Gene: SERPINE2

5270
GDN|GDNPF|PI-7|PI7|PN-1|PN1|PNI
serpin family E member 2
protein-coding
2q36.1
Ensembl:ENSG00000135919 MIM:177010 Vega:OTTHUMG00000133163 UniprotKB:P07093
NG_032907.1
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.596e-1 (AD)  9.520e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg08529333chr2:224904837SERPINE2Promoter6.184e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPE0.883
DDAH10.873
PGM10.87
ABHD17C0.864
GLUD10.86
WWC10.855
SLC1A20.844
NADK20.841
ZFYVE210.837
ETFA0.835

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.657
OR4F29-0.59
OR6C74-0.334
CETP-0.314
KRTAP4-5-0.308
GADL1-0.3
OR52E4-0.28
MCTP2-0.279
DPPA4-0.273
C2orf83-0.273

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of SERPINE2 mRNA"26377693
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of SERPINE2 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SERPINE2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SERPINE2 mRNA21632981|2164198
D000393Air PollutantsAir Pollutants analog results in increased expression of SERPINE2 mRNA21757418
D000447AldehydesAldehydes results in increased expression of SERPINE2 mRNA25014914
D019386AlendronateAlendronate affects the expression of SERPINE2 mRNA16079270
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SERPINE2 mRNA16483693
C015001arsenitearsenite results in decreased expression of SERPINE2 mRNA23974009
C015001arsenitearsenite results in decreased expression of SERPINE2 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of SERPINE2 mRNA]18929588
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of SERPINE2 mRNA"25757056
D001379AzathioprineAzathioprine results in increased expression of SERPINE2 mRNA22623647
C547126AZM551248AZM551248 results in increased expression of SERPINE2 mRNA22323515
D001542BenomylBenomyl results in increased expression of SERPINE2 mRNA25530041
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of SERPINE2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SERPINE2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SERPINE2 mRNA22228805|2261060
D004958EstradiolEstradiol results in decreased expression of SERPINE2 mRNA24349563
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINE2 mRNA19619570
D004958EstradiolEstradiol results in increased expression of SERPINE2 mRNA19619570
C006780bisphenol Abisphenol A results in decreased expression of SERPINE2 mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SERPINE2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of SERPINE2 mRNA25594700|2606340
C006780bisphenol Abisphenol A results in decreased expression of SERPINE2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SERPINE2 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of SERPINE2 mRNA26079696
C584509C646 compoundC646 compound results in increased expression of SERPINE2 mRNA26191083
D002104CadmiumCadmium results in increased expression of SERPINE2 mRNA17547211
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SERPINE2 mRNA17547211
C006698carbendazimcarbendazim results in increased expression of SERPINE2 mRNA25530041
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of SERPINE2 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of SERPINE2 mRNA27339419
D005023Ethylene ChlorohydrinEthylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE2 mRNA]26962056
C100187chloropicrinchloropicrin results in decreased expression of SERPINE2 mRNA26352163
D002737ChloropreneChloroprene results in decreased expression of SERPINE2 mRNA23125180
D002994ClofibrateClofibrate results in decreased expression of SERPINE2 mRNA17585979
D003024ClozapineClozapine results in increased expression of SERPINE2 mRNA15354176
D003024ClozapineClozapine results in increased expression of SERPINE2 protein15354176
C018021cobaltous chloridecobaltous chloride results in increased expression of SERPINE2 mRNA22941251
D019327Copper SulfateCopper Sulfate results in increased expression of SERPINE2 mRNA19549813
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA]18200517
D003513CycloheximideCycloheximide results in increased expression of SERPINE2 mRNA19684285
D003513Cycloheximide[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SERPINE2 mRNA19684285
D016572CyclosporineCyclosporine results in increased expression of SERPINE2 mRNA20106945|2163298
D013759DronabinolDronabinol results in decreased expression of SERPINE2 mRNA12237329
D003907DexamethasoneDexamethasone results in decreased expression of SERPINE2 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SERPINE2 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of SERPINE2 mRNA14618091
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SERPINE2 mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of SERPINE2 mRNA28962523
D002945CisplatinCisplatin results in increased expression of SERPINE2 mRNA24280081|2759478
D002945CisplatinSERPINE2 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin results in increased expression of SERPINE2 mRNA24280081
D004008DiclofenacDiclofenac results in decreased expression of SERPINE2 mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of SERPINE2 mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein27097221
D004041Dietary FatsRosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]27097221
D004041Dietary Fatssarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]27097221
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SERPINE2 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of SERPINE2 mRNA16002434
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of SERPINE2 mRNA17547211
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of SERPINE2 mRNA28939011
D004147DioxinsDioxins affects the expression of SERPINE2 mRNA20463971
D004237DiuronDiuron results in decreased expression of SERPINE2 mRNA25152437
D000431EthanolEthanol results in increased expression of SERPINE2 mRNA24355176
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SERPINE2 mRNA16079270
D005047EtoposideEtoposide results in increased expression of SERPINE2 mRNA25270620
D005472FluorouracilSERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
D005485FlutamideFlutamide results in decreased expression of SERPINE2 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of SERPINE2 mRNA27664576
