Gene: PKD2

5311
APKD2|PC2|PKD4|Pc-2|TRPP2
polycystin 2, transient receptor potential cation channel
protein-coding
4q22.1
Ensembl:ENSG00000118762 MIM:173910 Vega:OTTHUMG00000160982 UniprotKB:Q13563
NG_008604.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  2.730e-1 (ND)   (Frontal_Cortex)
2.222e-1 (AD)  3.590e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NKTR0.891
AGO40.889
TTC170.88
ANKHD10.878
SPG110.871
PAN30.867
MAML10.867
NEK90.867
ZSCAN300.865
RBL20.865

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.557
OR4F29-0.536
KLRC2-0.222
LCN1-0.216
PAGE4-0.213
OXT-0.204
HCRT-0.201
MUC12-0.199
AVP-0.193
LHX5-0.189

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of PKD2 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PKD2 protein27818125
D000584AmilorideAmiloride results in decreased activity of [PKD2 protein binds to PKD2 protein]19193631
D000584AmilorideAmiloride results in decreased activity of [PKD2 protein binds to TRPC1 protein]19193631
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PKD2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PKD2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PKD2 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PKD2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PKD2 mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of PKD2 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PKD2 mRNA26079696
D002118CalciumPKD2 protein promotes the reaction [PAFAH1B1 protein results in increased abundance of Calcium]15001556
D002118CalciumPKD2 protein results in increased transport of Calcium15100357
D002118CalciumIFT88 protein affects the reaction [PKD2 protein results in increased uptake of Calcium]16396941
D000069287CapecitabinePKD2 protein results in decreased susceptibility to Capecitabine16734730
C018021cobaltous chloridecobaltous chloride results in decreased expression of PKD2 mRNA19376846
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PKD2 mRNA15467011
D016572CyclosporineCyclosporine results in decreased expression of PKD2 mRNA25562108
C014347decitabinedecitabine results in increased expression of PKD2 mRNA19194470
D004221DisulfiramDisulfiram results in decreased expression of PKD2 mRNA20530235
D004237DiuronDiuron results in decreased expression of PKD2 mRNA25152437
C025034doxifluridinePKD2 protein results in decreased susceptibility to doxifluridine16734730
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PKD2 mRNA22079256
D005682GadoliniumGadolinium results in decreased activity of PKD2 protein16396941
D005839GentamicinsGentamicins results in increased expression of PKD2 protein mutant form15001556
D005839GentamicinsGentamicins results in decreased expression of PKD2 mRNA22061828
D006851Hydrochloric AcidHydrochloric Acid results in decreased activity of [PKD2 protein binds to PKD2 protein]19193631
C016927isepamicinisepamicin results in increased expression of PKD2 protein mutant form15001556
C045463leflunomideleflunomide results in decreased expression of PKD2 mRNA28988120
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PKD2 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PKD2 mRNA26378955
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PKD2 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PKD2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PKD2 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PKD2 mRNA25380136
D017239PaclitaxelPKD2 protein results in increased susceptibility to Paclitaxel16734730
C016030pantogabpantogab results in decreased expression of PKD2 mRNA17379144
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PKD2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of PKD2 mRNA19482888
C006253pirinixic acidpirinixic acid results in decreased expression of PKD2 mRNA20059764
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of PKD2 mRNA]20059764
D010936Plant ExtractsPlant Extracts results in increased expression of PKD2 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PKD2 mRNA21334430
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PKD2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PKD2 mRNA22079256
C059514resveratrolresveratrol results in increased expression of PKD2 protein25505154
C079198S 1 (combination)PKD2 protein results in decreased susceptibility to S 1 (combination)16734730
C010327salinomycinsalinomycin results in decreased expression of PKD2 mRNA19682730
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PKD2 mRNA25351596
C017947sodium arsenitesodium arsenite results in increased expression of PKD2 mRNA20308225
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PKD2 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of PKD2 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PKD2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKD2 mRNA24680724
D013893ThiramThiram results in decreased expression of PKD2 mRNA20530235
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PKD2 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PKD2 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of PKD2 mRNA22378314
D014520UrethaneUrethane results in decreased expression of PKD2 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of PKD2 mRNA23179753
D015029ZeranolZeranol results in increased expression of PKD2 protein27224899

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IPI16223735  
GO:0005244voltage-gated ion channel activity-IDA11854751  
GO:0005245voltage-gated calcium channel activity-IDA11252306  15692563  
GO:0005248voltage-gated sodium channel activity-IDA11252306  
GO:0005248voltage-gated sodium channel activity-IMP27071085  
GO:0005249voltage-gated potassium channel activity-IMP27071085  
GO:0005262calcium channel activity-IBA21873635  
GO:0005267potassium channel activity-IDA26269590  
GO:0005267potassium channel activity-ISS-  
GO:0005509calcium ion binding-IDA24990821  
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI9171830  9192675  10097141  10760273  12525172  12809519  
15123714  15194699  15692563  16223735  16311606  20168298  
25416956  
GO:0008092cytoskeletal protein binding-IDA10760273  
GO:0015271outward rectifier potassium channel activity-ISS-  
GO:0022843voltage-gated cation channel activity-IDA11252306  
GO:0042802identical protein binding-IPI20168298  
GO:0042802identical protein binding-ISS-  
GO:0042803protein homodimerization activity-IDA9192675  
GO:0042805actinin binding-IDA15843396  
GO:0043398HLH domain binding-IPI16311606  
GO:0044325ion channel binding-IPI10097141  
GO:0048763calcium-induced calcium release activity-IDA11854751  
GO:0051117ATPase binding-ISS-  
GO:0051219phosphoprotein binding-IPI19801576  
GO:0051371muscle alpha-actinin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001658branching involved in ureteric bud morphogenesis-IEP11891195  
GO:0001889liver development-IEP11891195  
GO:0001892embryonic placenta development-ISS-  
GO:0001947heart looping-IMP21719175  
GO:0003127detection of nodal flow-ISS-  
GO:0006816calcium ion transport-IDA11252306  
GO:0006816calcium ion transport-ISS-  
GO:0007050cell cycle arrest-ISS-  
GO:0007259JAK-STAT cascade-ISS-  
GO:0007368determination of left/right symmetry-ISS-  
GO:0007507heart development-IEP11891195  
GO:0008285negative regulation of cell proliferation-NAS18664456  
GO:0021510spinal cord development-IEP11891195  
GO:0021915neural tube development-IEP11891195  
GO:0031587positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity-IMP16223735  
GO:0031659positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle-IDA16311606  
GO:0034614cellular response to reactive oxygen species-NAS18417208  
GO:0035502metanephric part of ureteric bud development-IEP11891195  
GO:0035725sodium ion transmembrane transport-IDA11252306  
GO:0035725sodium ion transmembrane transport-IMP27071085  
GO:0035904aorta development-IEP11891195  
GO:0042127regulation of cell proliferation-IMP15001556  
GO:0042994cytoplasmic sequestering of transcription factor-IMP16311606  
GO:0045429positive regulation of nitric oxide biosynthetic process-IMP19265036  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA16311606  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP9192675  
GO:0050982detection of mechanical stimulus-IBA21873635  
