Gene info: ID 5319

Gene: PLA2G1B

GENE ID: 5319

Synonyms: PLA2|PLA2A|PPLA2

Description: phospholipase A2 group IB

Gene type: protein-coding

Location: 12q24.31

dbXrefs: Ensembl:ENSG00000170890 MIM:172410 Vega:OTTHUMG00000169343 UniprotKB:P04054

RefSeq: NC_000012.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.333e-1 (AD) 7.623e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CELA3B	0.967
GP2	0.958
CTRB1	0.956
CELA3A	0.954
CPB1	0.952
CPA1	0.943
CTRB2	0.942
PNLIPRP1	0.935
CLPS	0.919
SPINK1	0.914

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
TM4SF20	-0.216
KRTAP5-7	-0.192
KRTAP5-8	-0.187
SH2D1B	-0.187
PSG11	-0.184
FOXN4	-0.184
CYP2A6	-0.18
XCR1	-0.176
CCDC63	-0.172
ASTN2	-0.17

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00795	Sulfasalazine	Small Molecule	599-79-1	Approved	Target
DB02210	Hexane-1,6-Diol	Small Molecule	629-11-8	Experimental	Target
DB02448	N-Tridecanoic Acid	Small Molecule	638-53-9	Experimental	Target
DB02659	Cholic Acid	Small Molecule	81-25-4	Approved	Target
DB02795	P-Anisic Acid	Small Molecule	100-09-4	Experimental	Target
DB02938	Heptanoic Acid	Small Molecule		Experimental\|Investigational	Target
DB03565	1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine	Small Molecule		Experimental	Target
DB03587	Pyruvaldehyde	Small Molecule	78-98-8	Experimental	Target
DB03633	Lpc-Ether	Small Molecule		Experimental	Target
DB04552	Niflumic Acid	Small Molecule	4394-00-7	Approved	Target
DB07657	PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER	Small Molecule		Experimental	Target
DB07836	1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL	Small Molecule		Experimental	Target
DB09061	Cannabidiol	Small Molecule	13956-29-1	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [PLA2G1B protein results in increased abundance of Calcium]"	15528384
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[PLA2G1B protein results in increased abundance of Calcium] which results in increased expression of CXCL8 protein]"	15528384
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]	15528384
C404910	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane	"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of PLA2G1B mRNA]"	19414516
D000082	Acetaminophen	Acetaminophen results in decreased expression of PLA2G1B mRNA	29067470
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PLA2G1B mRNA	22100608
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PLA2G1B mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PLA2G1B mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PLA2G1B mRNA	20458559
D001241	Aspirin	Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA]	10706128
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of PLA2G1B mRNA	12883083
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PLA2G1B mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PLA2G1B mRNA	22300585
C006780	bisphenol A	bisphenol A results in decreased expression of PLA2G1B mRNA	12075121\|2518105
D002118	Calcium	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [PLA2G1B protein results in increased abundance of Calcium]"	15528384
D002118	Calcium	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[PLA2G1B protein results in increased abundance of Calcium] which results in increased expression of CXCL8 protein]"	15528384
D002118	Calcium	PLA2G1B protein results in increased abundance of Calcium	15528384
D002118	Calcium	[PLA2G1B protein results in increased abundance of Calcium] which results in increased expression of CXCL8 protein	15528384
D002994	Clofibrate	Clofibrate results in decreased expression of PLA2G1B mRNA	22300585
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G1B mRNA]	11007951
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PLA2G1B mRNA]	27941970
D003907	Dexamethasone	Dexamethasone inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]	15528384
D003907	Dexamethasone	Dexamethasone results in increased expression of PLA2G1B mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of PLA2G1B mRNA]	20032058
D004041	Dietary Fats	Dietary Fats results in decreased expression of PLA2G1B mRNA	25016146
D004533	Egtazic Acid	Egtazic Acid results in decreased activity of PLA2G1B protein	15528384
D004785	Environmental Pollutants	Environmental Pollutants results in decreased expression of PLA2G1B mRNA	24534155
C046855	epostane	[epostane co-treated with Dinoprost] results in increased expression of PLA2G1B mRNA	20739670
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PLA2G1B mRNA	15901920
C069837	fullerene C60	fullerene C60 results in increased expression of PLA2G1B mRNA	19167457
D019833	Genistein	Genistein results in decreased expression of PLA2G1B mRNA	15901920
C029424	hydrazine	hydrazine results in decreased expression of PLA2G1B mRNA	15282401
C051890	irinotecan	irinotecan affects the expression of PLA2G1B mRNA	20097248
D007501	Iron	Iron deficiency results in increased expression of PLA2G1B mRNA	19821111
C008261	lead acetate	lead acetate results in increased expression of PLA2G1B mRNA	20542052
C008261	lead acetate	lead acetate results in increased expression of PLA2G1B mRNA	11578147
D008555	Melitten	Melitten results in increased activity of PLA2G1B protein	9092818
C005219	methyl cellosolve	methyl cellosolve results in increased expression of PLA2G1B mRNA	19643169
D015655	1-Methyl-4-phenylpyridinium	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PLA2G1B mRNA]	12710931
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PLA2G1B mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PLA2G1B mRNA"	25554681\|2562005
C028007	nickel monoxide	nickel monoxide results in increased expression of PLA2G1B mRNA	19167457
D005996	Nitroglycerin	Nitroglycerin results in increased expression of PLA2G1B mRNA	12102619
D010126	Ozone	Ozone results in decreased expression of PLA2G1B mRNA	16716893
D015232	Dinoprostone	PLA2G1B protein results in increased chemical synthesis of Dinoprostone	10706128
C005556	propionaldehyde	propionaldehyde results in decreased expression of PLA2G1B mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of PLA2G1B mRNA	24780913
D015237	Dinoprost	[epostane co-treated with Dinoprost] results in increased expression of PLA2G1B mRNA	20739670
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]	15528384
C502851	quinocetone	quinocetone results in increased expression of PLA2G1B mRNA	27046791
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of PLA2G1B mRNA	27862939
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]	15528384
D013467	Sulindac	Sulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA]	10706128
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of PLA2G1B mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G1B mRNA]	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PLA2G1B mRNA	11007951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PLA2G1B mRNA	21570461
C009495	titanium dioxide	titanium dioxide results in increased expression of PLA2G1B mRNA	23409001
C113580	U 0126	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PLA2G1B mRNA]	12710931
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of PLA2G1B mRNA	16330358
C025643	vinclozolin	vinclozolin affects the expression of PLA2G1B mRNA	19015723

