Gene: PIGR

5284
-
polymeric immunoglobulin receptor
protein-coding
1q32.1
Ensembl:ENSG00000162896 MIM:173880 Vega:OTTHUMG00000036581 UniprotKB:P01833
NG_012927.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.125e-1 (AD)  1.087e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg12751565chr1:207119987PIGRPromoter7.133e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC26A30.54
AGR20.537
ZG160.534
CEACAM70.528
TMPRSS20.525
KRT200.519
CRISP30.518
KLK30.505
ACPP0.502
MUC70.493

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
R3HDML-0.221
PXT1-0.209
HNRNPCL1-0.204
MND1-0.204
ZBTB49-0.202
GOLT1A-0.202
BAAT-0.196
OPN1SW-0.194
MARCH10-0.19
IL12B-0.189

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of PIGR mRNA"18281256
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PIGR mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PIGR mRNA]"19467301
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PIGR mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of PIGR mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of PIGR mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of PIGR mRNA17562736
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of PIGR mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PIGR mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PIGR mRNA19770486
D019386AlendronateAlendronate affects the expression of PIGR mRNA16079270
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PIGR mRNA16483693
D001151ArsenicArsenic affects the expression of PIGR mRNA28793237
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PIGR mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PIGR mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of PIGR mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PIGR mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PIGR mRNA19770486
D004958EstradiolEstradiol results in increased expression of PIGR mRNA15289156
C006780bisphenol Abisphenol A results in increased methylation of PIGR promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of PIGR mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PIGR mRNA27339419
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PIGR mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PIGR mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of PIGR mRNA27858113
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of PIGR mRNA17383702
D003520CyclophosphamideCyclophosphamide results in increased expression of PIGR mRNA15331540
D016572CyclosporineCyclosporine results in decreased expression of PIGR mRNA19770486
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of PIGR mRNA28962523
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PIGR mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of PIGR mRNA19467301
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PIGR mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of PIGR mRNA]17942915
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of PIGR mRNA15171707
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PIGR mRNA15289156
D004237DiuronDiuron results in decreased expression of PIGR mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PIGR mRNA16079270
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PIGR mRNA12655037|1583489
C056933fumonisin B1fumonisin B1 results in decreased expression of PIGR mRNA16221962
C039281furanfuran results in decreased expression of PIGR mRNA25539665
C039281furanfuran results in increased methylation of PIGR gene22079235
D019833GenisteinGenistein results in increased expression of PIGR mRNA15289156
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PIGR mRNA25613284
D001556LindaneLindane results in increased expression of PIGR mRNA17785943
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PIGR mRNA19465457
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of PIGR protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PIGR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of PIGR mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of PIGR mRNA19167457
D052638Particulate MatterParticulate Matter results in increased expression of PIGR protein17520064
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PIGR mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of PIGR mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of PIGR mRNA19482888
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of PIGR mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of PIGR mRNA16221962|1742611
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of PIGR mRNA]20059764
C006253pirinixic acidpirinixic acid results in decreased expression of PIGR mRNA16940010
D010936Plant ExtractsPlant Extracts results in decreased expression of PIGR mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PIGR mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of PIGR mRNA21278054
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PIGR mRNA16079270
D012822Silicon DioxideSilicon Dioxide results in increased expression of PIGR mRNA22431001
D053260SootSoot results in increased expression of PIGR mRNA22461453|2655175
D013739TestosteroneTestosterone results in decreased expression of PIGR mRNA21073676
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PIGR mRNA21570461
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PIGR mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of PIGR mRNA17656681|2355797
C009495titanium dioxidetitanium dioxide results in increased expression of PIGR mRNA21259345|2776080
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in increased expression of PIGR mRNA24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PIGR mRNA20133372
D014212TretinoinTretinoin results in increased expression of PIGR mRNA23830798
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of PIGR mRNA16141432
C057693troglitazonetroglitazone results in increased expression of PIGR mRNA28973697
D014635Valproic AcidValproic Acid results in increased methylation of PIGR gene29154799
D014635Valproic AcidValproic Acid affects the expression of PIGR mRNA17292431
D001335Vehicle EmissionsVehicle Emissions affects the expression of PIGR mRNA18192680
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PIGR gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of PIGR protein17520064
C029297vinylidene chloridevinylidene chloride results in decreased expression of PIGR mRNA26682919
D015032ZincZinc deficiency results in increased expression of PIGR mRNA20857495
D015034Zinc OxideZinc Oxide analog results in increased expression of PIGR mRNA27215404
C088658zoledronic acidzoledronic acid results in increased expression of PIGR mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001792polymeric immunoglobulin receptor activity-IDA22022593  
GO ID GO Term Qualifier Evidence PubMed
GO:0001580detection of chemical stimulus involved in sensory perception of bitter taste-IDA24248522  
GO:0001895retina homeostasis-HEP23580065  
GO:0002415immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor-IDA22022593  
GO:0007173epidermal growth factor receptor signaling pathway-IDA22022593  
GO:0038093Fc receptor signaling pathway-IDA22022593  
GO:0043113receptor clustering-IDA22022593  
GO:0043312neutrophil degranulation-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-HDA16502470  22664934  23580065  
GO:0005615extracellular space-IDA24248522  
GO:0005886plasma membrane-IDA22022593  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS2920039  
GO:0035577azurophil granule membrane-TAS-  
GO:0043235receptor complex-IDA23382219  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
KEGG ID KEGG Term
hsa04672Intestinal immune network for IgA production
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21512171Bronchial secretory immunoglobulin a deficiency correlates with airway inflammation and progression of chronic obstructive pulmonary disease. (2011 Aug 1)Polosukhin VVAm J Respir Crit Care Med
24117840Downregulation of polymeric immunoglobulin receptor and secretory IgA antibodies in eosinophilic upper airway diseases. (2013 Dec)Hupin CAllergy
22053820Sputum proteomics identifies elevated PIGR levels in smokers and mild-to-moderate COPD. (2012 Feb 3)Ohlmeier SJ Proteome Res