Gene: PLA2G2A

5320
MOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2
phospholipase A2 group IIA
protein-coding
1p36.13
Ensembl:ENSG00000188257 MIM:172411 Vega:OTTHUMG00000002699 UniprotKB:P14555
NG_012928.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.449e-1 (AD)  9.004e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MB0.656
DES0.645
COMP0.639
FABP40.631
CD360.613
TNNC10.602
CSRP30.596
ANKRD10.591
KRT10.585
APOBEC20.582

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF575-0.365
ZNF835-0.341
SAC3D1-0.33
RNFT2-0.328
TEX29-0.309
KIRREL3-0.305
E2F1-0.302
MYH7B-0.302
KPTN-0.3
TMCC2-0.299

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00328IndomethacinSmall Molecule53-86-1Approved|InvestigationalTarget
DB00586DiclofenacSmall Molecule15307-86-5ApprovedTarget
DB01381Ginkgo bilobaSmall Molecule-Approved|Investigational|NutraceuticalTarget
DB019551,4-ButanediolSmall Molecule110-63-4ExperimentalTarget
DB020801-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)BenzeneSmall MoleculeExperimentalTarget
DB02325Isopropyl AlcoholSmall Molecule67-63-0Approved|InvestigationalTarget
DB02448N-Tridecanoic AcidSmall Molecule638-53-9ExperimentalTarget
DB02504[3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic AcidSmall MoleculeExperimentalTarget
DB029364-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric AcidSmall MoleculeExperimentalTarget
DB03017Lauric AcidSmall Molecule143-07-7Approved|ExperimentalTarget
DB03121(1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acidSmall Molecule59283-35-1ExperimentalTarget
DB034716-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic AcidSmall MoleculeExperimentalTarget
DB03784ElaidoylamideSmall MoleculeExperimentalTarget
DB041121-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl SulfideSmall MoleculeExperimentalTarget
DB04287(S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic AcidSmall MoleculeExperimentalTarget
DB04786SuraminSmall Molecule145-63-1Approved|InvestigationalTarget
DB05737Varespladib methylSmall Molecule172733-08-3InvestigationalTarget
ID Drug Name Action PubMed
C07841513-cis-12-(3'-carboxyphenyl)retinoic acid13-cis-12-(3'-carboxyphenyl)retinoic acid binds to and results in decreased activity of PLA2G2A protein7814386
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein]19765281
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [IL1B protein results in increased expression of PLA2G2A mRNA]19375465
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein]19765281
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PLA2G2A mRNA24835565
C5032115-(4-benzyloxyphenyl)-4S-(7-phenylheptanoylamino)pentanoic acid5-(4-benzyloxyphenyl)-4S-(7-phenylheptanoylamino)pentanoic acid results in decreased activity of PLA2G2A protein12967936
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PLA2G2A mRNA29067470
C056165acetovanilloneacetovanillone inhibits the reaction [IL1B protein results in increased expression of PLA2G2A mRNA]19375465
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PLA2G2A gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLA2G2A mRNA16483693
D000872AnthocyaninsAnthocyanins results in increased expression of PLA2G2A mRNA18803703
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PLA2G2A mRNA24449571
D001397AzoxymethaneAzoxymethane results in increased activity of PLA2G2A protein10025872
D001397AzoxymethaneAzoxymethane results in increased expression of PLA2G2A mRNA10025872
D001397AzoxymethaneAzoxymethane results in increased expression of PLA2G2A protein10025872
D001397AzoxymethaneUrsodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased activity of PLA2G2A protein]10025872
D001397AzoxymethaneUrsodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PLA2G2A mRNA]10025872
D001397AzoxymethaneUrsodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PLA2G2A protein]10025872
C487081belinostatbelinostat results in increased expression of PLA2G2A mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLA2G2A mRNA22300585
D004958EstradiolEstradiol results in increased expression of PLA2G2A protein18191855
C006780bisphenol Abisphenol A results in decreased methylation of PLA2G2A promoter27312807
C006780bisphenol Abisphenol A affects the expression of PLA2G2A mRNA25181051
C500927bolinaquinonebolinaquinone inhibits the reaction [Zymosan results in increased activity of PLA2G2A protein]12604694
C086539BQ 788BQ 788 inhibits the reaction [EDN3 protein inhibits the reaction [PLA2G2A protein affects the uptake of Calcium]]15695168
D002104CadmiumCadmium results in decreased expression of PLA2G2A mRNA24376830
D002104CadmiumCadmium results in increased expression of PLA2G2A mRNA25808797
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
D002118CalciumBQ 788 inhibits the reaction [EDN3 protein inhibits the reaction [PLA2G2A protein affects the uptake of Calcium]]15695168
