Gene: PIK3R1

5295
AGM7|GRB1|IMD36|p85|p85-ALPHA
phosphoinositide-3-kinase regulatory subunit 1
protein-coding
5q13.1
Ensembl:ENSG00000145675 MIM:171833 Vega:OTTHUMG00000131251 UniprotKB:P27986
NG_012849.2
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.116e-2 (AD)  3.942e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26804336chr5:67521733PIK3R1Promoter3.263e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NLK0.951
RAPGEF20.949
AKT30.948
ADAM220.942
SATB10.942
FAM131B0.94
HSPA12A0.94
DOCK30.94
GSK3B0.939
ATP9A0.937

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.55
OR4F29-0.542
MDFI-0.469
ZNF114-0.459
CSAG1-0.454
RAB13-0.444
MYL3-0.444
TFPI2-0.444
TMEM102-0.441
RNF135-0.436

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01064IsoprenalineSmall Molecule7683-59-2Approved|InvestigationalTarget
DB05210SF1126Small Molecule-InvestigationalTarget
DB06486EnzastaurinSmall Molecule170364-57-5InvestigationalTarget
DB08059(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of PIK3R1 mRNA"26377693
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PIK3R1 mRNA"19162173
C07258116-hydroxycleroda-3,13(14)-dien-15,16-olide"16-hydroxycleroda-3,13(14)-dien-15,16-olide results in decreased phosphorylation of PIK3R1 protein"21530604
C5131151-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester inhibits the reaction [VEGFA protein results in increased phosphorylation of PIK3R1 protein]21769449
C5131151-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester inhibits the reaction [VEGFA protein results in increased phosphorylation of PIK3R1 protein]]"21769449
C0192732,2-bis(4-glycidyloxyphenyl)propane"2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [1-(methylimino-N-oxy)-6-(2-morpholinoethoxy)-3-phenyl-1H-indene-2-carboxylic acid ethyl ester inhibits the reaction [VEGFA protein results in increased phosphorylation of PIK3R1 protein]]"21769449
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA"28433925
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PIK3R1 mRNA"12606953
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PIK3R1 protein"12606953
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of PIK3R1 mRNA28522335
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PIK3R1 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PIK3R1 mRNA"23196670
C4734683,5,3',4',5'-pentahydroxy-stilbene"3,5,3',4',5'-pentahydroxy-stilbene inhibits the reaction [EGF protein results in increased activity of PIK3R1 protein]"12687016
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of PIK3R1 mRNA14610520
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIK3R1 mRNA"27188386
C4664205,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein binds to PIK3R1 protein]]"19682478
C4664205,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein]]"19682478
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIK3R1 mRNA"27188386
C5582866,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose"6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalose analog results in decreased expression of PIK3R1 mRNA"25148938
C503142ABT-100ABT-100 results in decreased phosphorylation of PIK3R1 protein15930366
D000082AcetaminophenAcetaminophen results in decreased expression of PIK3R1 mRNA27761495
D020106AcrylamideAcrylamide results in increased expression of PIK3R1 mRNA22197712
D000255Adenosine TriphosphateAdenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]17550345
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PIK3R1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PIK3R1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PIK3R1 mRNA19770486
C103303alitretinoinalitretinoin results in increased expression of PIK3R1 mRNA16288212
C103303alitretinoinalitretinoin results in increased expression of PIK3R1 protein16288212
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PIK3R1 mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of PIK3R1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PIK3R1 mRNA16483693
D000872AnthocyaninsAnthocyanins results in increased expression of PIK3R1 mRNA18803703
D001115ArecolineArecoline results in increased expression of PIK3R1 mRNA20724125
D001151ArsenicArsenic results in decreased expression of PIK3R1 mRNA19945496
C015001arsenitearsenite promotes the reaction [PIK3R1 protein results in increased expression of HIF1A mRNA]20835880
C015001arsenitearsenite promotes the reaction [PIK3R1 protein results in increased expression of HIF1A protein]20835880
C015001arsenitePIK3R1 gene mutant form inhibits the reaction [arsenite affects the localization of HSF1 protein]20835880
C015001arsenitePIK3R1 gene mutant form inhibits the reaction [arsenite results in increased expression of HIF1A protein]20835880
C015001arsenitePIK3R1 gene mutant form inhibits the reaction [arsenite results in increased expression of HSF1 protein]20835880
