Gene: PLAT

5327
T-PA|TPA
plasminogen activator, tissue type
protein-coding
8p11.21
Ensembl:ENSG00000104368 MIM:173370 Vega:OTTHUMG00000164072 UniprotKB:P00750
NG_023264.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.326e-1 (AD)  8.330e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg11530213chr8:42037966PLAT7.200e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LMO20.776
FN10.768
EMP20.767
TAGLN20.762
CDH50.76
HLA-E0.755
ICAM20.749
ACVRL10.749
VEGFC0.743
TM4SF10.738

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYADML2-0.425
KCNB2-0.374
BCL11A-0.366
NEUROD6-0.349
SVOP-0.348
DRD5-0.348
KCNA2-0.346
EIF4E1B-0.34
HCN1-0.338
KCNJ6-0.337

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00013UrokinaseBiotechDrug9039-53-6Approved|Investigational|WithdrawnTarget
DB00513Aminocaproic AcidSmall Molecule60-32-2Approved|InvestigationalTarget
DB01050IbuprofenSmall Molecule15687-27-1ApprovedTarget
DB01088IloprostSmall Molecule78919-13-8Approved|InvestigationalTarget
DB06404Human C1-esterase inhibitorBiotechDrugApprovedTarget
DB076845-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACIDSmall MoleculeExperimentalTarget
DB09213DexibuprofenSmall Molecule51146-56-6Approved|InvestigationalTarget
DB09228Conestat alfaBiotechDrug80295-38-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of PLAT mRNA25827057
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of PLAT mRNA25827057
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran inhibits the reaction [Estradiol results in increased secretion of PLAT protein]"3119194
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of PLAT mRNA"25710175
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of PLAT mRNA"26644586
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PLAT mRNA"25380136
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]]18419748
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of PLAT mRNA]18419748
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased secretion of PLAT protein]18419748
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C0513274-amidino-2-nitrophenyl 4'-anisatePLAT protein results in increased metabolism of 4-amidino-2-nitrophenyl 4'-anisate3101668
C0951704-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
C0951704-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
C0100244-aminophenylmercuriacetate4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
C0100244-aminophenylmercuriacetate4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
C0022024-oxoretinoic acid4-oxoretinoic acid results in increased expression of PLAT mRNA15982314
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in decreased activity of PLAT protein]"24599349
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] affects the expression of PLAT mRNA"25790727
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] results in decreased expression of PLAT mRNA"25790727
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] results in decreased expression of PLAT protein"25790727
D000082AcetaminophenPLAT protein results in increased susceptibility to Acetaminophen22507835
D000082AcetaminophenAcetaminophen affects the expression of PLAT mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLAT mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLAT mRNA19770486
D000447AldehydesAldehydes results in increased expression of PLAT mRNA25014914
C103303alitretinoinalitretinoin results in increased expression of PLAT mRNA15982314
D000602Amino Acids, Peptides, and Proteins"Amino Acids, Peptides, and Proteins results in increased expression of and results in increased activity of PLAT protein"24599349
D000602Amino Acids, Peptides, and Proteins"Amino Acids, Peptides, and Proteins results in increased expression of PLAT mRNA"24599349
D000602Amino Acids, Peptides, and Proteins"U 0126 inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased activity of PLAT protein]"24599349
D000602Amino Acids, Peptides, and Proteins"U 0126 inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of PLAT mRNA]"24599349
D0157614-Aminopyridine[Bicuculline co-treated with 4-Aminopyridine co-treated with Dizocilpine Maleate] results in decreased susceptibility to PLAT protein19911010
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLAT mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of PLAT mRNA20458559|2252195
C015001arsenitearsenite results in decreased expression of PLAT mRNA11864708
D001205Ascorbic Acid[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Endosulfan results in increased activity of PLAT protein]21804306
D001205Ascorbic AcidAscorbic Acid promotes the reaction [Vitamin E results in increased activity of PLAT protein]21804306
D001241AspirinAspirin results in decreased activity of PLAT protein10439430
C010038azelaic acidazelaic acid results in decreased expression of and results in decreased secretion of PLAT protein8635147
C010038azelaic acidazelaic acid results in decreased expression of PLAT mRNA8635147
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PLAT mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PLAT mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLAT mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PLAT mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PLAT mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLAT mRNA21569818
