Gene: PF4

5196
CXCL4|PF-4|SCYB4
platelet factor 4
protein-coding
4q13.3
Ensembl:ENSG00000163737 MIM:173460 Vega:OTTHUMG00000130009 UniprotKB:P02776
NG_032897.1
PubMed
0   ANCO-SNPs
ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.629e-1 (AD)  5.973e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
H3F3C0.626
MROH90.601
GPR180.586
MTRNR2L100.585
OR51I20.583
MTRNR2L30.582
CEACAM60.582
CXCR30.568
TRPV40.568
IRGM0.566

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.44
CDT1-0.419
HDDC3-0.418
F7-0.412
LRRC45-0.411
HAS1-0.409
TMEM221-0.407
EXTL1-0.404
CYS1-0.402
C3orf18-0.399

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00055Drotrecogin alfaBiotechDrug98530-76-8Approved|Investigational|WithdrawnTarget
DB01109HeparinSmall Molecule9005-49-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PF4 mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of PF4 mRNA]"22698814
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PF4 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PF4 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of PF4 mRNA17562736
D000171AcroleinAcrolein results in increased expression of PF4 protein20678513
D020106AcrylamideAcrylamide results in decreased expression of PF4 mRNA28959563
D000244Adenosine DiphosphateAdenosine Diphosphate results in increased secretion of PF4 protein19428933
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PF4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PF4 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PF4 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PF4 mRNA24449571
D001104ArbutinArbutin results in decreased expression of PF4 mRNA17103032
D001151ArsenicArsenic affects the expression of PF4 protein24675094
D001241AspirinAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PF4 protein]17303692
D001554BenzeneBenzene affects the expression of PF4 mRNA17119257
D001554BenzeneBenzene results in decreased expression of PF4 mRNA15929907
D001554BenzeneBenzene results in decreased expression of PF4 protein16286641
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PF4 mRNA18164116
D019817Benzoic AcidBenzoic Acid analog inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased secretion of PF4 protein]22273509
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PF4 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PF4 mRNA21839799
C095105bexarotenebexarotene results in increased expression of PF4 mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of PF4 mRNA26911702
C006780bisphenol Abisphenol A affects the expression of PF4 mRNA25181051
C006794brevianamide Abrevianamide A results in increased expression of PF4 mRNA19818335
C117446cangrelorcangrelor inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased secretion of PF4 protein]22273509
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PF4 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PF4 mRNA16239168
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of PF4 mRNA19395590
D020111Chlorodiphenyl (54% Chlorine)[Chlorodiphenyl (54% Chlorine) co-treated with Tetrachlorodibenzodioxin] results in increased expression of PF424582691
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of PF4 mRNA23650126
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PF4 mRNA20938992
D003035CobaltTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA]23503329
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA23503329
D003042CocaineCocaine results in increased expression of PF4 protein10814631
D003436Croton OilCroton Oil results in increased expression of PF4 mRNA19647056
C038459curdlancurdlan affects the expression of PF4 mRNA19904525
D003907DexamethasoneDexamethasone results in increased expression of PF4 mRNA21041162
D003907DexamethasoneTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA]23503329
D003907Dexamethasone[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA23503329
D003994Bucladesine[Bucladesine co-treated with Tetrachlorodibenzodioxin] results in increased expression of PF4 mRNA21979172
D003994BucladesineBucladesine results in increased expression of PF4 mRNA21979172
D002945CisplatinCisplatin results in decreased expression of PF4 mRNA22023808
D004041Dietary FatsDietary Fats results in decreased expression of PF4 mRNA18042831
C058705diethyl malatediethyl malate affects the expression of PF4 mRNA24814887
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PF4 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PF4 mRNA21041162
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of PF4 mRNA"27840820
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of PF4 mRNA19647056
D004317DoxorubicinDoxorubicin results in decreased expression of PF4 mRNA25896364
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of PF4 mRNA21040762