C015001arsenitePIK3R1 gene mutant form inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]20835880
D001205Ascorbic AcidAscorbic Acid results in decreased expression of PIK3R1 mRNA15372504
D001241AspirinAspirin results in decreased expression of PIK3R1 mRNA20457246
D001280AtrazineAtrazine results in increased expression of PIK3R1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of PIK3R1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PIK3R1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PIK3R1 mRNA19770486|2222880
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PIK3R1 mRNA23735875
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PIK3R1 mRNA"28529061
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in decreased expression of PIK3R1 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of PIK3R1 mRNA25210133
D004958EstradiolEstradiol results in decreased expression of PIK3R1 protein22142692
C095105bexarotenebexarotene promotes the reaction [rosiglitazone results in increased expression of PIK3R1 mRNA]10548525
D001663BilirubinBilirubin results in decreased expression of PIK3R1 mRNA20196124
C006780bisphenol Abisphenol A results in decreased expression of PIK3R1 mRNA22576693
C006780bisphenol Abisphenol A results in increased expression of PIK3R1 mRNA21890461
C006780bisphenol Abisphenol A results in increased methylation of PIK3R1 gene22576693
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PIK3R1 mRNA25594700|2606340
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of PIK3R1 protein22142692
C006780bisphenol Abisphenol A results in increased expression of PIK3R1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PIK3R1 gene28505145
C462945BMS 649[BMS 961 co-treated with BMS 649] results in increased expression of PIK3R1 mRNA16288212
C462945BMS 649[BMS 961 co-treated with BMS 649] results in increased expression of PIK3R1 protein16288212
C514178BMS 961[BMS 961 co-treated with BMS 649] results in increased expression of PIK3R1 mRNA16288212
C514178BMS 961[BMS 961 co-treated with BMS 649] results in increased expression of PIK3R1 protein16288212
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of PIK3R1 mRNA15336504
D002104CadmiumCadmium results in decreased expression of PIK3R1 mRNA22666406
C040048caffeic acidcaffeic acid results in increased expression of PIK3R1 mRNA21870829
D002211CapsaicinPIK3R1 gene mutant form inhibits the reaction [NGF protein results in increased susceptibility to Capsaicin]17324588
D002220CarbamazepineCarbamazepine affects the expression of PIK3R1 mRNA24752500
C084597chlorcyclizinechlorcyclizine results in increased expression of PIK3R1 mRNA21058326
D002726Chlorogenic AcidChlorogenic Acid results in increased expression of PIK3R1 mRNA21870829
D002857ChromiumChromium inhibits the reaction [Dietary Fats results in decreased expression of PIK3R1 protein]20513351
D002922CiguatoxinsCiguatoxins affects the expression of PIK3R1 mRNA18353800
C029010cinnamic acidcinnamic acid results in increased expression of PIK3R1 mRNA21870829
C018021cobaltous chloridecobaltous chloride results in decreased expression of PIK3R1 mRNA19320972
C024989coenzyme Q10coenzyme Q10 inhibits the reaction [APP protein results in decreased expression of PIK3R1 protein]22186599
D016572CyclosporineCyclosporine results in decreased expression of PIK3R1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of PIK3R1 mRNA19770486|2383089
D003630DaunorubicinPIK3R1 affects the susceptibility to Daunorubicin17545624
D003907DexamethasoneDexamethasone results in increased expression of PIK3R1 mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of PIK3R1 protein15576458
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PIK3R1 mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of PIK3R122733784
D003907DexamethasoneDexamethasone results in increased expression of PIK3R1 mRNA22733784
D003907DexamethasoneDexamethasone results in increased expression of PIK3R1 protein22733784|2829296
D003907DexamethasonePIK3R1 mutant form inhibits the reaction [Dexamethasone results in decreased expression of and results in increased phosphorylation of IRS1 protein]22733784
D003907DexamethasonePIK3R1 mutant form inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]22733784
D003907DexamethasonePIK3R1 mutant form inhibits the reaction [Dexamethasone results in decreased phosphorylation of RPS6KB1 protein]22733784
D003907DexamethasonePIK3R1 mutant form inhibits the reaction [Dexamethasone results in increased expression of FBXO32 mRNA]22733784
D003907DexamethasonePIK3R1 mutant form inhibits the reaction [Dexamethasone results in increased expression of FOXO3 mRNA]22733784
D003907DexamethasonePIK3R1 mutant form inhibits the reaction [Dexamethasone results in increased expression of TRIM63 mRNA]22733784
