Gene: ATP6V1C1

528
ATP6C|ATP6D|VATC|Vma5
ATPase H+ transporting V1 subunit C1
protein-coding
8q22.3
Ensembl:ENSG00000155097 MIM:603097 Vega:OTTHUMG00000164761 UniprotKB:P21283
NC_000008.11
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.680e-1 (AD)  9.796e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP2K40.984
ATP6V1A0.984
PPP3CB0.981
TRIM370.98
GLS0.978
UBE2K0.976
WDR470.976
MOAP10.975
SNAP910.975
ATP6V1B20.974

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.534
CSAG1-0.494
OR4F29-0.49
HEY2-0.471
RAI14-0.459
MYL3-0.457
RNF135-0.439
TFPI2-0.437
REST-0.434
MAGEA12-0.432

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01694D-tartaric acidSmall Molecule147-71-7ExperimentalTarget
DB09552ThonzoniumSmall Molecule25466-36-8ApprovedTarget
ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of ATP6V1C1 mRNA"22101062
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of ATP6V1C1 mRNA"20453058
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of ATP6V1C1 mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP6V1C1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP6V1C1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ATP6V1C1 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP6V1C1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP6V1C1 mRNA"27188386
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of ATP6V1C1 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ATP6V1C1 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ATP6V1C1 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of ATP6V1C1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of ATP6V1C1 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of ATP6V1C1 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ATP6V1C1 mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of ATP6V1C1 mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ATP6V1C1 mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ATP6V1C1 mRNA23650126
D004390ChlorpyrifosChlorpyrifos results in increased expression of ATP6V1C1 mRNA20691718
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ATP6V1C1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of ATP6V1C1 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of ATP6V1C1 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of ATP6V1C1 mRNA27989131
D002945CisplatinATP6V1C1 mRNA affects the susceptibility to Cisplatin18610736
D004147DioxinsDioxins affects the expression of ATP6V1C1 mRNA20463971
D018120FinasterideFinasteride results in increased expression of ATP6V1C1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of ATP6V1C1 mRNA23649840
D005839GentamicinsGentamicins results in increased expression of ATP6V1C1 mRNA22061828
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of ATP6V1C1 mRNA17183730
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATP6V1C1 mRNA25613284
C410337K 7174K 7174 results in increased expression of ATP6V1C1 mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of ATP6V1C1 mRNA16807920
D008344Maneb[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]23963992
D008344ManebSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]23963992
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]23963992
C042720mercuric bromidemercuric bromide results in increased expression of ATP6V1C1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP6V1C1 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ATP6V1C1 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ATP6V1C1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ATP6V1C1 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ATP6V1C1 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of ATP6V1C1 mRNA24136188
D009532NickelNickel results in decreased expression of ATP6V1C1 mRNA23195993
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ATP6V1C1 mRNA20971185
D010269Paraquat[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]23963992
D010269ParaquatSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]23963992
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ATP6V1C1 mRNA18593933
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ATP6V1C1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of ATP6V1C1 mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of ATP6V1C1 mRNA23557933
D011794QuercetinQuercetin results in decreased expression of ATP6V1C1 mRNA15309432
D011794QuercetinQuercetin results in decreased expression of ATP6V1C1 protein14750173
D012643SeleniumSelenium results in decreased expression of ATP6V1C1 mRNA19244175
D012838SilymarinSilymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]23963992
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ATP6V1C1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ATP6V1C1 mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ATP6V1C1 mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ATP6V1C1 mRNA28065790
C012589trichostatin Atrichostatin A affects the expression of ATP6V1C1 mRNA28542535
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of ATP6V1C1 mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ATP6V1C1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ATP6V1C1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ATP6V1C1 mRNA23179753|2627250
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ATP6V1C1 gene25560391
D014810Vitamin EVitamin E results in decreased expression of ATP6V1C1 mRNA19244175
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ATP6V1C1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005215transporter activity-NAS8250920  
GO:0005515protein binding-IPI16415858  
GO:0008553proton-exporting ATPase activity, phosphorylative mechanism-IBA21873635  
GO:0046961proton-transporting ATPase activity, rotational mechanism-IBA21873635  
GO:0046961proton-transporting ATPase activity, rotational mechanism-TAS8250920  
GO ID GO Term Qualifier Evidence PubMed
GO:0008286insulin receptor signaling pathway-TAS-  
GO:0015991ATP hydrolysis coupled proton transport-IEA-  
GO:0016241regulation of macroautophagy-NAS22982048  
GO:0033572transferrin transport-TAS-  
GO:0034220ion transmembrane transport-TAS-  
GO:1902600proton transmembrane transport-TAS8250920  
GO ID GO Term Qualifier Evidence PubMed
GO:0000221vacuolar proton-transporting V-type ATPase, V1 domain-IBA21873635  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-ISS-  
GO:0016469proton-transporting two-sector ATPase complex-TAS8250920  
GO:0031410cytoplasmic vesicle-IEA-  
GO:0045177apical part of cell-IEA-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00190Oxidative phosphorylation
hsa01100Metabolic pathways
hsa04145Phagosome
hsa04966Collecting duct acid secretion
hsa05110Vibrio cholerae infection
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05323Rheumatoid arthritis
Reactome ID Reactome Term Evidence
R-HSA-1222556ROS, RNS production in phagocytesTAS
R-HSA-162582Signal TransductionTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-77387Insulin receptor recyclingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-917937Iron uptake and transportTAS
R-HSA-917977Transferrin endocytosis and recyclingTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26984774Expression of ATP6V1C1 during oral carcinogenesis. (2016)Oliveira Alves MGBiotech Histochem
20404513Measurement of ATP6V1C1 expression in brush cytology samples as a diagnostic and prognostic marker in oral squamous cell carcinoma. (2010 Jun 15)Perez-Sayans MCancer Biol Ther