Gene: VIT

5212
VIT1
vitrin
protein-coding
2p22.2
Ensembl:ENSG00000205221 MIM:617693 Vega:OTTHUMG00000152149 UniprotKB:Q6UXI7
NG_050963.1
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.588e-2 (AD)  2.801e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNK10.742
OTUB20.712
GPR610.711
KCNK90.71
SLC8A30.706
KCNS20.706
RGS60.703
MCHR10.703
PTPRR0.702
SORBS20.702

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FXYD3-0.571
ANKFN1-0.539
TMEM176A-0.537
STON2-0.509
PHF21B-0.503
TTC38-0.501
AGTRAP-0.5
TMEM176B-0.492
NFATC1-0.491
RFX4-0.489

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of VIT mRNA19933214
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of VIT mRNA25088246
C006632arsenic trioxidearsenic trioxide results in decreased expression of VIT mRNA19128835|2670570
C547126AZM551248AZM551248 results in decreased expression of VIT mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of VIT mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of VIT mRNA22228805
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of VIT mRNA28628672
C006780bisphenol A[potassium bromate co-treated with bisphenol A] affects the expression of VIT mRNA27082013
C006780bisphenol Abisphenol A results in decreased expression of VIT mRNA25181051
D002104CadmiumCadmium results in decreased expression of VIT mRNA24376830
D003471CuprizoneCuprizone results in increased expression of VIT mRNA26577399
D016572CyclosporineCyclosporine results in increased methylation of VIT promoter27989131
D003907DexamethasoneDexamethasone results in increased expression of VIT mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of VIT mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of VIT mRNA28628672
D002945CisplatinVIT mRNA results in increased susceptibility to Cisplatin25199881
D004041Dietary FatsDietary Fats results in increased expression of VIT mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of VIT mRNA17394237
D004317DoxorubicinVIT mRNA results in increased susceptibility to Doxorubicin25199881
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of VIT mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of VIT mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of VIT mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of VIT mRNA28628672
D008727MethotrexateVIT mRNA results in increased susceptibility to Methotrexate25199881
D008748Methylcholanthrene[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of VIT mRNA23519560
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of VIT mRNA"20188158
D009532NickelNickel results in decreased expression of VIT mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of VIT mRNA22714537
D017239PaclitaxelVIT mRNA results in increased susceptibility to Paclitaxel25199881
D000073878Palm OilPalm Oil results in increased expression of VIT mRNA18042831
C019536potassium bromate[potassium bromate co-treated with bisphenol A] affects the expression of VIT mRNA27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [potassium bromate affects the expression of VIT mRNA]27082013
D011374ProgesteroneProgesterone results in increased expression of VIT mRNA22238285
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of VIT mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of VIT mRNA23806026
D012969Sodium FluorideSodium Fluoride results in increased expression of VIT mRNA27257137
D013755Tetradecanoylphorbol Acetate[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of VIT mRNA23519560
C009495titanium dioxidetitanium dioxide results in increased expression of VIT mRNA23557971
D019772TopotecanVIT mRNA results in increased susceptibility to Topotecan25199881
C012589trichostatin Atrichostatin A results in increased expression of VIT mRNA26705709
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of VIT mRNA19042947
D014635Valproic AcidValproic Acid results in increased expression of VIT mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of VIT mRNA17963808
D014750VincristineVIT mRNA results in increased susceptibility to Vincristine25199881

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005539glycosaminoglycan binding-IBA21873635  
GO:0005539glycosaminoglycan binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003429growth plate cartilage chondrocyte morphogenesis-IBA21873635  
GO:0010811positive regulation of cell-substrate adhesion-IBA21873635  
GO:0010811positive regulation of cell-substrate adhesion-IEA-  
GO:0030198extracellular matrix organization-IBA21873635  
GO:0030198extracellular matrix organization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005614interstitial matrix-IBA21873635  
GO:0005614interstitial matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19026740Beta-carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells. (2009 Jan 15)van Helden YGFree Radic Biol Med
29247592Relationship between smoking and total antioxidant status, total oxidant status, oxidative stress index, vit C, vit E. (2017 Dec 16)Karademirci MClin Respir J
18694616Serum folate is associated with coronary heart disease independently of homocysteine in Turkish men. (2008 Oct)Onat AClin Nutr
11276923Associations of age, smoking habits and diabetes with plasma vitamin C of elderly of the POLA study. (2001 Jan)Birlouez-Aragon IInt J Vitam Nutr Res
11125545Sex steroids, biochemical markers, bone mineral density and histomorphometry in male osteoporosis patients. (2000 Sep-Oct)Fassbender WJIn Vivo
10344454Effect of vitamin E supplementation on post-exercise plasma lipid peroxidation and blood antioxidant status in smokers: with special reference to haemoconcentration effect. (1999 May)Surmen-Gur EEur J Appl Physiol Occup Physiol
24640211Sickle cell disease with osteogenesis imperfecta. (2013 Jun)Patil PLJ Assoc Physicians India
21916812Evaluation of the levels of oxidative stress factors and ischemia modified albumin in the cord blood of smoker and non-smoker pregnant women. (2012 Jul)Sahinli ASJ Matern Fetal Neonatal Med
19938001Evaluation of lead exposure in battery-manufacturing workers with focus on different biomarkers. (2010 May)Kasuba VJ Appl Toxicol
17133733Biochemistry of homocysteine in health and diseases. (2006 Oct)Ramakrishnan SIndian J Biochem Biophys