D003907DexamethasonePIK3R1 protein affects the reaction [Dexamethasone results in decreased expression of AKT1 protein]28292967
D003907DexamethasonePIK3R1 protein affects the reaction [Dexamethasone results in increased phosphorylation of LIPE protein]28292967
D003907DexamethasonePIK3R1 protein affects the reaction [Dexamethasone results in increased phosphorylation of PLIN1 protein]28292967
D003907DexamethasonePIK3R1 protein affects the reaction [Dexamethasone results in increased secretion of INS1 protein]28292967
D003907DexamethasonePIK3R1 protein affects the susceptibility to Dexamethasone22733784
D003907DexamethasoneDexamethasone results in increased expression of PIK3R1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA]20032058
C042577diallyl trisulfidePIK3R1 protein promotes the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]25896937
C042577diallyl trisulfidePIK3R1 protein promotes the reaction [diallyl trisulfide results in increased expression of NFE2L2 protein]25896937
D002945CisplatinPIK3R1 results in decreased susceptibility to Cisplatin21571862
D004008DiclofenacDiclofenac affects the expression of PIK3R1 mRNA24752500
D004008DiclofenacDiclofenac results in increased expression of PIK3R1 mRNA26934552
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of PIK3R1 mRNA]"19467301
D004041Dietary Fats"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein binds to PIK3R1 protein]]"19682478
D004041Dietary Fats"5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinato iron(III) chloride inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein]]"19682478
D004041Dietary FatsChromium inhibits the reaction [Dietary Fats results in decreased expression of PIK3R1 protein]20513351
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PIK3R1 mRNA28433925
D004041Dietary FatsDietary Fats inhibits the reaction [INS1 protein binds to PIK3R1 protein]19682478
D004041Dietary FatsDietary Fats inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein]19682478
D004041Dietary FatsDietary Fats results in decreased expression of PIK3R1 mRNA24398136
D004041Dietary FatsDietary Fats results in decreased expression of PIK3R1 protein20513351
D004041Dietary FatsDietary Fats results in increased expression of PIK3R1 mRNA19467301
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of PIK3R1 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA"28433925
D004237DiuronDiuron results in decreased expression of PIK3R1 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of PIK3R1 mRNA25896364
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased activity of [PIK3CA protein binds to PIK3R1 protein]"25856345
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of PIK3R1 mRNA"27369806
D004642EmodinEmodin affects the expression of PIK3R1 protein19549930
C118739entinostatentinostat results in decreased expression of PIK3R1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PIK3R1 mRNA"27188386
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of PIK3R1 promoter27415467
D000431EthanolEthanol results in increased expression of PIK3R1 protein22459179
D000431EthanolEthanol affects the expression of PIK3R1 mRNA11772933
D000431EthanolEthanol results in increased expression of PIK3R1 mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of PIK3R1 mRNA]"20655511
D005054EugenolEugenol results in increased expression of PIK3R1 mRNA21870829
D005054EugenolEugenol results in increased expression of PIK3R1 mRNA20724125
C020748ferrous sulfateferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]17172471
C020748ferrous sulfatePIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]17172471
C020748ferrous sulfatePIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]17172471
C020748ferrous sulfatePIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]17172471
C020748ferrous sulfatePIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]17172471
C020748ferrous sulfatePIK3R1 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]17172471
C004999ferulic acidferulic acid results in increased expression of PIK3R1 mRNA21870829
D005485FlutamideFlutamide results in decreased expression of PIK3R1 mRNA21126777
D005492Folic AcidFolic Acid affects the expression of PIK3R1 mRNA16361273
D004397FonofosFonofos results in increased methylation of PIK3R1 promoter22847954
D005503Food AdditivesFood Additives results in increased expression of PIK3R1 mRNA18803703
D005557FormaldehydeFormaldehyde results in decreased expression of PIK3R1 mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of PIK3R1 mRNA23649840
C039281furanfuran results in decreased expression of PIK3R1 mRNA25539665
C054597garcinolgarcinol results in decreased phosphorylation of and results in decreased activity of PIK3R1 protein16052481
C106014geduningedunin results in decreased expression of PIK3R1 mRNA17010675
