Gene: PHF2

5253
CENP-35|GRC5|JHDM1E|KDM7C
PHD finger protein 2
protein-coding
9q22.31
Ensembl:ENSG00000197724 MIM:604351 Vega:OTTHUMG00000020253 UniprotKB:O75151
NG_047001.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.489e-1 (AD)  6.686e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11793637chr9:93653617 (GRCh38.p7)A>G / A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABL10.901
CTDSP20.886
PHF21A0.88
SGPL10.871
LSM14A0.87
PPFIA10.861
KAT6A0.859
HNRNPUL10.856
WWC30.855
PRPF38B0.854

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.684
OR4F5-0.669
CRH-0.24
NMU-0.23
SULT2B1-0.205
ABCC12-0.176
PNOC-0.173
KRT5-0.169
TGM3-0.162
LYPD8-0.161

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0331461-hydroxypyrene1-hydroxypyrene results in increased expression of PHF2 mRNA21854004
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of PHF2 mRNA21983209|2414075
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF2 mRNA"27188386
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of PHF2 mRNA"21854004
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PHF2 mRNA24449571
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of PHF2 mRNA26424790
C547126AZM551248AZM551248 results in decreased expression of PHF2 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PHF2 mRNA22228805
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of PHF2 mRNA26424790
C006780bisphenol Abisphenol A results in increased expression of PHF2 mRNA25047013
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PHF2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PHF2 mRNA27178563
C006780bisphenol Abisphenol A results in increased expression of PHF2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PHF2 mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of PHF2 mRNA26079696
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of PHF2 mRNA26424790
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PHF2 mRNA28628672
D004147DioxinsDioxins affects the expression of PHF2 mRNA20463971
C012301domoic aciddomoic acid results in increased expression of PHF2 mRNA18936300
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of PHF2 intron27776689
D005839GentamicinsGentamicins results in increased expression of PHF2 mRNA22061828
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PHF2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PHF2 mRNA28628672
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PHF2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PHF2 mRNA23649840
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PHF2 mRNA25729387
C005556propionaldehydepropionaldehyde results in decreased expression of PHF2 mRNA26079696
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of PHF2 mRNA"26680231
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHF2 mRNA21570461
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PHF2 mRNA25729387
C012589trichostatin Atrichostatin A results in decreased expression of PHF2 mRNA15901671
C012589trichostatin Atrichostatin A affects the expression of PHF2 mRNA28542535
C057693troglitazonetroglitazone results in decreased expression of PHF2 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased expression of PHF2 mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHF2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PHF2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PHF2 mRNA23179753|2438349

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003713transcription coactivator activitycontributes_toIDA21532585  
GO:0005506iron ion binding-IDA21167174  
GO:0005515protein binding-IPI21532585  
GO:0008270zinc ion binding-IDA20129925  
GO:0032452histone demethylase activityNOTIDA21167174  
GO:0032452histone demethylase activity-TAS-  
GO:0032454histone demethylase activity (H3-K9 specific)-IDA21532585  
GO:0035064methylated histone binding-IDA20129925  21167174  
GO:0051213dioxygenase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-TAS21532585  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006482protein demethylation-IDA21532585  
GO:0033169histone H3-K9 demethylation-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:0061188negative regulation of chromatin silencing at rDNA-IMP20129925  
GO ID GO Term Qualifier Evidence PubMed
GO:0000776kinetochore-IDA20813266  
GO:0000777condensed chromosome kinetochore-IEA-  
GO:0005634nucleus-TAS10051327  
GO:0005654nucleoplasm-TAS-  
GO:0005730nucleolus-IDA20129925  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-3214842HDMs demethylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal