Gene: PI3

5266
ESI|SKALP|WAP3|WFDC14|cementoin
peptidase inhibitor 3
protein-coding
20q13.12
Ensembl:ENSG00000124102 MIM:182257 Vega:OTTHUMG00000032567 UniprotKB:P19957
NC_000020.11
PubMed
0   ANCO-SNPs
CD|ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.854e-1 (AD)  2.589e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSTA0.671
KRT6A0.65
SPRR2D0.637
SPINK50.637
KRT6B0.622
SPRR1A0.61
MUC210.606
SPRR1B0.606
GBP60.598
SPRR2A0.59

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF425-0.305
GREB1-0.289
RSPH10B-0.287
CILP2-0.282
KSR2-0.28
NEK10-0.279
CSRNP3-0.275
TRIM72-0.274
FAM86JP-0.274
TCTE1-0.273

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of PI3 mRNA"24172598
D000082AcetaminophenAcetaminophen results in decreased expression of PI3 mRNA26690555|2906747
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PI3 mRNA21298039
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PI3 mRNA"24160326|2575705
C547126AZM551248AZM551248 results in decreased expression of PI3 mRNA22323515
D004958EstradiolEstradiol affects the expression of PI3 mRNA22574217
C018475butyraldehydebutyraldehyde results in increased expression of PI3 mRNA26079696
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PI3 mRNA20971185
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] affects the expression of PI3 mRNA20705681
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PI3 mRNA21527772
D004237DiuronDiuron metabolite results in increased expression of PI3 mRNA24172598
D007840LatexLatex analog results in increased expression of PI3 mRNA24768652
D008070LipopolysaccharidesPI3 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC mRNA]21419012
D008070LipopolysaccharidesPI3 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MUC5AC protein]21419012
D008727MethotrexatePI3 protein affects the susceptibility to Methotrexate16217747
D009532NickelNickel results in increased expression of PI3 mRNA24768652|2558310
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PI3 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of PI3 mRNA20971185
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] affects the expression of PI3 mRNA20705681
D052638Particulate MatterParticulate Matter results in increased expression of PI3 mRNA28341207
C046012pentanalpentanal results in increased expression of PI3 mRNA26079696
D010476PerfumePerfume results in increased expression of PI3 mRNA24768652
D000068718Rosuvastatin CalciumRosuvastatin Calcium results in decreased expression of PI3 mRNA18192897
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of PI3 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PI3 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of PI3 mRNA28595984
D012967Sodium Dodecyl SulfateSodium Dodecyl Sulfate results in decreased expression of PI3 mRNA17936526
C024746tobacco tartobacco tar results in increased expression of PI3 mRNA19559774
C057693troglitazonetroglitazone results in decreased expression of PI3 mRNA25572481
C057693troglitazonetroglitazone results in increased expression of PI3 mRNA19140230
C088658zoledronic acidzoledronic acid results in increased expression of PI3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004866endopeptidase inhibitor activity-TAS2394696  
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO:0030280structural constituent of epidermis-IDA7543090  
GO ID GO Term Qualifier Evidence PubMed
GO:0007620copulation-IEA-  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0018149peptide cross-linking-IDA7543090  
GO:0019730antimicrobial humoral response-TAS-  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-IDA7543090  
GO:0001533cornified envelope-TAS-  
GO:0005576extracellular region-TAS-  
GO:0005829cytosol-TAS-  
GO:0031012extracellular matrix-TAS8476637  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6803157Antimicrobial peptidesTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18793110Pharmacological approaches to improve endothelial repair mechanisms. (2008 Sep)Besler CExpert Rev Cardiovasc Ther
16461845Tissue factor in cardiovascular diseases: molecular mechanisms and clinical implications. (2006 Feb 7)Steffel JCirculation
25567618Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency. (2015 Mar)Suzuki NHum Reprod
23438328Systemic inflammation is associated with differential gene expression and airway neutrophilia in asthma. (2013 Apr)Fu JJOMICS
16777389Acute effect of cigarette smoke on TNF-alpha release by macrophages mediated through the erk1/2 pathway. (2006 Jun)Demirjian LBiochim Biophys Acta
23954767Curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on Nrf2 activation and protection against acrolein-induced ARPE-19 cell toxicity. (2013 Nov 1)Li YToxicol Appl Pharmacol
26100595Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production. (2015 Aug)Pelissier-Rota MAInt J Biochem Cell Biol
16414349PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity. (2006 Feb 24)Zhang XBiochem Biophys Res Commun
26932165Protective effects of elafin against adult asthma. (2016 Mar-Apr)Tsai YSAllergy Asthma Proc