Gene: PKP2

5318
ARVD9
plakophilin 2
protein-coding
12p11.21
Ensembl:ENSG00000057294 MIM:602861 Vega:OTTHUMG00000169500 UniprotKB:Q99959
NG_009000.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.091e-1 (AD)  7.172e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GAD20.818
RGS80.801
KIT0.788
HAPLN10.788
IGF10.781
SLC10A40.777
SLC32A10.769
BTBD110.767
ERBB40.761
DLX60.758

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFB3-0.481
ROM1-0.462
GNG8-0.454
CSAG1-0.447
OTOS-0.438
PLEKHF1-0.425
RARRES3-0.417
PSTPIP1-0.414
AQP1-0.413
CRYAA-0.41

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolPKP2 protein results in increased susceptibility to 1-UFT protocol16734730
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PKP2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of PKP2 protein"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C496492abrineabrine results in increased expression of PKP2 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of PKP2 mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of PKP2 mRNA17562736
C015001arsenitearsenite results in increased expression of PKP2 mRNA18929588
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PKP2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PKP2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PKP2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PKP2 mRNA21839799
D004958EstradiolEstradiol affects the expression of PKP2 mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in decreased expression of PKP2 mRNA20404318
D004958EstradiolEstradiol results in increased expression of PKP2 mRNA15289156
C006780bisphenol Abisphenol A affects the expression of PKP2 mRNA25181051
D000069287CapecitabinePKP2 protein results in increased susceptibility to Capecitabine16734730
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PKP2 mRNA27339419
D002330CarmustineCarmustine results in increased expression of PKP2 mRNA16005536
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of PKP2 mRNA26272509
D003042CocaineCocaine results in increased expression of PKP2 mRNA27899881
D003471CuprizoneCuprizone results in decreased expression of PKP2 mRNA26577399
D003471CuprizoneCuprizone results in increased expression of PKP2 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of PKP2 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of PKP2 mRNA21198554
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PKP2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PKP2 mRNA27392435
D002945CisplatinCisplatin results in increased phosphorylation of PKP2 protein22006019
D004041Dietary FatsDietary Fats results in increased expression of PKP2 mRNA19030233
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PKP2 mRNA15289156
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PKP2 mRNA21658437
D002117CalcitriolCalcitriol results in increased expression of PKP2 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of PKP2 mRNA21592394
C025034doxifluridinePKP2 protein results in increased susceptibility to doxifluridine16734730
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PKP2 mRNA22079256
D005557FormaldehydeFormaldehyde results in increased expression of PKP2 mRNA27664576
C039281furanfuran results in increased expression of PKP2 mRNA25539665
D019833GenisteinGenistein results in increased expression of PKP2 mRNA15289156
D005897GlafenineGlafenine results in increased expression of PKP2 mRNA24136188
C004312glycidolglycidol results in increased expression of PKP2 mRNA24915197
D017313FenretinideFenretinide results in decreased expression of PKP2 mRNA28973697
D007213IndomethacinIndomethacin results in increased expression of PKP2 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PKP2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PKP2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PKP2 mRNA24796395
D007608Kainic AcidKainic Acid results in decreased expression of PKP2 mRNA17997037
D007657Ketone BodiesKetone Bodies results in increased expression of PKP2 mRNA16807920
C045463leflunomideleflunomide results in increased expression of PKP2 mRNA19751817
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of PKP2 mRNA26667767
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PKP2 mRNA25613284
C042720mercuric bromidemercuric bromide results in increased expression of PKP2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride affects the expression of PKP2 mRNA20353558
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of PKP2 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of PKP2 mRNA19564919
D008727MethotrexateMethotrexate results in increased expression of PKP2 mRNA16005536
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PKP2 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PKP2 mRNA23179753|2718838
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PKP2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of PKP2 mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of PKP2 mRNA21664453
D015735MifepristoneMifepristone results in decreased expression of PKP2 mRNA25972201
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PKP2 mRNA"25554681
D010100OxygenOxygen deficiency affects the expression of PKP2 mRNA17193925
D017239PaclitaxelPKP2 protein results in decreased susceptibility to Paclitaxel16734730
D010416PentachlorophenolPentachlorophenol results in increased expression of PKP2 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of PKP2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PKP2 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of PKP2 mRNA18445702
