Gene info: ID 5308

Gene: PITX2

GENE ID: 5308

Synonyms: ARP1|ASGD4|Brx1|IDG2|IGDS|IGDS2|IHG2|IRID2|Otlx2|PTX2|RGS|RIEG|RIEG1|RS

Description: paired like homeodomain 2

Gene type: protein-coding

Location: 4q25

dbXrefs: Ensembl:ENSG00000164093 MIM:601542 Vega:OTTHUMG00000132837 UniprotKB:Q99697

RefSeq: NG_007120.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.196e-1 (AD) 1.555e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DCAF4L2	0.71
OR51F1	0.709
OR4D11	0.697
DPPA4	0.694
KRTAP24-1	0.68
OR51S1	0.672
FOXI2	0.664
MROH5	0.657
FOXD3	0.653
OR51D1	0.65

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C21orf58	-0.375
NYAP1	-0.373
ZBTB45	-0.37
NAT8L	-0.367
LYNX1	-0.365
CORO2B	-0.359
PANX2	-0.353
PDK2	-0.352
DBH	-0.35
EXTL1	-0.35

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PITX2 mRNA"	19114083
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of PITX2 mRNA	22841810\|2414075
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C496492	abrine	abrine results in decreased expression of PITX2 mRNA	22595364
D020106	Acrylamide	Acrylamide results in increased expression of PITX2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of PITX2 gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of PITX2 mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PITX2 mRNA	16483693
C015001	arsenite	arsenite results in increased methylation of PITX2 promoter	23974009
D001280	Atrazine	Atrazine results in decreased expression of PITX2 mRNA	25929836
C487081	belinostat	belinostat results in increased expression of PITX2 mRNA	26272509
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PITX2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PITX2 mRNA	22300585
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PITX2 mRNA	21839799
D004958	Estradiol	Estradiol results in decreased expression of PITX2 mRNA	20106945
C006780	bisphenol A	bisphenol A affects the expression of PITX2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of PITX2 mRNA	27178563
C584509	C646 compound	C646 compound results in increased expression of PITX2 mRNA	26921506
D002110	Caffeine	Caffeine results in decreased expression of PITX2 mRNA	20864626
D002220	Carbamazepine	Carbamazepine affects the expression of PITX2 mRNA	22634333
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PITX2 gene	20938992
D016572	Cyclosporine	Cyclosporine results in decreased expression of PITX2 mRNA	20106945
D003561	Cytarabine	Cytarabine results in decreased expression of PITX2 mRNA	21198554
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PITX2 mRNA"	22485181
C061365	flusilazole	flusilazole affects the expression of PITX2 mRNA	22634333
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PITX2 gene	20938992
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PITX2 mRNA	20044591
D007213	Indomethacin	Indomethacin results in decreased expression of PITX2 mRNA	25972201
D018021	Lithium Chloride	Lithium Chloride promotes the reaction [PITX2 protein binds to FGF16 promoter]	24253043
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PITX2 gene	20938992
C013598	methoxyacetic acid	methoxyacetic acid results in decreased expression of PITX2 mRNA	20864626
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of PITX2 mRNA	20864626
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PITX2 mRNA	26011545
C028577	monobutyl phthalate	monobutyl phthalate results in decreased expression of PITX2 mRNA	20864626
D009532	Nickel	Nickel results in decreased expression of PITX2 mRNA	24768652\|2558310
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PITX2 mRNA	27935865
C558013	NSC 689534	NSC 689534 results in decreased expression of PITX2 mRNA	20971185
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of PITX2 mRNA	26272509
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PITX2 mRNA	26272509
C006253	pirinixic acid	NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of PITX2 mRNA]	17950772
C006253	pirinixic acid	pirinixic acid results in decreased expression of PITX2 mRNA	17950772
D010936	Plant Extracts	Plant Extracts results in decreased expression of PITX2 mRNA	23557933
D011794	Quercetin	Quercetin results in increased expression of PITX2 mRNA	15309432
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of PITX2 mRNA	23806026
D019821	Simvastatin	Simvastatin results in decreased expression of PITX2 mRNA	19262002
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PITX2 mRNA	16962184\|2157046
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PITX2 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PITX2 mRNA	16922920
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PITX2 mRNA	17586704
D014212	Tretinoin	Tretinoin results in increased expression of PITX2 mRNA	21934132
D014212	Tretinoin	Tretinoin results in decreased expression of PITX2 mRNA	20488242
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of PITX2 mRNA	24935251\|2627250
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased methylation of PITX2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of PITX2 mRNA	23179753\|2352703
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of PITX2 gene	25560391
D002762	Cholecalciferol	Cholecalciferol results in increased expression of PITX2 mRNA	17170073
D024483	Vitamin K 3	Vitamin K 3 affects the expression of PITX2 mRNA	20044591
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PITX2 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of PITX2 mRNA	26272509
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PITX2 mRNA	27935865

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000976	transcription regulatory region sequence-specific DNA binding	-	IDA	9685346
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0001085	RNA polymerase II transcription factor binding	-	IBA	21873635
GO:0001102	RNA polymerase II activating transcription factor binding	-	IPI	9685346
GO:0003700	DNA-binding transcription factor activity	-	IDA	15385555
GO:0003713	transcription coactivator activity	-	IDA	9685346
GO:0005515	protein binding	-	IPI	16449236 19174163 23088713 25241761
GO:0008134	transcription factor binding	-	IPI	15385555
GO:0031490	chromatin DNA binding	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001569	branching involved in blood vessel morphogenesis	-	IEA	-
GO:0001570	vasculogenesis	-	IEA	-
GO:0001701	in utero embryonic development	-	IEA	-
GO:0001764	neuron migration	-	IEA	-
GO:0002074	extraocular skeletal muscle development	-	IEA	-
GO:0003171	atrioventricular valve development	-	IEA	-
GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	-	ISS	-
GO:0003350	pulmonary myocardium development	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IDA	15385555
GO:0006357	regulation of transcription by RNA polymerase II	-	IDA	23975681
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0007368	determination of left/right symmetry	-	ISS	-
GO:0007520	myoblast fusion	-	IEA	-
GO:0008584	male gonad development	-	IEA	-
GO:0008585	female gonad development	-	IEA	-
GO:0009653	anatomical structure morphogenesis	-	IBA	21873635
GO:0009725	response to hormone	-	IEA	-
GO:0016055	Wnt signaling pathway	-	IEA	-
GO:0021763	subthalamic nucleus development	-	IEA	-
GO:0021855	hypothalamus cell migration	-	IEA	-
GO:0030334	regulation of cell migration	-	IEA	-
GO:0031076	embryonic camera-type eye development	-	IEA	-
GO:0033189	response to vitamin A	-	IEA	-
GO:0035116	embryonic hindlimb morphogenesis	-	IEA	-
GO:0035315	hair cell differentiation	-	IC	19251162
GO:0035886	vascular smooth muscle cell differentiation	-	IEA	-
GO:0035993	deltoid tuberosity development	-	IMP	18312615
GO:0042475	odontogenesis of dentin-containing tooth	-	IEA	-
GO:0042476	odontogenesis	-	IMP	14630904
GO:0043010	camera-type eye development	-	IMP	9618168
GO:0043388	positive regulation of DNA binding	-	IEA	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	9685346 19251162
GO:0045944	positive regulation of transcription by RNA polymerase II	-	TAS	-
GO:0048536	spleen development	-	ISS	-
GO:0048557	embryonic digestive tract morphogenesis	-	IEA	-
GO:0055009	atrial cardiac muscle tissue morphogenesis	-	IEA	-
GO:0055015	ventricular cardiac muscle cell development	-	IEA	-
GO:0060126	somatotropin secreting cell differentiation	-	TAS	10372733
GO:0060127	prolactin secreting cell differentiation	-	TAS	10372733
GO:0060412	ventricular septum morphogenesis	-	IEA	-
GO:0060460	left lung morphogenesis	-	IEA	-
GO:0060577	pulmonary vein morphogenesis	-	IEA	-
GO:0060578	superior vena cava morphogenesis	-	IEA	-
GO:0061031	endodermal digestive tract morphogenesis	-	IEA	-
GO:0061072	iris morphogenesis	-	IMP	9437321
GO:0061325	cell proliferation involved in outflow tract morphogenesis	-	ISS	-
GO:0070986	left/right axis specification	-	ISS	-
GO:2000288	positive regulation of myoblast proliferation	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	19251162
GO:0005654	nucleoplasm	-	TAS	-
GO:0005667	transcription factor complex	-	IDA	15385555
GO:0005737	cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04350	TGF-beta signaling pathway

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	TAS
R-HSA-8866906	TFAP2 (AP-2) family regulates transcription of other transcription factors	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23599765	Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. (2013 Apr)	Zhao Y	Oncol Lett
22776031	Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke. (2012 Jul 9)	Hacke W	BMC Med