D019207beta Carotene[BCO1 protein affects the susceptibility to beta Carotene] which affects the expression of PLAT mRNA24657404
D004958Estradiol"2,3,7,8-tetrachlorodibenzofuran inhibits the reaction [Estradiol results in increased secretion of PLAT protein]"3119194
D004958EstradiolEstradiol affects the expression of PLAT mRNA22574217
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PLAT mRNA20823114
D004958Estradiol[Estradiol co-treated with norethindrone acetate] results in decreased expression of PLAT protein17393018
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA19619570
D004958EstradiolEstradiol results in increased expression of PLAT mRNA15219790|1961957
D004958EstradiolEstradiol results in increased secretion of PLAT protein3119194
D004958EstradiolTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of PLAT protein]3119194
D004958EstradiolEstradiol results in increased expression of PLAT mRNA20838740
C095105bexarotenebexarotene results in increased expression of PLAT mRNA17178900
D001640Bicuculline[Bicuculline co-treated with 4-Aminopyridine co-treated with Dizocilpine Maleate] results in decreased susceptibility to PLAT protein19911010
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLAT mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of PLAT mRNA23019147
C006780bisphenol Abisphenol A results in decreased expression of PLAT mRNA26063408
C006780bisphenol Abisphenol A affects the expression of PLAT mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PLAT mRNA20147733
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]10856522
D002084Butylated HydroxytolueneButylated Hydroxytoluene inhibits the reaction [LPA protein modified form results in increased expression of PLAT protein]10856522
C018475butyraldehydebutyraldehyde results in increased expression of PLAT mRNA26079696
D020148Butyric AcidButyric Acid results in increased activity of PLAT protein23378038
D002104CadmiumCadmium results in increased expression of PLAT mRNA21694771
D019256Cadmium ChlorideCadmium Chloride affects the expression of PLAT mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PLAT promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of PLAT mRNA25979313
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of PLAT mRNA25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PLAT mRNA25827057
D002251Carbon TetrachloridePLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]18279442
D002251Carbon TetrachloridePLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]18279442
D002251Carbon TetrachloridePLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]18279442
D002251Carbon TetrachloridePLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein]17944888
D002251Carbon TetrachloridePLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP2 protein]17944888
D002251Carbon TetrachloridePLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP9 protein]17944888
D002251Carbon TetrachloridePLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]17944888
D002392CatechinCatechin results in increased expression of PLAT mRNA11236827
D002392CatechinCatechin results in increased expression of PLAT protein11236827
D002392CatechinDactinomycin inhibits the reaction [Catechin results in increased expression of PLAT mRNA]11236827
D002392CatechinCatechin results in increased expression of PLAT mRNA17478321
D002518Ceramides[Daunorubicin results in increased abundance of Ceramides] which results in increased secretion of PLAT protein11107162
D002518Ceramides[N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein11107162
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of PLAT mRNA18636392
D002737ChloropreneChloroprene results in increased expression of PLAT mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAT mRNA20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PLAT mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PLAT mRNA27858113
C418118CI 1044CI 1044 results in increased expression of PLAT mRNA17569694
D003078ColchicineColchicine results in increased expression of PLAT mRNA20624997
D003300Copper[Copper results in increased oxidation of LPA protein] which results in decreased secretion of PLAT protein11681624
D019327Copper SulfateCopper Sulfate results in decreased expression of PLAT mRNA19549813
D003471CuprizoneCuprizone results in increased expression of PLAT mRNA26577399
D003513CycloheximideCycloheximide promotes the reaction [Isoproterenol results in increased expression of PLAT mRNA]2477232
D016572CyclosporineCyclosporine results in decreased expression of PLAT mRNA19159671|2214713
D016572CyclosporineCyclosporine results in increased expression of PLAT mRNA15339989
D003561CytarabineCytarabine results in decreased expression of PLAT mRNA21198554
D015638Cytochalasin DCytochalasin D results in increased expression of PLAT12371961
D003609DactinomycinDactinomycin inhibits the reaction [Catechin results in increased expression of PLAT mRNA]11236827
D003609DactinomycinDactinomycin inhibits the reaction [Quercetin results in increased expression of PLAT mRNA]11236827
D003609DactinomycinDactinomycin inhibits the reaction [resveratrol results in increased expression of PLAT mRNA]11236827
