Gene: PLA2G1B

5319
PLA2|PLA2A|PPLA2
phospholipase A2 group IB
protein-coding
12q24.31
Ensembl:ENSG00000170890 MIM:172410 Vega:OTTHUMG00000169343 UniprotKB:P04054
NC_000012.12
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.333e-1 (AD)  7.623e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CELA3B0.967
GP20.958
CTRB10.956
CELA3A0.954
CPB10.952
CPA10.943
CTRB20.942
PNLIPRP10.935
CLPS0.919
SPINK10.914

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TM4SF20-0.216
KRTAP5-7-0.192
KRTAP5-8-0.187
SH2D1B-0.187
PSG11-0.184
FOXN4-0.184
CYP2A6-0.18
XCR1-0.176
CCDC63-0.172
ASTN2-0.17

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00795SulfasalazineSmall Molecule599-79-1ApprovedTarget
DB02210Hexane-1,6-DiolSmall Molecule629-11-8ExperimentalTarget
DB02448N-Tridecanoic AcidSmall Molecule638-53-9ExperimentalTarget
DB02659Cholic AcidSmall Molecule81-25-4ApprovedTarget
DB02795P-Anisic AcidSmall Molecule100-09-4ExperimentalTarget
DB02938Heptanoic AcidSmall MoleculeExperimental|InvestigationalTarget
DB035651-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-PhosphoethanolamineSmall MoleculeExperimentalTarget
DB03587PyruvaldehydeSmall Molecule78-98-8ExperimentalTarget
DB03633Lpc-EtherSmall MoleculeExperimentalTarget
DB04552Niflumic AcidSmall Molecule4394-00-7ApprovedTarget
DB07657PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTERSmall MoleculeExperimentalTarget
DB078361-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOLSmall MoleculeExperimentalTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [PLA2G1B protein results in increased abundance of Calcium]"15528384
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[PLA2G1B protein results in increased abundance of Calcium] which results in increased expression of CXCL8 protein]"15528384
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]15528384
C4049102,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane"2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of PLA2G1B mRNA]"19414516
D000082AcetaminophenAcetaminophen results in decreased expression of PLA2G1B mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PLA2G1B mRNA22100608
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLA2G1B mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PLA2G1B mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of PLA2G1B mRNA20458559
D001241AspirinAspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA]10706128
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of PLA2G1B mRNA12883083
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLA2G1B mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLA2G1B mRNA22300585
C006780bisphenol Abisphenol A results in decreased expression of PLA2G1B mRNA12075121|2518105
D002118Calcium"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [PLA2G1B protein results in increased abundance of Calcium]"15528384
D002118Calcium"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[PLA2G1B protein results in increased abundance of Calcium] which results in increased expression of CXCL8 protein]"15528384
D002118CalciumPLA2G1B protein results in increased abundance of Calcium15528384
D002118Calcium[PLA2G1B protein results in increased abundance of Calcium] which results in increased expression of CXCL8 protein15528384
D002994ClofibrateClofibrate results in decreased expression of PLA2G1B mRNA22300585
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G1B mRNA]11007951
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PLA2G1B mRNA]27941970
D003907DexamethasoneDexamethasone inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]15528384
D003907DexamethasoneDexamethasone results in increased expression of PLA2G1B mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of PLA2G1B mRNA]20032058
D004041Dietary FatsDietary Fats results in decreased expression of PLA2G1B mRNA25016146
D004533Egtazic AcidEgtazic Acid results in decreased activity of PLA2G1B protein15528384
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of PLA2G1B mRNA24534155
C046855epostane[epostane co-treated with Dinoprost] results in increased expression of PLA2G1B mRNA20739670
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PLA2G1B mRNA15901920
C069837fullerene C60fullerene C60 results in increased expression of PLA2G1B mRNA19167457
D019833GenisteinGenistein results in decreased expression of PLA2G1B mRNA15901920
C029424hydrazinehydrazine results in decreased expression of PLA2G1B mRNA15282401
C051890irinotecanirinotecan affects the expression of PLA2G1B mRNA20097248
D007501IronIron deficiency results in increased expression of PLA2G1B mRNA19821111
C008261lead acetatelead acetate results in increased expression of PLA2G1B mRNA20542052
C008261lead acetatelead acetate results in increased expression of PLA2G1B mRNA11578147
D008555MelittenMelitten results in increased activity of PLA2G1B protein9092818
C005219methyl cellosolvemethyl cellosolve results in increased expression of PLA2G1B mRNA19643169
D0156551-Methyl-4-phenylpyridiniumU 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PLA2G1B mRNA]12710931
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PLA2G1B mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PLA2G1B mRNA"25554681|2562005
C028007nickel monoxidenickel monoxide results in increased expression of PLA2G1B mRNA19167457
