Gene: PKP1

5317
B6P
plakophilin 1
protein-coding
1q32.1
Ensembl:ENSG00000081277 MIM:601975 Vega:OTTHUMG00000035729 UniprotKB:Q13835
NG_023337.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.609e-1 (AD)  6.558e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL22A10.567
PRSS120.566
SDC10.564
LRMP0.564
EPHA80.554
ADAMTS160.553
KCNK90.541
CACNA1G0.539
CCDC30.538
MAMLD10.538

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDO-0.36
RIBC1-0.336
MBNL3-0.323
C9orf170-0.323
CPSF4L-0.317
LHPP-0.317
HOGA1-0.316
S100A1-0.315
RFTN2-0.313
CMTM5-0.313

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PKP1 mRNA"18648102
C496492abrineabrine results in decreased expression of PKP1 mRNA22595364
D020106AcrylamideAcrylamide results in increased expression of PKP1 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PKP1 mRNA21298039
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PKP1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of PKP1 protein25419056
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of PKP1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PKP1 mRNA22228805
D004958EstradiolEstradiol results in increased expression of PKP1 mRNA19484750
C006780bisphenol Abisphenol A affects the expression of PKP1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PKP1 gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of PKP1 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PKP1 mRNA20938992
D003471CuprizoneCuprizone results in decreased expression of PKP1 mRNA26577399
D003907DexamethasoneDexamethasone results in increased expression of PKP1 mRNA22733784
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PKP1 mRNA28962523
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PKP1 mRNA20920545
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of PKP1 mRNA17317680
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PKP1 mRNA20938992
D004397FonofosFonofos results in increased methylation of PKP1 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of PKP1 mRNA19167457
C039281furanfuran results in increased expression of PKP1 mRNA27387713
C039281furanfuran results in increased methylation of PKP1 gene22079235
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PKP1 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of PKP1 mRNA24449571
C028007nickel monoxidenickel monoxide results in decreased expression of PKP1 mRNA19167457
D010278ParathionParathion results in increased methylation of PKP1 promoter22847954
C046012pentanalpentanal results in decreased expression of PKP1 mRNA26079696
C006253pirinixic acidpirinixic acid results in increased expression of PKP1 mRNA20813756
C005556propionaldehydepropionaldehyde results in decreased expression of PKP1 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of PKP1 mRNA24780913
D015474IsotretinoinIsotretinoin results in increased expression of PKP1 mRNA20436886
C012568terbufosterbufos results in increased methylation of PKP1 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PKP1 mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKP1 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PKP1 mRNA17035482|2756255
D014635Valproic AcidValproic Acid results in increased methylation of PKP1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI10852826  25225333  25416956  26275350  
GO:0005521lamin binding-IDA10852826  
GO:0019215intermediate filament binding-NAS10852826  
GO:0030280structural constituent of epidermis-NAS7527055  
GO:0045296cadherin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007155cell adhesion-NAS10852826  
GO:0007165signal transduction-NAS7527055  
GO:0009966regulation of signal transduction-IBA21873635  
GO:0010628positive regulation of gene expression-IMP25225333  
GO:0031424keratinization-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0045110intermediate filament bundle assembly-IBA21873635  
GO:0045110intermediate filament bundle assembly-IDA10852826  
GO:0070268cornification-TAS-  
GO:0098609cell-cell adhesion-IBA21873635  
GO:0098609cell-cell adhesion-IEA-  
GO:1902373negative regulation of mRNA catabolic process-IMP25225333  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005634nucleus-NAS9369526  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005882intermediate filament-TAS7527055  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IBA21873635  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0030057desmosome-NAS7527055  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0101003ficolin-1-rich granule membrane-TAS-  
GO:1990124messenger ribonucleoprotein complex-IDA25225333  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109581ApoptosisTAS
R-HSA-111465Apoptotic cleavage of cellular proteinsTAS
R-HSA-1266738Developmental BiologyTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-351906Apoptotic cleavage of cell adhesion proteinsTAS
R-HSA-5357801Programmed Cell DeathTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS
R-HSA-75153Apoptotic execution phaseTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer