Gene: PLAGL1

5325
LOT1|ZAC|ZAC1
PLAG1 like zinc finger 1
protein-coding
6q24.2
Ensembl:ENSG00000118495 MIM:603044 Vega:OTTHUMG00000015738 UniprotKB:Q9UM63
NG_009384.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.997e-1 (AD)  4.964e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20443501chr6:144329962PLAGL1Promoter3.970e-4Alcohol use disorders26763658
cg25350411chr6:144328917PLAGL1Promoter5.736e-4Alcohol use disorders26763658
cg09293391chr6:144386418PLAGL13.320e-9Maternal smoking in pregnancy27040690
cg12444861chr6:144386275PLAGL15.820e-8Maternal smoking in pregnancy27040690
cg09293391chr6:144386418PLAGL15.860e-9Maternal smoking in pregnancy27040690
cg02849309chr6:144386280PLAGL16.250e-9Maternal smoking in pregnancy27040690
cg01595870chr6:144386416PLAGL11.760e-8Maternal smoking in pregnancy27040690
cg12444861chr6:144386275PLAGL11.840e-8Maternal smoking in pregnancy27040690
cg09293391chr6:144386418PLAGL14.050e-9Maternal smoking in pregnancy27040690
cg01595870chr6:144386416PLAGL13.980e-8Maternal smoking in pregnancy27040690
cg06271237chr6:144263369PLAGL11.700e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RINT10.853
RASAL20.834
PPIP5K20.833
DOPEY10.833
PHTF10.831
MYSM10.831
ARMCX40.829
DOPEY20.828
ZNF3820.827
NSUN40.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.381
BCL7C-0.376
HIGD1B-0.376
ROM1-0.361
S100A1-0.36
COPZ2-0.36
MTRNR2L9-0.351
MYOM1-0.349
MYL3-0.348
RAB13-0.344

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLAGL1 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PLAGL1 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLAGL1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLAGL1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLAGL1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLAGL1 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of PLAGL1 mRNA"20406850
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAGL1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLAGL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAGL1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLAGL1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PLAGL1 mRNA25458485
D000082AcetaminophenAcetaminophen affects the expression of PLAGL1 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PLAGL1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLAGL1 mRNA16483693
D001151ArsenicArsenic affects the methylation of PLAGL1 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PLAGL1 mRNA"17331233
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of PLAGL1 mRNA26377693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PLAGL1 mRNA"20018196
C095105bexarotenebexarotene results in decreased expression of PLAGL1 mRNA16648578
C006780bisphenol Abisphenol A affects the expression of PLAGL1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLAGL1 mRNA28628672
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of PLAGL1 mRNA18958704
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PLAGL1 mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PLAGL1 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PLAGL1 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of PLAGL1 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PLAGL1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PLAGL1 mRNA16239168
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of PLAGL1 mRNA16934159
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAGL1 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of PLAGL1 mRNA19376846
D003042CocaineCocaine results in increased expression of PLAGL1 mRNA27899881
D003078ColchicineColchicine results in increased expression of PLAGL1 mRNA20624997
C030973cupric oxidecupric oxide results in decreased expression of PLAGL1 mRNA22077320
D003471CuprizoneCuprizone results in increased expression of PLAGL1 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of PLAGL1 mRNA25562108
C014347decitabinedecitabine results in increased expression of PLAGL1 mRNA16367923
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLAGL1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PLAGL1 mRNA21266533
D004026DieldrinDieldrin results in decreased expression of PLAGL1 mRNA23041725
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PLAGL1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PLAGL1 mRNA17555576
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PLAGL1 mRNA23649840
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAGL1 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of PLAGL1 mRNA19167457
D005947GlucoseGlucose results in decreased expression of PLAGL1 mRNA17178593
D017313FenretinideFenretinide results in decreased expression of PLAGL1 mRNA28973697
D017313FenretinideFenretinide results in increased expression of PLAGL1 mRNA16467112
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLAGL1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PLAGL1 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of PLAGL1 mRNA20003209
C011890kojic acidkojic acid results in increased expression of PLAGL1 mRNA16595896
D007854LeadLead results in increased methylation of PLAGL1 gene26115033
C008261lead acetatelead acetate results in decreased expression of PLAGL1 mRNA22641619
D018021Lithium ChlorideLithium Chloride results in decreased expression of PLAGL1 mRNA23527032
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of PLAGL1 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of PLAGL1 mRNA19564919
