Gene info: ID 5272

Gene: SERPINB9

GENE ID: 5272

Synonyms: CAP-3|CAP3|PI-9|PI9

Description: serpin family B member 9

Gene type: protein-coding

Location: 6p25.2

dbXrefs: Ensembl:ENSG00000170542 MIM:601799 Vega:OTTHUMG00000014131 UniprotKB:P50453

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.137e-1 (AD) 6.476e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CHSY1	0.83
TNFRSF10B	0.829
PXN	0.815
STAT3	0.806
IL6R	0.806
MAP3K8	0.802
SCML1	0.802
MALT1	0.801
RIT1	0.798
B4GALT1	0.794

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.389
OR4F29	-0.388
NKX2-8	-0.346
LYPD8	-0.307
CRH	-0.303
CPLX3	-0.3
MYCNOS	-0.298
NMU	-0.293
WNT7A	-0.287
DRD5	-0.275

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00481	Raloxifene	Small Molecule	84449-90-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SERPINB9 mRNA"	19692669
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of SERPINB9 mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of SERPINB9 mRNA	19191707
C002202	4-oxoretinoic acid	4-oxoretinoic acid results in decreased expression of SERPINB9 mRNA	15982314
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of SERPINB9 mRNA	21420995\|2223033
C016601	afimoxifene	afimoxifene results in increased expression of SERPINB9 mRNA	14617632\|1723782
C016601	afimoxifene	ESR1 protein promotes the reaction [afimoxifene results in increased expression of SERPINB9 mRNA]	17237823
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of SERPINB9 mRNA	19770486
C103303	alitretinoin	alitretinoin results in decreased expression of SERPINB9 mRNA	15982314
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of SERPINB9 mRNA	28522335
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of SERPINB9 mRNA	24449571
C487081	belinostat	belinostat results in increased expression of SERPINB9 mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of SERPINB9 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of SERPINB9 mRNA	19770486
D004958	Estradiol	Butyrophenones inhibits the reaction [[Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB9 mRNA]	21041310
D004958	Estradiol	ESR1 protein promotes the reaction [Estradiol results in increased expression of SERPINB9 mRNA]	17237823
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of SERPINB9 mRNA	20660070
D004958	Estradiol	Estradiol promotes the reaction [ESR1 protein binds to SERPINB9 protein]	14617632
D004958	Estradiol	[Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB9 mRNA	21041310
D004958	Estradiol	Estradiol results in increased expression of SERPINB9 mRNA	10681578\|1723782
D004958	Estradiol	Estradiol results in increased expression of SERPINB9 protein	17237823
D004958	Estradiol	fulvestrant inhibits the reaction [Estradiol results in increased expression of SERPINB9 mRNA]	17237823
D004958	Estradiol	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of SERPINB9 mRNA]	17237823
C006780	bisphenol A	bisphenol A results in decreased expression of SERPINB9 mRNA	25181051\|2698221
C006780	bisphenol A	bisphenol A results in increased expression of SERPINB9 mRNA	12075121
D002065	Buspirone	Buspirone results in decreased expression of SERPINB9 mRNA	24136188
D002090	Butyrophenones	Butyrophenones inhibits the reaction [[Estradiol results in increased activity of ESR1 protein] which results in increased expression of SERPINB9 mRNA]	21041310
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of SERPINB9 mRNA	25993096
D000074262	Canola Oil	Canola Oil metabolite results in decreased expression of SERPINB9 mRNA	27363782
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of SERPINB9 mRNA	17484886
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of SERPINB9 mRNA	26272509
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SERPINB9 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of SERPINB9 mRNA	24386269
D019327	Copper Sulfate	Copper Sulfate results in increased expression of SERPINB9 mRNA	19549813
D003513	Cycloheximide	Cycloheximide promotes the reaction [moxestrol results in increased expression of SERPINB9 mRNA]	10681578
D016572	Cyclosporine	Cyclosporine results in decreased expression of SERPINB9 mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in decreased expression of SERPINB9 mRNA	19770486
D016572	Cyclosporine	Cyclosporine results in increased expression of SERPINB9 mRNA	23958496
D003561	Cytarabine	Cytarabine results in decreased expression of SERPINB9 mRNA	21198554
C000944	dicrotophos	dicrotophos results in increased expression of SERPINB9 mRNA	28302478
D002117	Calcitriol	Calcitriol results in increased expression of SERPINB9 mRNA	16002434
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of SERPINB9 mRNA	25380136
D004726	Endosulfan	Endosulfan results in increased expression of SERPINB9 mRNA	26615145
C118739	entinostat	entinostat results in increased expression of SERPINB9 mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SERPINB9 mRNA	22079256
D000431	Ethanol	Ethanol results in decreased expression of SERPINB9 mRNA	28986285
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of SERPINB9 mRNA	12075121
C082360	fipronil	fipronil results in increased expression of SERPINB9 mRNA	23962444
C070081	fulvestrant	fulvestrant inhibits the reaction [Estradiol results in increased expression of SERPINB9 mRNA]	17237823
C070081	fulvestrant	fulvestrant inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]	10681578
D019833	Genistein	Genistein results in increased expression of SERPINB9 mRNA	12075121
D005839	Gentamicins	Gentamicins results in increased expression of SERPINB9 mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of SERPINB9 mRNA	24136188
D017313	Fenretinide	Fenretinide results in increased expression of SERPINB9 mRNA	28973697
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of SERPINB9 mRNA	19376150
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINB9 mRNA	25613284
C544151	jinfukang	jinfukang results in decreased expression of SERPINB9 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of SERPINB9 mRNA	24796395\|2675264
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINB9 mRNA	12177049
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of SERPINB9 protein	12177049
