Gene: PLAG1

5324
PSA|SGPA|ZNF912
PLAG1 zinc finger
protein-coding
8q12.1
Ensembl:ENSG00000181690 MIM:603026 Vega:OTTHUMG00000164310 UniprotKB:Q6DJT9
NG_023310.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.709e-1 (AD)  6.356e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNAJC100.804
NHLRC30.783
CCNT20.777
PHTF20.776
ALG130.774
MYSM10.77
RECK0.769
WDR110.768
PRKAA10.768
TPP20.767

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.404
WNT7B-0.39
LYPD1-0.374
EYA2-0.37
HPR-0.355
PLA2G5-0.355
NR0B1-0.337
PPP1R3G-0.332
RLBP1-0.327
ADAMTSL5-0.323

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of PLAG1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLAG1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLAG1 mRNA"27188386
D000447AldehydesAldehydes results in increased expression of PLAG1 mRNA25014914
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLAG1 mRNA21632981
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of PLAG1 mRNA26496021
C006780bisphenol Abisphenol A affects the methylation of PLAG1 promoter27334623
C006780bisphenol Abisphenol A affects the expression of PLAG1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of PLAG1 mRNA26496021
C018475butyraldehydebutyraldehyde results in increased expression of PLAG1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride affects the methylation of PLAG1 promoter22457795
D016572CyclosporineCyclosporine results in decreased expression of PLAG1 mRNA25562108
D016572CyclosporineCyclosporine results in increased methylation of PLAG1 promoter27989131
D003907DexamethasoneDexamethasone results in increased expression of PLAG1 mRNA16144937
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PLAG1 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PLAG1 mRNA26924002
D005557FormaldehydeFormaldehyde results in decreased expression of PLAG1 mRNA20655997
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PLAG1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PLAG1 mRNA27392435
C045463leflunomideleflunomide results in increased expression of PLAG1 mRNA28988120
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PLAG1 mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PLAG1 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PLAG1 mRNA26924002
D009532NickelNickel results in decreased expression of PLAG1 mRNA24768652|2558310
C046012pentanalpentanal results in increased expression of PLAG1 mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLAG1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PLAG1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PLAG1 mRNA19710929
C005556propionaldehydepropionaldehyde results in increased expression of PLAG1 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of PLAG1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PLAG1 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PLAG1 mRNA25895662
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of PLAG1 mRNA20189893
D014520UrethaneUrethane results in increased expression of PLAG1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PLAG1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PLAG1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in decreased methylation of PLAG1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PLAG1 mRNA19101580
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PLAG1 gene25560391
C025643vinclozolinvinclozolin results in increased expression of PLAG1 mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10646861  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA10646861  
GO:0003677DNA binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS9722527  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0010629negative regulation of gene expression-IEA-  
GO:0022612gland morphogenesis-IEA-  
GO:0035264multicellular organism growth-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA10646861  
GO:0060252positive regulation of glial cell proliferation-IEA-  
GO:0060736prostate gland growth-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23116464Beckwith Wiedemann imprinting defect found in leucocyte but not buccal DNA in a child born small for gestational age. (2012 Nov 1)Murphy RBMC Med Genet