Gene: PEX1

5189
HMLR1|PBD1A|PBD1B|ZWS|ZWS1
peroxisomal biogenesis factor 1
protein-coding
7q21.2
Ensembl:ENSG00000127980 MIM:602136 Vega:OTTHUMG00000023926 UniprotKB:O43933
NG_008341.1
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.316e-1 (AD)  7.742e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7809455chr7:92506759 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs3213609chr7:92501715 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6944759chr7:92486787 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RCOR30.923
NHLRC30.916
MON20.913
MED140.911
IBTK0.91
CREBZF0.907
KLHDC10.901
ZNF280D0.9
WDR110.9
SLC11A20.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.474
OR4F29-0.452
MTRNR2L6-0.423
MTRNR2L9-0.418
MTRNR2L10-0.411
MTRNR2L8-0.356
MTRNR2L2-0.352
FOXJ1-0.323
OR4F16-0.32
CCDC102A-0.32

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of PEX1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of PEX1 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of PEX1 mRNA19420014
D000638AmiodaroneAmiodarone results in increased expression of PEX1 mRNA24489787
D001280AtrazineAtrazine results in decreased expression of PEX1 mRNA22378314
D002922CiguatoxinsCiguatoxins affects the expression of PEX1 mRNA18353800
D002994ClofibrateClofibrate results in increased expression of PEX1 mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of PEX1 mRNA19549813
C000944dicrotophosdicrotophos results in decreased expression of PEX1 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PEX1 mRNA17555576
D017313FenretinideFenretinide results in increased expression of PEX1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PEX1 mRNA20044591
D008094LithiumLithium results in increased expression of PEX1 mRNA19949822
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PEX1 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PEX1 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of PEX1 promoter"26251327
D008777MethyltestosteroneMethyltestosterone results in decreased expression of PEX1 mRNA29191790
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of PEX1 mRNA22401849
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PEX1 mRNA19429403|2093613
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PEX1 mRNA19429403
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PEX1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PEX1 mRNA18301758|2381119
C006253pirinixic acidpirinixic acid results in increased expression of PEX1 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of PEX1 mRNA23018184
D012643SeleniumSelenium results in decreased expression of PEX1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PEX1 mRNA25351596
D012969Sodium FluorideSodium Fluoride results in increased expression of PEX1 protein28918527
D012999SomanSoman results in decreased expression of PEX1 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of PEX1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PEX1 mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PEX1 mRNA26232522
C012589trichostatin Atrichostatin A affects the expression of PEX1 mRNA28542535
D014635Valproic AcidValproic Acid results in increased expression of PEX1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of PEX1 mRNA24489787
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PEX1 gene25560391
D014810Vitamin EVitamin E results in decreased expression of PEX1 mRNA19244175
D015032ZincZinc deficiency results in increased expression of PEX1 mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI9588209  16257970  
GO:0005524ATP binding-IMP16854980  
GO:0008022protein C-terminus binding-IPI16854980  
GO:0016887ATPase activity-IBA21873635  
GO:0042623ATPase activity, coupled-IMP16854980  
GO:0044877protein-containing complex binding-IDA16854980  
GO ID GO Term Qualifier Evidence PubMed
GO:0006625protein targeting to peroxisome-IMP11439091  16854980  
GO:0006625protein targeting to peroxisome-TAS-  
GO:0007031peroxisome organization-IBA21873635  
GO:0007031peroxisome organization-IMP11439091  
GO:0016558protein import into peroxisome matrix-IBA21873635  
GO:0016558protein import into peroxisome matrix-IMP9398847  
GO:0060152microtubule-based peroxisome localization-IMP16449325  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA9588209  
GO:0005777peroxisome-IDA16854980  
GO:0005778peroxisomal membrane-HDA21525035  
GO:0005778peroxisomal membrane-IBA21873635  
GO:0005778peroxisomal membrane-IDA11439091  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA16854980  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA18570454  
KEGG ID KEGG Term
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-9033241Peroxisomal protein importTAS
R-HSA-9033241Peroxisomal protein importIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal