Gene: SERPINA1

5265
A1A|A1AT|AAT|PI|PI1|PRO2275|alpha1AT|nNIF
serpin family A member 1
protein-coding
14q32.13
Ensembl:ENSG00000197249 MIM:107400 Vega:OTTHUMG00000150355 UniprotKB:P01009
NG_008290.1
PubMed
0   ANCO-SNPs
ND
20   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.334e-1 (AD)  7.118e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD300A0.937
LCP10.929
ABI30.927
HCK0.926
FCGR2A0.924
SIGLEC90.918
LAIR10.915
SPI10.915
LRRC250.914
TLR20.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.531
MARCH4-0.516
NEUROD6-0.5
ST6GAL2-0.499
SLC7A4-0.494
ZSCAN1-0.494
CPLX3-0.487
ATP2C2-0.484
TMEM179-0.48
DLK2-0.477

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB019982-[3,4-Dihydroxy-2-Hydroxymethyl-5-(2-Hydroxy-Nonyl)-Tetrahydro-Furan-2-Yloxy]-6-Hydroxymethyl-Tetra Hydro-Pyran-3,4,5-TriolSmall MoleculeExperimentalTarget
DB03345Beta-MercaptoethanolSmall Molecule60-24-2ExperimentalTarget
DB05481Recombinant alpha 1-antitrypsinSmall Molecule-InvestigationalTarget
DB05961PPL-100Small Molecule612547-11-2InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0810141,2-bis(2,4,6-tribromophenoxy)ethane"1,2-bis(2,4,6-tribromophenoxy)ethane results in decreased expression of SERPINA1 mRNA"28249227
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of SERPINA1 mRNA"25614096
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of SERPINA1 mRNA25088246
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of SERPINA1 mRNA"20206263
C0415944-nonylphenol4-nonylphenol affects the expression of SERPINA1 mRNA15792627
D000082AcetaminophenAcetaminophen results in decreased expression of SERPINA1 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of SERPINA1 protein22230336
D000082AcetaminophenAcetaminophen results in increased expression of SERPINA1 protein16687475
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of SERPINA1 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of SERPINA1 mRNA28522335
D000638AmiodaroneAmiodarone affects the expression of SERPINA1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SERPINA1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents affects the expression of SERPINA1 mRNA24449571
D001194AsbestosSERPINA1 gene polymorphism results in increased susceptibility to Asbestos12368052|1474804
D001241AspirinAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SERPINA1 protein]17303692
D001379Azathioprine[Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of SERPINA1 protein8614026
C487081belinostatbelinostat results in decreased expression of SERPINA1 mRNA27188386
D001553BenzbromaroneBenzbromarone affects the expression of SERPINA1 mRNA19483382
D053119BenzophenanthridinesBenzophenanthridines analog results in decreased expression of SERPINA1 mRNA22120849
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SERPINA1 mRNA20440473
D004958EstradiolESR1 protein affects the reaction [Estradiol results in increased expression of SERPINA1 mRNA]14699072
D004958EstradiolEstradiol affects the expression of SERPINA1 mRNA14699072
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA1 mRNA19619570
D004958EstradiolEstradiol results in increased expression of SERPINA1 mRNA16202921|1961957
C095105bexarotenebexarotene results in decreased expression of SERPINA1 mRNA16648578
C018467Bisecurin IBisecurin I results in increased expression of SERPINA1 protein4058912
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of SERPINA1 mRNA"20162321
C006780bisphenol Abisphenol A results in increased expression of SERPINA1 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of SERPINA1 mRNA27104808
C006780bisphenol Abisphenol A results in decreased expression of SERPINA1 mRNA25181051
D002104Cadmium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of SERPINA1 mRNA21481475
D002104CadmiumSERPINA1 protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SERPINA1 mRNA12760830
D019256Cadmium ChlorideCadmium Chloride affects the expression of SERPINA1 mRNA22110744
D002110CaffeineCaffeine results in increased expression of SERPINA1 mRNA18444173
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of SERPINA1 protein8614026
D004390ChlorpyrifosChlorpyrifos results in increased expression of SERPINA1 mRNA21356183
C022990chromic chloridechromic chloride results in decreased activity of SERPINA1 protein12122574
C022990chromic chloridechromic chloride results in decreased activity of SERPINA1 protein12122574
C034172chromozym PLSERPINA1 protein affects the metabolism of chromozym PL6333300
D002994ClofibrateClofibrate affects the expression of SERPINA1 mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of SERPINA1 mRNA12851107|1496536
C018021cobaltous chloridecobaltous chloride results in decreased secretion of SERPINA1 protein22079246
C018021cobaltous chloridecobaltous chloride results in decreased expression of SERPINA1 mRNA24386269
D003300CopperSERPINA1 protein binds to Copper23896426
D003300CopperCopper results in decreased expression of SERPINA1 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of SERPINA1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SERPINA1 mRNA27989131
C093628cyproconazolecyproconazole affects the expression of SERPINA1 mRNA21621602
D003561CytarabineCytarabine results in increased expression of SERPINA1 mRNA19194470
C014347decitabinedecitabine results in increased expression of SERPINA1 mRNA19194470
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SERPINA1 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of SERPINA1 protein10380089
D003907DexamethasoneDexamethasone results in increased N-linked glycosylation of SERPINA1 protein8392465
D003976DiazinonDiazinon results in increased methylation of SERPINA1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SERPINA1 mRNA21266533
D002117CalcitriolCalcitriol results in increased expression of SERPINA1 mRNA26485663
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of SERPINA1 mRNA27638505
D004317DoxorubicinDoxorubicin results in increased secretion of SERPINA1 protein28885000
C118739entinostatentinostat results in decreased expression of SERPINA1 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SERPINA1 mRNA17557909
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased expression of SERPINA1 protein10928463
D019304Ethinyl Estradiol-Norgestrel CombinationEthinyl Estradiol-Norgestrel Combination results in increased expression of SERPINA1 protein4058912
D005001EthionineEthionine affects the expression of SERPINA1 mRNA19483382
C034096ethoxyacetic acidethoxyacetic acid affects the expression of SERPINA1 mRNA21621602
C061365flusilazoleflusilazole affects the expression of SERPINA1 mRNA21621602
D005485FlutamideFlutamide results in decreased expression of SERPINA1 protein17311803
C069837fullerene C60fullerene C60 results in increased expression of SERPINA1 mRNA19167457
C039281furanfuran binds to SERPINA1 protein22240984
D019833GenisteinGenistein results in decreased expression of SERPINA1 mRNA18444173
D019833GenisteinGenistein results in increased expression of SERPINA1 mRNA20884965
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of SERPINA1 mRNA21782745
D019833GenisteinGenistein results in decreased expression of SERPINA1 mRNA12075121
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of SERPINA1 mRNA22467014
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SERPINA1 mRNA20044591
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of SERPINA1 mRNA16849584
C492448ICG 001ICG 001 results in increased expression of SERPINA1 mRNA26191083
D007213IndomethacinSERPINA1 protein mutant form results in increased susceptibility to Indomethacin17006946
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of SERPINA1 mRNA12539871
D007854LeadSERPINA1 protein binds to Lead23896426
D008070LipopolysaccharidesLipopolysaccharides affects the expression of SERPINA1 mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of SERPINA1 mRNA]28070326
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINA1 mRNA26378955
C013598methoxyacetic acidmethoxyacetic acid affects the expression of SERPINA1 mRNA21621602
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of SERPINA1 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of SERPINA1 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SERPINA1 mRNA23179753|2718838
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of SERPINA1 mRNA27544571
C043243methyl tert-butyl ethermethyl tert-butyl ether results in decreased expression of SERPINA1 mRNA24128854
D015735MifepristoneMifepristone results in increased expression of SERPINA1 mRNA19439560
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SERPINA1 mRNA"22076105
C031721naphthalenenaphthalene metabolite binds to SERPINA1 protein16453347
C031721naphthalenenaphthalene metabolite binds to SERPINA1 protein15892573
D009532NickelNickel binds to SERPINA1 protein modified form25579632
D009532NickelNickel results in increased expression of SERPINA1 mRNA25583101
D009532NickelSERPINA1 protein binds to Nickel23896426
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of SERPINA1 protein19716841
C464660obeticholic acidobeticholic acid results in decreased expression of SERPINA1 mRNA27939613
C025589ochratoxin Aochratoxin A results in increased acetylation of SERPINA1 promoter29098329
C025589ochratoxin A[ochratoxin A results in increased acetylation of SERPINA1 promoter] which results in increased expression of SERPINA1 mRNA29098329|2909832
C025589ochratoxin Aochratoxin A results in increased expression of SERPINA1 mRNA29098329
D009853OmeprazoleOmeprazole affects the expression of SERPINA1 mRNA19483382
C410127PCB 180PCB 180 affects the expression of SERPINA1 mRNA21703328
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of SERPINA1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of SERPINA1 mRNA17383973
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SERPINA1 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SERPINA1 mRNA18467677
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of SERPINA1 mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of SERPINA1 mRNA17383973
C415326phenoxyacetic acidphenoxyacetic acid affects the expression of SERPINA1 mRNA21621602
C006253pirinixic acidpirinixic acid results in decreased expression of SERPINA1 mRNA18467677
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of SERPINA1 mRNA]18467677
C006253pirinixic acidpirinixic acid affects the expression of SERPINA1 mRNA19483382
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of SERPINA1 mRNA]28070326
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SERPINA1 mRNA22714537
C045950propiconazolepropiconazole affects the expression of SERPINA1 mRNA17383973
C005556propionaldehydepropionaldehyde results in decreased expression of SERPINA1 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of SERPINA1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of SERPINA1 mRNA24780913
C059514resveratrolresveratrol results in increased expression of SERPINA1 mRNA25888808
C541923sandostatinLARsandostatinLAR results in decreased expression of SERPINA1 mRNA17210224
D012643Selenium[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of SERPINA1 mRNA21481475
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SERPINA1 mRNA25895662
D020123SirolimusSirolimus affects the localization of SERPINA1 protein20511674
D012906SmokeSmoke results in increased expression of SERPINA1 mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of SERPINA1 mRNA16882884
C017947sodium arsenitesodium arsenite affects the expression of SERPINA1 mRNA17450228
C016104sodium bichromatesodium bichromate results in decreased expression of SERPINA1 mRNA12760830
C016104sodium bichromatesodium bichromate affects the expression of SERPINA1 mRNA22110744
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINA1 mRNA26378955
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of SERPINA1 mRNA22467014
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [SERPINA1 protein mutant form results in increased activity of CASP7 protein]17559149
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]17559149
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid inhibits the reaction [SERPINA1 protein mutant form results in increased cleavage of and results in increased activity of CASP4 protein]17559149
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINA1 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPINA1 mRNA19619570|2129612
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SERPINA1 mRNA15644576
D019284ThapsigarginThapsigargin results in increased expression of SERPINA1 protein21692457
D013806TheophyllineSERPINA1 gene affects the susceptibility to Theophylline17943569
D013853ThioacetamideThioacetamide affects the expression of SERPINA1 mRNA19483382
C096900thrombin receptor-activating peptide SFLLRNPNDKYAspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SERPINA1 protein]17303692
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of SERPINA1 protein17303692
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SERPINA1 mRNA27865774|2806579
