression of PER1 mRNA]17761890
D009020MorphineMorphine affects the expression of PER1 mRNA19383088
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PER1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of PER1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PER1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PER1 mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PER1 mRNA19812364
D009532NickelNickel results in increased expression of PER1 mRNA23195993
D009538NicotineNicotine results in increased expression of PER1 mRNA17456735
D009638NorepinephrineNorepinephrine results in increased expression of PER1 mRNA12729908
D010126OzoneOzone results in increased expression of PER1 mRNA19555225
D010269ParaquatParaquat results in increased expression of PER1 mRNA12595580
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PER1 mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of PER1 mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of PER1 mRNA23892564
D010634PhenobarbitalPhenobarbital results in decreased expression of PER1 mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of PER1 mRNA19270015
D010656PhenylephrineU 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA]12729908
C006253pirinixic acidpirinixic acid results in decreased expression of PER1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of PER1 mRNA18445702
D011239PrednisolonePrednisolone results in increased expression of PER1 mRNA16269518
D011239PrednisolonePrednisolone results in increased expression of PER1 protein16269518
D011239PrednisolonePrednisolone results in increased expression of PER1 mRNA16269518
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of PER1 mRNA]20096720
D011374ProgesteroneProgesterone results in increased expression of PER1 mRNA18037150|2009672
D011374ProgesteroneMifepristone inhibits the reaction [Progesterone results in increased expression of PER1 mRNA]17761890
D011374ProgesteroneProgesterone results in increased expression of PER1 mRNA17761890
D011374ProgesteroneProgesterone results in increased expression of PER1 protein17761890
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PER1 mRNA16054899
D012402RotenoneMelatonin affects the reaction [Rotenone affects the expression of PER1 mRNA]25430725
D012402RotenoneRotenone affects the expression of PER1 mRNA25430725
C459379SCH 351591SCH 351591 results in increased expression of PER1 mRNA20585143
D012822Silicon DioxideSilicon Dioxide results in increased expression of PER1 mRNA19073995
C016104sodium bichromatesodium bichromate results in increased expression of PER1 mRNA17685462
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN mRNA]"26781276
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary deficiency affects the reaction [[PER2 protein co-treated with PER1 protein co-treated with PER3 protein] affects the expression of REN protein]"26781276
D012999SomanSoman results in increased expression of PER1 mRNA19281266
D053260SootSoot results in increased expression of PER1 mRNA26551751
D013467SulindacSulindac results in decreased expression of PER1 mRNA24136188
D013629TamoxifenTamoxifen affects the expression of PER1 mRNA20937368
D013629TamoxifenTamoxifen results in increased expression of PER1 mRNA25123088
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of PER1 mRNA]20032058
D013749TetrachlorodibenzodioxinPER1 affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]20371273
D013749TetrachlorodibenzodioxinPER1 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]19038280
D013749TetrachlorodibenzodioxinPER1 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]19038280
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PER1 mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PER1 mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PER1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PER1 mRNA16556773|2010695
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PER1 protein20106950
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PER1 mRNA23871856
D013755Tetradecanoylphorbol AcetateAHR protein inhibits the reaction [[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA]23291558
D013755Tetradecanoylphorbol Acetate[Colforsin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PER1 mRNA23291558
D019284ThapsigarginThapsigargin results in increased expression of PER1 mRNA21694771
D019284ThapsigarginThapsigargin results in increased expression of PER1 mRNA12729908
C009495titanium dioxidetitanium dioxide results in increased expression of PER1 mRNA23409001|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PER1 mRNA20133372
D014212TretinoinTretinoin results in increased expression of PER1 mRNA17069763
C012589trichostatin Atrichostatin A results in increased expression of PER1 mRNA15901671
D014280TriglyceridesPER1 gene mutant form inhibits the reaction [Ethanol results in increased abundance of Triglycerides]24144995
D014280TriglyceridesPER1 protein promotes the reaction [Ethanol results in increased abundance of Triglycerides]24144995
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PER1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PER1 mRNA29024780
C010809tulobuteroltulobuterol results in increased expression of PER1 mRNA17364588
C113580U 0126U 0126 inhibits the reaction [Phenylephrine results in increased expression of PER1 mRNA]12729908
D014520UrethaneUrethane results in increased expression of PER1 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of PER1 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of PER1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of PER1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of PER1 mRNA17963808
D014635Valproic AcidValproic Acid results in increased expression of PER1 mRNA15799026|2922923
D014635Valproic AcidValproic Acid results in increased expression of PER1 mRNA15901671
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PER1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PER1 mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical promotes the reaction [LEP gene mutant form results in increased expression of PER1 mRNA]"24525044
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of PER1 mRNA"24525044
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PER1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000976transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA18411297  
GO:0000989transcription factor activity, transcription factor binding-IBA21873635  
GO:0001222transcription corepressor binding-IBA21873635  
GO:0005515protein binding-IPI23503662  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-IEA-  
GO:0019900kinase binding-IPI15917222  
GO:0031490chromatin DNA binding-ISS-  
GO:0031625ubiquitin protein ligase binding-IPI15917222  
GO:0070888E-box binding-IDA18411297  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0002028regulation of sodium ion transport-ISS-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007623circadian rhythm-IEP14645221  
GO:0009416response to light stimulus-IBA21873635  
GO:0009649entrainment of circadian clock-TAS9323128  
GO:0010608posttranscriptional regulation of gene expression-ISS-  
GO:0032922circadian regulation of gene expression-IBA21873635  
GO:0032922circadian regulation of gene expression-IDA18411297  24005054  
GO:0042634regulation of hair cycle-IMP24005054  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling-ISS-  
GO:0043153entrainment of circadian clock by photoperiod-IBA21873635  
GO:0043153entrainment of circadian clock by photoperiod-ISS-  
GO:0043966histone H3 acetylation-IDA14645221  
GO:0043967histone H4 acetylation-IDA14645221  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046329negative regulation of JNK cascade-ISS-  
GO:0051591response to cAMP-IEA-  
GO:0070932histone H3 deacetylation-ISS-  
GO:0097167circadian regulation of translation-ISS-  
GO:1900015regulation of cytokine production involved in inflammatory response-ISS-  
GO:1900744regulation of p38MAPK cascade-ISS-  
GO:2000323negative regulation of glucocorticoid receptor signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA24005054  
GO:0005829cytosol-IDA-  
KEGG ID KEGG Term
hsa04710Circadian rhythm
Reactome ID Reactome Term Evidence
R-HSA-400253Circadian ClockIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26512752Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV. (2015)Lee KAChronobiol Int
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One
27070740The effect of chronic morphine or methadone exposure and withdrawal on clock gene expression in the rat suprachiasmatic nucleus and AA-NAT activity in the pineal gland. (2016 Jul 18)Pacesova DPhysiol Res
25677407Clock genes in human alcohol abuse and comorbid conditions. (2015 Jun)Partonen TAlcohol
29144171Circadian gene methylation in rotating-shift nurses: a cross-sectional study. (2018 Jan)Reszka EChronobiol Int
26842248Chronic Alcohol Consumption in Rats Leads to Desynchrony in Diurnal Rhythms and Molecular Clocks. (2016 Feb)Guo RAlcohol Clin Exp Res
17992597Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction. (2007 Aug)Esquifino AIEndocrine
17106427Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia. (2006 Dec)Malison RTPsychiatr Genet
20205566Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men. (2010 Jan)Ando HChronobiol Int
21828288Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking. (2011 Oct)Dong LAm J Psychiatry
22832735A promoter polymorphism in the Per3 gene is associated with alcohol and stress response. (2012 Jan 31)Wang XTransl Psychiatry