Gene: PFKP

5214
ATP-PFK|PFK-C|PFK-P|PFKF
phosphofructokinase, platelet
protein-coding
10p15.2
Ensembl:ENSG00000067057 MIM:171840 Vega:OTTHUMG00000017556 UniprotKB:Q01813
NG_051598.1
PubMed|SNP Mapped
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.883e-1 (AD)  1.934e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2306311chr10:3134197 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4881084chr10:3108179 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25707945chr10:3147707PFKPGene body1.307e-4Alcohol use disorders26763658
cg06187344chr10:3151576PFKPGene body6.005e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HK10.96
CLSTN10.942
APBA20.941
ATP6AP10.939
ANXA60.939
TOLLIP0.937
ATP13A20.937
GPI0.937
AP2A20.936
FARSA0.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.583
OR4F29-0.538
REST-0.471
RAI14-0.466
ASB4-0.463
EBF1-0.454
TFPI2-0.448
SH2D1A-0.441
KLRB1-0.439
IL18RAP-0.437

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of PFKP mRNA"20453058
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PFKP mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PFKP mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PFKP mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PFKP mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PFKP mRNA"25510870
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PFKP mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PFKP mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of PFKP mRNA15084756
D016604Aflatoxin B1Aflatoxin B1 affects the expression of PFKP protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PFKP mRNA22100608|2715375
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PFKP mRNA19770486
D000452AldrinAldrin results in decreased expression of PFKP mRNA18579281
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of PFKP mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PFKP mRNA16483693
D034341Aristolochic AcidsAristolochic Acids results in increased expression of PFKP mRNA19717638
C006632arsenic trioxidearsenic trioxide results in decreased expression of PFKP protein25419056
D001280AtrazineAtrazine results in decreased expression of PFKP mRNA25929836
C406592azaspiracidazaspiracid results in increased expression of PFKP mRNA28939011
C547126AZM551248AZM551248 results in increased expression of PFKP mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PFKP mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PFKP mRNA19770486
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PFKP mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PFKP mRNA]25566086
C044887beta-methylcholinebeta-methylcholine affects the expression of PFKP mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of PFKP mRNA25047013
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PFKP mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PFKP mRNA12075121|2518105
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PFKP mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PFKP mRNA15003993
C037123cadmium sulfatecadmium sulfate results in increased expression of PFKP mRNA19274763
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PFKP mRNA20360939
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PFKP mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PFKP mRNA23650126
C100187chloropicrinchloropicrin results in increased expression of PFKP mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PFKP mRNA20938992
D002994ClofibrateClofibrate results in increased expression of PFKP mRNA17585979
D003022ClotrimazoleClotrimazole affects the localization of PFKP protein12126931
D003024ClozapineClozapine results in increased expression of PFKP mRNA15860345
D060729Coal AshCoal Ash results in decreased expression of PFKP mRNA19000753
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PFKP mRNA15467011
D019327Copper SulfateCopper Sulfate results in increased expression of PFKP mRNA19549813
D019327Copper SulfateCopper Sulfate results in decreased expression of PFKP mRNA18579281
D016572CyclosporineCyclosporine results in increased expression of PFKP mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of PFKP mRNA21198554
D0174851-Deoxynojirimycin[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PFKP protein]25446853
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PFKP mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PFKP mRNA28628672
D003976DiazinonDiazinon results in increased methylation of PFKP gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PFKP mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PFKP mRNA17379624|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PFKP mRNA21266533
D002945CisplatinPFKP protein affects the susceptibility to Cisplatin16217747
D004041Dietary Fats[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PFKP protein]25446853
D004041Dietary Fats[Dietary Fats co-treated with Streptozocin] results in decreased expression of PFKP protein25446853
D004041Dietary FatsDietary Fats results in decreased expression of PFKP mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of PFKP mRNA20360939
C042080diisodecyl phthalatediisodecyl phthalate results in increased expression of PFKP mRNA25270620
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PFKP mRNA25380136
D004317DoxorubicinDoxorubicin results in increased expression of PFKP mRNA19915844
D004317DoxorubicinRazoxane inhibits the reaction [Doxorubicin results in increased expression of PFKP mRNA]19915844
D004726Endosulfan[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of PFKP mRNA26159488
C118739entinostatentinostat results in increased expression of PFKP mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PFKP mRNA12075121
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PFKP mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PFKP mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of PFKP mRNA23649840
D019833GenisteinGenistein results in increased expression of PFKP mRNA12075121
D005839GentamicinsGentamicins results in increased expression of PFKP mRNA22061828
D005944GlucosamineGlucosamine results in increased expression of PFKP mRNA17178593
D006220HaloperidolHaloperidol results in increased expression of PFKP mRNA15860345
C016517indole-3-carbinolindole-3-carbinol affects the expression of PFKP mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PFKP mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PFKP mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PFKP mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PFKP mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PFKP mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PFKP mRNA23086925
D007657Ketone BodiesKetone Bodies results in increased expression of PFKP mRNA16807920
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PFKP mRNA25613284
C042720mercuric bromidemercuric bromide results in increased expression of PFKP mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PFKP mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PFKP mRNA23179753|2718838
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PFKP mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PFKP mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PFKP mRNA"28087314
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of PFKP mRNA25270620
D008777MethyltestosteroneMethyltestosterone results in increased expression of PFKP mRNA29191790
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PFKP mRNA25380136
D009532NickelNickel results in increased expression of PFKP mRNA24768652|2558310
C025589ochratoxin Aochratoxin A results in increased expression of PFKP mRNA19717638
C030110oxaliplatinoxaliplatin results in decreased expression of PFKP mRNA17762391
D010100OxygenOxygen deficiency results in increased expression of PFKP mRNA20042640
D010100OxygenOxygen deficiency affects the expression of PFKP mRNA17193925
D010100OxygenOxygen deficiency results in increased expression of PFKP mRNA20880076
D000073878Palm OilPalm Oil results in decreased expression of PFKP mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PFKP mRNA26272509
D010269ParaquatParaquat results in decreased expression of PFKP mRNA21371552
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PFKP mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PFKP mRNA26272509
D010852PicrotoxinPicrotoxin results in decreased expression of PFKP mRNA15170462
C006253pirinixic acidpirinixic acid results in decreased expression of PFKP mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of PFKP mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of PFKP mRNA19162173
D011134Polysaccharides[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PFKP protein]25446853
D011794QuercetinQuercetin results in increased expression of PFKP mRNA19729006|2163298
C502851quinocetonequinocetone results in decreased expression of PFKP mRNA27046791
D011929RazoxaneRazoxane inhibits the reaction [Doxorubicin results in increased expression of PFKP mRNA]19915844
C059514resveratrolresveratrol results in increased expression of PFKP protein25505154
D012524SarinSarin results in decreased expression of PFKP mRNA19522546
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PFKP mRNA25895662
D012969Sodium FluorideSodium Fluoride results in increased expression of PFKP protein28918527
D013311Streptozocin[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of PFKP protein]25446853
D013311Streptozocin[Dietary Fats co-treated with Streptozocin] results in decreased expression of PFKP protein25446853
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PFKP mRNA"26680231
D0150852,4,5-Trichlorophenoxyacetic Acid"2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PFKP mRNA"18579281
D014284TriiodothyronineTriiodothyronine results in increased expression of PFKP mRNA15507505
D013749Tetrachlorodibenzodioxin[Endosulfan co-treated with Tetrachlorodibenzodioxin] results in increased expression of PFKP mRNA26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PFKP mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PFKP mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PFKP gene]20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PFKP mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PFKP mRNA20819909
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PFKP mRNA20959002
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of PFKP mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PFKP mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of PFKP mRNA22378314
D013849ThimerosalThimerosal results in decreased expression of PFKP mRNA27188386
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PFKP mRNA28065790
D014212TretinoinTretinoin results in decreased expression of PFKP mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PFKP mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of PFKP mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PFKP mRNA19042947
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PFKP mRNA29024780
D014415TunicamycinTunicamycin results in decreased expression of PFKP mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PFKP mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PFKP mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of PFKP gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PFKP mRNA19136453|2054688
D014635Valproic AcidValproic Acid results in decreased expression of PFKP mRNA15901671
D014639VanadiumVanadium results in decreased expression of PFKP mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PFKP gene25560391
D014752Vinyl ChlorideVinyl Chloride results in decreased expression of PFKP mRNA18579281
C029297vinylidene chloridevinylidene chloride results in increased expression of PFKP mRNA26682919
D014810Vitamin EVitamin E results in increased expression of PFKP mRNA19244175
D024483Vitamin K 3Vitamin K 3 results in decreased expression of PFKP mRNA25270620
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PFKP mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PFKP mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00038726-phosphofructokinase activity-EXP2960695  6444721  6451249  7825568  
GO:00038726-phosphofructokinase activity-IBA21873635  
GO:00038726-phosphofructokinase activity-ISS-  
GO:00038726-phosphofructokinase activity-TAS1834056  
GO:0005524ATP binding-IEA-  
GO:0044877protein-containing complex binding-IDA23209302  
GO:0045296cadherin binding-HDA25468996  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006002fructose 6-phosphate metabolic process-IEA-  
GO:0061621canonical glycolysis-TAS-  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005737cytoplasm-IDA25468996  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00030Pentose phosphate pathway
hsa00051Fructose and mannose metabolism
hsa00052Galactose metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70171GlycolysisTAS
R-HSA-70326Glucose metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20712903Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. (2010 Aug 16)Morgan ARBMC Med Genet