GO:0050982detection of mechanical stimulus-ISS-  
GO:0051209release of sequestered calcium ion into cytosol-IDA11854751  
GO:0051209release of sequestered calcium ion into cytosol-IMP19265036  
GO:0051289protein homotetramerization-IDA28092368  
GO:0051298centrosome duplication-NAS18725310  
GO:0060315negative regulation of ryanodine-sensitive calcium-release channel activity-ISS-  
GO:0060674placenta blood vessel development-ISS-  
GO:0061333renal tubule morphogenesis-ISS-  
GO:0061441renal artery morphogenesis-IEP11891195  
GO:0070588calcium ion transmembrane transport-IDA11854751  
GO:0071158positive regulation of cell cycle arrest-IMP16311606  
GO:0071277cellular response to calcium ion-ISS-  
GO:0071320cellular response to cAMP-IMP26269590  
GO:0071464cellular response to hydrostatic pressure-IDA16025301  
GO:0071470cellular response to osmotic stress-IDA16025301  
GO:0071498cellular response to fluid shear stress-IMP19265036  
GO:0071805potassium ion transmembrane transport-IDA26269590  
GO:0071805potassium ion transmembrane transport-IMP27071085  
GO:0071805potassium ion transmembrane transport-ISS-  
GO:0071910determination of liver left/right asymmetry-IMP21719175  
GO:0072075metanephric mesenchyme development-IEP11891195  
GO:0072164mesonephric tubule development-IEP11891195  
GO:0072177mesonephric duct development-IEP11891195  
GO:0072208metanephric smooth muscle tissue development-IEP11891195  
GO:0072214metanephric cortex development-IEP11891195  
GO:0072218metanephric ascending thin limb development-IEP11891195  
GO:0072219metanephric cortical collecting duct development-IEP11891195  
GO:0072235metanephric distal tubule development-IEP11891195  
GO:0072284metanephric S-shaped body morphogenesis-IEP11891195  
GO:0090279regulation of calcium ion import-IDA11854751  
GO:2000134negative regulation of G1/S transition of mitotic cell cycle-IMP16311606  
GO ID GO Term Qualifier Evidence PubMed
GO:0002133polycystin complex-ISS-  
GO:0005737cytoplasm-IDA10770959  
GO:0005737cytoplasm-IMP16311606  
GO:0005783endoplasmic reticulum-IDA10760273  15123714  15692563  19801576  
GO:0005783endoplasmic reticulum-IMP16223735  
GO:0005789endoplasmic reticulum membrane-IDA11854751  15001556  
GO:0005886plasma membrane-IDA15692563  16025301  
GO:0005887integral component of plasma membrane-IDA21044049  26269590  28092368  
GO:0005887integral component of plasma membrane-IMP27071085  
GO:0005911cell-cell junctioncolocalizes_withISS-  
GO:0005929cilium-ISS-  
GO:0009925basal plasma membrane-IDA10770959  
GO:0016020membrane-IBA21873635  
GO:0030027lamellipodium-IDA10760273  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0031514motile cilium-ISS-  
GO:0031941filamentous actincolocalizes_withIDA16025301  
GO:0036064ciliary basal body-IDA15337773  
GO:0045180basal cortex-IDA10770959  
GO:0060170ciliary membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  
GO:0071458integral component of cytoplasmic side of endoplasmic reticulum membrane-IDA21044049  
GO:0071556integral component of lumenal side of endoplasmic reticulum membrane-IDA21044049  
GO:0072686mitotic spindle-IDA15123714  
GO:0097730non-motile cilium-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-1852241Organelle biogenesis and maintenanceIEA
R-HSA-5617833Cilium AssemblyTAS
R-HSA-5617833Cilium AssemblyIEA
R-HSA-5620916VxPx cargo-targeting to ciliumTAS
R-HSA-5620916VxPx cargo-targeting to ciliumIEA
R-HSA-5620920Cargo trafficking to the periciliary membraneTAS
R-HSA-5620920Cargo trafficking to the periciliary membraneIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27921038The Clinical Manifestation and Management of Autosomal Dominant Polycystic Kidney Disease in China. (2016 Oct)Xue CKidney Dis (Basel)
27921039Clinical Manifestation and Management of ADPKD in Western Countries. (2016 Oct)Sommerer CKidney Dis (Basel)
25821920Sperm mRNAs and microRNAs as candidate markers for the impact of toxicants on human spermatogenesis: an application to tobacco smoking. (2015 Jun)Metzler-Guillemain CSyst Biol Reprod Med
20301424Polycystic Kidney Disease, Autosomal Dominant (1993)Harris PC-