Gene: SERPINI2

5276
MEPI|PANCPIN|PI14|TSA2004
serpin family I member 2
protein-coding
3q26.1
Ensembl:ENSG00000114204 MIM:605587 Vega:OTTHUMG00000158231 UniprotKB:O75830
NC_000003.12
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.767e-1 (AD)  2.420e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4955672chr3:167457459 (GRCh38.p7)C>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
B3GALT50.59
NUCB20.575
DOCK110.556
GINS30.555
TEKT10.55
NSUN30.543
PLB10.54
PDE10A0.538
SPAG10.538
C7orf570.538

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PYGM-0.249
DIO2-0.249
GRHL2-0.249
SOHLH1-0.242
TPSD1-0.24
RSPO1-0.238
NANOS3-0.22
OR4F5-0.21
MTRNR2L6-0.208
NXPH3-0.206

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of SERPINI2 mRNA"20816883
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SERPINI2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SERPINI2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of SERPINI2 mRNA24449571
C006780bisphenol Abisphenol A results in decreased expression of SERPINI2 mRNA25181051|2717856
D002922CiguatoxinsCiguatoxins affects the expression of SERPINI2 mRNA18353800
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of SERPINI2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of SERPINI2 mRNA"25620056
C017947sodium arsenitesodium arsenite affects the methylation of SERPINI2 gene28589171
C016104sodium bichromatesodium bichromate results in decreased expression of SERPINI2 mRNA22561333
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SERPINI2 mRNA26377647
C034028vanadyl sulfatevanadyl sulfate results in increased expression of SERPINI2 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions affects the methylation of SERPINI2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004867serine-type endopeptidase inhibitor activity-IBA21873635  
GO:0005515protein binding-IPI16189514  16713569  21516116  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0010951negative regulation of endopeptidase activity-IBA21873635  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19334046Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer. (2009 Jun)Boelens MCJ Pathol
29288362Identification of genes highly downregulated in pancreatic cancer through a meta-analysis of microarray datasets: implications for discovery of novel tumor-suppressor genes and therapeutic targets. (2018 Feb)Goonesekere NCWJ Cancer Res Clin Oncol