Gene: PFKFB3

5209
IPFK2|PFK2|iPFK-2
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
protein-coding
10p15.1
Ensembl:ENSG00000170525 MIM:605319 Vega:OTTHUMG00000017621 UniprotKB:Q16875
NC_000010.11
SNP Mapped
0   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.277e-1 (AD)  6.761e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00122944chr10:6227266PFKFB31.100e-10Smoking27651444
cg18262201chr10:6187854PFKFB31.100e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WBP1L0.803
YTHDF10.792
CDC42SE10.779
P4HB0.776
PTPN90.773
GALNT20.771
GRAMD1A0.77
SHC10.77
FAM20C0.769
EIF4A10.766

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.584
OR4F29-0.548
RERGL-0.232
TDGF1-0.226
OR6C74-0.208
CHP2-0.197
EDN3-0.188
CASP12-0.182
TNFRSF13B-0.174
C17orf112-0.169

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PFKFB3 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PFKFB3 mRNA"28903501
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PFKFB3 mRNA"25614096
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of PFKFB3 mRNA"20206263
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of PFKFB3 mRNA18544908
D000082AcetaminophenAcetaminophen affects the expression of PFKFB3 mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of PFKFB3 mRNA25458485
D000082AcetaminophenAcetaminophen affects the expression of PFKFB3 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of PFKFB3 mRNA18544908
D000117AcetylglucosamineAcetylglucosamine results in increased expression of PFKFB3 mRNA18047607
D000255Adenosine TriphosphateAdenosine Triphosphate inhibits the reaction [Pentachlorophenol results in increased expression of PFKFB3 mRNA]24642059
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PFKFB3 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PFKFB3 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of PFKFB3 mRNA21757418
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of PFKFB3 mRNA"23195993
D000638AmiodaroneAmiodarone affects the expression of PFKFB3 mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PFKFB3 mRNA16483693
D000667AmpicillinAmpicillin results in increased expression of PFKFB3 mRNA21632981
D001151ArsenicArsenic affects the methylation of PFKFB3 gene25304211
D001151ArsenicArsenic results in decreased expression of PFKFB3 mRNA16835338
D001241AspirinAspirin results in decreased expression of PFKFB3 mRNA11906190
D001507BeclomethasoneBeclomethasone results in increased expression of PFKFB3 mRNA23656298
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PFKFB3 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PFKFB3 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PFKFB3 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PFKFB3 mRNA20127859|2261060
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PFKFB3 mRNA"19150397
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PFKFB3 protein19448625
D004958EstradiolEstradiol results in decreased expression of PFKFB3 mRNA20106945|2163298
D004958EstradiolEstradiol results in increased expression of PFKFB3 mRNA23019147
C044887beta-methylcholinebeta-methylcholine affects the expression of PFKFB3 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of PFKFB3 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PFKFB3 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of PFKFB3 mRNA25979313
C100187chloropicrinchloropicrin results in increased expression of PFKFB3 mRNA26352163
D002737ChloropreneChloroprene results in increased expression of PFKFB3 mRNA23125180
D002746ChlorpromazineChlorpromazine affects the expression of PFKFB3 mRNA25064622
D004390ChlorpyrifosChlorpyrifos results in increased expression of PFKFB3 mRNA21356183
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of PFKFB3 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in increased expression of PFKFB3 mRNA24612858
C018021cobaltous chloridecobaltous chloride results in increased expression of PFKFB3 mRNA19320972|1937684
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PFKFB3 mRNA]22202117
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of PFKFB3 mRNA26033743
D003300CopperCopper deficiency results in increased expression of PFKFB3 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of PFKFB3 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of PFKFB3 mRNA27523638
D016572CyclosporineCyclosporine affects the expression of PFKFB3 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of PFKFB3 mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased expression of PFKFB3 mRNA19770486
C014347decitabinedecitabine results in increased expression of PFKFB3 mRNA21856257
D003907DexamethasoneDexamethasone results in increased expression of PFKFB3 mRNA23946490
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA16931933
D019259Lamivudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA16931933