C001277geldanamycingeldanamycin results in increased expression of PIK3R1 mRNA26705709
D005947GlucoseGlucose promotes the reaction [PIK3R1 protein binds to IRS1 protein]10430617
D006046Gold[Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA19695318
D017313FenretinideFenretinide results in decreased expression of PIK3R1 mRNA28973697
D006834HydrazinesHydrazines results in decreased expression of PIK3R1 mRNA21647536
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of PIK3R1 protein27494022
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of PIK3R1 mRNA19208803
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of PIK3R1 protein19208803
C016517indole-3-carbinolindole-3-carbinol affects the expression of PIK3R1 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PIK3R1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIK3R1 mRNA25613284
D007501IronIron promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]17172471
D007501IronPIK3R1 protein affects the reaction [Iron results in increased phosphorylation of AKT1 protein]17172471
D007501IronPIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK1 protein]17172471
D007501IronPIK3R1 protein affects the reaction [Iron results in increased phosphorylation of MAPK3 protein]17172471
D007501IronPIK3R1 protein affects the reaction [Iron results in increased phosphorylation of NFKBIA protein]17172471
D007501IronPIK3R1 protein affects the reaction [Iron results in increased secretion of TNF protein]17172471
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PIK3R1 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of PIK3R1 mRNA20003209
C515747isosteviol[isosteviol co-treated with Palmitic Acid] results in increased expression of PIK3R1 mRNA22479612
C515747isosteviolisosteviol results in increased expression of PIK3R1 mRNA22479612
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PIK3R1 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PIK3R1 mRNA23828858|2479639
C410337K 7174K 7174 results in decreased expression of PIK3R1 mRNA24086573
D007854LeadLead affects the expression of PIK3R1 mRNA28903495
C533894LG 100815LG 100815 results in decreased expression of PIK3R1 mRNA16951191
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in decreased expression of PIK3R1 protein"19800873
C002385linsidominelinsidomine inhibits the reaction [INS1 protein binds to PIK3R1 protein]19682478
C002385linsidominelinsidomine inhibits the reaction [INS1 protein results in increased activity of PIK3R1 protein]19682478
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PIK3R1 mRNA21641980
D008558MelphalanMelphalan results in decreased expression of PIK3R1 mRNA22363485
D008628MercuryMercury results in decreased expression of PIK3R1 mRNA12730625
D008687MetforminMetformin results in increased expression of PIK3R1 mRNA21870829
D008694MethamphetamineMethamphetamine results in increased methylation of PIK3R1 promoter26307267
D008727MethotrexateMethotrexate affects the expression of PIK3R1 mRNA18502557
D008731MethoxychlorMethoxychlor results in decreased expression of PIK3R1 mRNA23303685
D008731MethoxychlorMethoxychlor results in increased methylation of PIK3R1 gene23303685
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to PIK3R1 promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride affects the expression of PIK3R1 mRNA20864626
D008767Methylmercury CompoundsPIK3R1 protein promotes the reaction [Methylmercury Compounds results in increased activity of NFE2L2 protein]18815141
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PIK3R1 mRNA26011545
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of PIK3R1 mRNA19945496
D009151Mustard GasMustard Gas results in decreased expression of PIK3R1 mRNA18955075
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of PIK3R1 mRNA"29244179
C554954N-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochlorideN-((3S)-1-azabicyclo(2.2.2)oct-3-yl)-1H-indazole-3-carboxamide hydrochloride results in increased expression of PIK3R1 mRNA28174063
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PIK3R1 mRNA"21624382
C017096n-butoxyethanoln-butoxyethanol results in increased expression of PIK3R1 mRNA19812364
D026422S-NitrosoglutathionePIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]11514583
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of PIK3R1 mRNA]"20655511
C025256nonylphenolnonylphenol results in decreased expression of PIK3R1 protein27832966
C025256nonylphenolwortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein]27832966
C464660obeticholic acidobeticholic acid results in decreased expression of PIK3R1 mRNA27939613
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of PIK3R1 mRNA"16951191
D010100OxygenOxygen deficiency results in increased expression of PIK3R1 mRNA19640849
D010100OxygenPIK3R1 protein promotes the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]19640849
D010100OxygenPIK3R1 protein promotes the reaction [Oxygen deficiency results in increased expression of CD36 protein]19640849
D010100OxygenPIK3R1 protein promotes the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]19640849
D010100OxygenPIK3R1 protein promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]19640849
D010100OxygenOxygen deficiency results in decreased phosphorylation of PIK3R1 protein25352008
D010100OxygenOxygen deficiency results in increased expression of PIK3R1 mRNA26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of PIK3R1 mRNA]26476374
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in decreased phosphorylation of PIK3R1 protein]25352008
D019308Palmitic Acid[isosteviol co-treated with Palmitic Acid] results in increased expression of PIK3R1 mRNA22479612
D010269ParaquatParaquat results in increased expression of PIK3R1 mRNA12595580
D010278ParathionParathion results in increased methylation of PIK3R1 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of PIK3R1 mRNA17450221
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of PIK3R1 mRNA22790973
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PIK3R1 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PIK3R1 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of PIK3R1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of PIK3R1 mRNA12082028
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PIK3R1 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of PIK3R1 mRNA23811191
C006253pirinixic acidpirinixic acid results in increased expression of PIK3R1 mRNA18445702
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA19695318
C045950propiconazolepropiconazole results in decreased expression of PIK3R1 mRNA21278054
D019269Phosphatidylinositol 4,5-Diphosphate"Phosphatidylinositol 4,5-Diphosphate inhibits the reaction [[PIK3CA protein co-treated with PIK3R1 protein] results in increased phosphorylation of [PIK3CA protein co-treated with PIK3R1 protein]]"19036708
D019269Phosphatidylinositol 4,5-Diphosphate"Phosphatidylinositol 4,5-Diphosphate results in increased activity of PIK3R1 protein"19036708
D011794QuercetinQuercetin results in decreased expression of PIK3R1 protein modified form26311153
D011794QuercetinQuercetin results in decreased phosphorylation of PIK3R1 protein25658812
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of PIK3R1 mRNA]26476374
C012526quercitrinquercitrin affects the expression of PIK3R1 mRNA25193878
C059514resveratrolAdenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]]17550345
C059514resveratrolresveratrol results in decreased activity of [IRS1 protein binds to PIK3R1 protein]17550345
C059514resveratrolresveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]17550345
C059514resveratrolresveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CB protein]17550345
C059514resveratrolresveratrol results in increased expression of PIK3R1 mRNA18089832
C059514resveratrolresveratrol results in increased expression of PIK3R1 protein18089832
C059514resveratrolresveratrol results in decreased expression of PIK3R1 mRNA22610192
C059514resveratrolresveratrol inhibits the reaction [INS1 protein promotes the reaction [IRS1 protein binds to PIK3R1 protein]]16626303
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in decreased phosphorylation of PIK3R1 protein]25352008
C009166retinol acetateretinol acetate results in increased expression of PIK3R1 mRNA16772331
C488333Ro 65-7199Ro 65-7199 results in decreased expression of PIK3R1 mRNA14610520
C089730rosiglitazonebexarotene promotes the reaction [rosiglitazone results in increased expression of PIK3R1 mRNA]10548525
C089730rosiglitazonerosiglitazone results in increased expression of PIK3R1 mRNA10548525
C541923sandostatinLARsandostatinLAR results in decreased expression of PIK3R1 mRNA17210224
D012503SaponinsSaponins results in decreased expression of PIK3R1 mRNA27369806
D012643SeleniumSelenium results in increased expression of PIK3R1 mRNA28810182
C078903seocalcitolseocalcitol results in increased expression of PIK3R1 mRNA12040012
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PIK3R1 mRNA19073995
D012834SilverSilver results in decreased expression of PIK3R1 mRNA27131904
D020123SirolimusSirolimus promotes the reaction [IRS1 protein binds to PIK3R1 protein]17908691
D012906SmokeSmoke results in decreased expression of PIK3R1 mRNA21095227
D012906SmokeSmoke affects the expression of PIK3R1 mRNA23693141
C009277sodium arsenatesodium arsenate results in decreased expression of PIK3R1 mRNA23922661
C009277sodium arsenatesodium arsenate results in increased expression of PIK3R1 mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of PIK3R1 mRNA19590694
C017947sodium arsenitesodium arsenite results in increased expression of PIK3R1 mRNA19072884