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SERPINB9 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINB9 mRNA	26378955
C042720	mercuric bromide	mercuric bromide results in increased expression of SERPINB9 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in decreased expression of SERPINB9 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in decreased expression of SERPINB9 mRNA	19564919
D008727	Methotrexate	Methotrexate results in decreased expression of SERPINB9 mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of SERPINB9 mRNA	23179753
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of SERPINB9 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of SERPINB9 mRNA	23649840
C011310	moxestrol	Cycloheximide promotes the reaction [moxestrol results in increased expression of SERPINB9 mRNA]	10681578
C011310	moxestrol	fulvestrant inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]	10681578
C011310	moxestrol	IL1B protein inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]	12177049
C011310	moxestrol	moxestrol promotes the reaction [ESR1 protein binds to SERPINB9 protein]	14617632
C011310	moxestrol	moxestrol results in increased expression of SERPINB9 mRNA	10681578\|1217704
C011310	moxestrol	moxestrol results in increased expression of SERPINB9 protein	10681578
C011310	moxestrol	Tamoxifen analog inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]	10681578
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of SERPINB9 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of SERPINB9 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of SERPINB9 mRNA	25380136
C051752	nefazodone	nefazodone results in decreased expression of SERPINB9 mRNA	24136188
D009532	Nickel	Nickel results in increased expression of SERPINB9 mRNA	24768652\|2558310
C029938	nickel sulfate	nickel sulfate results in increased expression of SERPINB9 mRNA	22714537
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of SERPINB9 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of SERPINB9 mRNA	25729387
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of SERPINB9 mRNA	26272509
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of SERPINB9 protein	26178269
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of SERPINB9 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of SERPINB9 mRNA	20813756
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SERPINB9 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of SERPINB9 mRNA	22079256\|2271453
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of SERPINB9 mRNA	20660070
D011794	Quercetin	Quercetin results in increased expression of SERPINB9 mRNA	15309432
D020849	Raloxifene Hydrochloride	[Raloxifene Hydrochloride binds to ESR1 protein] which binds to SERPINB9 protein	14617632
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of SERPINB9 mRNA]	17237823
C031389	resorcinol	resorcinol results in increased expression of SERPINB9 mRNA	22623647
D015474	Isotretinoin	Isotretinoin results in decreased expression of SERPINB9 mRNA	15982314
D012293	Rifampin	[Rifampin co-treated with NR1I2 protein] results in increased expression of SERPINB9 mRNA	21127053
D012293	Rifampin	Rifampin results in increased expression of SERPINB9 mRNA	24552687
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in decreased expression of SERPINB9 mRNA	19564919
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of SERPINB9 mRNA	25351596
D012834	Silver	Silver results in increased expression of SERPINB9 mRNA	26014281
C017947	sodium arsenite	sodium arsenite results in increased expression of SERPINB9 mRNA	22714537
D012999	Soman	Soman results in decreased expression of SERPINB9 mRNA	19281266
D053260	Soot	Soot results in increased expression of SERPINB9 mRNA	22461453
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SERPINB9 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SERPINB9 mRNA	26378955
D016559	Tacrolimus	Tacrolimus results in increased expression of SERPINB9 mRNA	23958496
D013629	Tamoxifen	Tamoxifen analog inhibits the reaction [moxestrol results in increased expression of SERPINB9 mRNA]	10681578
D013629	Tamoxifen	Tamoxifen analog results in increased expression of SERPINB9 mRNA	10681578
D013629	Tamoxifen	Tamoxifen affects the expression of SERPINB9 mRNA	20937368
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SERPINB9 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of SERPINB9 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of SERPINB9 mRNA	19692669\|2172422
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SERPINB9 mRNA	12177049
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of SERPINB9 protein	12177049
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SERPINB9 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in increased expression of SERPINB9 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of SERPINB9 mRNA	23557971
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of SERPINB9 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of SERPINB9 mRNA	25729387
D014212	Tretinoin	Tretinoin metabolite results in decreased expression of SERPINB9 mRNA	15982314
D014212	Tretinoin	Tretinoin results in increased expression of SERPINB9 mRNA	21934132\|2372400
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of SERPINB9 mRNA	24935251\|2627250
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SERPINB9 mRNA"	26179874
D014520	Urethane	Urethane results in increased expression of SERPINB9 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of SERPINB9 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of SERPINB9 mRNA	23179753\|2438349
D014635	Valproic Acid	Valproic Acid results in increased methylation of SERPINB9 gene	29154799
D014635	Valproic Acid	Valproic Acid affects the expression of SERPINB9 mRNA	17292431
D014640	Vancomycin	Vancomycin results in decreased expression of SERPINB9 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of SERPINB9 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of SERPINB9 mRNA	19015723
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SERPINB9 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of SERPINB9 mRNA	26272509
D015032	Zinc	Zinc results in decreased expression of SERPINB9 mRNA	18316168