D002955LeucovorinSERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
D019833GenisteinGenistein results in increased expression of SERPINE2 mRNA26865667
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of SERPINE2 mRNA22634610
D012701SerotoninRosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]27097221
D012701Serotoninsarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]24107419|2709722
D012701Serotoninsarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]27097221
D012701Serotonin[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA24107419|2709722
D012701Serotonin[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein27097221
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of SERPINE2 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of SERPINE2 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SERPINE2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SERPINE2 mRNA25613284
C051890irinotecanSERPINE2 mRNA results in increased susceptibility to [Leucovorin co-treated with Fluorouracil co-treated with irinotecan]17327601
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SERPINE2 mRNA28628672
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of SERPINE2 mRNA15476862
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of SERPINE2 mRNA15182950
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SERPINE2 mRNA26752646
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SERPINE2 mRNA26644586
D007854LeadLead affects the expression of SERPINE2 mRNA28903495
D001556LindaneLindane results in decreased expression of SERPINE2 mRNA17785943
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of SERPINE2 mRNA"24972896
D008070LipopolysaccharidesEthylene Chlorohydrin promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE2 mRNA]26962056
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SERPINE2 mRNA27339419
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of SERPINE2 mRNA26962056
D008070LipopolysaccharidesVinyl Chloride metabolite promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE2 mRNA]26962056
D008727MethotrexateMethotrexate results in increased expression of SERPINE2 mRNA21678067
D008770MethylnitrosoureaMethylnitrosourea results in increased expression of SERPINE2 mRNA25270620
C008493methylselenic acidmethylselenic acid results in increased expression of SERPINE2 mRNA18548127
D008777MethyltestosteroneMethyltestosterone results in decreased expression of SERPINE2 mRNA29191790
D015735MifepristoneMifepristone results in decreased expression of SERPINE2 mRNA25972201
C500085muraglitazarmuraglitazar results in increased expression of SERPINE2 mRNA21515302
D009151Mustard GasMustard Gas results in increased expression of SERPINE2 mRNA18955075
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of SERPINE2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SERPINE2 mRNA"25554681
D009532NickelNickel results in increased expression of SERPINE2 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of SERPINE2 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of SERPINE2 mRNA22714537
D008939MitotaneMitotane results in increased expression of SERPINE2 mRNA22966885
D000073878Palm OilPalm Oil affects the expression of SERPINE2 mRNA19680557
C046012pentanalpentanal results in increased expression of SERPINE2 mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SERPINE2 mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SERPINE2 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SERPINE2 mRNA28511854
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of SERPINE2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of SERPINE2 mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINE2 mRNA"27188386
D010705PhosgenePhosgene affects the expression of SERPINE2 mRNA16300373
D011374ProgesteroneProgesterone results in decreased expression of SERPINE2 mRNA20726854
C045950propiconazolepropiconazole results in increased expression of SERPINE2 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of SERPINE2 mRNA26079696
D011794QuercetinQuercetin results in increased expression of SERPINE2 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of SERPINE2 mRNA14699072
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of SERPINE2 mRNA16079270
C089730rosiglitazonerosiglitazone results in increased expression of SERPINE2 mRNA21515302
D000068718Rosuvastatin CalciumRosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]27097221
D000068718Rosuvastatin CalciumRosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]27097221
D012402RotenoneRotenone results in increased expression of SERPINE2 mRNA19013527|2790060
C064294sarpogrelatesarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]27097221
C064294sarpogrelatesarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]24107419|2709722
C064294sarpogrelatesarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]27097221
C064294sarpogrelatesarpogrelate results in decreased expression of SERPINE2 mRNA24107419
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SERPINE2 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of SERPINE2 mRNA22431001
C017947sodium arsenitesodium arsenite results in increased expression of SERPINE2 mRNA22714537
D012969Sodium FluorideSodium Fluoride results in increased expression of SERPINE2 protein28918527
D013311Streptozocin[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein27097221
D013311StreptozocinRosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]27097221
D013311Streptozocinsarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]27097221
D013605T-2 ToxinT-2 Toxin results in decreased expression of SERPINE2 mRNA26141394
C013698tallowtallow affects the expression of SERPINE2 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of SERPINE2 mRNA20937368
C087114tebuconazoletebuconazole results in increased expression of SERPINE2 mRNA26852204
C501413tesaglitazartesaglitazar results in increased expression of SERPINE2 mRNA21515302
D013739TestosteroneTestosterone results in increased expression of SERPINE2 mRNA20844152
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPINE2 mRNA24349563
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of SERPINE2 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERPINE2 mRNA22298810