D018038Sodium SeleniteSodium Selenite results in increased expression of PIK3R1 mRNA14714311
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PIK3R1 mRNA21641980
D013629TamoxifenTamoxifen results in increased expression of PIK3R1 mRNA20937368
C012568terbufosterbufos results in increased methylation of PIK3R1 promoter22847954
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PIK3R1 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PIK3R1 mRNA17101203
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PIK3R1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to PIK3R1 promoter]19654925
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of PIK3R1 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA19770486|2266640
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PIK3R1 mRNA18691609
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PIK3R1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PIK3R1 mRNA25613284
D045162ThiazolidinedionesThiazolidinediones results in increased expression of PIK3R1 mRNA21870829
D013853ThioacetamideThioacetamide results in decreased expression of PIK3R1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of PIK3R1 mRNA23557971|2912861
C495469trans-3-(4'-hydroxyphenyl)-2-propenoic acidtrans-3-(4'-hydroxyphenyl)-2-propenoic acid results in increased expression of PIK3R1 mRNA21870829
D014212TretinoinTretinoin results in increased expression of PIK3R1 mRNA23830798
D014212TretinoinPIK3R1 protein promotes the reaction [Tretinoin results in increased activity of AKT1 protein]16288212
D014212TretinoinTretinoin results in increased expression of PIK3R1 mRNA16288212
D014212TretinoinTretinoin results in increased expression of PIK3R1 protein16288212
C012589trichostatin Atrichostatin A results in decreased expression of PIK3R1 mRNA24935251
C050414tripterinetripterine results in decreased expression of PIK3R1 mRNA17010675
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PIK3R1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PIK3R1 mRNA29024780
D014415TunicamycinTunicamycin results in decreased expression of PIK3R1 mRNA17127020
D014501UraniumUranium affects the expression of PIK3R1 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of PIK3R1 mRNA15672453
D014520UrethaneUrethane results in increased expression of PIK3R1 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of PIK3R1 mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of PIK3R1 mRNA17292431
D014638VanadatesVanadates results in increased expression of PIK3R1 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PIK3R1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PIK3R1 mRNA23034163
D014810Vitamin EVitamin E results in decreased expression of PIK3R1 mRNA19244175
C009687wortmanninwortmannin results in decreased activity of PIK3R1 protein19036708
C009687wortmanninwortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein]27832966
C088658zoledronic acidzoledronic acid results in increased expression of PIK3R1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001784phosphotyrosine residue binding-IPI20624904  
GO:0005068transmembrane receptor protein tyrosine kinase adaptor activity-ISS-  
GO:0005158insulin receptor binding-IPI7537849  
GO:0005159insulin-like growth factor receptor binding-IPI7541045  
GO:0005168neurotrophin TRKA receptor binding-IPI15488758  
GO:0005515protein binding-IPI1314164  1330535  1380456  1382595  7536927  7537096  
7568038  7584133  7589433  7629060  7642581  7642582  
7657594  7680095  7680644  7692233  7782332  7797556  
7807015  8034624  8146197  8183372  8276809  8382612  
8564419  8603569  8621719  8662998  8670861  9153411  
9160881  9398332  9417079  9593725  9658397  9813138  
9890970  10500481  10572067  10660596  10752619  10811803  
10820259  10967104  10978177  11123912  11403293  11416002  
11710529  11796522  11896612  14632132  15324660  15536084  
15556646  15581361  16043515  16150444  16219545  16230374  
16253990  16273093  16638574  16843263  16858407  16917505  
16982329  17043237  17353931  17474147  17500595  18059340  
18412956  19380743  19574958  19805105  19807924  19864249  
19903481  20007781  20018188  20227043  20541701  20598684  
20711237  20713702  20936779  21075308  21241768  21278786  
21706016  21827948  21946561  22020336  22402981  22439932  
22810585  23065768  23246379  23275563  23397142  23604317  
23617393  23643389  23676467  23853584  24189400  24498420  
24728074  25241761  25253337  25284480  25416956  26496610  
27135603  27478041  28169297  29568061  
GO:0008134transcription factor binding-IPI20348923  
GO:00163031-phosphatidylinositol-3-kinase activity-TAS-  
GO:0019903protein phosphatase binding-IPI14699157  
GO:0035014phosphatidylinositol 3-kinase regulator activity-ISS-  
GO:0036312phosphatidylinositol 3-kinase regulatory subunit binding-IEA-  
