Gene: PITX1

5307
BFT|CCF|LBNBG|POTX|PTX1
paired like homeodomain 1
protein-coding
5q31.1
Ensembl:ENSG00000069011 MIM:602149 Vega:OTTHUMG00000149983 UniprotKB:P78337
NG_012114.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.387e-1 (AD)  3.483e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MUC210.815
CRNN0.786
KRT40.774
SPRR1A0.771
SPRR2D0.769
SPINK50.756
KRT130.751
TMPRSS11B0.748
SPRR30.745
KRT150.74

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR2C1-0.224
IL17C-0.217
PCDHB6-0.214
OPN1SW-0.214
BACH2-0.208
VPS13C-0.207
C16orf87-0.206
ZNF674-0.206
TRIM73-0.204
GSTCD-0.199

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PITX1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PITX1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PITX1 mRNA24449571
C015001arsenitearsenite results in increased methylation of PITX1 promoter23974009
D001241AspirinAspirin results in increased expression of PITX1 mRNA11906190
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PITX1 mRNA18164116
D004958EstradiolEstradiol affects the expression of PITX1 mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of PITX1 mRNA20404318
D004958EstradiolEstradiol results in increased expression of PITX1 mRNA21795739
D004958Estradiol[Dieldrin co-treated with Estradiol] results in decreased expression of PITX1 mRNA23041725
C006780bisphenol Abisphenol A affects the methylation of PITX1 promoter27334623
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PITX1 promoter22457795
D003561CytarabineCytarabine results in decreased expression of PITX1 mRNA21198554
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PITX1 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PITX1 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PITX1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PITX1 mRNA27392435
C121718dicyclanildicyclanil results in increased expression of PITX1 mRNA15664270
D004026Dieldrin[Dieldrin co-treated with Estradiol] results in decreased expression of PITX1 mRNA23041725
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PITX1 mRNA18164116
D004317DoxorubicinDoxorubicin results in increased expression of PITX1 mRNA16404146
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PITX1 mRNA23550701
C070081fulvestrantfulvestrant inhibits the reaction [Genistein results in decreased expression of PITX1 mRNA]21810550
C070081fulvestrantfulvestrant inhibits the reaction [Genistein results in increased expression of PITX1 mRNA]22553218
D019833Genisteinfulvestrant inhibits the reaction [Genistein results in decreased expression of PITX1 mRNA]21810550
D019833Genisteinfulvestrant inhibits the reaction [Genistein results in increased expression of PITX1 mRNA]22553218
D019833GenisteinGenistein results in increased expression of and results in increased localization of PITX1 protein21810550
D019833GenisteinGenistein results in increased expression of PITX1 mRNA21810550
D007052IbuprofenIbuprofen results in increased expression of PITX1 mRNA28201806
C492448ICG 001ICG 001 results in increased expression of PITX1 mRNA26191083
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PITX1 mRNA27392435
C410337K 7174K 7174 results in decreased expression of PITX1 mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PITX1 mRNA23179753
D059808PolyphenolsPolyphenols results in decreased expression of PITX1 mRNA16293270
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of PITX1 mRNA19244175
D012643SeleniumSelenium results in increased expression of PITX1 mRNA19244175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PITX1 mRNA24058054
D013974ThyroxineThyroxine results in decreased expression of PITX1 mRNA17403546
D014212TretinoinTretinoin results in decreased expression of PITX1 mRNA23810783
D014212TretinoinTretinoin results in decreased expression of PITX1 protein23810783
D014635Valproic AcidValproic Acid results in increased methylation of PITX1 gene29154799
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of PITX1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IBA21873635  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0001085RNA polymerase II transcription factor binding-IPI26612202  
GO:0001190transcriptional activator activity, RNA polymerase II transcription factor binding-IEA-  
GO:0003700DNA-binding transcription factor activity-ISS-  
GO:0005515protein binding-IPI16189514  25416956  25910212  
GO:0043565sequence-specific DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001501skeletal system development-TAS9070926  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0009653anatomical structure morphogenesis-IBA21873635  
GO:0009653anatomical structure morphogenesis-TAS9070926  
GO:0014707branchiomeric skeletal muscle development-IEA-  
GO:0021983pituitary gland development-IEA-  
GO:0035116embryonic hindlimb morphogenesis-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048625myoblast fate commitment-IEA-  
GO:0051216cartilage development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA17984056  
GO:0005667transcription factor complex-IEA-  
GO:0005730nucleolus-IDA-  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24932901Etiopathogenesis of equinovarus foot malformations. (2014 Aug)Bacino CAEur J Med Genet