Gene: PIGF

5281
-
phosphatidylinositol glycan anchor biosynthesis class F
protein-coding
2p21
Ensembl:ENSG00000151665 MIM:600153 Vega:OTTHUMG00000128816 UniprotKB:Q07326
NC_000002.12
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.433e-1 (AD)  7.744e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASCC10.812
LMAN10.798
TMCO10.793
RAB9A0.789
PPP2R5A0.787
TMED50.786
PEX20.783
TMED70.782
BCCIP0.781
SERP10.78

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.499
OR4F29-0.465
NKD2-0.286
REM1-0.253
KRTAP16-1-0.231
KCNG2-0.221
MYLK2-0.218
SULT2B1-0.217
PHOSPHO1-0.216
SLC28A2-0.208

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen affects the expression of PIGF mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of PIGF mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PIGF mRNA19770486
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of PIGF mRNA16631469
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PIGF mRNA19770486
C044887beta-methylcholinebeta-methylcholine affects the expression of PIGF mRNA21179406
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIGF mRNA28628672
C006780bisphenol Abisphenol A affects the expression of PIGF mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PIGF mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PIGF mRNA27339419
C018021cobaltous chloridecobaltous chloride results in decreased expression of PIGF mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PIGF mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PIGF mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIGF mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PIGF mRNA27392435
D002945CisplatinCisplatin results in increased expression of PIGF mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of PIGF mRNA28302478
D004147DioxinsDioxins affects the expression of PIGF mRNA20463971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PIGF mRNA22079256
D006046GoldGold results in decreased expression of PIGF mRNA25523186
D017313FenretinideFenretinide results in increased expression of PIGF mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIGF mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PIGF mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIGF mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PIGF mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PIGF mRNA23458150
C568376MT19c compoundMT19c compound results in increased expression of PIGF mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PIGF mRNA"25554681
D009538NicotineNicotine results in increased expression of PIGF mRNA16949557
D010126Ozone"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of PIGF mRNA"23246600
D010936Plant ExtractsPlant Extracts results in increased expression of PIGF mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PIGF mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PIGF mRNA22079256|2271453
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PIGF mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of PIGF mRNA25613284
D014635Valproic AcidValproic Acid affects the expression of PIGF mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of PIGF gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PIGF mRNA19101580|2915479
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PIGF gene25560391
C111237vorinostatvorinostat results in increased expression of PIGF mRNA27188386
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Ozone] results in increased expression of PIGF mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004307ethanolaminephosphotransferase activity-TAS8463218  
GO ID GO Term Qualifier Evidence PubMed
GO:0006506GPI anchor biosynthetic process-ISS-  
GO:0016254preassembly of GPI anchor in ER membrane-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-ISS-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00563Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-162710Synthesis of glycosylphosphatidylinositol (GPI)TAS
R-HSA-162710Synthesis of glycosylphosphatidylinositol (GPI)IEA
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsTAS
R-HSA-163125Post-translational modification: synthesis of GPI-anchored proteinsIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-597592Post-translational protein modificationTAS
R-HSA-597592Post-translational protein modificationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21534854Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. (2011 Jun)Wa Law LJ Matern Fetal Neonatal Med
25118498Reference values for placental growth factor (PlGF) concentration and uterine artery doppler pulsatility index (PI) at 11-13(+6) weeks of gestation in the Polish population. (2014 Jul)Kosinski PGinekol Pol
22359227Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors. (2012 Aug 15)Kim WYCancer
24501799[The effect of tobacco smoking on serum concentration of selected angiogenic factors and somatomedin C in pregnant women and umbilical cord blood]. (2013)Chelchowska MPrzegl Lek