D008713MethimazoleMethimazole results in increased expression of PLAGL1 mRNA22504374
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAGL1 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of PLAGL1 mRNA21678067
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PLAGL1 mRNA23179753
D008942MitoxantronePLAGL1 protein affects the susceptibility to Mitoxantrone16217747
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of PLAGL1 mRNA20886546
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in increased expression of PLAGL1 mRNA16467112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PLAGL1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PLAGL1 mRNA"25554681
C022838nickel chloridenickel chloride results in decreased expression of PLAGL1 mRNA12839937
C022838nickel chloridenickel chloride affects the expression of PLAGL1 mRNA22546817
C028007nickel monoxidenickel monoxide results in decreased expression of PLAGL1 mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of PLAGL1 mRNA22714537
C029938nickel sulfatenickel sulfate results in decreased expression of PLAGL1 mRNA16166746
D016912Levonorgestrel[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PLAGL1 mRNA19074003
C558013NSC 689534NSC 689534 results in increased expression of PLAGL1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PLAGL1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PLAGL1 mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PLAGL1 mRNA"25510870
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAGL1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PLAGL1 mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of PLAGL1 mRNA16985257
C006253pirinixic acidpirinixic acid results in increased expression of PLAGL1 mRNA12832660
D010938Plant OilsPlant Oils results in increased expression of PLAGL1 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of PLAGL1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PLAGL1 mRNA22079256
D011441PropylthiouracilPropylthiouracil results in increased expression of PLAGL1 mRNA22504374|2478091
D011794QuercetinQuercetin results in increased expression of PLAGL1 mRNA21632981
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of PLAGL1 mRNA19564919
C017947sodium arsenitesodium arsenite results in decreased expression of PLAGL1 mRNA22714537
D013629TamoxifenTamoxifen affects the expression of PLAGL1 mRNA17555576
D043343Testosterone PropionateTestosterone Propionate results in decreased expression of PLAGL1 mRNA15601916
C010792testosterone undecanoate[testosterone undecanoate co-treated with Levonorgestrel] results in decreased expression of PLAGL1 mRNA19074003
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of PLAGL1 mRNA25172293
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PLAGL1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of PLAGL1 mRNA25729387
D014192TrapidilTrapidil affects the reaction [PTH protein affects the expression of PLAGL1 mRNA]18635661
D014212TretinoinTretinoin results in increased expression of PLAGL1 mRNA21934132|2372400
D014212TretinoinTretinoin results in increased expression of PLAGL1 mRNA16604517
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PLAGL1 gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLAGL1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PLAGL1 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of PLAGL1 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased methylation of PLAGL1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PLAGL1 mRNA19101580|2493525
D014635Valproic AcidValproic Acid results in increased expression of PLAGL1 mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PLAGL1 gene25560391
D014747VinblastineVinblastine results in increased expression of PLAGL1 mRNA20624997
C029297vinylidene chloridevinylidene chloride results in decreased expression of PLAGL1 mRNA26682919
D012256RiboflavinRiboflavin affects the expression of PLAGL116109485
D014810Vitamin EVitamin E results in decreased expression of PLAGL1 mRNA19244175
C111237vorinostatvorinostat results in decreased expression of PLAGL1 mRNA27188386
D015032ZincZinc deficiency results in decreased expression of PLAGL1 mRNA19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IBA21873635  
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IDA9671765  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IBA21873635  
GO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IDA9671765  
GO:0003677DNA binding-IDA15888726  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0006915apoptotic process-TAS9671765  
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest-TAS-  
GO:0007050cell cycle arrest-TAS9184226  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA9671765  15888726  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0005794Golgi apparatus-IDA-  
GO:0016604nuclear body-IBA21873635  
GO:0016604nuclear body-IDA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-6791312TP53 Regulates Transcription of Cell Cycle GenesTAS
R-HSA-6804115TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19155788Study of the genetic variability of ZAC1 (PLAGL1) in French population-based samples. (2009 Feb)Goumidi LJ Hypertens
23609933Associations between antibiotic exposure during pregnancy, birth weight and aberrant methylation at imprinted genes among offspring. (2013 Jul)Vidal ACInt J Obes (Lond)
22677950Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements. (2012 Jul)Liu YEpigenetics