D004041Dietary FatsDietary Fats results in decreased expression of PFKFB3 mRNA18042831|1845759
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of PFKFB3 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of PFKFB3 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PFKFB3 mRNA20360939
C012301domoic aciddomoic acid results in decreased expression of PFKFB3 mRNA18936300
C118739entinostatentinostat results in decreased expression of PFKFB3 mRNA27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PFKFB3 mRNA22079256
D004918Erythromycin EstolateErythromycin Estolate results in decreased expression of PFKFB3 mRNA24412560
D000431EthanolEthanol results in decreased expression of PFKFB3 mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PFKFB3 mRNA25064622
C024565ethylene dichlorideethylene dichloride results in decreased expression of PFKFB3 mRNA28189721
D019833GenisteinGenistein results in decreased expression of PFKFB3 mRNA22553218
C568713GSK1210151AGSK1210151A promotes the reaction [Oxygen deficiency results in increased expression of PFKFB3 mRNA]27292261
C568713GSK1210151AGSK1210151A results in increased expression of PFKFB3 mRNA27292261
C554645GSK525762AGSK525762A promotes the reaction [Oxygen deficiency results in increased expression of PFKFB3 mRNA]27292261
C554645GSK525762AGSK525762A results in increased expression of PFKFB3 mRNA27292261
D006834HydrazinesHydrazines results in decreased expression of PFKFB3 mRNA21647536
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PFKFB3 mRNA26846883
D019469Indinavir[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA16931933
D007559IvermectinIvermectin results in increased expression of PFKFB3 mRNA26443706
C410337K 7174K 7174 results in decreased expression of PFKFB3 mRNA24086573
C119620kenpaullonekenpaullone results in decreased expression of PFKFB3 mRNA17993264
C067713lactacystinlactacystin results in increased expression of PFKFB3 protein19448625
C045463leflunomideleflunomide results in increased expression of PFKFB3 mRNA28988120
D008627Mercuric ChlorideMercuric Chloride results in increased expression of PFKFB3 mRNA16507785
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PFKFB3 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PFKFB3 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PFKFB3 mRNA23649840
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of PFKFB3 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA16357179
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PFKFB3 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PFKFB3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PFKFB3 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PFKFB3 mRNA"25554681|2562005
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PFKFB3 mRNA19812364
D009532NickelNickel results in increased expression of PFKFB3 mRNA23195993
C022838nickel chloridenickel chloride results in increased expression of PFKFB3 mRNA24612858
C022838nickel chloridenickel chloride results in increased expression of PFKFB3 mRNA17312168
C029938nickel sulfatenickel sulfate results in increased expression of PFKFB3 mRNA17382205
C570897NSC668394NSC668394 results in increased expression of PFKFB3 mRNA27137931
D010100OxygenGSK1210151A promotes the reaction [Oxygen deficiency results in increased expression of PFKFB3 mRNA]27292261
D010100OxygenGSK525762A promotes the reaction [Oxygen deficiency results in increased expression of PFKFB3 mRNA]27292261
D010100OxygenIL15 protein promotes the reaction [Oxygen deficiency results in increased expression of PFKFB3 mRNA]27129235
D010100OxygenOxygen deficiency results in increased expression of PFKFB3 mRNA16025159|2004264
D010100OxygenOxygen deficiency results in increased expression of PFKFB3 mRNA20880076|2353931
D000073878Palm OilPalm Oil results in decreased expression of PFKFB3 mRNA18042831
D010269ParaquatParaquat affects the expression of PFKFB3 mRNA25064622
D010416PentachlorophenolAdenosine Triphosphate inhibits the reaction [Pentachlorophenol results in increased expression of PFKFB3 mRNA]24642059
D010416PentachlorophenolPentachlorophenol results in increased expression of PFKFB3 mRNA24642059
D010416PentachlorophenolPentachlorophenol results in increased expression of PFKFB3 mRNA23892564
D010634PhenobarbitalPhenobarbital results in increased expression of PFKFB3 mRNA19270015
D010795Phthalic AcidsPhthalic Acids results in decreased expression of PFKFB3 mRNA21061450
C006253pirinixic acidpirinixic acid results in increased expression of PFKFB3 mRNA17426115
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PFKFB3 mRNA21334430
D059808PolyphenolsPolyphenols results in decreased expression of PFKFB3 mRNA16293270
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PFKFB3 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PFKFB3 mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of PFKFB3 mRNA28903501
