Gene: PHB

5245
HEL-215|HEL-S-54e|PHB1
prohibitin
protein-coding
17q21.33
Ensembl:ENSG00000167085 MIM:176705 Vega:OTTHUMG00000134271 UniprotKB:P35232
NG_023046.1
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.192e-1 (AD)  1.825e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARK70.942
COPS60.941
PSMB60.941
UBL50.939
SOD10.938
EIF3I0.937
VPS720.936
FAM32A0.936
NDUFA80.934
HAX10.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.847
OR4F29-0.81
MTRNR2L6-0.247
IL18RAP-0.243
OR6C74-0.229
PZP-0.224
C8orf74-0.222
KCNJ15-0.218
FOXL1-0.215
P2RY14-0.214

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of PHB mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PHB mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of PHB mRNA"20702594
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PHB mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]23254195
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB protein results in decreased activity of FSHB protein]23254195
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PHB protein23254195
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PHB mRNA"12376462
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PHB protein"12376462
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PHB mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to PHB protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PHB protein]26598702
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of PHB mRNA12419474
D000082AcetaminophenAcetaminophen results in decreased expression of PHB mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of PHB mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PHB mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PHB mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PHB mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of PHB protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of PHB protein26597043
D013196Dihydrotestosterone[Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to PHB protein]18487222
D013196DihydrotestosteronePHB protein promotes the reaction [bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]18487222
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of PHB mRNA23254195
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of PHB protein23254195
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PHB mRNA16483693
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PHB protein]26598702
D001241AspirinAspirin results in decreased expression of PHB mRNA14976132
D001280AtrazineAtrazine results in decreased expression of PHB mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PHB protein"20416286
D004958Estradiol2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]23254195
D004958EstradiolPHB protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]23254195
C053541bicalutamideAR protein promotes the reaction [bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]]18487222
C053541bicalutamidebicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]18487222
C053541bicalutamide[Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to PHB protein]18487222
C053541bicalutamidePHB protein promotes the reaction [bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]18487222
C053541bicalutamidePHB protein promotes the reaction [bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]]18487222
D001663BilirubinBilirubin results in decreased expression of PHB mRNA20196124
C006780bisphenol Abisphenol A affects the expression of PHB mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PHB mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of PHB mRNA18958704
C013418bromfenacoumbromfenacoum results in increased expression of PHB protein28903499
C515564bromovaninbromovanin results in increased expression of PHB protein21419150
D002066BusulfanBusulfan affects the expression of PHB mRNA15388331
C026105butylidenephthalidebutylidenephthalide results in decreased expression of PHB protein23770345
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PHB protein22081424
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PHB mRNA22230729
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PHB protein22230729
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA]"20230807
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PHB mRNA24763279
D002713ChlorineChlorine results in increased expression of PHB mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of PHB mRNA18636392
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PHB mRNA28472532
C041167chromium nitratechromium nitrate results in decreased expression of PHB protein22144121
C402823CLIK 148CLIK 148 results in increased expression of PHB protein21484410
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PHB mRNA17585979
D002994ClofibrateClofibrate results in increased expression of PHB mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PHB mRNA]17585979
D002994ClofibrateClofibrate results in decreased expression of PHB mRNA22300585
D002994ClofibrateClofibrate results in increased expression of PHB protein16470657
C018021cobaltous chloridecobaltous chloride results in decreased expression of PHB mRNA19320972
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PHB mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of PHB mRNA19549813
D003474CurcuminCurcumin results in decreased expression of PHB protein19137819
D016572CyclosporineCyclosporine results in decreased expression of PHB mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of PHB mRNA19770486
C017160cypermethrincypermethrin results in decreased expression of PHB protein21561882
D013759DronabinolDronabinol results in increased expression of PHB protein18163980
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PHB mRNA]27941970
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PHB protein20935162
D004052Diethylnitrosamine[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of PHB protein20935162
D002117CalcitriolCalcitriol results in decreased expression of PHB mRNA12875902
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PHB mRNA"12376462
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PHB protein"12376462
D004237DiuronDiuron results in increased expression of PHB mRNA21551480
D004298DopamineDopamine results in increased expression of PHB protein24675778
D004837Epinephrine[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein19464573
D004837EpinephrineEpinephrine results in increased expression of PHB protein19464573
D000431EthanolEthanol results in increased expression of PHB protein20621659
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PHB mRNA16174780|1755557
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHB mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PHB mRNA16174780
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PHB mRNA23649840
C506425eurycomanoneeurycomanone results in decreased expression of PHB protein21903368
D015025ZearalenoneZearalenone results in increased expression of PHB protein25058043
D018120FinasterideFinasteride results in increased expression of PHB mRNA24136188
C043562flavoneflavone results in decreased expression of PHB protein14750173
D005485FlutamideFlutamide results in increased expression of PHB mRNA24136188
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of PHB mRNA21782745
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PHB mRNA24763279
D006820Hyaluronic AcidHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PHB protein]23178681
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of PHB mRNA17183730
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PHB mRNA20044591
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PHB mRNA12419474
D006861Hydrogen PeroxideHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of PHB protein]23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PHB protein23178681
C492448ICG 001ICG 001 results in increased expression of PHB mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of PHB mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHB mRNA25613284
C410337K 7174K 7174 results in decreased expression of PHB mRNA24086573
D007649KetamineKetamine results in increased expression of PHB protein18504422
D007854LeadLead affects the expression of PHB mRNA28903495
C008261lead acetatelead acetate results in decreased expression of PHB protein21247988
C045463leflunomideleflunomide results in increased expression of PHB mRNA24136188
D008094LithiumLithium results in increased expression of PHB protein18296634
D008627Mercuric ChlorideMercuric Chloride affects the expression of PHB mRNA20353558
D008694MethamphetamineMethamphetamine results in increased expression of PHB protein19826936
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of PHB mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of PHB mRNA21782745
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PHB mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PHB mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium affects the expression of PHB protein24675778
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA]"20230807
D015741MetriboloneMetribolone results in decreased expression of PHB protein17152098
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of PHB protein20553848
C051752nefazodonenefazodone results in increased expression of PHB mRNA24136188
C022838nickel chloridenickel chloride affects the expression of PHB mRNA21496282
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PHB mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of PHB mRNA]"20230807
C012655nimesulidenimesulide results in increased expression of PHB mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PHB mRNA20971185
C025589ochratoxin Aochratoxin A results in increased expression of PHB protein19445961
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of PHB mRNA18636392
D010261ParaoxonParaoxon results in decreased expression of PHB protein20931991
D010416PentachlorophenolPentachlorophenol results in increased expression of PHB mRNA23892564
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of PHB protein26168851
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PHB mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PHB mRNA19162173
D010634Phenobarbital[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of PHB protein20935162
D010634PhenobarbitalPhenobarbital results in increased expression of PHB mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of PHB mRNA18301758|2005976
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of PHB mRNA]20059764
C006253pirinixic acidpirinixic acid results in increased expression of PHB mRNA19162173|2248451
D010894PiroxicamPiroxicam results in decreased expression of PHB mRNA21858171
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PHB protein22144121
D011192Potassium DichromatePotassium Dichromate results in increased expression of PHB protein18563748
D011374ProgesteronePHB protein inhibits the reaction [FSHB protein results in increased secretion of Progesterone]23254195
D011748PyrogallolPyrogallol results in increased expression of PHB mRNA20362636
C005266quinomethionatequinomethionate affects the expression of PHB mRNA15387888
D012402RotenoneRotenone results in increased expression of PHB protein21536665
D012402RotenoneRotenone results in increased expression of PHB protein21536665
C078903seocalcitolseocalcitol results in decreased expression of PHB mRNA12040012
C017947sodium arsenitesodium arsenite affects the methylation of PHB gene28589171
D053260SootSoot results in decreased expression of PHB protein24464499
D013311StreptozocinStreptozocin results in decreased expression of PHB protein21136691
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of PHB mRNA"26680231
D013605T-2 ToxinT-2 Toxin affects the expression of PHB protein26141394
D013629TamoxifenTamoxifen affects the expression of PHB mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHB mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHB mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PHB mRNA21354282
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PHB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PHB protein19492234
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PHB protein12361703
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PHB mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of PHB protein"25852303
D019284ThapsigarginThapsigargin results in decreased expression of PHB mRNA22378314
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PHB protein22595367
D014212TretinoinTretinoin results in decreased expression of PHB mRNA12875902|2372400
C023764triciribinetriciribine results in increased expression of PHB protein23254195
D014266TrientineTrientine results in decreased expression of PHB protein21136691
D014303TrinitrotolueneTrinitrotoluene affects the expression of PHB mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PHB mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of PHB mRNA22378314
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of PHB mRNA17183730
D014635Valproic AcidValproic Acid affects the expression of PHB mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PHB mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of PHB mRNA17292431
C025643vinclozolinvinclozolin results in decreased expression of PHB mRNA23034163
D014810Vitamin EVitamin E results in increased expression of PHB mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of PHB mRNA20044591
D019820Xanthine[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of PHB protein19464573

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IEA-  
GO:0001850complement component C3a binding-IDA17070910  
GO:0001851complement component C3b binding-IDA17070910  
GO:0005515protein binding-IPI11302691  12065415  16319068  16964284  20134482  20195357  
21746876  24380853  
GO:0008022protein C-terminus binding-IPI19906925  
GO:0019899enzyme binding-IPI23921388  
GO:0031871proteinase activated receptor binding-IPI24732013  
GO:0042826histone deacetylase binding-IPI16964284  
GO:0044212transcription regulatory region DNA binding-IDA18487222  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA16964284  
GO:0001649osteoblast differentiation-HDA16210410  
GO:0006355regulation of transcription, DNA-templated-IDA14500729  
GO:0006851mitochondrial calcium ion transmembrane transport-TAS-  
GO:0007005mitochondrion organization-IMP17008324  
GO:0007165signal transduction-TAS16130169  
GO:0008285negative regulation of cell proliferation-IMP18487222  
GO:0010628positive regulation of gene expression-IGI26310625  
GO:0010942positive regulation of cell death-IGI26310625  
GO:0010944negative regulation of transcription by competitive promoter binding-IDA18487222  
GO:0016575histone deacetylation-IDA12466959  
GO:0030308negative regulation of cell growth-IMP12065415  
GO:0042177negative regulation of protein catabolic process-IMP24732013  
GO:0042981regulation of apoptotic process-TAS16130169  
GO:0045745positive regulation of G-protein coupled receptor protein signaling pathway-IMP24732013  
GO:0045892negative regulation of transcription, DNA-templated-IDA12065415  12566959  
GO:0045892negative regulation of transcription, DNA-templated-IMP18487222  
GO:0045893positive regulation of transcription, DNA-templated-IDA14500729  
GO:0045917positive regulation of complement activation-IDA17070910  
GO:0050821protein stabilization-IMP17008324  
GO:0050847progesterone receptor signaling pathway-IDA16964284  
GO:0060766negative regulation of androgen receptor signaling pathway-IDA16964284  
GO:0060766negative regulation of androgen receptor signaling pathway-IMP18487222  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IMP24732013  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP22417827  
GO:0071354cellular response to interleukin-6-IDA17324931  
GO:0071897DNA biosynthetic process-IEA-  
GO:2000323negative regulation of glucocorticoid receptor signaling pathway-IDA16964284  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA16964284  24732013  
GO:0005634nucleus-TAS16130169  
GO:0005654nucleoplasm-IDA12466959  
GO:0005737cytoplasm-IDA16964284  
GO:0005739mitochondrion-HDA20833797  
GO:0005739mitochondrion-IDA24732013  
GO:0005743mitochondrial inner membrane-IDA17008324  
GO:0005743mitochondrial inner membrane-TAS14500729  
GO:0005769early endosome-IDA24732013  
GO:0005886plasma membrane-IDA24732013  
GO:0005887integral component of plasma membrane-IDA15274632  
GO:0009986cell surface-IDA22417827  24732013  
GO:0016020membrane-HDA16210410  19946888  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673000RAF activationTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS
R-HSA-8949215Mitochondrial calcium ion transportTAS
R-HSA-8949664Processing of SMDT1TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20030709Prohibitin is expressed in pancreatic beta-cells and protects against oxidative and proapoptotic effects of ethanol. (2010 Jan)Lee JHFEBS J