Gene: SERPINB5

5268
PI5|maspin
serpin family B member 5
protein-coding
18q21.33
Ensembl:ENSG00000206075 MIM:154790 Vega:OTTHUMG00000141307 UniprotKB:P36952
NC_000018.10
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.933e-1 (AD)  4.705e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DSC30.849
FLG20.788
KLK110.787
LAD10.779
CASP140.753
KRT140.751
NCCRP10.719
SLURP10.716
CALML50.696
KRT20.692

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCLY-0.344
FAM43B-0.338
TRAPPC9-0.336
PLA2G6-0.33
MAGIX-0.325
ZFP41-0.323
TMEM53-0.323
ZNF835-0.32
WDR24-0.312
E2F1-0.307

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB04530S,S-(2-Hydroxyethyl)ThiocysteineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0131862,3-pentanedione"2,3-pentanedione results in decreased expression of SERPINB5 mRNA"25710175
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SERPINB5 mRNA"15059925
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of SERPINB5 protein26194647
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SERPINB5 mRNA12419474
D000082AcetaminophenAcetaminophen results in decreased expression of SERPINB5 mRNA17585979
D020106AcrylamideAcrylamide results in increased expression of SERPINB5 mRNA28959563
C106812adefovir dipivoxiladefovir dipivoxil results in increased expression of SERPINB5 mRNA25596134
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SERPINB5 mRNA16483693
D001151ArsenicArsenic results in increased expression of SERPINB5 mRNA19945496
C006632arsenic trioxideSERPINB5 protein results in decreased susceptibility to arsenic trioxide20707922
D001241AspirinAspirin results in increased expression of SERPINB5 protein16546864
C547126AZM551248AZM551248 results in decreased expression of SERPINB5 mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SERPINB5 mRNA"19150397
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINB5 mRNA19619570
D004958Estradiol[Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA22403704
D004958EstradiolEstradiol results in increased expression of SERPINB5 mRNA19619570|2260985
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of SERPINB5 mRNA17404688
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in increased expression of SERPINB5 mRNA]25210133
D004958EstradiolEstradiol results in increased expression of SERPINB5 mRNA19484750|2521013
C006780bisphenol Abisphenol A results in decreased expression of SERPINB5 mRNA20678512
C006780bisphenol A[bisphenol A results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA22403704
C006780bisphenol Abisphenol A results in decreased expression of SERPINB5 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SERPINB5 mRNA12414654
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINB5 mRNA20360939
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of SERPINB5 mRNA18636392
C100187chloropicrinchloropicrin affects the expression of SERPINB5 mRNA26352163
C031180chrysenechrysene results in increased expression of SERPINB5 mRNA26377693
C059262cidofovircidofovir results in increased expression of SERPINB5 mRNA25596134
D003474CurcuminCurcumin results in increased expression of SERPINB5 mRNA17290611|1994467
D003474CurcuminCurcumin results in increased expression of SERPINB5 protein19944674
D003474Curcumin[Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein19944674
D003474Curcumin[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein19944674
D003634DDT[DDT results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA22403704
C014347decitabinedecitabine affects the expression of SERPINB5 mRNA16799634
C014347decitabine[decitabine co-treated with trichostatin A] results in decreased methylation of SERPINB5 promoter18291368
C014347decitabinedecitabine results in decreased methylation of SERPINB5 gene18060631
C014347decitabinedecitabine results in increased expression of SERPINB5 mRNA18060631|1829136
D003840Deoxycholic AcidSERPINB5 protein results in decreased susceptibility to Deoxycholic Acid12507930
D003847DeoxyglucoseDeoxyglucose analog results in increased expression of SERPINB5 protein27931795
D002945CisplatinCisplatin results in increased expression of SERPINB5 mRNA19561079
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINB5 mRNA20360939
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SERPINB5 mRNA15171707
D002117CalcitriolCalcitriol results in increased expression of SERPINB5 mRNA26485663
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of SERPINB5 mRNA"26388957
D0198131,2-Dimethylhydrazine"[NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of SERPINB5 mRNA"26388957
D017292DoxazosinSERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA mRNA alternative form]16007219
D017292DoxazosinSERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA protein]16007219
D017292DoxazosinSERPINB5 protein promotes the reaction [Doxazosin results in increased expression of BAX protein]16007219
D017292DoxazosinSERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA]16007219
D017292DoxazosinSERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein]16007219
D017292DoxazosinSERPINB5 protein results in increased susceptibility to Doxazosin16007219
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of SERPINB5 mRNA25839702
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SERPINB5 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SERPINB5 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SERPINB5 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SERPINB5 mRNA17557909