C118739entinostatentinostat results in decreased expression of PF4 mRNA27188386
C004912ethylbenzeneethylbenzene results in decreased expression of PF4 mRNA20955722
D005485FlutamideFlutamide results in decreased expression of PF4 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PF4 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of PF4 mRNA19167457
C039281furanfuran results in decreased expression of PF4 mRNA26194646
D005665FurosemideFurosemide results in decreased expression of PF4 mRNA16526316
D006118GriseofulvinGriseofulvin affects the expression of PF4 mRNA12735108
D006493HeparinHeparin binds to PF4 protein20162249|8282825
D006493Heparin[Heparin binds to PF4 protein] which binds to FCGR2A protein8282825
D006493HeparinHeparin results in increased secretion of PF4 protein2437338|2709525
D006493HeparinHeparin binds to PF4 protein10073268|7923645
D017313FenretinideFenretinide results in decreased expression of PF4 mRNA28973697
D0150561-Methyl-3-isobutylxanthineTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA]23503329
D0150561-Methyl-3-isobutylxanthine[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA23503329
C018086isobutyl nitriteisobutyl nitrite results in increased expression of PF4 mRNA16288974
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PF4 mRNA15788441
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PF4 protein15788441
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Melatonin] results in increased expression of PF4 mRNA21461237
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PF4 mRNA21979172
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PF4 mRNA26378955
D008550Melatonin[Lipopolysaccharides co-treated with Melatonin] results in increased expression of PF4 mRNA21461237
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PF4 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of PF4 mRNA17400583
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PF4 mRNA"25926378
D008752Methylene ChlorideMethylene Chloride results in decreased expression of PF4 mRNA20955722
D015735MifepristoneMifepristone results in decreased expression of PF4 mRNA25972201
C523799MRK 003PF4 results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of PF4 mRNA18988085
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of PF4 mRNA"25926378
C031721naphthalenenaphthalene results in increased expression of PF4 mRNA18978301
C490266neoechinulin Aneoechinulin A results in increased expression of PF4 mRNA19818335
D009532NickelTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA]23503329
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA23503329
D009661NortriptylineNortriptyline affects the expression of PF4 protein10770450
D010081OxazoloneOxazolone results in increased expression of PF4 mRNA19647056
D000073878Palm OilPalm Oil results in decreased expression of PF4 mRNA18042831
D017374ParoxetineParoxetine results in decreased expression of PF4 protein10770450
D017035PravastatinPravastatin results in decreased expression of PF4 mRNA27225895
D017035PravastatinPravastatin results in decreased expression of PF4 mRNA27225895
D011285Pregnenolone CarbonitrileNR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of PF4 mRNA]22698814
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PF4 mRNA22698814
D011374ProgesteroneProgesterone results in increased expression of PF4 mRNA19690047
C059514resveratrolresveratrol results in decreased expression of PF4 mRNA19228061
D020280SertralineSertraline results in decreased expression of PF4 protein15932816
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PF4 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of PF4 mRNA22431001
C017947sodium arsenitesodium arsenite results in increased expression of PF4 mRNA21911445
D012999SomanSoman results in increased expression of PF4 mRNA19281266
D013241SterigmatocystinSterigmatocystin results in increased expression of PF4 mRNA19818335
C024075styrofoamstyrofoam analog results in increased secretion of PF4 protein19428933
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PF4 mRNA26378955
D013749Tetrachlorodibenzodioxin[Bucladesine co-treated with Tetrachlorodibenzodioxin] results in increased expression of PF4 mRNA21979172
D013749Tetrachlorodibenzodioxin[Chlorodiphenyl (54% Chlorine) co-treated with Tetrachlorodibenzodioxin] results in increased expression of PF424582691
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TNF protein] affects the expression of PF4 mRNA21979172
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PF4 mRNA21041162|2197917
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PF4 mRNA11752688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PF4 mRNA20059583|2095900
C096900thrombin receptor-activating peptide SFLLRNPNDKYAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PF4 protein]17303692