D003630Daunorubicin[Daunorubicin results in increased abundance of Ceramides] which results in increased secretion of PLAT protein11107162
D003634DDTDDT results in decreased expression of PLAT mRNA25014179
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PLAT mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased activity of PLAT protein1656149
D003907DexamethasoneDexamethasone results in decreased expression of PLAT mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLAT mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLAT mRNA16054899
D003907DexamethasoneDexamethasone inhibits the reaction [IL1B protein results in increased activity of PLAT protein]15963473
D003907DexamethasoneDexamethasone inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]15963473
D003907DexamethasoneDexamethasone results in decreased activity of PLAT protein3127913
D003907DexamethasoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]]15963473
D003907DexamethasoneRU 43044 inhibits the reaction [Dexamethasone inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]]15963473
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PLAT mRNA21266533
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PLAT mRNA20823114
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PLAT mRNA27392435
D002945CisplatinCisplatin results in increased expression of PLAT mRNA27392435
D002945CisplatinCisplatin results in increased expression of PLAT mRNA21151649
C023635dienogest[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PLAT protein15288212
D004041Dietary FatsDietary Fats results in increased expression of PLAT mRNA18042831
C014476diethyl maleatediethyl maleate results in decreased expression of PLAT mRNA25270620
C014476diethyl maleatediethyl maleate results in increased expression of PLAT mRNA21161181
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PLAT mRNA25380136
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of PLAT mRNA17374397
D004176DipyridamoleDipyridamole results in increased secretion of PLAT protein15733978
D004176DipyridamoleKT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein]15733978
D004237DiuronDiuron results in decreased expression of PLAT mRNA21551480
D016291Dizocilpine Maleate[Bicuculline co-treated with 4-Aminopyridine co-treated with Dizocilpine Maleate] results in decreased susceptibility to PLAT protein19911010
D016291Dizocilpine Maleate[Potassium Chloride co-treated with Dizocilpine Maleate] results in decreased susceptibility to PLAT protein19911010
D004298DopaminePLAT protein promotes the reaction [Morphine results in increased secretion of Dopamine]16619846
D004492Edetic AcidEdetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
D004492Edetic AcidEdetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
D004492Edetic AcidEdetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein]21615740
C035276eicosapentaenoic acid ethyl estereicosapentaenoic acid ethyl ester results in increased expression of PLAT protein14614217
D004726Endosulfan[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Endosulfan results in increased activity of PLAT protein]21804306
D004726EndosulfanEndosulfan results in increased activity of PLAT protein21804306
C045651epigallocatechin gallate[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of PLAT mRNA12628509
C454300estradiol valerate-dienogest[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased expression of PLAT protein15288212
D000431EthanolEthanol results in increased expression of PLAT mRNA17478321
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with dienogest] results in decreased expression of PLAT protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with estradiol valerate-dienogest] results in decreased expression of PLAT protein15288212
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PLAT protein12618251
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLAT protein12618251
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of PLAT protein12618251|1515779
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased activity of PLAT protein12618251
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of PLAT protein12618251
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with norgestimate] results in increased activity of PLAT protein12618251
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in decreased expression of PLAT protein12618251
C442659ethinyl estradiol-desogestrel combinationethinyl estradiol-desogestrel combination results in increased activity of PLAT protein12618251
D005054EugenolEugenol results in increased expression of PLAT mRNA17374397
C504383fenbuconazolefenbuconazole results in increased expression of PLAT mRNA15942997
D005472FluorouracilFluorouracil results in increased expression of PLAT mRNA16101138
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAT mRNA20938992
C039281furanfuran results in increased expression of PLAT mRNA27387713
D019833GenisteinGenistein results in increased expression of PLAT mRNA23019147
D019833GenisteinGenistein results in increased expression of PLAT mRNA20838740
C017338geranylgeraniolgeranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT]12753293
C017338geranylgeraniolgeranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]12371961
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein]10412747
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in decreased expression of PLAT protein12618251
C033273Gestodene[Ethinyl Estradiol co-treated with Gestodene] results in increased activity of PLAT protein12618251
D005944GlucosamineGlucosamine results in increased expression of PLAT mRNA17178593
D005947GlucoseGlucose results in increased expression of PLAT mRNA17178593
C081021Go 6976Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
C081021Go 6976Go 6976 inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of PLAT mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of PLAT mRNA26644586
C412815GW 4064GW 4064 promotes the reaction [NR1H4 protein binds to PLAT gene]20091679
D006493HeparinHeparin results in increased expression of PLAT mRNA14630814|1619036
D006493HeparinHeparin results in increased expression of PLAT protein14630814|1619036
D006493HeparinHeparin inhibits the reaction [Phorbol Esters results in increased expression of PLAT mRNA]1310687
D006493HeparinHeparin inhibits the reaction [Phorbol Esters results in increased expression of PLAT protein]1310687
C495287HMR 3339HMR 3339 results in decreased expression of PLAT protein16202731
D017313FenretinideFenretinide results in increased expression of PLAT mRNA28973697
D006854HydrocortisoneHydrocortisone results in decreased activity of PLAT protein8921802
C065679icatibanticatibant results in decreased expression of PLAT protein16321614
D007213IndomethacinIndomethacin inhibits the reaction [GNRH1 protein results in increased expression of PLAT mRNA]16514196
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLAT mRNA28628672
C051890irinotecanirinotecan analog results in decreased expression of PLAT mRNA18927307
C051890irinotecanirinotecan results in increased expression of PLAT mRNA20097248
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PLAT mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLAT mRNA16054899
D007545IsoproterenolCycloheximide promotes the reaction [Isoproterenol results in increased expression of PLAT mRNA]2477232
D007545IsoproterenolIsoproterenol results in increased expression of PLAT mRNA2477232
D007545IsoproterenolIsoproterenol results in increased secretion of PLAT protein2477232
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PLAT mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of PLAT mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLAT mRNA25961927|2664458
D007649KetamineKetamine results in increased expression of PLAT mRNA20080153
C073601KT 5823KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein]15733978
C008261lead acetatelead acetate affects the activity of PLAT protein2143947
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 affects the expression of PLAT mRNA"18986645
C433788lipopolysaccharide, E. coli O26-B6"[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of PLAT mRNA"18986645
D008070Lipopolysaccharides[[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA21097750
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLAT protein27098997
D008070LipopolysaccharidesPlant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of PLAT protein]27098997
D019808LosartanLosartan results in decreased expression of PLAT mRNA15100363
D008148Lovastatingeranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein]10412747
D008148LovastatinLovastatin results in increased expression of PLAT10412747
D008148LovastatinMevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein]10412747
D008294MalathionMalathion results in decreased expression of PLAT mRNA16079077
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of PLAT mRNA20823114
D008687MetforminMetformin results in increased activity of PLAT protein1900072
D008694MethamphetamineMethamphetamine results in increased expression of PLAT mRNA15659235
D008694MethamphetamineRaclopride inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA]15659235
D008694MethamphetamineSCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA]15659235
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in increased expression of PLAT mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of PLAT mRNA19564919
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAT mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of PLAT mRNA21678067
D008777MethyltestosteroneMethyltestosterone results in increased expression of PLAT mRNA29191790
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT]12753293
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]12371961
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Lovastatin results in increased expression of PLAT protein]10412747
D015735MifepristoneMifepristone results in increased expression of PLAT mRNA17584828
D015735MifepristoneMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]]15963473
D015735MifepristoneMifepristone results in decreased expression of PLAT mRNA25972201
D008942MitoxantronePLAT protein affects the susceptibility to Mitoxantrone16217747
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of PLAT protein24625837
D009020MorphinePLAT protein affects the susceptibility to Morphine16619846
D009020MorphineMorphine results in increased expression of PLAT mRNA16619846
D009020MorphineMorphine results in increased expression of PLAT protein16619846
D009020MorphineNaloxone affects the reaction [Morphine results in increased expression of PLAT mRNA]16619846
D009020MorphineNaloxone affects the reaction [Morphine results in increased expression of PLAT protein]16619846
D009020MorphinePLAT protein promotes the reaction [Morphine results in increased secretion of Dopamine]16619846
C523799MRK 003MRK 003 results in decreased expression of PLAT mRNA21169257
C523799MRK 003PLAT results in increased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas affects the expression of PLAT mRNA15651846
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
C064769N-acetylsphingosine[N-acetylsphingosine results in increased abundance of Ceramides] which results in increased secretion of PLAT protein11107162
D009270NaloxoneNaloxone affects the reaction [Morphine results in increased expression of PLAT mRNA]16619846
D009270NaloxoneNaloxone affects the reaction [Morphine results in increased expression of PLAT protein]16619846
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PLAT mRNA"25790727
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] affects the expression of PLAT mRNA"25790727
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] results in decreased expression of PLAT mRNA"25790727
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] results in decreased expression of PLAT protein"25790727
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PLAT protein"25790727
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PLAT mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PLAT mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of PLAT mRNA18978301
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PLAT mRNA25380136
C029938nickel sulfatenickel sulfate results in increased expression of PLAT mRNA16780908|1737439
C029938nickel sulfatenickel sulfate results in increased expression of PLAT mRNA16100012
D009538NicotineNicotine affects the expression of PLAT mRNA18986645
D009538Nicotine"[Nicotine co-treated with lipopolysaccharide, E. coli O26-B6] affects the expression of PLAT mRNA"18986645
D009538NicotineNicotine results in increased expression of PLAT mRNA11166759|1715178
D009538NicotineNicotine results in increased expression of PLAT protein17151781
D009569Nitric OxidePLAT protein affects the reaction [NOS1 protein results in increased chemical synthesis of Nitric Oxide]18195371
D009569Nitric OxidePLAT protein results in increased secretion of Nitric Oxide18195371
D004963EstrenesEstrenes analog results in increased expression of PLAT mRNA15219790
C024262norethindrone acetate[Estradiol co-treated with norethindrone acetate] results in decreased expression of PLAT protein17393018
C017576norgestimate[Ethinyl Estradiol co-treated with norgestimate] results in decreased expression of PLAT protein12618251
C017576norgestimate[Ethinyl Estradiol co-treated with norgestimate] results in increased activity of PLAT protein12618251
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in decreased expression of PLAT protein12618251|1515779
D016912Levonorgestrel[Ethinyl Estradiol co-treated with Levonorgestrel] results in increased activity of PLAT protein12618251
C072936notoginsenoside R1notoginsenoside R1 results in increased expression of PLAT mRNA8018658|9220151
C072936notoginsenoside R1notoginsenoside R1 results in increased expression of PLAT protein8018658|9220151
C072936notoginsenoside R1notoginsenoside R1 results in increased expression of [PLAT protein binds to SERPINE1 protein]8018658
C570897NSC668394NSC668394 results in increased expression of PLAT mRNA27137931
C558013NSC 689534NSC 689534 results in increased expression of PLAT mRNA20971185
C516519NuvaRingNuvaRing results in decreased expression of PLAT protein15157790
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PLAT mRNA25729387
D010081OxazoloneOxazolone results in increased expression of PLAT mRNA17374397
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of PLAT mRNA18636392
D010126OzoneOzone results in increased expression of PLAT mRNA20980218
D000073878Palm OilPalm Oil results in increased expression of PLAT mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PLAT mRNA26272509
D052638Particulate MatterParticulate Matter affects the expression of PLAT protein23231781
C046012pentanalpentanal results in increased expression of PLAT mRNA26079696
D020913PerindoprilPerindopril promotes the reaction [KNG1 protein alternative form results in increased secretion of PLAT protein]12706934
D010616PhenanthrenesPhenanthrenes inhibits the reaction [PLAT protein results in increased activity of GRIN2D protein]19911010
D010616PhenanthrenesPhenanthrenes results in decreased susceptibility to PLAT protein19911010
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PLAT mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of PLAT mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [PLAT protein results in increased activity of RELA protein]19095969
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [PLAT protein results in increased expression of and results in increased activity of MMP9 protein]19095969
C005435phenylmethylpyrazolonephenylmethylpyrazolone inhibits the reaction [PLAT protein results in increased expression of MMP9 mRNA]19095969
