Gene: SERPINB8

5271
C18orf53|CAP2|HMSD|HSMD-v|PI-8|PI8|PSS5
serpin family B member 8
protein-coding
18q22.1
Ensembl:ENSG00000166401 MIM:601697 Vega:OTTHUMG00000060596 UniprotKB:P50452
NG_052876.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.999e-1 (AD)  4.825e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NAMPT0.863
DRAM10.791
AAED10.787
SPOCD10.781
IFI160.781
SERPINB10.779
ANXA20.776
DDX210.767
ELK30.767
STK100.765

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCRT1-0.468
DBP-0.405
RASL10B-0.399
EXTL1-0.397
ASPDH-0.396
KCNN1-0.389
KCNQ4-0.384
WNT7A-0.382
FAM57B-0.381
PANX2-0.374

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0326681-nitropyrene1-nitropyrene results in increased expression of SERPINB8 mRNA19041380
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of SERPINB8 mRNA19933214
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of SERPINB8 mRNA"19561079
D000082AcetaminophenAcetaminophen results in increased expression of SERPINB8 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SERPINB8 mRNA21641981
D000393Air PollutantsAir Pollutants analog results in increased expression of SERPINB8 mRNA21757418
D000447AldehydesAldehydes results in increased expression of SERPINB8 mRNA25014914
C103303alitretinoinalitretinoin results in decreased expression of SERPINB8 mRNA15982314
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SERPINB8 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SERPINB8 mRNA21871943|2623829
C006780bisphenol Abisphenol A affects the expression of SERPINB8 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of SERPINB8 mRNA26496021
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of SERPINB8 mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of SERPINB8 mRNA26079696
D002104CadmiumCadmium results in increased expression of SERPINB8 mRNA21172416
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SERPINB8 protein24527689
D003033Coal TarCoal Tar results in decreased expression of SERPINB8 mRNA27858113
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of SERPINB8 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of SERPINB8 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of SERPINB8 mRNA25562108
D003703DemecolcineDemecolcine results in increased expression of SERPINB8 mRNA23649840
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SERPINB8 mRNA27392435
D002945CisplatinCisplatin results in increased expression of SERPINB8 mRNA19561079|2759478
D002117CalcitriolCalcitriol results in increased expression of SERPINB8 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of SERPINB8 mRNA21592394
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of SERPINB8 mRNA28939011
D004178DiquatDiquat results in increased expression of SERPINB8 mRNA21172416
D004726EndosulfanEndosulfan results in increased expression of SERPINB8 mRNA26615145
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of SERPINB8 mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of SERPINB8 mRNA23649840
D017313FenretinideFenretinide results in decreased expression of SERPINB8 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of SERPINB8 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINB8 mRNA25613284
D007501IronIron deficiency results in increased expression of SERPINB8 mRNA20368581
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SERPINB8 mRNA27392435
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SERPINB8 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SERPINB8 mRNA26378955
D008727MethotrexateMethotrexate affects the expression of SERPINB8 mRNA18502557
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of SERPINB8 mRNA23649840
C523799MRK 003SERPINB8 results in decreased susceptibility to MRK 00319903844
C028007nickel monoxidenickel monoxide results in increased expression of SERPINB8 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of SERPINB8 mRNA20971185
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of SERPINB8 mRNA24888373
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of SERPINB8 mRNA18593933
C046012pentanalpentanal results in increased expression of SERPINB8 mRNA26079696
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of SERPINB8 mRNA28973697
D010936Plant ExtractsPlant Extracts results in increased expression of SERPINB8 mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of SERPINB8 mRNA23370395
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of SERPINB8 mRNA24888373
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of SERPINB8 mRNA28903501
C005556propionaldehydepropionaldehyde results in increased expression of SERPINB8 mRNA26079696
D015474IsotretinoinIsotretinoin results in decreased expression of SERPINB8 mRNA15982314
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB8 mRNA21127053
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of SERPINB8 mRNA25895662
D012834SilverSilver results in decreased expression of SERPINB8 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of SERPINB8 mRNA12760830|2145756
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of SERPINB8 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of SERPINB8 mRNA26378955
C061133tamibarotenetamibarotene affects the expression of SERPINB8 mRNA15498508
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of SERPINB8 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of SERPINB8 mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of SERPINB8 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERPINB8 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SERPINB8 mRNA19933214
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINB8 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SERPINB8 mRNA22363418
D014212TretinoinTretinoin affects the expression of SERPINB8 mRNA15498508
D014212TretinoinTretinoin metabolite results in decreased expression of SERPINB8 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of SERPINB8 mRNA15982314
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of SERPINB8 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of SERPINB8 mRNA29024780
D014520UrethaneUrethane results in increased expression of SERPINB8 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of SERPINB8 mRNA29154799
D014750VincristineVincristine results in increased expression of SERPINB8 mRNA23649840
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of SERPINB8 mRNA18593933
D015032ZincZinc results in decreased expression of SERPINB8 mRNA18316168

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0004867serine-type endopeptidase inhibitor activity-IDA8530382  
GO:0005515protein binding-IPI8530382  
GO ID GO Term Qualifier Evidence PubMed
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IDA8530382  
GO:0090136epithelial cell-cell adhesion-IMP27476651  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA8530382  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-75205Dissolution of Fibrin ClotTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23541940TNIP1/ANXA6 and CSMD1 variants interacting with cigarette smoking, alcohol intake affect risk of psoriasis. (2013 May)Yin XYJ Dermatol Sci
23577725Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis. (2013 May)Naj ACAnn Hum Genet