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of SERPINA1 protein27189315
C032910triadimefontriadimefon affects the expression of SERPINA1 mRNA17383973
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SERPINA1 mRNA19448997
D014425TurpentineTurpentine results in increased expression of SERPINA1 mRNA14555839
D014635Valproic AcidValproic Acid results in decreased expression of SERPINA1 mRNA23179753|2718838
C029297vinylidene chloridevinylidene chloride results in decreased expression of SERPINA1 mRNA26682919
D015032ZincSERPINA1 protein binds to Zinc23896426
C031238zinc sulfide[Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of SERPINA1 mRNA21481475
C088658zoledronic acidzoledronic acid results in increased expression of SERPINA1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IPI15853774  
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-IDA15795238  
GO:0004867serine-type endopeptidase inhibitor activity-NAS12878203  
GO:0005515protein binding-IPI11057674  12860985  12878203  15271889  15845869  16192646  
16321984  17380188  20477988  22115549  23826168  
GO:0042802identical protein binding-IPI11057674  18923394  21909074  22405009  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0006953acute-phase response-IEA-  
GO:0007596blood coagulation-IEA-  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0043312neutrophil degranulation-TAS-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0048208COPII vesicle coating-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  23580065  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA6980881  25645918  
GO:0005615extracellular space-IMP16192646  
GO:0005783endoplasmic reticulum-IDA20477988  23826168  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005794Golgi apparatus-IDA20477988  
GO:0030134COPII-coated ER to Golgi transport vesicle-TAS-  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane-TAS-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-204005COPII-mediated vesicle transportTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5694530Cargo concentration in the ERTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22912729SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort. (2012)Thun GAPLoS One
19515129Cluster headache and Alpha 1-antitrypsin deficiency. (2010 Jan)Summ OCephalalgia
23030783Distribution and levels of alpha-1-antitrypsin in the lung and plasma in smokers and chronic obstructive pulmonary disease. (2013 Jan)Linja-aho AAPMIS
20301692Alpha-1 Antitrypsin Deficiency (1993)Stoller JK-
17389752Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency. (2007 Sep)Demeo DLThorax
21778810Genetics of COPD. (2011 Sep)Nakamura HAllergol Int
18565211Hereditary alpha-1-antitrypsin deficiency and its clinical consequences. (2008 Jun 19)Fregonese LOrphanet J Rare Dis
28380308Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups. (2017 Aug)Foreman MGAnn Am Thorac Soc
24213563Interactions between SERPINA1 PiMZ genotype, occupational exposure and lung function decline. (2014 Apr)Mehta AJOccup Environ Med
25938284The impact of smoke exposure on the clinical phenotype of alpha-1 antitrypsin deficiency in Ireland: exploiting a national registry to understand a rare disease. (2015 May)O'Brien MECOPD
27189315The human placental proteome is affected by maternal smoking. (2016 Aug)Huuskonen PReprod Toxicol
18353624Alpha-1 antitrypsin Null mutations and severity of emphysema. (2008 Jun)Fregonese LRespir Med
21702661The role of proteases, endoplasmic reticulum stress and SERPINA1 heterozygosity in lung disease and alpha-1 anti-trypsin deficiency. (2011 Jun)Greene CMExpert Rev Respir Med
25425243Identification and characterisation of eight novel SERPINA1 Null mutations. (2014 Nov 26)Ferrarotti IOrphanet J Rare Dis
26771213Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. (2016 Jul 1)Hobbs BDAm J Respir Crit Care Med
16278826Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. (2006 Jan)Chappell SHum Mutat
28723059Alpha 1 Antitrypsin Deficiency (2018 Jan)Meseeha M-
29453277Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema. (2018 Mar 13)Borel FProc Natl Acad Sci U S A
15994391The protease inhibitor PI*S allele and COPD: a meta-analysis. (2005 Jul)Dahl MEur Respir J
29432934Alpha-1 antitrypsin deficiency: From the lung to the heart? (2018 Mar)Curjuric IAtherosclerosis