Gene info: ID 5268

Gene Symbol	Pearson Correlation Coefficient
DSC3	0.849
FLG2	0.788
KLK11	0.787
LAD1	0.779
CASP14	0.753
KRT14	0.751
NCCRP1	0.719
SLURP1	0.716
CALML5	0.696
KRT2	0.692

Gene Symbol	Pearson Correlation Coefficient
SCLY	-0.344
FAM43B	-0.338
TRAPPC9	-0.336
PLA2G6	-0.33
MAGIX	-0.325
ZFP41	-0.323
TMEM53	-0.323
ZNF835	-0.32
WDR24	-0.312
E2F1	-0.307

DrugBank
CTD

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB04530	S,S-(2-Hydroxyethyl)Thiocysteine	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C013186	2,3-pentanedione	"2,3-pentanedione results in decreased expression of SERPINB5 mRNA"	25710175
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of SERPINB5 mRNA"	15059925
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of SERPINB5 protein	26194647
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of SERPINB5 mRNA	12419474
D000082	Acetaminophen	Acetaminophen results in decreased expression of SERPINB5 mRNA	17585979
D020106	Acrylamide	Acrylamide results in increased expression of SERPINB5 mRNA	28959563
C106812	adefovir dipivoxil	adefovir dipivoxil results in increased expression of SERPINB5 mRNA	25596134
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of SERPINB5 mRNA	16483693
D001151	Arsenic	Arsenic results in increased expression of SERPINB5 mRNA	19945496
C006632	arsenic trioxide	SERPINB5 protein results in decreased susceptibility to arsenic trioxide	20707922
D001241	Aspirin	Aspirin results in increased expression of SERPINB5 protein	16546864
C547126	AZM551248	AZM551248 results in decreased expression of SERPINB5 mRNA	22323515
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SERPINB5 mRNA"	19150397
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINB5 mRNA	19619570
D004958	Estradiol	[Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA	22403704
D004958	Estradiol	Estradiol results in increased expression of SERPINB5 mRNA	19619570\|2260985
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of SERPINB5 mRNA	17404688
D004958	Estradiol	ESR1 protein promotes the reaction [Estradiol results in increased expression of SERPINB5 mRNA]	25210133
D004958	Estradiol	Estradiol results in increased expression of SERPINB5 mRNA	19484750\|2521013
C006780	bisphenol A	bisphenol A results in decreased expression of SERPINB5 mRNA	20678512
C006780	bisphenol A	[bisphenol A results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA	22403704
C006780	bisphenol A	bisphenol A results in decreased expression of SERPINB5 mRNA	25181051
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of SERPINB5 mRNA	12414654
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINB5 mRNA	20360939
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of SERPINB5 mRNA	18636392
C100187	chloropicrin	chloropicrin affects the expression of SERPINB5 mRNA	26352163
C031180	chrysene	chrysene results in increased expression of SERPINB5 mRNA	26377693
C059262	cidofovir	cidofovir results in increased expression of SERPINB5 mRNA	25596134
D003474	Curcumin	Curcumin results in increased expression of SERPINB5 mRNA	17290611\|1994467
D003474	Curcumin	Curcumin results in increased expression of SERPINB5 protein	19944674
D003474	Curcumin	[Curcumin results in increased expression of SERPINB5] which results in decreased expression of BCL2 protein	19944674
D003474	Curcumin	[Curcumin results in increased expression of SERPINB5] which results in increased expression of TP53 protein	19944674
D003634	DDT	[DDT results in increased activity of ESR1 protein] which results in increased expression of SERPINB5 mRNA	22403704
C014347	decitabine	decitabine affects the expression of SERPINB5 mRNA	16799634
C014347	decitabine	[decitabine co-treated with trichostatin A] results in decreased methylation of SERPINB5 promoter	18291368
C014347	decitabine	decitabine results in decreased methylation of SERPINB5 gene	18060631
C014347	decitabine	decitabine results in increased expression of SERPINB5 mRNA	18060631\|1829136
D003840	Deoxycholic Acid	SERPINB5 protein results in decreased susceptibility to Deoxycholic Acid	12507930
D003847	Deoxyglucose	Deoxyglucose analog results in increased expression of SERPINB5 protein	27931795
D002945	Cisplatin	Cisplatin results in increased expression of SERPINB5 mRNA	19561079
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SERPINB5 mRNA	20360939
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of SERPINB5 mRNA	15171707
D002117	Calcitriol	Calcitriol results in increased expression of SERPINB5 mRNA	26485663
D019813	1,2-Dimethylhydrazine	"1,2-Dimethylhydrazine results in decreased expression of SERPINB5 mRNA"	26388957
D019813	1,2-Dimethylhydrazine	"[NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of SERPINB5 mRNA"	26388957
D017292	Doxazosin	SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA mRNA alternative form]	16007219
D017292	Doxazosin	SERPINB5 protein promotes the reaction [Doxazosin results in decreased expression of VEGFA protein]	16007219
D017292	Doxazosin	SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of BAX protein]	16007219
D017292	Doxazosin	SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 mRNA]	16007219
D017292	Doxazosin	SERPINB5 protein promotes the reaction [Doxazosin results in increased expression of SMAD4 protein]	16007219
D017292	Doxazosin	SERPINB5 protein results in increased susceptibility to Doxazosin	16007219
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of SERPINB5 mRNA	25839702
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of SERPINB5 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SERPINB5 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SERPINB5 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SERPINB5 mRNA	17557909
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of SERPINB5 mRNA	17317680
