Gene: PFN1

5216
ALS18
profilin 1
protein-coding
17p13.2
Ensembl:ENSG00000108518 MIM:176610 Vega:OTTHUMG00000099396 UniprotKB:P07737
NG_032945.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.735e-1 (AD)  8.089e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD630.931
MYL60.909
U2AF10.906
PPIB0.902
EIF4A10.898
PPP4C0.894
SEC61B0.893
GNAI20.893
PTMA0.891
IMPDH20.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.755
OR4F29-0.751
OR2T10-0.154
SIGLEC6-0.12
NPBWR1-0.115
SSX5-0.114
OR4K13-0.112
SERPINA11-0.107
HS6ST3-0.103
GPR52-0.103

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB079087-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARINSmall MoleculeExperimentalTarget
DB11638ArtenimolSmall Molecule71939-50-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0247092,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone"2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone binds to PFN1 protein"16533022
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PFN1 mRNA12958071
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PFN1 mRNA"25380136
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of PFN1 mRNA15135645
D000082AcetaminophenAcetaminophen affects the expression of PFN1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PFN1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PFN1 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PFN1 mRNA16483693
D001241AspirinAspirin results in decreased expression of PFN1 mRNA15928584
D001280AtrazineAtrazine results in decreased expression of PFN1 mRNA25275270
D001280AtrazineAtrazine results in decreased expression of PFN1 protein25275270
D001280AtrazineAtrazine results in increased expression of PFN1 mRNA22378314
D001374AzacitidineAzacitidine results in increased expression of PFN1 mRNA20823114
C004456beauvericinbeauvericin results in decreased expression of PFN1 mRNA29203277
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PFN1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PFN1 protein25628927
D001564Benzo(a)pyrenePARG affects the reaction [Benzo(a)pyrene results in increased expression of PFN1 protein]25628927
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PFN1 mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PFN1 mRNA19687787
D004958EstradiolEstradiol results in increased expression of PFN1 mRNA19687787
C006780bisphenol Abisphenol A results in decreased expression of PFN1 mRNA26364221
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PFN1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PFN1 mRNA25181051
D002330CarmustineCarmustine results in decreased expression of PFN1 mRNA15980968
C099555CD 437CD 437 results in decreased expression of PFN1 mRNA12958071
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of PFN1 mRNA18178546
C100187chloropicrinchloropicrin results in decreased expression of PFN1 mRNA26352163
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PFN1 mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of PFN1 mRNA19320972
D003042CocaineCocaine results in increased expression of PFN1 mRNA12629581
D003300CopperPFN1 protein binds to Copper14534351
D016578Crack CocaineCrack Cocaine results in decreased expression of PFN1 mRNA12629581
C030973cupric oxidecupric oxide results in decreased expression of PFN1 protein25470785
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of PFN1 mRNA17383702
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PFN1 mRNA28628672
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PFN1 mRNA17602206
C039060dihydroartemisinindihydroartemisinin analog binds to PFN1 protein26340163
D004317DoxorubicinDoxorubicin affects the expression of PFN1 protein29385562
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PFN1 protein23301498
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PFN1 mRNA17942748
D005485FlutamideFlutamide results in increased expression of PFN1 mRNA24136188
D019833GenisteinGenistein results in increased expression of PFN1 mRNA16169203
D005897GlafenineGlafenine results in increased expression of PFN1 mRNA24136188
D006108GraphiteGraphite results in increased expression of PFN1 protein22157353
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PFN1 mRNA17183730
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PFN1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PFN1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of PFN1 mRNA28628672
C410337K 7174K 7174 results in decreased expression of PFN1 mRNA24086573
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PFN1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PFN1 protein"22001959
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PFN1 protein"22157353
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PFN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PFN1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of PFN1 mRNA24136188
D009538NicotineNicotine results in decreased expression of PFN1 mRNA11478936
D010126OzoneOzone results in increased expression of PFN1 mRNA16183385
D010126OzoneOzone results in increased expression of PFN1 protein16183385
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PFN1 protein19954255
