Gene: PIGC

5279
GPI2|GPIBD16|MRT62
phosphatidylinositol glycan anchor biosynthesis class C
protein-coding
1q24.3
Ensembl:ENSG00000135845 MIM:601730 Vega:OTTHUMG00000034751 UniprotKB:Q92535
NG_050631.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.554e-3 (AD)  8.176e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BLMH0.884
SSB0.881
NGDN0.877
APTX0.873
PSMC20.873
SNRPB20.872
SRSF70.871
BUB30.871
GDI20.87
RTCB0.869

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.606
OR4F29-0.568
MTRNR2L6-0.294
MTRNR2L9-0.294
MTRNR2L10-0.279
KCNK5-0.256
RSPO1-0.251
DIO2-0.249
RNF223-0.24
P2RY14-0.234

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PIGC mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of PIGC mRNA21420995
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PIGC mRNA24449571
D001280AtrazineAtrazine results in decreased expression of PIGC mRNA22378314
D004958EstradiolEstradiol results in decreased expression of PIGC mRNA23019147
D004958Estradiol[Dieldrin co-treated with Estradiol] results in decreased expression of PIGC mRNA23041725
C006780bisphenol Abisphenol A results in decreased expression of PIGC mRNA26364221
C006780bisphenol Abisphenol A affects the expression of PIGC mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PIGC mRNA25181051
D002104CadmiumCadmium results in increased expression of PIGC mRNA24376830
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PIGC promoter22457795
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA]"20230807
D004390ChlorpyrifosChlorpyrifos results in decreased expression of PIGC mRNA18668222
C018021cobaltous chloridecobaltous chloride results in decreased expression of PIGC mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PIGC mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PIGC mRNA25562108
C089595cylindrospermopsincylindrospermopsin results in increased expression of PIGC mRNA24921660
C000944dicrotophosdicrotophos results in decreased expression of PIGC mRNA28302478
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in decreased expression of PIGC mRNA23041725
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PIGC mRNA17555576
D018120FinasterideFinasteride results in increased expression of PIGC mRNA24136188
D005485FlutamideFlutamide results in increased expression of PIGC mRNA24136188
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIGC protein18951874
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PIGC mRNA24796395|2530787
D008344Maneb[Paraquat co-treated with Maneb] results in increased expression of PIGC mRNA18386188
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA]"20230807
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PIGC mRNA"25554681
C051752nefazodonenefazodone results in increased expression of PIGC mRNA24136188
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of PIGC mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIGC mRNA]"20230807
D010269Paraquat[Paraquat co-treated with Maneb] results in increased expression of PIGC mRNA18386188
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PIGC mRNA22714537
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PIGC mRNA25351596
D019821SimvastatinSimvastatin results in decreased expression of PIGC mRNA19262002
D013467SulindacSulindac results in increased expression of PIGC mRNA24136188
D013629TamoxifenTamoxifen affects the expression of PIGC mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PIGC mRNA11007951
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of PIGC mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PIGC mRNA21215274
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of PIGC protein18951874
D014520UrethaneUrethane results in decreased expression of PIGC mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PIGC mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PIGC mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of PIGC gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PIGC gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-TAS8806613  
GO:0017176phosphatidylinositol N-acetylglucosaminyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006506GPI anchor biosynthetic process-TAS8806613  
GO:0016254preassembly of GPI anchor in ER membrane-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000506glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex-IBA21873635  
GO:0000506glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex-IDA10944123  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-162710Synthesis of glycosylphosphatidylinositol (GPI)TAS
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23978819Generalization of adiposity genetic loci to US Hispanic women. (2013 Aug 26)Graff MNutr Diabetes