Gene: PGC

5225
PEPC|PGII
progastricsin
protein-coding
6p21.1
Ensembl:ENSG00000096088 MIM:169740 Vega:OTTHUMG00000014683 UniprotKB:P20142
NC_000006.12
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.232e-2 (AD)  6.591e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LIPF0.951
PGA30.853
GIF0.749
ATP4B0.74
PGA40.717
CHIA0.692
TFF20.685
MUC5AC0.679
AGR20.659
TFF10.629

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SP9-0.245
SNAP25-AS1-0.229
CHAF1A-0.211
CLGN-0.206
LRRIQ4-0.204
C1orf100-0.202
DNAH10OS-0.201
C1QTNF2-0.198
BAAT-0.197
C10orf82-0.197

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PGC mRNA"25510870
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of PGC mRNA"17547211
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PGC mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PGC mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PGC mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PGC mRNA"25510870
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PGC mRNA"23196670
D000082AcetaminophenAcetaminophen results in decreased expression of PGC mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PGC gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PGC mRNA16483693
D000667AmpicillinAmpicillin results in increased expression of PGC mRNA21632981
D000965AntimonyAntimony results in decreased expression of PGC mRNA17547211
D000966Antimony Potassium TartrateAntimony Potassium Tartrate results in decreased expression of PGC mRNA17547211
C006632arsenic trioxidearsenic trioxide results in decreased expression of PGC mRNA17547211
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of PGC mRNA20106945
C006780bisphenol Abisphenol A affects the expression of PGC mRNA25181051
D002104CadmiumCadmium results in decreased expression of PGC mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PGC mRNA17547211
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PGC gene20938992
D002857ChromiumChromium results in decreased expression of PGC mRNA17547211
D019327Copper SulfateCopper Sulfate results in decreased expression of PGC mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PGC mRNA20106945|2163298
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PGC mRNA28962523
C000944dicrotophosdicrotophos results in decreased expression of PGC mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of PGC mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of PGC mRNA21592394
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of PGC mRNA17547211
C024565ethylene dichlorideethylene dichloride results in increased expression of PGC mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PGC gene20938992
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of PGC mRNA16206274
C410337K 7174K 7174 results in decreased expression of PGC mRNA24086573
D008628MercuryMercury results in decreased expression of PGC mRNA17547211
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PGC gene20938992
C022838nickel chloridenickel chloride results in decreased expression of PGC mRNA17547211
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PGC mRNA"25510870
C006253pirinixic acidpirinixic acid results in increased expression of PGC mRNA20813756
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PGC mRNA17547211
D011192Potassium DichromatePotassium Dichromate results in decreased expression of PGC mRNA23608068
D011794QuercetinQuercetin results in increased expression of PGC mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of PGC mRNA21632981
D013629TamoxifenTamoxifen results in decreased expression of PGC mRNA15590111
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of PGC mRNA21592394
D013739TestosteroneTestosterone results in increased expression of PGC mRNA21592394
C009495titanium dioxidetitanium dioxide results in decreased expression of PGC mRNA23409001
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PGC mRNA"26179874
D014635Valproic AcidValproic Acid results in increased methylation of PGC gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PGC gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004190aspartic-type endopeptidase activity-IBA21873635  
GO:0004190aspartic-type endopeptidase activity-IMP12759353  
GO ID GO Term Qualifier Evidence PubMed
GO:0002803positive regulation of antibacterial peptide production-IMP12759353  
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IEA-  
GO:0007586digestion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA12759353  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20807714TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia? (2010 Dec)Remels AHFASEB J
25736869Molecular responses in the telomere-mitochondrial axis of ageing in the elderly: a candidate gene approach. (2015 Jan)Pieters NMech Ageing Dev
24026667A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. (2013 Oct)Luo CBiogerontology
20682457Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence. (2010 Sep 30)Brody ALPsychiatry Res
24705155alpha,beta-Unsaturated aldehyde crotonaldehyde triggers cardiomyocyte contractile dysfunction: role of TRPV1 and mitochondrial function. (2014 Apr)Pei ZPharmacol Res
11868396[Gender and relation of life-style to morale in older people living in regional cities]. (2002 Jan)Demura SNihon Eiseigaku Zasshi