D015073	2-Acetylaminofluorene	TRP53 protein modified form affects the reaction [2-Acetylaminofluorene affects the expression of SERPINB5 mRNA]	17317680
D005472	Fluorouracil	[Fluorouracil co-treated with irinotecan] results in decreased expression of SERPINB5 mRNA	16391804
D005472	Fluorouracil	Fluorouracil results in increased expression of SERPINB5 mRNA	17982676
D005472	Fluorouracil	SERPINB5 protein results in increased susceptibility to Fluorouracil	16331619
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in increased expression of SERPINB5 mRNA]	15016801
D005472	Fluorouracil	TP53 protein promotes the reaction [Fluorouracil results in increased expression of SERPINB5 mRNA]	17982676
D005557	Formaldehyde	Formaldehyde results in decreased expression of SERPINB5 mRNA	28937961
D005557	Formaldehyde	Formaldehyde results in increased expression of SERPINB5 mRNA	23649840
C039281	furan	furan results in increased expression of SERPINB5 mRNA	27387713
D005665	Furosemide	Furosemide results in increased expression of SERPINB5 mRNA	16526316
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of SERPINB5 mRNA	12414654
C051890	irinotecan	[Fluorouracil co-treated with irinotecan] results in decreased expression of SERPINB5 mRNA	16391804
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of SERPINB5 mRNA	24796395
C031895	lead chromate	lead chromate results in increased expression of SERPINB5 mRNA	23584427
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINB5 mRNA	26378955
D008727	Methotrexate	Methotrexate results in increased expression of SERPINB5 mRNA	21678067
C008493	methylselenic acid	methylselenic acid affects the expression of SERPINB5 mRNA	14617803
C008493	methylselenic acid	methylselenic acid results in increased expression of SERPINB5 mRNA	18548127
D015741	Metribolone	Metribolone results in decreased expression of SERPINB5 protein	17152098
C063855	microcystin RR	microcystin RR results in decreased expression of SERPINB5 protein	19111056
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of SERPINB5 mRNA	19945496
C500085	muraglitazar	muraglitazar results in increased expression of SERPINB5 mRNA	21515302
D009151	Mustard Gas	Mustard Gas results in decreased expression of SERPINB5 mRNA	18955075
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of SERPINB5 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of SERPINB5 mRNA"	25554681
C016340	o,p'-DDT	"o,p'-DDT results in increased expression of SERPINB5 mRNA"	22609851
D010100	Oxygen	Oxygen deficiency results in increased expression of SERPINB5 mRNA	25596134
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of SERPINB5 mRNA	18636392
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of SERPINB5 mRNA	18692542
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of SERPINB5 mRNA	16221955
C479580	procyanidin B2	procyanidin B2 results in increased expression of SERPINB5 mRNA	25839702
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of SERPINB5 mRNA	17404688
C037219	quinoline	quinoline analog results in increased expression of SERPINB5 protein	18645022
C059514	resveratrol	resveratrol results in increased expression of SERPINB5 protein	23272133
C089730	rosiglitazone	rosiglitazone results in increased expression of SERPINB5 mRNA	21515302
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of SERPINB5 protein	28918527
D012999	Soman	Soman results in decreased expression of SERPINB5 mRNA	19281266
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINB5 mRNA	26378955
C025462	sulindac sulfide	sulindac sulfide results in decreased expression of SERPINB5 mRNA	15897233
D013629	Tamoxifen	Tamoxifen affects the expression of SERPINB5 mRNA	17555576
C112765	tanespimycin	tanespimycin results in increased expression of SERPINB5 mRNA	19514085
C501413	tesaglitazar	tesaglitazar results in increased expression of SERPINB5 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINB5 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINB5 mRNA	19619570
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of SERPINB5 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of SERPINB5 mRNA	17035482
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of SERPINB5 mRNA	28065790
C012589	trichostatin A	[decitabine co-treated with trichostatin A] results in decreased methylation of SERPINB5 promoter	18291368
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of SERPINB5 mRNA	17982090
C057693	troglitazone	troglitazone results in increased expression of SERPINB5 mRNA	21515302
D014635	Valproic Acid	Valproic Acid results in increased expression of SERPINB5 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in increased methylation of SERPINB5 gene	29154799
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of SERPINB5 mRNA	12414654

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004867	serine-type endopeptidase inhibitor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	16049006 20211623

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002009	morphogenesis of an epithelium	-	IEA	-
GO:0010951	negative regulation of endopeptidase activity	-	IBA	21873635
GO:0010951	negative regulation of endopeptidase activity	-	IEA	-
GO:0030198	extracellular matrix organization	-	IEA	-
GO:0050678	regulation of epithelial cell proliferation	-	IEA	-
GO:0060512	prostate gland morphogenesis	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	16049006

PMID	Title (Year)	Author	Journal
25775950	Association between SNPs in Serpin gene family and risk of esophageal squamous cell carcinoma. (2015 Aug)	Meng H	Tumour Biol
22011669	Genome-wide analysis of DNA methylation and the gene expression change in lung cancer. (2012 Jan)	Kwon YJ	J Thorac Oncol

Gene: SERPINB5

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)