D005996NitroglycerinNitroglycerin results in increased expression of PLA2G1B mRNA12102619
D010126OzoneOzone results in decreased expression of PLA2G1B mRNA16716893
D015232DinoprostonePLA2G1B protein results in increased chemical synthesis of Dinoprostone10706128
C005556propionaldehydepropionaldehyde results in decreased expression of PLA2G1B mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLA2G1B mRNA24780913
D015237Dinoprost[epostane co-treated with Dinoprost] results in increased expression of PLA2G1B mRNA20739670
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]15528384
C502851quinocetonequinocetone results in increased expression of PLA2G1B mRNA27046791
D012969Sodium FluorideSodium Fluoride results in increased expression of PLA2G1B mRNA27862939
D012460SulfasalazineSulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]15528384
D013467SulindacSulindac promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA]10706128
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of PLA2G1B mRNA]20032058
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G1B mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLA2G1B mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLA2G1B mRNA21570461
C009495titanium dioxidetitanium dioxide results in increased expression of PLA2G1B mRNA23409001
C113580U 0126U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PLA2G1B mRNA]12710931
C034028vanadyl sulfatevanadyl sulfate results in increased expression of PLA2G1B mRNA16330358
C025643vinclozolinvinclozolin affects the expression of PLA2G1B mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004623phospholipase A2 activity-IDA1918029  
GO:0004623phospholipase A2 activity-TAS-  
GO:0005102signaling receptor binding-IDA1918029  
GO:0005102signaling receptor binding-IPI7721806  
GO:0005509calcium ion binding-IDA7060561  
GO:0032052bile acid binding-ISS7060561  
GO:0047498calcium-dependent phospholipase A2 activity-IDA7060561  
GO:0102567phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)-IEA-  
GO:0102568phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-ISS15528384  16005851  
GO:0002227innate immune response in mucosa-IDA12860195  
GO:0002446neutrophil mediated immunity-ISS16005851  
GO:0006633fatty acid biosynthetic process-IDA1918029  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0007015actin filament organization-TAS9886417  
GO:0007165signal transduction-TAS9886417  
GO:0008284positive regulation of cell proliferation-IDA1918029  
GO:0010524positive regulation of calcium ion transport into cytosol-ISS15528384  
GO:0016042lipid catabolic process-IDA7060561  
GO:0019370leukotriene biosynthetic process-ISS16005851  
GO:0019731antibacterial humoral response-IDA12860195  
GO:0030593neutrophil chemotaxis-ISS16005851  
GO:0032431activation of phospholipase A2 activity-TAS17981679  
GO:0032637interleukin-8 production-ISS15528384  
GO:0032869cellular response to insulin stimulus-ISS1918029  
GO:0035556intracellular signal transduction-ISS15528384  
GO:0036148phosphatidylglycerol acyl-chain remodeling-TAS-  
GO:0036149phosphatidylinositol acyl-chain remodeling-TAS-  
GO:0036150phosphatidylserine acyl-chain remodeling-TAS-  
GO:0036151phosphatidylcholine acyl-chain remodeling-TAS-  
GO:0036152phosphatidylethanolamine acyl-chain remodeling-TAS-  
GO:0045944positive regulation of transcription by RNA polymerase II-ISS15528384  
GO:0046324regulation of glucose import-ISS1918029  
GO:0046470phosphatidylcholine metabolic process-IDA7060561  
GO:0048146positive regulation of fibroblast proliferation-IDA1918029  
GO:0050482arachidonic acid secretion-TAS12423354  
GO:0050714positive regulation of protein secretion-TAS17981679  
GO:0050778positive regulation of immune response-ISS16005851  
GO:0050830defense response to Gram-positive bacterium-IDA12860195  
GO:0051092positive regulation of NF-kappaB transcription factor activity-ISS15528384  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IDA12860195  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA7060561  12860195  
GO:0005829cytosol-IDA-  
GO:0009986cell surface-IDA1918029  
GO:0030141secretory granule-IEA-  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
hsa00565Ether lipid metabolism
hsa00590Arachidonic acid metabolism
hsa00591Linoleic acid metabolism
hsa00592alpha-Linolenic acid metabolism
hsa01100Metabolic pathways
hsa04010MAPK signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04370VEGF signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04730Long-term depression
hsa04912GnRH signaling pathway
hsa04972Pancreatic secretion
hsa04975Fat digestion and absorption
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482788Acyl chain remodelling of PCTAS
R-HSA-1482801Acyl chain remodelling of PSTAS
R-HSA-1482839Acyl chain remodelling of PETAS
R-HSA-1482922Acyl chain remodelling of PITAS
R-HSA-1482925Acyl chain remodelling of PGTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27994470Identification of feature genes for smoking-related lung adenocarcinoma based on gene expression profile data. (2016)Liu YOnco Targets Ther
29288362Identification of genes highly downregulated in pancreatic cancer through a meta-analysis of microarray datasets: implications for discovery of novel tumor-suppressor genes and therapeutic targets. (2018 Feb)Goonesekere NCWJ Cancer Res Clin Oncol