D010703Phorbol EstersHeparin inhibits the reaction [Phorbol Esters results in increased expression of PLAT mRNA]1310687
D010703Phorbol EstersHeparin inhibits the reaction [Phorbol Esters results in increased expression of PLAT protein]1310687
D010703Phorbol EstersPhorbol Esters results in increased expression of PLAT mRNA1310687
D010703Phorbol EstersPhorbol Esters results in increased expression of PLAT protein1310687
D010703Phorbol EstersStaurosporine inhibits the reaction [Phorbol Esters results in increased expression of PLAT mRNA]1310687
D010703Phorbol EstersStaurosporine inhibits the reaction [Phorbol Esters results in increased expression of PLAT protein]1310687
C004479pimagedinepimagedine inhibits the reaction [LPA protein modified form results in decreased expression of PLAT protein]10856522
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PLAT mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of PLAT mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of PLAT mRNA20813756
D010894PiroxicamPiroxicam results in decreased expression of PLAT mRNA21858171
D010936Plant ExtractsPlant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of PLAT protein]27098997
D010938Plant OilsPlant Oils results in decreased expression of PLAT mRNA23370395
D011189Potassium Chloride[Potassium Chloride co-treated with Dizocilpine Maleate] results in decreased susceptibility to PLAT protein19911010
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PLAT mRNA22714537
D011241PrednisonePrednisone results in increased expression of PLAT protein10452346
C035988procymidoneprocymidone results in decreased expression of PLAT mRNA15686871
D011374ProgesteroneProgesterone results in increased expression of PLAT mRNA21795739
D011374ProgesteroneProgesterone results in decreased expression of PLAT mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of PLAT mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PLAT mRNA24780913
C028025protoporphyrin IXprotoporphyrin IX results in decreased expression of PLAT protein23624237
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Valproic Acid results in increased activity of PLAT protein]23378038
D011794Quercetin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin promotes the reaction [SP1 protein binds to PLAT promoter]]18419748
D011794Quercetin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of PLAT mRNA]18419748
D011794Quercetin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased secretion of PLAT protein]18419748
D011794QuercetinDactinomycin inhibits the reaction [Quercetin results in increased expression of PLAT mRNA]11236827
D011794QuercetinQuercetin promotes the reaction [SP1 protein binds to PLAT promoter]18419748
D011794QuercetinQuercetin results in decreased expression of PLAT mRNA21632981
D011794QuercetinQuercetin results in increased expression of PLAT mRNA11236827|1841974
D011794QuercetinQuercetin results in increased expression of PLAT protein11236827
D011794QuercetinQuercetin results in increased secretion of PLAT protein18419748
D011794QuercetinQuercetin results in increased expression of PLAT mRNA17478321|1809536
D020891RacloprideRaclopride inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA]15659235
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of PLAT protein16167916
C059514resveratrolDactinomycin inhibits the reaction [resveratrol results in increased expression of PLAT mRNA]11236827
C059514resveratrolresveratrol results in increased expression of PLAT mRNA11236827
C059514resveratrolresveratrol results in increased expression of PLAT protein11236827
C059514resveratrol"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine inhibits the reaction [resveratrol results in decreased activity of PLAT protein]"24599349
C059514resveratrolresveratrol results in decreased expression of and results in decreased activity of PLAT protein24599349
D015474IsotretinoinIsotretinoin results in increased expression of PLAT mRNA15982314
D012176RetinoidsRetinoids results in increased expression of PLAT7556191
D012176RetinoidsRo 41-5253 inhibits the reaction [Retinoids results in increased expression of PLAT]7556191
D012293RifampinRifampin results in decreased expression of PLAT mRNA24552687
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Retinoids results in increased expression of PLAT]7556191
C116926rofecoxibrofecoxib results in increased expression of PLAT mRNA16580899
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PLAT mRNA16054899
C000589029RU24858RU24858 inhibits the reaction [IL1B protein results in increased activity of PLAT protein]15963473
C000589029RU24858RU24858 inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]15963473
C085917RU 43044RU 43044 inhibits the reaction [Dexamethasone inhibits the reaction [IL1B protein results in increased expression of PLAT mRNA]]15963473
C534628SCH 23390SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA]15659235
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in increased expression of PLAT mRNA19564919
D012715Sesame OilSesame Oil results in decreased expression of PLAT mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PLAT mRNA25895662
D019821Simvastatingeranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT]12753293
D019821Simvastatingeranylgeraniol inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]12371961
