Gene: PKD1

5310
PBP|PC1|Pc-1|TRPP1
polycystin 1, transient receptor potential channel interacting
protein-coding
16p13.3
Ensembl:ENSG00000008710 MIM:601313 Vega:OTTHUMG00000155795 UniprotKB:P98161
NG_008617.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.146e-2 (AD)  7.659e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg00263650chr16:2159464PKD1Gene body3.138e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SIN3B0.942
GGT70.941
KCNT10.941
DPH10.94
DGKQ0.939
SRRM30.937
CELSR30.937
CUL90.936
CHRD0.936
ABCC80.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.528
OR4F29-0.485
ZNF114-0.442
C9orf135-0.435
TFPI2-0.424
PROK2-0.421
YES1-0.41
PHEX-0.405
AGTR1-0.404
LRAT-0.403

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of PKD1 mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of PKD1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of PKD1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased activity of PKD1 protein25858767
D000109AcetylcholinePKD1 protein affects the susceptibility to Acetylcholine18679710
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PKD1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PKD1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PKD1 mRNA24449571
D001151ArsenicArsenic affects the methylation of PKD1 gene25304211
D001280AtrazineAtrazine results in decreased expression of PKD1 mRNA26518232
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of PKD1 mRNA21635667
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PKD1 gene25435355
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of BRD4 protein]]25877301
D004958EstradiolEstradiol affects the expression of PKD1 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PKD1 mRNA19693291
D004958EstradiolEstradiol results in increased expression of PKD1 mRNA19693291
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PKD1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of PKD1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PKD1 mRNA28628672
D002110CaffeinePKD1 protein affects the reaction [Caffeine affects the abundance of Calcium]18679710
D002110CaffeinePKD1 protein affects the susceptibility to Caffeine18679710
D002118CalciumPKD1 protein promotes the reaction [PAFAH1B1 protein results in increased abundance of Calcium]15001556
D002118CalciumPKD1 protein affects the reaction [Caffeine affects the abundance of Calcium]18679710
D002118CalciumPKD1 protein affects the reaction [Thapsigargin affects the abundance of Calcium]18679710
D002994ClofibrateClofibrate results in decreased expression of PKD1 mRNA23811191
D019327Copper SulfateCopper Sulfate results in increased expression of PKD1 mRNA19549813
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PKD1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PKD1 mRNA28628672
D003976DiazinonDiazinon affects the expression of PKD1 mRNA22546817
C000944dicrotophosdicrotophos results in increased expression of PKD1 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PKD1 mRNA17555576
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of PKD1 gene16724327
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of PKD1 mRNA27776689
D005419FlavonoidsFlavonoids results in decreased expression of PKD1 mRNA18035473
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of PKD1 mRNA22584684
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PKD1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PKD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PKD1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PKD1 mRNA28628672
C561695(+)-JQ1 compoundBRD4 mutant form inhibits the reaction [(+)-JQ1 compound inhibits the reaction [PKD1 gene mutant form results in decreased expression of CDKN1A mRNA]]25877301
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [PKD1 gene mutant form results in decreased expression of CDKN1A mRNA]25877301
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [PKD1 gene mutant form results in increased expression of MYC mRNA]25877301
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [PKD1 gene mutant form results in increased expression of MYC protein]25877301
C561695(+)-JQ1 compoundMYC protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [PKD1 gene mutant form results in decreased expression of CDKN1A mRNA]]25877301
D007649KetamineKetamine results in increased expression of PKD1 mRNA20080153
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PKD1 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PKD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PKD1 mRNA"25554681
C030110oxaliplatinoxaliplatin results in decreased expression of PKD1 mRNA17762391
D010656PhenylephrinePKD1 protein affects the susceptibility to Phenylephrine18679710
C006253pirinixic acidpirinixic acid results in decreased expression of PKD1 mRNA23811191
D011189Potassium ChloridePKD1 protein affects the susceptibility to Potassium Chloride18679710
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PKD1 mRNA19693291
D012643SeleniumSelenium results in increased expression of PKD1 mRNA19244175
D018038Sodium SeleniteSodium Selenite results in increased expression of PKD1 mRNA18175754
C533237STA 9090benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of BRD4 protein]]25877301
C533237STA 9090STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of BRD4 protein]25877301
C533237STA 9090STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of MYC mRNA]25877301
C533237STA 9090STA 9090 inhibits the reaction [PKD1 gene mutant form results in increased expression of MYC protein]25877301
D013467SulindacSulindac results in increased expression of PKD1 mRNA11906190
D013629TamoxifenTamoxifen affects the expression of PKD1 mRNA17555576
D013739TestosteroneTestosterone results in decreased expression of PKD1 mRNA19693291
D019284ThapsigarginPKD1 protein affects the reaction [Thapsigargin affects the abundance of Calcium]18679710
D019284ThapsigarginPKD1 protein affects the susceptibility to Thapsigargin18679710
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PKD1 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PKD1 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PKD1 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of PKD1 mRNA19140230
D014520UrethaneUrethane results in increased expression of PKD1 mRNA28818685
D014810Vitamin EVitamin E results in increased expression of PKD1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005262calcium channel activity-ISS-  
GO:0005515protein binding-IPI10097141  15563610  19556541  20168298  20856870  24939912  
GO:0019901protein kinase binding-IPI17980165  
GO:0019904protein domain specific binding-IPI9171830  
GO:0030246carbohydrate binding-IEA-  
GO:0044325ion channel binding-IPI9192675  
GO ID GO Term Qualifier Evidence PubMed
GO:0001502cartilage condensation-IEA-  
GO:0001701in utero embryonic development-ISS-  
GO:0001822kidney development-ISS-  
GO:0001889liver development-IEA-  
GO:0001892embryonic placenta development-ISS-  
GO:0006611protein export from nucleus-ISS-  
GO:0007050cell cycle arrest-ISS-  
GO:0007156homophilic cell adhesion via plasma membrane adhesion molecules-TAS10861291  
GO:0007160cell-matrix adhesion-TAS7663510  
GO:0007161calcium-independent cell-matrix adhesion-TAS10861291  
GO:0007204positive regulation of cytosolic calcium ion concentration-IEA-  
GO:0007259JAK-STAT cascade-ISS-  
GO:0007507heart development-IEP11891195  
GO:0009653anatomical structure morphogenesis-TAS9326937  
GO:0018105peptidyl-serine phosphorylation-ISS-  
GO:0021510spinal cord development-IEP11891195  
GO:0021915neural tube development-IEP11891195  
GO:0030010establishment of cell polarity-IEA-  
GO:0030155regulation of cell adhesion-IEA-  
GO:0031659positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle-IDA16311606  
GO:0032092positive regulation of protein binding-ISS-  
GO:0034405response to fluid shear stress-IEA-  
GO:0036303lymph vessel morphogenesis-IEA-  
GO:0042994cytoplasmic sequestering of transcription factor-ISS-  
GO:0043588skin development-IEP11891195  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16311606  
GO:0048565digestive tract development-IEP11891195  
GO:0048754branching morphogenesis of an epithelial tube-IDA12482949  
GO:0048806genitalia development-IEP11891195  
GO:0050982detection of mechanical stimulus-ISS-  
GO:0051216cartilage development-IEP11891195  
GO:0060236regulation of mitotic spindle organization-IEA-  
GO:0060428lung epithelium development-IEP11891195  
GO:0060674placenta blood vessel development-ISS-  
GO:0061136regulation of proteasomal protein catabolic process-IDA23001567  
GO:0070588calcium ion transmembrane transport-ISS-  
GO:0072164mesonephric tubule development-IEP11891195  
GO:0072177mesonephric duct development-IEP11891195  
GO:0072205metanephric collecting duct development-IEP11891195  
GO:0072218metanephric ascending thin limb development-IEP11891195  
GO:0072237metanephric proximal tubule development-IEP11891195  
GO:0072287metanephric distal tubule morphogenesis-IEP11891195  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0002133polycystin complex-ISS-  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membrane-IDA23001567  
GO:0005887integral component of plasma membrane-TAS7663510  
GO:0005929cilium-ISS-  
GO:0009986cell surface-IEA-  
GO:0016021integral component of membrane-NAS10097141  
GO:0016323basolateral plasma membrane-IDA10770959  
GO:0016328lateral plasma membrane-IEA-  
GO:0030660Golgi-associated vesicle membrane-TAS-  
GO:0031514motile cilium-ISS-  
GO:0060170ciliary membrane-TAS-  
GO:0070062extracellular exosome-HDA19056867  
GO:0070062extracellular exosome-IDA15326289  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5617833Cilium AssemblyIEA
R-HSA-5620916VxPx cargo-targeting to ciliumTAS
R-HSA-5620916VxPx cargo-targeting to ciliumIEA
R-HSA-5620920Cargo trafficking to the periciliary membraneTAS
R-HSA-5620920Cargo trafficking to the periciliary membraneIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27921038The Clinical Manifestation and Management of Autosomal Dominant Polycystic Kidney Disease in China. (2016 Oct)Xue CKidney Dis (Basel)
27921039Clinical Manifestation and Management of ADPKD in Western Countries. (2016 Oct)Sommerer CKidney Dis (Basel)
12798348Molecular pathogenesis of subarachnoid haemorrhage. (2003 Sep)Zhang BInt J Biochem Cell Biol
20301424Polycystic Kidney Disease, Autosomal Dominant (1993)Harris PC-