Gene: CFP

5199
BFD|PFC|PFD|PROPERDIN
complement factor properdin
protein-coding
Xp11.23
Ensembl:ENSG00000126759 MIM:300383 Vega:OTTHUMG00000021451 UniprotKB:P27918
NG_009893.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LY6G5B0.733
AKR7L0.699
HPX0.679
CCDC840.678
PRR220.651
NPEPL10.646
FBXL60.638
MYL50.637
MBD60.617
ZNF5960.613

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BTBD8-0.272
CRYBG3-0.265
OR4F5-0.255
ZBED6-0.246
OR4F29-0.245
DLEU1-0.244
AKAP14-0.24
KLRG1-0.237
FAM19A4-0.233
TSPAN19-0.229

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of CFP mRNA"19162173
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of CFP mRNA"27291303
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of CFP mRNA"21920950
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CFP mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of CFP mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of CFP gene27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CFP mRNA28522335
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CFP mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CFP mRNA24449571
D001152ArsenicalsArsenicals results in increased expression of CFP mRNA28625800
D001280AtrazineAtrazine results in decreased expression of CFP mRNA22982499
D001554BenzeneBenzene results in increased expression of CFP mRNA15120971|1512265
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CFP mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CFP mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CFP mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of CFP gene25435355
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CFP mRNA]22228805
D004958EstradiolEstradiol results in increased expression of CFP mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of CFP mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of CFP mRNA27104808
C006780bisphenol Abisphenol A results in decreased expression of CFP mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CFP mRNA27339419
C026690cerous chloridecerous chloride results in increased expression of CFP mRNA23573234
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CFP mRNA18178546
D019327Copper SulfateCopper Sulfate results in increased expression of CFP mRNA19549813
C526360dechlorane plusdechlorane plus results in increased expression of CFP mRNA22913625
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of CFP mRNA27392435
D002945CisplatinCisplatin results in decreased expression of CFP mRNA27392435
D002945CisplatinCisplatin results in increased expression of CFP mRNA27594783
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in increased expression of CFP mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of CFP mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of CFP mRNA15238619|2260994
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CFP mRNA25380136
C024629dimethyl phthalatedimethyl phthalate results in increased expression of CFP mRNA26924002
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CFP mRNA12072388
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CFP mRNA15576828|1755790
D005485FlutamideFlutamide results in decreased expression of CFP mRNA24136188
C056933fumonisin B1fumonisin B1 results in increased expression of CFP mRNA16221962
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CFP mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of CFP mRNA27392435
C544151jinfukangjinfukang results in decreased expression of CFP mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of CFP mRNA27432991
C008261lead acetatelead acetate results in increased expression of CFP mRNA20542052
D008070LipopolysaccharidesCFP gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of C3 protein]17916747
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CFP mRNA27339419
C517284monomethyl phthalatemonomethyl phthalate results in increased expression of CFP mRNA26924002
C523799MRK 003CFP results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CFP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CFP mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CFP mRNA"27106021
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of CFP mRNA25380136
D009532NickelNickel results in increased expression of CFP mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of CFP mRNA19167457
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CFP mRNA"19013360
D000073878Palm OilPalm Oil results in decreased expression of CFP mRNA18042831
D010578PetroleumPetroleum affects the expression of CFP mRNA25208076
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of CFP mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of CFP mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of CFP mRNA23811191
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of CFP mRNA25905778
C059514resveratrolresveratrol results in increased expression of CFP mRNA23419489
D012822Silicon DioxideSilicon Dioxide results in decreased expression of CFP mRNA23221170
C009277sodium arsenatesodium arsenate results in decreased expression of CFP mRNA23922661
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of CFP mRNA25905778
C016766sulforafansulforafan results in increased expression of CFP mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CFP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CFP mRNA15652763
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CFP mRNA16267337
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CFP mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of CFP mRNA24675092
C009495titanium dioxidetitanium dioxide results in increased expression of CFP mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CFP mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CFP mRNA20133372
C057693troglitazonetroglitazone results in increased expression of CFP mRNA28973697
D014635Valproic AcidValproic Acid results in increased methylation of CFP gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of CFP gene25560391
C025643vinclozolinvinclozolin results in increased expression of CFP mRNA23034163
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of CFP mRNA"25208076

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI28480349  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006955immune response-TAS8530058  
GO:0006956complement activation-TAS-  
GO:0006957complement activation, alternative pathway-TAS-  
GO:0030449regulation of complement activation-TAS-  
GO:0042742defense response to bacterium-TAS8530058  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-TAS8530058  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0035580specific granule lumen-TAS-  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:1904724tertiary granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-166658Complement cascadeTAS
R-HSA-166663Initial triggering of complementTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-173736Alternative complement activationTAS
R-HSA-174577Activation of C3 and C5TAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-3906995Diseases associated with O-glycosylation of proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-5083635Defective B3GALTL causes Peters-plus syndrome (PpS)TAS
R-HSA-5173105O-linked glycosylationTAS
R-HSA-5173214O-glycosylation of TSR domain-containing proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26998717Reticular Pseudodrusen in Intermediate Age-Related Macular Degeneration: Prevalence, Detection, Clinical, Environmental, and Genetic Associations. (2016 Mar)Wu ZInvest Ophthalmol Vis Sci
28492733Simultaneous Determination of Furan and Vinyl Acetate in Vapor Phase of Mainstream Cigarette Smoke by GC-MS. (2017 May)Xu AAn Acad Bras Cienc
20351960Performance of QuantiFERON-TB Gold test compared to tuberculin skin test in detecting latent tuberculosis infection in HIV- positive individuals in Iran. (2010 Jan)Mardani MAnn Thorac Med
26521141Roflumilast partially reverses smoke-induced mucociliary dysfunction. (2015 Oct 31)Schmid ARespir Res