D002118CalciumEDN3 protein inhibits the reaction [PLA2G2A protein affects the uptake of Calcium]15695168
D002118CalciumPLA2G2A protein results in increased uptake of Calcium15695168
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PLA2G2A mRNA24763279
D002791Cholesterol, Dietary"Cholesterol, Dietary results in increased expression of PLA2G2A protein"19237014
D002791Cholesterol, Dietary"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of PLA2G2A protein]"19237014
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PLA2G2A mRNA28472532
C418118CI 1044CI 1044 results in increased expression of PLA2G2A mRNA17569694
C039671ciglitazone[ciglitazone binds to PPARG protein alternative form] which results in increased expression of PLA2G2A mRNA16197558
D002994ClofibrateClofibrate results in decreased expression of PLA2G2A mRNA22300585
D005576ColforsinColforsin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLA2G2A mRNA]18200517
D016572CyclosporineCyclosporine results in decreased expression of PLA2G2A mRNA20106945|2163298
D016572CyclosporineCyclosporine results in decreased methylation of PLA2G2A promoter27989131
C014347decitabine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
C014347decitabinecaffeic acid phenethyl ester inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
C014347decitabineColforsin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
C014347decitabinedecitabine affects the expression of PLA2G2A mRNA23300844
C014347decitabinedecitabine results in decreased methylation of PLA2G2A promoter18953428
C014347decitabinedecitabine results in increased expression of PLA2G2A mRNA18320072|1895342
C014347decitabinedecitabine results in increased expression of PLA2G2A protein18953428
C014347decitabineIFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]18953428
C014347decitabinePlicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
C014347decitabineTetradecanoylphorbol Acetate inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
D003907DexamethasoneDexamethasone results in increased expression of PLA2G2A mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PLA2G2A mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of PLA2G2A mRNA14618091
D016264Dextran SulfateDextran Sulfate results in increased expression of PLA2G2A mRNA23894361
C023614dibenzofuranAHR protein promotes the reaction [dibenzofuran analog results in increased expression of PLA2G2A mRNA]20566336
C023614dibenzofurandibenzofuran analog results in increased expression of PLA2G2A mRNA20566336
D002945CisplatinCisplatin affects the expression of PLA2G2A mRNA23300844
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PLA2G2A mRNA28412506
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PLA2G2A mRNA21527772
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of PLA2G2A mRNA21878375
D004237DiuronDiuron results in decreased expression of PLA2G2A mRNA21551480
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of PLA2G2A mRNA"23262642
D004610Ellagic AcidEllagic Acid results in decreased expression of PLA2G2A mRNA20816778
C118739entinostatentinostat results in increased expression of PLA2G2A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [IL1B protein results in increased expression of PLA2G2A mRNA]19375465
D004917ErythromycinErythromycin results in decreased expression of PLA2G2A mRNA27503388
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PLA2G2A mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PLA2G2A mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLA2G2A mRNA17942748
D005503Food AdditivesFood Additives results in increased expression of PLA2G2A mRNA18803703
C069837fullerene C60fullerene C60 results in increased expression of PLA2G2A mRNA19167457
C039281furanfuran results in increased expression of PLA2G2A mRNA27387713
D019833GenisteinGenistein results in decreased expression of PLA2G2A mRNA20816778
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of PLA2G2A mRNA]17109745
D005944GlucosamineGlucosamine results in decreased expression of PLA2G2A mRNA17109745
D005944GlucosamineIL1B inhibits the reaction [Glucosamine results in decreased expression of PLA2G2A mRNA]17109745
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PLA2G2A mRNA24763279
D007052IbuprofenIbuprofen affects the expression of PLA2G2A mRNA17070997
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PLA2G2A mRNA28628672
C119389indoxamindoxam results in decreased activity of PLA2G2A protein11741884
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PLA2G2A mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLA2G2A mRNA25961927|2675264
C066407kaempferol-3-O-galactosidekaempferol-3-O-galactoside affects the activity of PLA2G2A protein8190018
