Gene: ACP1

52
HAAP|LMW-PTP|LMWPTP
acid phosphatase 1
protein-coding
2p25.3
Ensembl:ENSG00000143727 MIM:171500 Vega:OTTHUMG00000086933 UniprotKB:P24666
NG_012035.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.042e-1 (AD)  8.668e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACTR100.971
ZC3H150.97
RAB6A0.967
RAB11A0.967
RAB2A0.967
SUB10.966
UBE2N0.965
YWHAZ0.964
NDFIP10.962
DSTN0.962

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.684
OR4F29-0.656
MTRNR2L6-0.361
CSAG1-0.357
MTRNR2L10-0.35
MTRNR2L9-0.35
MAGEA12-0.341
CXCR2-0.324
VNN3-0.314
S100A12-0.3

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00173AdenineSmall Molecule73-24-5Approved|NutraceuticalTarget
DB042144-Nitrophenyl PhosphateSmall Molecule330-13-2ExperimentalTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ACP1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ACP1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ACP1 mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ACP1 mRNA"18648102
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ACP1 mRNA"19561079
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ACP1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACP1 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ACP1 mRNA27153756
D000616AminoglutethimideAminoglutethimide results in decreased expression of ACP1 protein26102013
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ACP1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of ACP1 mRNA24449571
D019817Benzoic AcidBenzoic Acid analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate]24287560
D019817Benzoic AcidBenzoic Acid analog results in decreased activity of ACP1 protein24287560
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to ACP1 promoter]19654925
C006780bisphenol Abisphenol A affects the expression of ACP1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ACP1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of ACP1 mRNA26079696
D002104CadmiumCadmium results in increased expression of ACP1 mRNA17327700
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ACP1 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ACP1 mRNA17327700
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ACP1 mRNA23650126
C100187chloropicrinchloropicrin results in decreased expression of ACP1 mRNA26352163|2847649
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ACP1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of ACP1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACP1 mRNA]17585979
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ACP1 mRNA17361019|2126653
C000944dicrotophosdicrotophos results in decreased expression of ACP1 mRNA28302478
D004178DiquatDiquat affects the expression of ACP1 mRNA22814884
D004317DoxorubicinACP1 protein affects the susceptibility to Doxorubicin16217747
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ACP1 mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACP1 mRNA17942748
C082360fipronilfipronil results in increased expression of ACP1 mRNA23962444
D005485FlutamideFlutamide results in increased expression of ACP1 mRNA24136188
D006046GoldGold results in decreased expression of ACP1 mRNA25523186
D017313FenretinideFenretinide results in decreased expression of ACP1 mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of ACP1 mRNA28201806
D007608Kainic AcidKainic Acid results in decreased expression of ACP1 mRNA17997037
D007854LeadLead affects the splicing of ACP1 mRNA28903495
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ACP1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ACP1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ACP1 mRNA19812364
C051752nefazodonenefazodone results in increased expression of ACP1 mRNA24136188
D009532NickelNickel results in increased expression of ACP1 mRNA24768652|2558310
D009538NicotineNicotine results in decreased expression of ACP1 mRNA17997037
C008644nitrophenylphosphateACP1 protein results in increased hydrolysis of nitrophenylphosphate24287560
C008644nitrophenylphosphateBenzoic Acid analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate]24287560
C008644nitrophenylphosphateThiazolidines analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate]24287560
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ACP1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of ACP1 mRNA25729387
D010269ParaquatParaquat results in decreased expression of ACP1 mRNA15458575
C046012pentanalpentanal results in decreased expression of ACP1 mRNA26079696
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of ACP1 protein19854247
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ACP1 protein22609092
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ACP1 mRNA18804290
C502851quinocetonequinocetone results in decreased expression of ACP1 protein27046791
C059514resveratrolresveratrol results in increased expression of ACP1 protein25505154
D012643SeleniumSelenium results in decreased expression of ACP1 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of ACP1 mRNA20308225
D012969Sodium FluorideSodium Fluoride results in decreased expression of ACP1 protein28918527
D012977Sodium NitriteSodium Nitrite results in increased activity of ACP1 protein26231821
D013629TamoxifenTamoxifen affects the expression of ACP1 mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ACP1 mRNA17942748
D053778ThiazolidinesThiazolidines analog inhibits the reaction [ACP1 protein results in increased hydrolysis of nitrophenylphosphate]24287560
D053778ThiazolidinesThiazolidines analog results in decreased activity of ACP1 protein24287560
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ACP1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ACP1 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of ACP1 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in increased expression of ACP1 mRNA19448997
D014415TunicamycinTunicamycin results in increased expression of ACP1 mRNA15458575
D014635Valproic AcidValproic Acid affects the expression of ACP1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of ACP1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of ACP1 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ACP1 gene25560391
D014747VinblastineACP1 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin results in increased expression of ACP1 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of ACP1 mRNA19244175
C111237vorinostatvorinostat results in increased expression of ACP1 protein20543569

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003993acid phosphatase activity-IEA-  
GO:0004726non-membrane spanning protein tyrosine phosphatase activity-IEA-  
GO:0005515protein binding-IPI9499402  15846844  25556234  
GO ID GO Term Qualifier Evidence PubMed
GO:0035335peptidyl-tyrosine dephosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA10940933  
GO:0005829cytosol-IEA-  
GO:0009898cytoplasmic side of plasma membrane-IDA10940933  
GO:0042383sarcolemma-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00740Riboflavin metabolism
hsa04520Adherens junction
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12495297Smoking and the genetics of signal transduction: an association study on retinopathy in type 1 diabetes. (2002 Dec)Magrini AAm J Med Sci
15359537Maternal cigarette smoking, metabolic enzyme polymorphism, and developmental events in the early stages of extrauterine life. (2004 Apr)Bottini NHum Biol
15368606Genetics of signal transduction and the effect of maternal smoking on sex ratio of offspring. (2004 Sep-Oct)Bottini NAm J Hum Biol
16973312ACP1 and offspring sex ratio in smoking puerperae: a study at population level. (2007 Jun)Gloria-Bottini FEarly Hum Dev
11369750The genetics of signal transduction and the effect of smoking on intrauterine growth. (2001 Apr)Bottini EInt J Epidemiol