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of SERPINB5 mRNA17317680
D0150732-AcetylaminofluoreneTRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]17317680
D005472Fluorouracil[Fluorouracil co-treated with irinotecan] results in decreased expression of SERPINB5 mRNA16391804
D005472FluorouracilFluorouracil results in increased expression of SERPINB5 mRNA17982676
D005472FluorouracilSERPINB5 protein results in increased susceptibility to Fluorouracil16331619
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in increased expression of SERPINB5 mRNA]15016801
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of SERPINB5 mRNA]17982676
D005557FormaldehydeFormaldehyde results in decreased expression of SERPINB5 mRNA28937961
D005557FormaldehydeFormaldehyde results in increased expression of SERPINB5 mRNA23649840
C039281furanfuran results in increased expression of SERPINB5 mRNA27387713
D005665FurosemideFurosemide results in increased expression of SERPINB5 mRNA16526316
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of SERPINB5 mRNA12414654
C051890irinotecan[Fluorouracil co-treated with irinotecan] results in decreased expression of SERPINB5 mRNA16391804
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SERPINB5 mRNA24796395
C031895lead chromatelead chromate results in increased expression of SERPINB5 mRNA23584427
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINB5 mRNA26378955
D008727MethotrexateMethotrexate results in increased expression of SERPINB5 mRNA21678067
C008493methylselenic acidmethylselenic acid affects the expression of SERPINB5 mRNA14617803
C008493methylselenic acidmethylselenic acid results in increased expression of SERPINB5 mRNA18548127
D015741MetriboloneMetribolone results in decreased expression of SERPINB5 protein17152098
C063855microcystin RRmicrocystin RR results in decreased expression of SERPINB5 protein19111056
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of SERPINB5 mRNA19945496
C500085muraglitazarmuraglitazar results in increased expression of SERPINB5 mRNA21515302
D009151Mustard GasMustard Gas results in decreased expression of SERPINB5 mRNA18955075
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SERPINB5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SERPINB5 mRNA"25554681
C016340o,p'-DDT"o,p'-DDT results in increased expression of SERPINB5 mRNA"22609851
D010100OxygenOxygen deficiency results in increased expression of SERPINB5 mRNA25596134
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of SERPINB5 mRNA18636392
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of SERPINB5 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SERPINB5 mRNA16221955
C479580procyanidin B2procyanidin B2 results in increased expression of SERPINB5 mRNA25839702
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of SERPINB5 mRNA17404688
C037219quinolinequinoline analog results in increased expression of SERPINB5 protein18645022
C059514resveratrolresveratrol results in increased expression of SERPINB5 protein23272133
C089730rosiglitazonerosiglitazone results in increased expression of SERPINB5 mRNA21515302
D012969Sodium FluorideSodium Fluoride results in increased expression of SERPINB5 protein28918527
D012999SomanSoman results in decreased expression of SERPINB5 mRNA19281266
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINB5 mRNA26378955
C025462sulindac sulfidesulindac sulfide results in decreased expression of SERPINB5 mRNA15897233
D013629TamoxifenTamoxifen affects the expression of SERPINB5 mRNA17555576
C112765tanespimycintanespimycin results in increased expression of SERPINB5 mRNA19514085
C501413tesaglitazartesaglitazar results in increased expression of SERPINB5 mRNA21515302
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINB5 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SERPINB5 mRNA19619570
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SERPINB5 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SERPINB5 mRNA17035482
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SERPINB5 mRNA28065790
C012589trichostatin A[decitabine co-treated with trichostatin A] results in decreased methylation of SERPINB5 promoter18291368
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of SERPINB5 mRNA17982090
C057693troglitazonetroglitazone results in increased expression of SERPINB5 mRNA21515302
D014635Valproic AcidValproic Acid results in increased expression of SERPINB5 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of SERPINB5 gene29154799
D024483Vitamin K 3Vitamin K 3 results in increased expression of SERPINB5 mRNA12414654

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0005515protein binding-IPI16049006  20211623  
GO ID GO Term Qualifier Evidence PubMed
GO:0002009morphogenesis of an epithelium-IEA-  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0030198extracellular matrix organization-IEA-  
GO:0050678regulation of epithelial cell proliferation-IEA-  
GO:0060512prostate gland morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IDA16049006  
KEGG ID KEGG Term
hsa04115p53 signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25775950Association between SNPs in Serpin gene family and risk of esophageal squamous cell carcinoma. (2015 Aug)Meng HTumour Biol
22011669Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. (2012 Jan)Kwon YJJ Thorac Oncol