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT]12753293
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA]12371961
D019821SimvastatinSimvastatin inhibits the reaction [TNF results in decreased expression of PLAT]12753293
D019821SimvastatinSimvastatin results in increased activity of PLAT protein12371961
D019821SimvastatinSimvastatin results in increased expression of PLAT12753293
D019821SimvastatinSimvastatin results in increased expression of PLAT mRNA12371961
D019821SimvastatinSimvastatin results in increased expression of PLAT protein12371961
D019821SimvastatinSimvastatin results in decreased expression of PLAT mRNA16414398
D012906SmokeSmoke analog results in decreased expression of PLAT protein20079143
C017947sodium arsenitesodium arsenite results in decreased expression of PLAT mRNA25270620
C017947sodium arsenitesodium arsenite results in increased expression of PLAT mRNA16014739
D012999SomanSoman results in increased expression of PLAT mRNA19281266
D053260SootSoot results in increased expression of PLAT mRNA26551751
D013015SotalolSotalol results in increased expression of PLAT protein9594410
D013148SpironolactoneSpironolactone results in increased expression of PLAT protein12424430
D019311StaurosporineStaurosporine inhibits the reaction [Phorbol Esters results in increased expression of PLAT mRNA]1310687
D019311StaurosporineStaurosporine inhibits the reaction [Phorbol Esters results in increased expression of PLAT protein]1310687
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
C049985staurosporine aglyconestaurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
D013467Sulindac[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of PLAT mRNA12628509
D016559TacrolimusTacrolimus results in decreased expression of PLAT mRNA25270620
D013744Tetanus ToxinTetanus Toxin inhibits the reaction [Zinc results in increased secretion of PLAT protein]21615740
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased secretion of PLAT protein]3119194
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLAT mRNA19619570
D013749Tetrachlorodibenzodioxin[[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNA21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLAT mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLAT mRNA27562557
D013749TetrachlorodibenzodioxinCGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLAT protein]12128104
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLAT mRNA11752688
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLAT protein12128104
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PLAT protein8018658
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of PLAT protein3119194
D013756Tetraethyl LeadTetraethyl Lead affects the activity of PLAT protein2143947
C488103tiplaxtinintiplaxtinin results in increased activity of PLAT protein23378038
C009495titanium dioxidetitanium dioxide results in increased expression of PLAT mRNA23565150|2776080
C009495titanium dioxidetitanium dioxide results in increased expression of PLAT protein23565150
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in decreased expression of PLAT mRNA24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution deficiency inhibits the reaction [[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in decreased expression of PLAT mRNA]24096154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PLAT mRNA28111298
D014050TolueneToluene results in increased expression of PLAT mRNA22967744
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PLAT mRNA25729387
C115645tPA stop[tPA stop results in decreased activity of PLAT protein] which results in decreased phosphorylation of and results in decreased activity of MAPK1 protein19911010
C115645tPA stop[tPA stop results in decreased activity of PLAT protein] which results in decreased phosphorylation of and results in decreased activity of MAPK3 protein19911010
C115645tPA stoptPA stop results in decreased activity of PLAT protein19911010
D014192TrapidilTrapidil affects the reaction [PTH protein affects the expression of PLAT mRNA]18635661
D014212TretinoinTretinoin metabolite results in increased expression of PLAT mRNA15982314
D014212TretinoinTretinoin results in decreased expression of PLAT mRNA21934132
D014212TretinoinTretinoin results in increased expression of PLAT mRNA15982314|1601251
D014212TretinoinTretinoin results in increased expression of PLAT protein11775254|8018658
D014212TretinoinTretinoin results in increased expression of PLAT mRNA16604517
D014212TretinoinTretinoin results in increased expression of PLAT mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PLAT mRNA24935251|2627250
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PLAT mRNA"26179874
C113580U 0126"U 0126 inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased activity of PLAT protein]"24599349
C113580U 0126"U 0126 inhibits the reaction [Amino Acids, Peptides, and Proteins results in increased expression of PLAT mRNA]"24599349
C113580U 0126U 0126 affects the susceptibility to PLAT protein19911010
C113580U 0126U 0126 inhibits the reaction [PLAT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19911010
C113580U 0126U 0126 inhibits the reaction [PLAT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19911010
