Gene: PFKFB2

5208
PFK-2/FBPase-2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
protein-coding
1q32.1
Ensembl:ENSG00000123836 MIM:171835 Vega:OTTHUMG00000036033 UniprotKB:O60825
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.319e-1 (AD)  1.445e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12088135chr1:207079566 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FKBP90.725
VWCE0.683
NAV20.681
HEXA0.679
PCCB0.677
RETSAT0.677
OGFRL10.662
HMGCS10.662
ASAH10.661
SC5D0.66

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.458
OR4F29-0.429
MIA-0.332
CELSR1-0.294
RAX2-0.289
EPPIN-0.282
C7orf61-0.28
NANOS2-0.273
HIST1H1T-0.271
S100A7-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0212962-ethoxyethanol2-ethoxyethanol results in increased expression of PFKFB2 mRNA19643169
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PFKFB2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PFKFB2 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PFKFB2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PFKFB2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PFKFB2 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PFKFB2 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of PFKFB2 mRNA25929836
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of PFKFB2 mRNA26377693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PFKFB2 mRNA]22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PFKFB2 mRNA"19150397
D004958EstradiolEstradiol affects the expression of PFKFB2 mRNA22574217
C006780bisphenol Abisphenol A affects the expression of PFKFB2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PFKFB2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PFKFB2 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PFKFB2 mRNA12734012
D002330CarmustineCarmustine results in decreased expression of PFKFB2 mRNA15980968
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PFKFB2 mRNA"27188386
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PFKFB220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PFKFB2 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PFKFB2 mRNA20938992
D002922CiguatoxinsCiguatoxins affects the expression of PFKFB2 mRNA18353800
D003300CopperCopper results in decreased expression of PFKFB2 mRNA22465980
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PFKFB2 mRNA23914054
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PFKFB2 mRNA27392435
D002117CalcitriolCalcitriol results in increased expression of PFKFB2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of PFKFB2 mRNA21592394
D015025ZearalenoneZearalenone results in decreased expression of PFKFB2 mRNA19371625
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PFKFB220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PFKFB2 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PFKFB2 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of PFKFB2 mRNA27664576
C039281furanfuran results in increased expression of PFKFB2 mRNA25539665
D017313FenretinideFenretinide results in increased expression of PFKFB2 mRNA28973697
C029424hydrazinehydrazine results in decreased expression of PFKFB2 mRNA15282401
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PFKFB2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of PFKFB2 mRNA27392435
D007854LeadLead affects the expression of PFKFB2 mRNA28903495
D016651Lithium CarbonateLithium Carbonate inhibits the reaction [Streptozocin results in decreased activity of PFKFB2 protein]10700396
D016651Lithium CarbonateLithium Carbonate results in decreased activity of PFKFB2 protein10700396
D008694MethamphetamineMethamphetamine results in decreased methylation of PFKFB2 promoter26307267
D008694MethamphetamineMethamphetamine results in increased expression of PFKFB2 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PFKFB220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PFKFB2 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PFKFB2 mRNA20938992
C005219methyl cellosolvemethyl cellosolve results in increased expression of PFKFB2 mRNA19643169
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PFKFB2 mRNA"26251327
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PFKFB2 mRNA"20188158
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of PFKFB2 promoter"26251327
D009151Mustard GasMustard Gas results in increased expression of PFKFB2 mRNA15674844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PFKFB2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PFKFB2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PFKFB2 mRNA"25620056
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PFKFB2 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of PFKFB2 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of PFKFB2 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of PFKFB2 mRNA19162173
D010936Plant ExtractsPlant Extracts results in increased expression of PFKFB2 mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of PFKFB2 mRNA16293270
D011374ProgesteroneProgesterone results in increased expression of PFKFB2 mRNA23018184
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of PFKFB2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PFKFB2 mRNA25895662
D013311StreptozocinLithium Carbonate inhibits the reaction [Streptozocin results in decreased activity of PFKFB2 protein]10700396
D013311StreptozocinStreptozocin results in decreased activity of PFKFB2 protein10700396
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of PFKFB2 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of PFKFB2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PFKFB2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PFKFB2 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PFKFB2 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PFKFB2 mRNA21889950
D013849ThimerosalThimerosal results in decreased expression of PFKFB2 mRNA27188386
C009495titanium dioxidetitanium dioxide affects the expression of PFKFB2 mRNA17656681
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PFKFB2 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PFKFB2 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of PFKFB2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PFKFB2 mRNA19136453|2142705
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PFKFB2 gene25560391
D015032ZincZinc results in decreased expression of PFKFB2 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of PFKFB2 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038736-phosphofructo-2-kinase activity-EXP2837207  9464277  10095107  15896703  
GO:00038736-phosphofructo-2-kinase activity-IBA21873635  
GO:00038736-phosphofructo-2-kinase activity-IDA11069105  
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity-IBA21873635  
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity-IEA-  
GO:0005515protein binding-IPI8387495  
GO:0005524ATP binding-IEA-  
GO:0019901protein kinase binding-IPI11069105  
GO ID GO Term Qualifier Evidence PubMed
GO:0006000fructose metabolic process-IEA-  
GO:0006003fructose 2,6-bisphosphate metabolic process-IBA21873635  
GO:0006003fructose 2,6-bisphosphate metabolic process-IEA-  
GO:0006007glucose catabolic process-IEA-  
GO:0006089lactate metabolic process-IEA-  
GO:0006096glycolytic process-IDA11069105  
GO:0009749response to glucose-IEA-  
GO:0016311dephosphorylation-IEA-  
GO:0032024positive regulation of insulin secretion-IEA-  
GO:0033133positive regulation of glucokinase activity-IEA-  
GO:0045821positive regulation of glycolytic process-TAS-  
GO:0046835carbohydrate phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00051Fructose and mannose metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70171GlycolysisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal