Gene info: ID 5309

Gene: PITX3

GENE ID: 5309

Description: paired like homeodomain 3

Gene type: protein-coding

Location: 10q24.32

dbXrefs: Ensembl:ENSG00000107859 MIM:602669 Vega:OTTHUMG00000018952 UniprotKB:O75364

RefSeq: NG_008147.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: OD|CD

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.106e-1 (AD) 4.705e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CLCF1	0.761
TNFRSF12A	0.755
HELB	0.725
MAFA	0.703
MAP2K3	0.7
FAM83G	0.697
ZNF878	0.691
RELB	0.689
FOSL1	0.681
SPHK1	0.68

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OMG	-0.398
B3GALT2	-0.372
KBTBD7	-0.364
LHX6	-0.359
ESRRG	-0.357
SLITRK1	-0.356
PLD5	-0.353
ERBB4	-0.352
CCDC177	-0.352
THNSL1	-0.352

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of PITX3 mRNA"	18648102
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PITX3 mRNA	16483693
D001374	Azacitidine	Azacitidine results in increased expression of PITX3 mRNA	27415467
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to PITX3 promoter]	19654925
C006780	bisphenol A	bisphenol A affects the methylation of PITX3 promoter	27334623
C006780	bisphenol A	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PITX3 promoter	23359474
C006780	bisphenol A	bisphenol A results in decreased expression of PITX3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased methylation of PITX3 promoter	28728135
D003042	Cocaine	Cocaine results in decreased expression of PITX3 protein	15094491
D003976	Diazinon	Diazinon results in increased methylation of PITX3 gene	22964155
D003993	Dibutyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PITX3 promoter	23359474
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of PITX3 mRNA	28962523
D004051	Diethylhexyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PITX3 promoter	23359474
D007980	Levodopa	PITX3 affects the susceptibility to Levodopa	17499513
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in decreased methylation of PITX3 promoter	27415467
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of PITX3 mRNA	27415467
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of PITX3 mRNA	12057914
D008694	Methamphetamine	Methamphetamine affects the expression of PITX3 mRNA	19564919
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in decreased expression of PITX3 mRNA	19564919
D009151	Mustard Gas	Mustard Gas results in increased expression of PITX3 mRNA	15674843
C006253	pirinixic acid	pirinixic acid results in decreased expression of PITX3 mRNA	23811191
D010936	Plant Extracts	Plant Extracts results in decreased expression of PITX3 mRNA	23557933
D012402	Rotenone	BDNF protein affects the reaction [PITX3 protein results in decreased susceptibility to Rotenone]	18646205
D012402	Rotenone	GDNF protein affects the reaction [PITX3 protein results in decreased susceptibility to Rotenone]	18646205
D012402	Rotenone	PITX3 protein results in decreased susceptibility to Rotenone	18646205
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in decreased expression of PITX3 mRNA	19564919
C534628	SCH 23390	SCH 23390 results in decreased expression of PITX3 mRNA	19564919
D013629	Tamoxifen	Tamoxifen results in decreased expression of PITX3 mRNA	25123088
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PITX3 mRNA	24058054
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PITX3 promoter]	19654925
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of PITX3 mRNA	28973375
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of PITX3 mRNA	28973375
D014520	Urethane	Urethane results in increased expression of PITX3 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of PITX3 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of PITX3 mRNA	28743636

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0001077	transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	-
GO:0001085	RNA polymerase II transcription factor binding	-	IBA	21873635
GO:0043565	sequence-specific DNA binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002088	lens development in camera-type eye	-	ISS	-
GO:0002089	lens morphogenesis in camera-type eye	-	ISS	-
GO:0006355	regulation of transcription, DNA-templated	-	ISS	-
GO:0006366	transcription by RNA polymerase II	-	IEA	-
GO:0007568	aging	-	IEA	-
GO:0007626	locomotory behavior	-	IEA	-
GO:0009653	anatomical structure morphogenesis	-	IBA	21873635
GO:0009887	animal organ morphogenesis	-	TAS	9620774
GO:0014014	negative regulation of gliogenesis	-	IEA	-
GO:0030901	midbrain development	-	ISS	-
GO:0035902	response to immobilization stress	-	IEA	-
GO:0042220	response to cocaine	-	IEA	-
GO:0043278	response to morphine	-	IEA	-
GO:0043525	positive regulation of neuron apoptotic process	-	IEA	-
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	-
GO:0048666	neuron development	-	IEA	-
GO:0070306	lens fiber cell differentiation	-	IEA	-
GO:0071542	dopaminergic neuron differentiation	-	ISS	-
GO:0071542	dopaminergic neuron differentiation	-	TAS	24431302
GO:1904313	response to methamphetamine hydrochloride	-	IEA	-
GO:1904935	positive regulation of cell proliferation in midbrain	-	IEA	-
GO:1990792	cellular response to glial cell derived neurotrophic factor	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	ISS	-
GO:0043025	neuronal cell body	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
15094491	Transcription factors specifying dopamine phenotype are decreased in cocaine users. (2004 Mar 1)	Bannon MJ	Neuroreport
24706046	Dysregulation of dopaminergic regulatory mechanisms in the mesolimbic pathway induced by morphine and morphine withdrawal. (2015 Jul)	Garcia-Perez D	Brain Struct Funct