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002020	protease binding	-	IPI	16267761
GO:0004867	serine-type endopeptidase inhibitor activity	-	IBA	21873635
GO:0004867	serine-type endopeptidase inhibitor activity	-	IDA	8910377 11485349
GO:0005515	protein binding	-	IPI	17479112 25416956
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	-	IDA	10790428
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	-	IMP	17479112

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002448	mast cell mediated immunity	-	IEP	15739160
GO:0006915	apoptotic process	-	IEA	-
GO:0006955	immune response	-	IDA	16306080
GO:0009617	response to bacterium	-	IDA	22090449
GO:0010628	positive regulation of gene expression	-	IMP	22090449
GO:0010951	negative regulation of endopeptidase activity	-	IBA	21873635
GO:0010951	negative regulation of endopeptidase activity	-	IMP	21795594
GO:0033668	negative regulation by symbiont of host apoptotic process	-	IMP	22090449
GO:0042270	protection from natural killer cell mediated cytotoxicity	-	IMP	21795594
GO:0043066	negative regulation of apoptotic process	-	IMP	17237823 17479112
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	-	IEA	-
GO:0071391	cellular response to estrogen stimulus	-	IEP	17237823

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IBA	21873635
GO:0005615	extracellular space	-	IDA	16267761
GO:0005622	intracellular	-	IDA	21795594 22090449
GO:0005634	nucleus	-	IDA	11463822 11485349
GO:0005654	nucleoplasm	-	IDA	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	IDA	11463822 15739160
GO:0005794	Golgi apparatus	-	IDA	-
GO:0005829	cytosol	-	IDA	11485349
GO:0016020	membrane	-	HDA	19946888
GO:0070062	extracellular exosome	-	HDA	20458337 23533145

KEGG ID	KEGG Term
hsa05146	Amoebiasis

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26318431	Genome-wide haplotype association analysis identifies SERPINB9, SERPINE2, GAK, and HSP90B1 as novel risk genes for oral squamous cell carcinoma. (2016 Feb)	Sun W	Tumour Biol