D011374ProgesteroneProgesterone results in decreased expression of PFKFB317510236
C045950propiconazolepropiconazole results in increased expression of PFKFB3 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of PFKFB3 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PFKFB3 mRNA21632981
D011794QuercetinQuercetin results in increased expression of PFKFB3 mRNA19729006
D015125OxyquinolineOxyquinoline results in decreased expression of PFKFB3 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA19059307
C031389resorcinolresorcinol results in increased expression of PFKFB3 mRNA22623647
C059514resveratrolresveratrol results in increased expression of PFKFB3 mRNA23419489
C010327salinomycinsalinomycin results in decreased expression of PFKFB3 mRNA19682730
D019258Saquinavir[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA16931933
D012643SeleniumSelenium results in increased expression of PFKFB3 mRNA28810182
C009250sevofluranesevoflurane affects the expression of PFKFB3 mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PFKFB3 mRNA23806026
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PFKFB3 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of PFKFB3 mRNA23221170
D012834SilverSilver results in increased expression of PFKFB3 mRNA26014281
C009277sodium arsenatesodium arsenate results in increased expression of PFKFB3 mRNA23922661
C017947sodium arsenitesodium arsenite affects the expression of PFKFB3 mRNA29319823
C016104sodium bichromatesodium bichromate results in increased expression of PFKFB3 mRNA24612858
D012999SomanSoman results in increased expression of PFKFB3 mRNA19281266
D053260SootSoot results in increased expression of PFKFB3 mRNA26551751
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of PFKFB3 mRNA20937368
D013739TestosteroneTestosterone results in increased expression of PFKFB3 mRNA21669218
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of PFKFB3 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PFKFB3 mRNA17884332
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PFKFB3 mRNA24680724|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PFKFB3 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PFKFB3 mRNA19770486|1993321
D013752TetracyclineTetracycline affects the expression of PFKFB3 mRNA25064622
D019284ThapsigarginThapsigargin results in decreased expression of PFKFB3 mRNA22378314
D013853ThioacetamideThioacetamide affects the expression of PFKFB3 mRNA25064622
C009495titanium dioxidetitanium dioxide results in decreased expression of PFKFB3 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PFKFB3 mRNA28065790
D014212TretinoinTretinoin results in increased expression of PFKFB3 mRNA15894607|2193413
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PFKFB3 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of PFKFB3 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of PFKFB3 mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of PFKFB3 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of PFKFB3 gene29154799
D014638VanadatesVanadates results in increased expression of PFKFB3 mRNA15297373
C025643vinclozolinvinclozolin results in increased expression of PFKFB3 mRNA23160963
C029297vinylidene chloridevinylidene chloride results in increased expression of PFKFB3 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of PFKFB3 mRNA27188386
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of PFKFB3 mRNA"24525044
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in decreased expression of PFKFB3 mRNA16931933
D015215Zidovudine[Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in decreased expression of PFKFB3 mRNA16931933
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of PFKFB3 mRNA16357179
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of PFKFB3 mRNA]22202117
D019287Zinc SulfateZinc Sulfate results in increased expression of PFKFB3 mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038736-phosphofructo-2-kinase activity-EXP2837207  9464277  10095107  15896703  
GO:00038736-phosphofructo-2-kinase activity-IBA21873635  
GO:00038736-phosphofructo-2-kinase activity-NAS8830046  
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity-IBA21873635  
GO:0004331fructose-2,6-bisphosphate 2-phosphatase activity-IEA-  
GO:0005524ATP binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006000fructose metabolic process-IEA-  
GO:0006003fructose 2,6-bisphosphate metabolic process-IBA21873635  
GO:0006003fructose 2,6-bisphosphate metabolic process-IEA-  
GO:0007420brain development-IEA-  
GO:0016311dephosphorylation-IEA-  
GO:0045821positive regulation of glycolytic process-TAS-  
GO:0046835carbohydrate phosphorylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00051Fructose and mannose metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70171GlycolysisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal