Gene: PIN1

5300
DOD|UBL5
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
protein-coding
19p13.2
Ensembl:ENSG00000127445 MIM:601052 Vega:OTTHUMG00000180388 UniprotKB:Q13526
NG_029167.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.840e-1 (AD)  4.340e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BABAM10.966
UBL4A0.963
RNF1870.962
PTGES20.96
TUSC20.96
AP2S10.958
OTUB10.958
REEP20.957
NT5C3B0.956
FARSA0.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.693
OR4F29-0.65
KCNJ15-0.456
REST-0.445
IL18RAP-0.438
EBF1-0.433
CXCR2-0.432
FCGR3B-0.426
MAGEA12-0.423
CST7-0.423

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01766Beta-(2-Naphthyl)-AlanineSmall Molecule-ExperimentalTarget
DB068673,6,9,12,15,18-HEXAOXAICOSANESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of PIN1 mRNA"20702594
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIN1 protein20804812
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PIN1 mRNA"21346803
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PIN1 mRNA12958071
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of PIN1 protein24140754
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal binds to PIN1 protein23231502
C0275764-hydroxy-2-nonenalPIN1 protein results in increased susceptibility to 4-hydroxy-2-nonenal23231502
D000082AcetaminophenAcetaminophen results in increased expression of PIN1 mRNA22230336
D000082AcetaminophenPIN1 gene polymorphism affects the susceptibility to Acetaminophen26104854
D000082AcetaminophenAcetaminophen affects the expression of PIN1 mRNA17562736
D001104ArbutinArbutin results in decreased expression of PIN1 mRNA17103032
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PIN1 mRNA20504355
C006780bisphenol Abisphenol A affects the expression of PIN1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PIN1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PIN1 mRNA18804290
C099555CD 437CD 437 results in decreased expression of PIN1 mRNA12958071
D002994ClofibrateClofibrate results in decreased expression of PIN1 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of PIN1 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of PIN1 mRNA24650576
D016572CyclosporineCyclosporine results in decreased expression of PIN1 mRNA20106945|2556210
C560298cysteinyl-arginyl-tyrosyl-prolyl-glutamyl-valyl-glutamyl-isoleucyl-cysteine (1-9) disulfidecysteinyl-arginyl-tyrosyl-prolyl-glutamyl-valyl-glutamyl-isoleucyl-cysteine (1-9) disulfide binds to and results in decreased activity of PIN1 protein21545152
D003976DiazinonDiazinon results in increased methylation of PIN1 gene22964155
C552250diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo(lmn)(3,8)phenanthroline-2,7-diacetate"diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo(lmn)(3,8)phenanthroline-2,7-diacetate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein]"23754278
C552250diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo(lmn)(3,8)phenanthroline-2,7-diacetate"diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo(lmn)(3,8)phenanthroline-2,7-diacetate results in decreased activity of PIN1 protein"23754278
D004317DoxorubicinDoxorubicin results in decreased expression of PIN1 protein26318906
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PIN1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PIN1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIN1 mRNA17942748
D005485FlutamideFlutamide results in increased expression of PIN1 mRNA24136188
D005839GentamicinsGentamicins results in increased expression of PIN1 mRNA22061828
C005134juglone"juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA]"23754278
C005134juglone"juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 protein]"23754278
C005134juglonejuglone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein]23754278
C005134juglonejuglone results in decreased activity of PIN1 protein21545152
D008727MethotrexatePIN1 protein affects the susceptibility to Methotrexate16217747
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of PIN1 protein26558463
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PIN1 mRNA]12710931
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PIN1 mRNA23754278
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein23754278
D0156551-Methyl-4-phenylpyridinium"diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo(lmn)(3,8)phenanthroline-2,7-diacetate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein]"23754278
D0156551-Methyl-4-phenylpyridiniumjuglone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein]23754278
D0156551-Methyl-4-phenylpyridiniumPIN1 mutant form inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]23754278
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PIN1 protein23754278
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA"20230807|2375427
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 protein"23754278
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA]"23754278
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"juglone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 protein]"23754278
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PIN1 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA]"20230807
C029938nickel sulfatenickel sulfate results in increased expression of PIN1 mRNA18651567
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of PIN1 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PIN1 mRNA]"20230807
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PIN1 mRNA19710929
D011794QuercetinQuercetin results in decreased expression of PIN1 protein20804812
C009277sodium arsenatesodium arsenate results in decreased expression of PIN1 mRNA23922661
C017947sodium arsenitesodium arsenite results in decreased expression of PIN1 mRNA19822182
D013629TamoxifenPIN1 protein results in decreased susceptibility to Tamoxifen19671742|2047900
D013629TamoxifenTamoxifen promotes the reaction [PIN1 protein binds to MAP2K1 protein]20479004
D013629TamoxifenTamoxifen affects the expression of PIN1 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PIN1 mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PIN1 mRNA17942748
D013755Tetradecanoylphorbol AcetateE2F4 protein promotes the reaction [PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein]]20479004
D013755Tetradecanoylphorbol AcetateEGR1 protein promotes the reaction [PIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein]]20479004
D013755Tetradecanoylphorbol AcetatePIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of E2F4 protein]20479004
D013755Tetradecanoylphorbol AcetatePIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGR1 protein]20479004
D013755Tetradecanoylphorbol AcetatePIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ERBB2 protein]20479004
D013755Tetradecanoylphorbol AcetatePIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MAP1LC3B protein]20479004
D013755Tetradecanoylphorbol AcetatePIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K1 protein]20479004
D013755Tetradecanoylphorbol AcetatePIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAP2K2 protein]20479004
D013755Tetradecanoylphorbol AcetatePIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]20479004
D013755Tetradecanoylphorbol AcetatePIN1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]20479004
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of PIN1 protein"25852303
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of PIN1 protein20109541
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PIN1 mRNA19042947
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PIN1 mRNA]12710931
D014635Valproic AcidValproic Acid affects the expression of PIN1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PIN1 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PIN1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003755peptidyl-prolyl cis-trans isomerase activity-IBA21873635  
GO:0003755peptidyl-prolyl cis-trans isomerase activity-IDA19122240  
GO:0003755peptidyl-prolyl cis-trans isomerase activity-NAS16697218  
GO:0003755peptidyl-prolyl cis-trans isomerase activity-TAS11533658  24964035  
GO:0003774motor activity-ISS-  
GO:0005515protein binding-IPI11470801  11940573  12397362  16189514  16476580  16554819  
17906639  18628984  19122240  19131971  19151708  19439498  
20179103  20179161  20622153  21516116  21741598  21743479  
21847096  21900206  21988832  22158035  23911326  24113655  
24265246  24267382  25416956  26655473  
GO:0008013beta-catenin binding-IPI11533658  
GO:0008013beta-catenin binding-ISS-  
GO:0031434mitogen-activated protein kinase kinase binding-IPI20179103  
GO:0032794GTPase activating protein binding-IPI20179103  
GO:0050815phosphoserine residue binding-IDA10037602  11533658  
GO:0050816phosphothreonine residue binding-IDA10037602  
GO:0050816phosphothreonine residue binding-IPI10037602  
GO:0051219phosphoprotein binding-ISS23362255  
GO ID GO Term Qualifier Evidence PubMed
GO:0000413protein peptidyl-prolyl isomerization-TAS11533658  
GO:0001932regulation of protein phosphorylation-IDA24964035  
GO:0001934positive regulation of protein phosphorylation-IGI19638580  
GO:0007049cell cycle-IEA-  
GO:0007088regulation of mitotic nuclear division-TAS10391244  
GO:0010468regulation of gene expression-IDA24964035  
GO:0030182neuron differentiation-ISS-  
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway-IDA19122240  
GO:0032091negative regulation of protein binding-IDA11533658  
GO:0032092positive regulation of protein binding-IDA24964035  
GO:0032465regulation of cytokinesis-IGI19638580  
GO:0032465regulation of cytokinesis-IMP19638580  
GO:0032480negative regulation of type I interferon production-TAS-  
GO:0035307positive regulation of protein dephosphorylation-TAS23362255  
GO:0042177negative regulation of protein catabolic process-IDA11533658  
GO:0043524negative regulation of neuron apoptotic process-IEA-  
GO:0043525positive regulation of neuron apoptotic process-IEA-  
GO:0043547positive regulation of GTPase activity-IMP20179103  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA11533658  
GO:0046785microtubule polymerizationNOTIDA26996940  
GO:0050808synapse organization-ISS-  
GO:0050821protein stabilization-IDA11533658  
GO:0050821protein stabilization-ISS-  
GO:0051443positive regulation of ubiquitin-protein transferase activity-IDA19122240  
GO:0060393regulation of pathway-restricted SMAD protein phosphorylation-IDA19122240  
GO:0061051positive regulation of cell growth involved in cardiac muscle cell development-IEA-  
GO:0070373negative regulation of ERK1 and ERK2 cascade-IDA20179103  
GO:0090263positive regulation of canonical Wnt signaling pathway-IDA11533658  
GO:1900180regulation of protein localization to nucleus-IDA11533658  
GO:1901796regulation of signal transduction by p53 class mediator-TAS-  
GO:2000146negative regulation of cell motility-IDA20179103  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16697218  20179103  
GO:0005634nucleus-TAS16697218  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA16697218  
GO:0005739mitochondrion-IEA-  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-ISS-  
GO:0016607nuclear speck-IEA-  
GO:0030496midbody-IDA19638580  
GO:0043005neuron projection-IEA-  
KEGG ID KEGG Term
hsa04622RIG-I-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1169408ISG15 antiviral mechanismTAS
R-HSA-1169410Antiviral mechanism by IFN-stimulated genesTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/betaTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-6804758Regulation of TP53 Activity through AcetylationTAS
R-HSA-6811555PI5P Regulates TP53 AcetylationTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-913531Interferon SignalingTAS
R-HSA-936440Negative regulators of DDX58/IFIH1 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28592245In silico identification of potential key regulatory factors in smoking-induced lung cancer. (2017 Jun 7)El-Aarag SABMC Med Genomics
21850685The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese populations. (2011 Nov)Lu JHum Mutat