GO:0043125ErbB-3 class receptor binding-IDA10572067  
GO:0043548phosphatidylinositol 3-kinase binding-ISS-  
GO:0043559insulin binding-IDA8440175  
GO:0043560insulin receptor substrate binding-ISS-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO:00469351-phosphatidylinositol-3-kinase regulator activity-IBA21873635  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001678cellular glucose homeostasis-ISS-  
GO:0001953negative regulation of cell-matrix adhesion-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0006606protein import into nucleus-IEA-  
GO:0007173epidermal growth factor receptor signaling pathway-TAS-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007411axon guidance-TAS-  
GO:0008286insulin receptor signaling pathway-IBA21873635  
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IEA-  
GO:0014065phosphatidylinositol 3-kinase signaling-IDA7782332  
GO:0014065phosphatidylinositol 3-kinase signaling-IMP21321938  
GO:0016032viral process-IEA-  
GO:0019221cytokine-mediated signaling pathway-TAS-  
GO:0030168platelet activation-TAS-  
GO:0030183B cell differentiation-IEA-  
GO:0030335positive regulation of cell migration-IEA-  
GO:0031295T cell costimulation-TAS-  
GO:0032760positive regulation of tumor necrosis factor production-IEA-  
GO:0032869cellular response to insulin stimulus-ISS-  
GO:0033120positive regulation of RNA splicing-IMP20348923  
GO:0034644cellular response to UV-IEA-  
GO:0034976response to endoplasmic reticulum stress-IDA20348923  
GO:0034976response to endoplasmic reticulum stress-ISS-  
GO:0036092phosphatidylinositol-3-phosphate biosynthetic process-IEA-  
GO:0038095Fc-epsilon receptor signaling pathway-TAS-  
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis-TAS-  
GO:0038128ERBB2 signaling pathway-TAS-  
GO:0042307positive regulation of protein import into nucleus-IDA20348923  
GO:0043066negative regulation of apoptotic process-IMP20348923  
GO:0043551regulation of phosphatidylinositol 3-kinase activity-IBA21873635  
GO:0043551regulation of phosphatidylinositol 3-kinase activity-ISS-  
GO:0045671negative regulation of osteoclast differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP20348923  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS-  
GO:0046326positive regulation of glucose import-ISS8052599  
GO:0046626regulation of insulin receptor signaling pathway-IEA-  
GO:0046854phosphatidylinositol phosphorylation-IBA21873635  
GO:0046854phosphatidylinositol phosphorylation-ISS-  
GO:0048009insulin-like growth factor receptor signaling pathway-IDA7782332  
GO:0048009insulin-like growth factor receptor signaling pathway-IPI7541045  
GO:0048010vascular endothelial growth factor receptor signaling pathway-TAS-  
GO:0048015phosphatidylinositol-mediated signaling-TAS-  
GO:0050821protein stabilization-IDA20348923  
GO:0050852T cell receptor signaling pathway-TAS-  
GO:0050900leukocyte migration-TAS-  
GO:0051492regulation of stress fiber assembly-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0060396growth hormone receptor signaling pathway-IDA7782332  
GO:1900103positive regulation of endoplasmic reticulum unfolded protein response-IMP20348923  
GO:1903078positive regulation of protein localization to plasma membrane-ISS8052599  
GO:2001275positive regulation of glucose import in response to insulin stimulus-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IDA20348923  
GO:0005801cis-Golgi network-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IEA-  
GO:0005942phosphatidylinositol 3-kinase complex-IBA21873635  
GO:0005942phosphatidylinositol 3-kinase complex-ISS-  
GO:0005943phosphatidylinositol 3-kinase complex, class IA-ISS-  
GO:0016020membrane-HDA19946888  
GO:1990578perinuclear endoplasmic reticulum membrane-IEA-  
KEGG ID KEGG Term
hsa04012ErbB signaling pathway
hsa04062Chemokine signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04150mTOR signaling pathway
hsa04210Apoptosis
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04510Focal adhesion
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04930Type II diabetes mellitus
hsa04960Aldosterone-regulated sodium reabsorption
hsa04973Carbohydrate digestion and absorption
hsa05100Bacterial invasion of epithelial cells
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05160Hepatitis C
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-109704PI3K CascadeTAS
R-HSA-112399IRS-mediated signallingTAS
R-HSA-114604GPVI-mediated activation cascadeTAS
R-HSA-1226099Signaling by FGFR in diseaseTAS
R-HSA-1227986Signaling by ERBB2TAS
R-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsTAS
R-HSA-1236394Signaling by ERBB4TAS
R-HSA-1250342PI3K events in ERBB4 signalingTAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1266695Interleukin-7 signalingIEA
R-HSA-1266695Interleukin-7 signalingTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1430728MetabolismTAS