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004623	phospholipase A2 activity	-	IDA	1918029
GO:0004623	phospholipase A2 activity	-	TAS	-
GO:0005102	signaling receptor binding	-	IDA	1918029
GO:0005102	signaling receptor binding	-	IPI	7721806
GO:0005509	calcium ion binding	-	IDA	7060561
GO:0032052	bile acid binding	-	ISS	7060561
GO:0047498	calcium-dependent phospholipase A2 activity	-	IDA	7060561
GO:0102567	phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)	-	IEA	-
GO:0102568	phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000187	activation of MAPK activity	-	ISS	15528384 16005851
GO:0002227	innate immune response in mucosa	-	IDA	12860195
GO:0002446	neutrophil mediated immunity	-	ISS	16005851
GO:0006633	fatty acid biosynthetic process	-	IDA	1918029
GO:0006654	phosphatidic acid biosynthetic process	-	TAS	-
GO:0007015	actin filament organization	-	TAS	9886417
GO:0007165	signal transduction	-	TAS	9886417
GO:0008284	positive regulation of cell proliferation	-	IDA	1918029
GO:0010524	positive regulation of calcium ion transport into cytosol	-	ISS	15528384
GO:0016042	lipid catabolic process	-	IDA	7060561
GO:0019370	leukotriene biosynthetic process	-	ISS	16005851
GO:0019731	antibacterial humoral response	-	IDA	12860195
GO:0030593	neutrophil chemotaxis	-	ISS	16005851
GO:0032431	activation of phospholipase A2 activity	-	TAS	17981679
GO:0032637	interleukin-8 production	-	ISS	15528384
GO:0032869	cellular response to insulin stimulus	-	ISS	1918029
GO:0035556	intracellular signal transduction	-	ISS	15528384
GO:0036148	phosphatidylglycerol acyl-chain remodeling	-	TAS	-
GO:0036149	phosphatidylinositol acyl-chain remodeling	-	TAS	-
GO:0036150	phosphatidylserine acyl-chain remodeling	-	TAS	-
GO:0036151	phosphatidylcholine acyl-chain remodeling	-	TAS	-
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	-	TAS	-
GO:0045944	positive regulation of transcription by RNA polymerase II	-	ISS	15528384
GO:0046324	regulation of glucose import	-	ISS	1918029
GO:0046470	phosphatidylcholine metabolic process	-	IDA	7060561
GO:0048146	positive regulation of fibroblast proliferation	-	IDA	1918029
GO:0050482	arachidonic acid secretion	-	TAS	12423354
GO:0050714	positive regulation of protein secretion	-	TAS	17981679
GO:0050778	positive regulation of immune response	-	ISS	16005851
GO:0050830	defense response to Gram-positive bacterium	-	IDA	12860195
GO:0051092	positive regulation of NF-kappaB transcription factor activity	-	ISS	15528384
GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	-	IDA	12860195

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	7060561 12860195
GO:0005829	cytosol	-	IDA	-
GO:0009986	cell surface	-	IDA	1918029
GO:0030141	secretory granule	-	IEA	-

KEGG ID	KEGG Term
hsa00564	Glycerophospholipid metabolism
hsa00565	Ether lipid metabolism
hsa00590	Arachidonic acid metabolism
hsa00591	Linoleic acid metabolism
hsa00592	alpha-Linolenic acid metabolism
hsa01100	Metabolic pathways
hsa04010	MAPK signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04370	VEGF signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04730	Long-term depression
hsa04912	GnRH signaling pathway
hsa04972	Pancreatic secretion
hsa04975	Fat digestion and absorption
hsa05145	Toxoplasmosis

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1482788	Acyl chain remodelling of PC	TAS
R-HSA-1482801	Acyl chain remodelling of PS	TAS
R-HSA-1482839	Acyl chain remodelling of PE	TAS
R-HSA-1482922	Acyl chain remodelling of PI	TAS
R-HSA-1482925	Acyl chain remodelling of PG	TAS
R-HSA-1483166	Synthesis of PA	TAS
R-HSA-1483206	Glycerophospholipid biosynthesis	TAS
R-HSA-1483257	Phospholipid metabolism	TAS
R-HSA-556833	Metabolism of lipids	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
27994470	Identification of feature genes for smoking-related lung adenocarcinoma based on gene expression profile data. (2016)	Liu Y	Onco Targets Ther
29288362	Identification of genes highly downregulated in pancreatic cancer through a meta-analysis of microarray datasets: implications for discovery of novel tumor-suppressor genes and therapeutic targets. (2018 Feb)	Goonesekere NCW	J Cancer Res Clin Oncol