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PFN1 protein26178269
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PFN1 protein28126411
D010634PhenobarbitalPhenobarbital affects the expression of PFN1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of PFN1 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PFN1 mRNA19710929
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PFN1 mRNA19687787
D011794QuercetinQuercetin results in increased expression of PFN1 protein14750173
D011794QuercetinQuercetin results in decreased expression of PFN1 protein18095365
D012176RetinoidsRetinoids results in decreased expression of PFN1 protein28886987
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of PFN1 mRNA19244175
D012643SeleniumSelenium results in increased expression of PFN1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of PFN1 protein25895662
C016104sodium bichromatesodium bichromate results in increased expression of PFN1 mRNA25993096
D010042OuabainOuabain affects the expression of PFN1 protein17268060
D010042OuabainOuabain results in decreased expression of PFN1 protein18247327
D013605T-2 ToxinT-2 Toxin affects the expression of PFN1 protein26141394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PFN1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PFN1 mRNA17942748
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PFN1 mRNA25613284
D013849ThimerosalThimerosal results in decreased expression of PFN1 mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased phosphorylation of PFN1 protein21439344
D014118Toxins, Biological"Toxins, Biological affects the expression of PFN1 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of PFN1 mRNA17218384
D014212TretinoinTretinoin results in increased expression of PFN1 protein17051635
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PFN1 mRNA"26179874
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PFN1 mRNA17183730
D014640VancomycinVancomycin results in decreased expression of PFN1 mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of PFN1 mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of PFN1 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of PFN1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000774adenyl-nucleotide exchange factor activity-IDA7758455  
GO:0003723RNA binding-HDA22681889  
GO:0003779actin binding-IBA21873635  
GO:0003779actin binding-IPI7758455  17914456  
GO:0003785actin monomer binding-IDA18573880  
GO:0005515protein binding-IPI9822597  9843499  16531231  17470807  18573880  18689676  
19000816  19338310  23153535  24700464  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IDA7758455  
GO:0017048Rho GTPase binding-IEA-  
GO:0045296cadherin binding-HDA25468996  
GO:0070064proline-rich region binding-IPI17914456  
GO ID GO Term Qualifier Evidence PubMed
GO:0001843neural tube closure-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0010634positive regulation of epithelial cell migration-IMP23153535  
GO:0030036actin cytoskeleton organization-IEA-  
GO:0030833regulation of actin filament polymerization-IBA21873635  
GO:0030837negative regulation of actin filament polymerization-IDA7758455  
GO:0030838positive regulation of actin filament polymerization-IGI23153535  
GO:0032232negative regulation of actin filament bundle assembly-IMP23153535  
GO:0032233positive regulation of actin filament bundle assembly-IBA21873635  
GO:0032781positive regulation of ATPase activity-IDA7758455  
GO:0050821protein stabilization-IDA18573880  
GO:0051497negative regulation of stress fiber assembly-IMP23153535  
GO:0060071Wnt signaling pathway, planar cell polarity pathway-TAS-  
GO:1900029positive regulation of ruffle assembly-IMP23153535  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA24700464  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA24700464  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-IEA-  
GO:0005925focal adhesion-HDA21423176  
GO:0005938cell cortex-IDA24700464  
GO:0016020membrane-HDA19946888  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04810Regulation of actin cytoskeleton
hsa05131Shigellosis
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-114608Platelet degranulation IEA
R-HSA-1266738Developmental BiologyTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194315Signaling by Rho GTPasesIEA
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195258RHO GTPase EffectorsIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-376176Signaling by ROBO receptorsTAS
R-HSA-3858494Beta-catenin independent WNT signalingTAS
R-HSA-4086400PCP/CE pathwayTAS
R-HSA-422475Axon guidanceTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS
R-HSA-5663220RHO GTPases Activate ForminsIEA
R-HSA-76002Platelet activation, signaling and aggregationIEA
R-HSA-76005Response to elevated platelet cytosolic Ca2+IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17295719Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. (2007 Mar)Wang JAlcohol Clin Exp Res
26311342Nicotine elevates sperm motility and induces Pfn1 promoter hypomethylation in mouse testis. (2015 Sep)Dai JAndrology