Gene: PFAS

5198
FGAMS|FGAR-AT|FGARAT|GATD8|PURL
phosphoribosylformylglycinamidine synthase
protein-coding
17p13.1
Ensembl:ENSG00000178921 MIM:602133 Vega:OTTHUMG00000108188 UniprotKB:O15067
NC_000017.11
PubMed
0   ANCO-SNPs
ND
2   
3.693e-1 (AD)  4.814e-3 (ND)   (Frontal_Cortex)
4.853e-1 (AD)  2.307e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF1230.928
HIF1AN0.927
MTOR0.923
MAP3K120.92
STRIP10.917
HECTD40.917
KDM2B0.913
GGA30.912
NICN10.91
DEPDC50.909

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.456
COPZ2-0.447
OR4F5-0.442
YES1-0.434
RAB13-0.429
MYL3-0.411
OR4F29-0.394
MTRNR2L6-0.392
ROM1-0.39
GNG11-0.39

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
DB00130L-GlutamineSmall Molecule56-85-9Approved|Investigational|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0293704-toluidine4-toluidine results in increased expression of PFAS mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of PFAS mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PFAS gene27153756
D001151ArsenicArsenic affects the methylation of PFAS gene25304211
C006632arsenic trioxide[arsenic trioxide co-treated with Ascorbic Acid] results in increased expression of PFAS mRNA25555879
C006632arsenic trioxidearsenic trioxide results in increased expression of PFAS mRNA25555879
D001205Ascorbic Acid[arsenic trioxide co-treated with Ascorbic Acid] results in increased expression of PFAS mRNA25555879
D001205Ascorbic AcidAscorbic Acid results in increased expression of PFAS mRNA25555879
D001280AtrazineAtrazine results in decreased expression of PFAS mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PFAS mRNA20064835
D004958EstradiolEstradiol results in increased expression of PFAS mRNA23019147
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of PFAS mRNA17404688
C006780bisphenol Abisphenol A results in decreased expression of PFAS mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PFAS mRNA25181051
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of PFAS protein23736079
C018021cobaltous chloridecobaltous chloride results in decreased expression of PFAS mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PFAS mRNA20971185
D016572CyclosporineCyclosporine results in decreased expression of PFAS mRNA25562108
C014347decitabinedecitabine affects the expression of PFAS mRNA23300844
D003703DemecolcineDemecolcine results in decreased expression of PFAS mRNA23649840
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PFAS mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PFAS mRNA17361019|2126653
D002945CisplatinCisplatin affects the expression of PFAS mRNA23300844
D002945CisplatinCisplatin results in decreased expression of PFAS mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of PFAS mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of PFAS mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of PFAS mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PFAS mRNA21592394
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PFAS protein23301498
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PFAS mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of PFAS mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of PFAS mRNA19167457
C039281furanfuran results in decreased expression of PFAS mRNA25539665
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PFAS mRNA25613284
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PFAS mRNA"24972896
D008727MethotrexatePFAS gene mutant form affects the susceptibility to Methotrexate19426680
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PFAS mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PFAS mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PFAS mRNA23649840
D009151Mustard GasMustard Gas results in decreased expression of PFAS mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PFAS mRNA"25554681
C022838nickel chloridenickel chloride results in decreased expression of PFAS mRNA17312168
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PFAS mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PFAS mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of PFAS mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of PFAS mRNA26516004
D052638Particulate MatterParticulate Matter results in increased expression of PFAS mRNA24769257
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PFAS mRNA22714537
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of PFAS mRNA17404688
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PFAS mRNA25895662
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PFAS mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PFAS mRNA21592394
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PFAS mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of PFAS mRNA22378314
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PFAS mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PFAS mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PFAS mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of PFAS mRNA22378314
D014520UrethaneUrethane results in decreased expression of PFAS mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of PFAS mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of PFAS mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PFAS gene25560391
D014750VincristineVincristine results in decreased expression of PFAS mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004642phosphoribosylformylglycinamidine synthase activity-IDA10548741  
GO:0004642phosphoribosylformylglycinamidine synthase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006189'de novo' IMP biosynthetic process-IEA-  
GO:0006189'de novo' IMP biosynthetic process-NAS10548741  
GO:0006541glutamine metabolic process-IEA-  
GO:0009168purine ribonucleoside monophosphate biosynthetic process-TAS-  
GO:0042493response to drug-IEA-  
GO:0097065anterior head development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-15869Metabolism of nucleotidesTAS
R-HSA-73817Purine ribonucleoside monophosphate biosynthesisTAS
R-HSA-8956320Nucleobase biosynthesisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25638654Concentration and correlations of perfluoroalkyl substances in whole blood among subjects from three different geographical areas in Korea. (2015 Apr 15)Cho CRSci Total Environ
29754000Changes in markers of liver function in relation to changes in perfluoroalkyl substances - A longitudinal study. (2018 May 10)Salihovic SEnviron Int