C096900thrombin receptor-activating peptide SFLLRNPNDKYBenzoic Acid analog inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased secretion of PF4 protein]22273509
C096900thrombin receptor-activating peptide SFLLRNPNDKYcangrelor inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY results in increased secretion of PF4 protein]22273509
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PF4 protein17303692
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY results in increased secretion of PF4 protein22273509
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of PF4 mRNA24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PF4 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PF4 protein20678513
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of PF4 mRNA"19647056
D014118Toxins, Biological"Toxins, Biological affects the expression of PF4 mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PF4 mRNA20955722
C057693troglitazonetroglitazone results in increased expression of PF4 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PF4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PF4 mRNA24383497|2493525
D014700VerapamilVerapamil results in decreased expression of PF4 protein2962587
C025643vinclozolinvinclozolin affects the expression of PF4 mRNA19015723
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of PF4 mRNA20370541
D015032ZincTNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA]23503329
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PF4 mRNA23503329

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19805618  
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-TAS12466273  
GO:0008201heparin binding-IDA9531587  
GO:0045236CXCR chemokine receptor binding-IBA21873635  
GO:0048248CXCR3 chemokine receptor binding-IDA12782716  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010628positive regulation of gene expression-IDA10666185  
GO:0010744positive regulation of macrophage derived foam cell differentiation-IDA17244792  
GO:0016525negative regulation of angiogenesis-IDA1688470  
GO:0019221cytokine-mediated signaling pathway-IDA12041672  
GO:0030168platelet activation-IDA11685038  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0030595leukocyte chemotaxis-IBA21873635  
GO:0030595leukocyte chemotaxis-IDA6945600  
GO:0032760positive regulation of tumor necrosis factor production-IDA10666185  
GO:0042127regulation of cell proliferation-IDA12782716  
GO:0042832defense response to protozoan-IDA23245326  
GO:0043950positive regulation of cAMP-mediated signaling-IDA12782716  
GO:0045347negative regulation of MHC class II biosynthetic process-IDA10666185  
GO:0045651positive regulation of macrophage differentiation-IDA10666185  
GO:0045652regulation of megakaryocyte differentiation-TAS-  
GO:0045653negative regulation of megakaryocyte differentiation-IDA2140694  
GO:0045918negative regulation of cytolysis-IDA10666185  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA12782716  
GO:0051873killing by host of symbiont cells-IDA23245326  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IBA21873635  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IDA23245326  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0071222cellular response to lipopolysaccharide-IBA21873635  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IDA10666185  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IDA23245326  
GO:0020005symbiont-containing vacuole membrane-IDA23245326  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0097679other organism cytoplasm-IDA23245326  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-162582Signal TransductionTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20034674Depression and platelet activation in outpatients with stable coronary heart disease: findings from the Heart and Soul Study. (2010 Feb 28)Gehi APsychiatry Res
21198559Circulating endothelial-coagulative activation markers after smoking cessation: a 12-month observational study. (2011 Jun)Caponnetto PEur J Clin Invest
1493667[Atherosclerosis: the risk factors]. (1992 Dec)Buschini MClin Ter
6602306[Evaluation of platelet function and coagulation in deafness and sudden vestibular disorders]. (1983 May 31)Calabrese SMinerva Med
2523551[Usefulness of several laboratory tests on prethrombotic status in arterial vascular pathology]. (1989 Jan)Arosio ERecenti Prog Med
17325440Absent post-ischemic increase of blood flowmotion in the cutaneous microcirculation of healthy chronic cigarette smokers. (2007)Rossi MClin Hemorheol Microcirc
2937746Ketanserin (S2-receptor blocking agent), platelet activity and chronic alcoholism. (1986)Santini PInt J Clin Pharmacol Res
26198856Anti-platelet factor 4/heparin antibody is associated with progression of peripheral arterial disease in hemodialysis patients. (2015 Sep)Chen YHInt Urol Nephrol