D014520UrethaneUrethane results in decreased expression of PLAT mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of PLAT mRNA24383497|2493525
D014635Valproic AcidPLAT gene mutant form results in decreased susceptibility to Valproic Acid23378038
D014635Valproic AcidPLAT protein mutant form results in decreased susceptibility to Valproic Acid23378038
D014635Valproic Acidpyrazolanthrone inhibits the reaction [Valproic Acid results in increased activity of PLAT protein]23378038
D014635Valproic AcidSERPINE1 protein inhibits the reaction [Valproic Acid results in increased activity of PLAT protein]23378038
D014635Valproic Acid[Valproic Acid results in decreased activity of SERPINE1 protein] which results in increased activity of PLAT protein23378038
D014635Valproic AcidValproic Acid results in increased activity of PLAT protein23378038
D014638VanadatesVanadates results in increased expression of PLAT mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PLAT gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of PLAT mRNA20980218
D014747VinblastineVinblastine results in increased expression of PLAT mRNA20624997
C025643vinclozolinvinclozolin results in decreased expression of PLAT mRNA15686871
D014750VincristineVincristine results in increased expression of PLAT mRNA20624997
D014807Vitamin DVitamin D results in decreased expression of PLAT25488441
D002762CholecalciferolCholecalciferol results in increased expression of PLAT mRNA17170073
D014810Vitamin E[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Endosulfan results in increased activity of PLAT protein]21804306
D014810Vitamin EAscorbic Acid promotes the reaction [Vitamin E results in increased activity of PLAT protein]21804306
D014810Vitamin EVitamin E results in increased activity of PLAT protein21804306
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAT mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PLAT mRNA26272509
D015032Zinc4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
D015032Zinc4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
D015032Zinc4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
D015032Zinc4-aminophenylmercuriacetate inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
D015032ZincBDNF protein affects the reaction [Zinc results in increased expression of PLAT mRNA]21615740
D015032ZincBDNF protein affects the reaction [Zinc results in increased expression of PLAT protein]21615740
D015032ZincEdetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
D015032ZincEdetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
D015032ZincEdetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein]21615740
D015032ZincGo 6976 inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
D015032ZincGo 6976 inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
D015032ZincN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
D015032ZincN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
D015032Zincstaurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLAT mRNA]21615740
D015032Zincstaurosporine aglycone inhibits the reaction [Zinc results in increased expression of PLAT protein]21615740
D015032ZincTetanus Toxin inhibits the reaction [Zinc results in increased secretion of PLAT protein]21615740
D015032ZincZinc results in increased expression of and results in increased activity of PLAT protein21615740
D015032ZincZinc results in increased expression of PLAT mRNA21615740
D015032ZincZinc results in increased secretion of PLAT protein21615740
D015032ZincZinc deficiency results in increased expression of PLAT mRNA19111725
D015032ZincZinc inhibits the reaction [Zinc deficiency results in increased expression of PLAT mRNA]19111725
C088658zoledronic acidzoledronic acid results in increased expression of PLAT mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-IDA1695900  8508955  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005102signaling receptor binding-IPI8186264  
GO:0005515protein binding-IPI2503541  10340997  12694198  24196407  
GO:0005515protein binding-TAS8186264  
GO:0051219phosphoprotein binding-IPI8186264  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0006464cellular protein modification process-TAS3087818  
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-TAS3087818  
GO:0007596blood coagulation-TAS3839198  
GO:0014909smooth muscle cell migration-IBA21873635  
GO:0014909smooth muscle cell migration-IEA-  
GO:0031639plasminogen activation-IBA21873635  
GO:0031639plasminogen activation-IDA12694198  17849409  24196407  
GO:0042730fibrinolysis-TAS-  
GO:0045861negative regulation of proteolysis-IDA1695900  
GO:0048008platelet-derived growth factor receptor signaling pathway-IBA21873635  
GO:0048008platelet-derived growth factor receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-IDA1632457  
GO:0009986cell surface-IDA1632457  
GO:0030141secretory granule-IEA-  
GO:0045177apical part of cell-IEA-  
GO:0062023collagen-containing extracellular matrixNOTIDA1632457  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-75205Dissolution of Fibrin ClotTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
1759983The PLAT Study: a multidisciplinary study of hemostatic function and conventional risk factors in vascular disease patients. (1991 Oct)Cortellaro MAtherosclerosis