C008261lead acetatelead acetate results in increased expression of PLA2G2A mRNA21891863
C008261lead acetatelead acetate results in increased expression of PLA2G2A mRNA11578147
C533894LG 100815LG 100815 results in increased expression of PLA2G2A mRNA16951191
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of PLA2G2A mRNA21878375
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLA2G2A protein15964894
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLA2G2A mRNA29248447
D008070LipopolysaccharidesIFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of PLA2G2A protein]21943492
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PLA2G2A mRNA21943492
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PLA2G2A protein21943492
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLA2G2A mRNA21943492
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLA2G2A protein21943492
C095553LY 311727LY 311727 results in decreased activity of PLA2G2A protein11741884
C015329lycopenelycopene inhibits the reaction [HMGB1 protein results in increased expression of and results in increased secretion of PLA2G2A protein]22429818
C501277Mangifera indica extractMangifera indica extract results in decreased activity of PLA2G2A protein15177302
C013592mangiferinmangiferin results in decreased activity of PLA2G2A protein15177302
D061965Matrix Metalloproteinase InhibitorsMatrix Metalloproteinase Inhibitors inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein]19765281
D008727MethotrexateMethotrexate results in increased expression of PLA2G2A mRNA17400583
D008777MethyltestosteroneMethyltestosterone results in decreased expression of PLA2G2A mRNA29191790
D009532NickelNickel results in increased expression of PLA2G2A mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of PLA2G2A mRNA19167457
C008655N'-nitrosonornicotineN'-nitrosonornicotine results in increased expression of PLA2G2A mRNA24835565
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of PLA2G2A mRNA"16951191
D017239PaclitaxelPaclitaxel results in increased expression of PLA2G2A mRNA18754875
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PLA2G2A mRNA26272509
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of PLA2G2A mRNA17097637
C118309petrosaspongiolide mpetrosaspongiolide m results in decreased activity of PLA2G2A protein15177302
D015232DinoprostoneDinoprostone results in increased expression of PLA2G2A protein15964894
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PLA2G2A mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of PLA2G2A mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of PLA2G2A mRNA19162173
D010656PhenylephrinePhenylephrine results in decreased expression of PLA2G2A mRNA18158353
D010705PhosgenePhosgene results in increased activity of PLA2G2A protein19235614
D064801Phospholipase A2 InhibitorsPhospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of PLA2G2A mRNA]19765281
D064801Phospholipase A2 InhibitorsPhospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein]19765281
D064801Phospholipase A2 InhibitorsPhospholipase A2 Inhibitors results in decreased expression of PLA2G2A mRNA19765281
C006253pirinixic acidpirinixic acid results in decreased expression of PLA2G2A mRNA17426115
D010936Plant ExtractsPlant Extracts results in decreased expression of PLA2G2A mRNA23557933
D010936Plant ExtractsPlant Extracts results in increased expression of PLA2G2A mRNA23262642
D028321Plant PreparationsPlant Preparations results in increased expression of PLA2G2A mRNA26945725
D008926PlicamycinPlicamycin inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
C079163quercetagetinquercetagetin affects the activity of PLA2G2A protein8190018
D011794QuercetinQuercetin results in decreased expression of PLA2G2A mRNA20816778
D011794QuercetinQuercetin results in increased expression of PLA2G2A mRNA21632981
C059514resveratrolresveratrol inhibits the reaction [IL1B protein results in increased expression of PLA2G2A mRNA]19375465
C116926rofecoxibrofecoxib affects the expression of PLA2G2A mRNA17070997
C089730rosiglitazone[rosiglitazone co-treated with IL1B protein] results in increased expression of PLA2G2A mRNA12897060
C484876scutellarinscutellarin affects the activity of PLA2G2A protein8190018
D019821Simvastatin"Simvastatin inhibits the reaction [Cholesterol, Dietary results in increased expression of PLA2G2A protein]"19237014
C017947sodium arsenitesodium arsenite affects the methylation of PLA2G2A gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of PLA2G2A mRNA22700541
C016104sodium bichromatesodium bichromate results in increased expression of PLA2G2A mRNA22561333
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of PLA2G2A mRNA16214533
D013629TamoxifenTamoxifen affects the expression of PLA2G2A mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLA2G2A mRNA20106945|2163298