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of SERPINE2 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPINE2 mRNA19619570|2315218
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SERPINE2 mRNA19684285
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERPINE2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERPINE2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPINE2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of SERPINE2 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of SERPINE2 mRNA22378314
D014118Toxins, Biological"Toxins, Biological affects the expression of SERPINE2 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of SERPINE2 mRNA21934132
D014241TrichloroethyleneTrichloroethylene results in decreased expression of SERPINE2 mRNA25549359
C012589trichostatin Atrichostatin A results in increased expression of SERPINE2 mRNA15901671
C012589trichostatin Atrichostatin A affects the expression of SERPINE2 mRNA28542535
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of SERPINE2 mRNA18200517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SERPINE2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SERPINE2 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of SERPINE2 mRNA19140230
C057693troglitazonetroglitazone results in increased expression of SERPINE2 mRNA21515302
D014415TunicamycinTunicamycin results in increased expression of SERPINE2 mRNA22378314
D014635Valproic AcidValproic Acid results in increased expression of SERPINE2 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of SERPINE2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SERPINE2 mRNA27188386
D014635Valproic AcidValproic Acid results in decreased methylation of SERPINE2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of SERPINE2 mRNA28001369
D014638VanadatesVanadates results in increased expression of SERPINE2 mRNA22714537
D014640VancomycinVancomycin results in decreased expression of SERPINE2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of SERPINE2 gene25560391
D014752Vinyl ChlorideVinyl Chloride metabolite promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE2 mRNA]26962056
C111237vorinostatvorinostat results in decreased expression of SERPINE2 mRNA27188386
C070417Win 55212-2Win 55212-2 results in decreased expression of SERPINE2 mRNA12237329
D015032ZincZinc deficiency results in decreased expression of SERPINE2 mRNA22171008

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-IDA3997857  19249338  19855083  
GO:0004867serine-type endopeptidase inhibitor activity-IMP19855083  
GO:0005102signaling receptor binding-IPI17379830  
GO:0005515protein binding-IPI3279057  19911255  25416956  
GO:0005539glycosaminoglycan binding-IDA19855083  
GO:0008201heparin binding-IDA1939253  3997857  
GO ID GO Term Qualifier Evidence PubMed
GO:0007596blood coagulation-TAS-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010757negative regulation of plasminogen activation-IMP19855083  
GO:0010766negative regulation of sodium ion transport-IEA-  
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0010955negative regulation of protein processing-IC19855083  
GO:0014067negative regulation of phosphatidylinositol 3-kinase signaling-IEA-  
GO:0021683cerebellar granular layer morphogenesis-IEA-  
GO:0030195negative regulation of blood coagulation-IC19855083  
GO:0030195negative regulation of blood coagulation-IDA17379830  
GO:0030308negative regulation of cell growth-IEA-  
GO:0030334regulation of cell migration-NAS2877744  
GO:0032940secretion by cell-IEA-  
GO:0033363secretory granule organization-IEA-  
GO:0042177negative regulation of protein catabolic process-IEA-  
GO:0042628mating plug formation-IEA-  
GO:0045861negative regulation of proteolysis-IDA3997857  17379830  
GO:0045879negative regulation of smoothened signaling pathway-IEA-  
GO:0048505regulation of timing of cell differentiation-IEA-  
GO:0048711positive regulation of astrocyte differentiation-IDA1691280  
GO:0050974detection of mechanical stimulus involved in sensory perception-IEA-  
GO:0051966regulation of synaptic transmission, glutamatergic-IEA-  
GO:0060291long-term synaptic potentiation-IEA-  
GO:0060384innervation-IEA-  
GO:0061108seminal vesicle epithelium development-IEA-  
GO:0090331negative regulation of platelet aggregation-ISS19855083  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IDA3997857  19855083  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005829cytosol-IDA19855083  
GO:0031091platelet alpha granule-IDA19855083  
GO:0031091platelet alpha granule-IMP19855083  
GO:0031232extrinsic component of external side of plasma membrane-IDA19855083  
GO:0031594neuromuscular junction-ISS2037625  
GO:0062023collagen-containing extracellular matrix-IDA3279057  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-140837Intrinsic Pathway of Fibrin Clot FormationTAS
R-HSA-140875Common Pathway of Fibrin Clot FormationTAS
R-HSA-140877Formation of Fibrin Clot (Clotting Cascade)TAS
R-HSA-75205Dissolution of Fibrin ClotTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21401569Combining disease models to test for gene-environment interaction in nuclear families. (2011 Dec)Hoffmann TJBiometrics
25517131Novel genes for airway wall thickness identified with combined genome-wide association and expression analyses. (2015 Mar 1)Dijkstra AEAm J Respir Crit Care Med
26986948An Interleukin 13 Polymorphism Is Associated with Symptom Severity in Adult Subjects with Ever Asthma. (2016)Accordini SPLoS One
22976395A bioinformatics strategy for detecting the complexity of Chronic Obstructive Pulmonary Disease in Northern Chinese Han Population. (2012)Hua LGenes Genet Syst
17970814Testing and estimating gene-environment interactions in family-based association studies. (2008 Jun)Vansteelandt SBiometrics
19111454Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. (2009 Apr)Kim WJRespir Med
26503507Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. (2015 Oct 26)Steele MPBMC Genomics
26318431Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma. (2016 Feb)Sun WTumour Biol
21778810Genetics of COPD. (2011 Sep)Nakamura HAllergol Int
16358219The SERPINE2 gene is associated with chronic obstructive pulmonary disease. (2006 Feb)Demeo DLAm J Hum Genet