C006253pirinixic acidpirinixic acid results in increased expression of PKP2 mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PKP2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PKP2 mRNA22079256
D011794QuercetinQuercetin results in decreased expression of PKP2 mRNA15309432|2163298
C059514resveratrol[Lipopolysaccharides co-treated with resveratrol] results in decreased expression of PKP2 mRNA26667767
C059514resveratrolresveratrol results in decreased expression of PKP2 mRNA22610192
C079198S 1 (combination)PKP2 protein results in increased susceptibility to S 1 (combination)16734730
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of PKP2 mRNA19564919
C534628SCH 23390SCH 23390 results in increased expression of PKP2 mRNA19564919
D012906SmokeSmoke results in decreased expression of PKP2 mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of PKP2 mRNA23922661
C016104sodium bichromatesodium bichromate results in increased expression of PKP2 mRNA25993096
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of PKP2 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PKP2 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKP2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PKP2 mRNA27913140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PKP2 mRNA22298810
D013853ThioacetamideThioacetamide results in increased expression of PKP2 mRNA23411599
D013866ThioguanineThioguanine results in increased expression of PKP2 mRNA16005536
D014212TretinoinTretinoin results in increased expression of PKP2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of PKP2 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of PKP2 mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PKP2 mRNA24935251|2627250
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PKP2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PKP2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PKP2 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PKP2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of PKP2 mRNA23034163
D015032ZincZinc deficiency results in increased expression of PKP2 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005080protein kinase C binding-IBA21873635  
GO:0005080protein kinase C binding-IPI18474624  
GO:0005515protein binding-IPI10852826  25416956  28169297  
GO:0017080sodium channel regulator activity-ISS-  
GO:0019215intermediate filament binding-IBA21873635  
GO:0019215intermediate filament binding-IDA10852826  
GO:0032947protein-containing complex scaffold activity-IBA21873635  
GO:0032947protein-containing complex scaffold activity-IMP18474624  
GO:0044325ion channel binding-ISS-  
GO:0045294alpha-catenin binding-IBA21873635  
GO:0045294alpha-catenin binding-IPI23136403  
GO:0045296cadherin binding-HDA25468996  
GO:0045296cadherin binding-IBA21873635  
GO:0086083cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication-IC22889254  
GO ID GO Term Qualifier Evidence PubMed
GO:0002159desmosome assembly-IMP18474624  
GO:0002934desmosome organization-IBA21873635  
GO:0007043cell-cell junction assembly-IBA21873635  
GO:0007507heart development-IBA21873635  
GO:0007507heart development-ISS-  
GO:0009966regulation of signal transduction-IBA21873635  
GO:0010765positive regulation of sodium ion transport-ISS-  
GO:0031424keratinization-TAS-  
GO:0034334adherens junction maintenance-IBA21873635  
GO:0045110intermediate filament bundle assembly-IBA21873635  
GO:0045110intermediate filament bundle assembly-IMP18474624  
GO:0048496maintenance of animal organ identity-IMP22889254  
GO:0055010ventricular cardiac muscle tissue morphogenesis-IMP22889254  
GO:0070268cornification-TAS-  
GO:0072659protein localization to plasma membrane-IBA21873635  
GO:0072659protein localization to plasma membrane-IMP23863954  
GO:0086002cardiac muscle cell action potential involved in contraction-IMP22889254  
GO:0086005ventricular cardiac muscle cell action potential-IMP22889254  
GO:0086019cell-cell signaling involved in cardiac conduction-IBA21873635  
GO:0086019cell-cell signaling involved in cardiac conduction-IMP22889254  
GO:0086064cell communication by electrical coupling involved in cardiac conduction-ISS-  
GO:0086073bundle of His cell-Purkinje myocyte adhesion involved in cell communication-IMP22889254  
GO:0086091regulation of heart rate by cardiac conduction-IMP17980246  22889254  
GO:0098609cell-cell adhesion-IBA21873635  
GO:0098609cell-cell adhesion-ISS-  
GO:0098609cell-cell adhesion-NAS8922383  
GO:0098911regulation of ventricular cardiac muscle cell action potential-IMP22889254  
GO ID GO Term Qualifier Evidence PubMed
GO:0001533cornified envelope-TAS-  
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-NAS8922383  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005882intermediate filament-IBA21873635  
GO:0005882intermediate filament-ISS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA20859650  23863954  
GO:0005886plasma membrane-TAS-  
GO:0005911cell-cell junction-IBA21873635  
GO:0005911cell-cell junction-ISS-  
GO:0005912adherens junction-ISS-  
GO:0005913cell-cell adherens junction-IBA21873635  
GO:0014704intercalated disc-IBA21873635  
GO:0014704intercalated disc-IDA22781308  
GO:0014704intercalated disc-ISS-  
GO:0016021integral component of membrane-TAS8922383  
GO:0030054cell junction-IDA-  
GO:0030057desmosome-ISS-  
GO:0030057desmosome-NAS8922383  
GO:1990124messenger ribonucleoprotein complexNOTIDA25225333  
KEGG ID KEGG Term
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28714806Loss of control over the ethanol consumption: differential transcriptional regulation in prefrontal cortex. (2017 Sep)de Paiva Lima CJ Neurogenet