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLA2G2A mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLA2G2A mRNA20566336
D013752TetracyclineTetracycline results in decreased expression of PLA2G2A mRNA16917069
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [IFNG protein promotes the reaction [decitabine results in increased expression of PLA2G2A protein]]18953428
D014212TretinoinTretinoin results in increased expression of PLA2G2A mRNA16249480|2383079
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PLA2G2A mRNA24935251|2627250
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PLA2G2A mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PLA2G2A mRNA17982090|1820051
C113580U 0126U 0126 affects the reaction [IL1B protein results in increased expression of PLA2G2A mRNA]19375465
C113580U 0126U 0126 affects the reaction [IL1B protein results in increased expression of PLA2G2A protein]19375465
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased activity of PLA2G2A protein]10025872
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PLA2G2A mRNA]10025872
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid inhibits the reaction [Azoxymethane results in increased expression of PLA2G2A protein]10025872
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PLA2G2A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PLA2G2A mRNA23179753|2438349
D014639VanadiumVanadium results in increased expression of PLA2G2A mRNA19000753
C545088varespladib methylvarespladib methyl inhibits the reaction [IL1B protein results in increased secretion of PLA2G2A protein]19765281
C025643vinclozolinvinclozolin affects the expression of PLA2G2A mRNA19015723
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLA2G2A mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PLA2G2A mRNA26272509
D015054Zymosanbolinaquinone inhibits the reaction [Zymosan results in increased activity of PLA2G2A protein]12604694
D015054ZymosanZymosan results in increased activity of PLA2G2A protein12604694

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004623phospholipase A2 activity-IDA17069818  
GO:0004623phospholipase A2 activity-TAS-  
GO:0005509calcium ion binding-IEA-  
GO:0005543phospholipid binding-IDA9032461  
GO:0047498calcium-dependent phospholipase A2 activity-TAS9272153  
GO:0102567phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)-IEA-  
GO:0102568phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006644phospholipid metabolic process-IDA17069818  
GO:0006654phosphatidic acid biosynthetic process-TAS-  
GO:0010744positive regulation of macrophage derived foam cell differentiation-TAS18827909  
GO:0016042lipid catabolic process-IEA-  
GO:0019730antimicrobial humoral response-TAS-  
GO:0034374low-density lipoprotein particle remodeling-TAS18827909  
GO:0036148phosphatidylglycerol acyl-chain remodeling-TAS-  
GO:0036149phosphatidylinositol acyl-chain remodeling-TAS-  
GO:0036150phosphatidylserine acyl-chain remodeling-TAS-  
GO:0036151phosphatidylcholine acyl-chain remodeling-TAS-  
GO:0036152phosphatidylethanolamine acyl-chain remodeling-TAS-  
GO:0046473phosphatidic acid metabolic process-IDA9032461  
GO:0050482arachidonic acid secretion-IEA-  
GO:0050729positive regulation of inflammatory response-TAS18827909  
GO:0050830defense response to Gram-positive bacterium-TAS18827909  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA22837859  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA23580065  
GO:0005615extracellular space-IDA17069818  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IEA-  
GO:0030141secretory granule-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00564Glycerophospholipid metabolism
hsa00565Ether lipid metabolism
hsa00590Arachidonic acid metabolism
hsa00591Linoleic acid metabolism
hsa00592alpha-Linolenic acid metabolism
hsa01100Metabolic pathways
hsa04010MAPK signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04370VEGF signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04730Long-term depression
hsa04912GnRH signaling pathway
hsa04972Pancreatic secretion
hsa04975Fat digestion and absorption
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482788Acyl chain remodelling of PCTAS
R-HSA-1482801Acyl chain remodelling of PSTAS
R-HSA-1482839Acyl chain remodelling of PETAS
R-HSA-1482922Acyl chain remodelling of PITAS
R-HSA-1482925Acyl chain remodelling of PGTAS
R-HSA-1483166Synthesis of PATAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-6803157Antimicrobial peptidesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27608594PLA2G2A polymorphisms are associated with metabolic syndrome and type 2 diabetes mellitus. Results from the genetics of atherosclerotic disease Mexican study. (2017 Oct)Monroy-Munoz IEImmunobiology