R-HSA-1433557Signaling by SCF-KITTAS
R-HSA-1483255PI MetabolismTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-1500931Cell-Cell communicationIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1643685DiseaseTAS
R-HSA-1643713Signaling by EGFR in CancerTAS
R-HSA-1660499Synthesis of PIPs at the plasma membraneTAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-166520Signaling by NTRKsIEA
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-177929Signaling by EGFRTAS
R-HSA-180292GAB1 signalosomeTAS
R-HSA-1839117Signaling by cytosolic FGFR1 fusion mutantsTAS
R-HSA-1839124FGFR1 mutant receptor activationTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-187037Signaling by NTRK1 (TRKA)TAS
R-HSA-190236Signaling by FGFRTAS
R-HSA-194138Signaling by VEGFTAS
R-HSA-194138Signaling by VEGFIEA
R-HSA-1963642PI3K events in ERBB2 signalingTAS
R-HSA-198203PI3K/AKT activationTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-202403TCR signalingTAS
R-HSA-202424Downstream TCR signalingTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosisTAS
R-HSA-2029485Role of phospholipids in phagocytosisTAS
R-HSA-210993Tie2 SignalingTAS
R-HSA-2172127DAP12 interactionsTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)TAS
R-HSA-2424491DAP12 signalingTAS
R-HSA-2428924IGF1R signaling cascadeTAS
R-HSA-2428928IRS-related events triggered by IGF1RTAS
R-HSA-2454202Fc epsilon receptor (FCERI) signalingTAS
R-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilizationTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373753Nephrin family interactionsIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389356CD28 co-stimulationTAS
R-HSA-389357CD28 dependent PI3K/Akt signalingTAS
R-HSA-392451G beta:gamma signalling through PI3KgammaTAS
R-HSA-397795G-protein beta:gamma signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-416482G alpha (12/13) signalling eventsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-430116GP1b-IX-V activation signallingTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayTAS
R-HSA-4420097VEGFA-VEGFR2 PathwayIEA
R-HSA-449147Signaling by InterleukinsIEA
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-451927Interleukin-2 family signalingTAS
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingIEA
R-HSA-512988Interleukin-3, 5 and GM-CSF signalingTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-5637810Constitutive Signaling by EGFRvIIITAS
R-HSA-5637812Signaling by EGFRvIII in CancerTAS
R-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in CancerTAS
R-HSA-5654687Downstream signaling of activated FGFR1TAS
R-HSA-5654689PI-3K cascade:FGFR1TAS
R-HSA-5654695PI-3K cascade:FGFR2TAS
R-HSA-5654696Downstream signaling of activated FGFR2TAS
R-HSA-5654708Downstream signaling of activated FGFR3TAS
R-HSA-5654710PI-3K cascade:FGFR3TAS
R-HSA-5654716Downstream signaling of activated FGFR4TAS
R-HSA-5654720PI-3K cascade:FGFR4TAS
R-HSA-5654736Signaling by FGFR1TAS
R-HSA-5654738Signaling by FGFR2TAS
R-HSA-5654741Signaling by FGFR3TAS
R-HSA-5654743Signaling by FGFR4TAS
R-HSA-5655253Signaling by FGFR2 in diseaseTAS
R-HSA-5655291Signaling by FGFR4 in diseaseTAS
R-HSA-5655302Signaling by FGFR1 in diseaseTAS
R-HSA-5655332Signaling by FGFR3 in diseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6785807Interleukin-4 and 13 signalingTAS
R-HSA-6806834Signaling by METTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-74751Insulin receptor signalling cascadeTAS
R-HSA-74752Signaling by Insulin receptorTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-8851907MET activates PI3K/AKT signalingTAS
R-HSA-8853334Signaling by FGFR3 fusions in cancerTAS
R-HSA-8853338Signaling by FGFR3 point mutants in cancerTAS
R-HSA-8853659RET signalingTAS
R-HSA-9006115Signaling by NTRK2 (TRKB)IEA
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesIEA
R-HSA-9028335Activated NTRK2 signals through PI3KIEA
R-HSA-912526Interleukin receptor SHC signalingTAS
R-HSA-912631Regulation of signaling by CBLIEA
R-HSA-912631Regulation of signaling by CBLTAS
R-HSA-983695Antigen activates B Cell Receptor (BCR) leading to generation of second messengersTAS
R-HSA-983705Signaling by the B Cell Receptor (BCR)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27605026A novel chi-square statistic for detecting group differences between pathways in systems epidemiology. (2016 Dec 20)Yuan ZStat Med
18245521Association between phosphatidylinositol 3-kinase regulatory subunit p85alpha Met326Ile genetic polymorphism and colon cancer risk. (2008 Feb 1)Li LClin Cancer Res
18335044Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents. (2008 Mar 12)Desrivieres SPLoS One
19183129Can we identify genes for alcohol consumption in samples ascertained for heterogeneous purposes? (2009 Apr)Hansell NKAlcohol Clin Exp Res