Gene: PLAU

5328
ATF|BDPLT5|QPD|UPA|URK|u-PA
plasminogen activator, urokinase
protein-coding
10q22.2
Ensembl:ENSG00000122861 MIM:191840 Vega:OTTHUMG00000018494 UniprotKB:P00749
NG_011904.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.765e-1 (AD)  2.655e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04939496chr10:75669647PLAU2.000e-11Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLEKHG20.789
VEGFC0.782
FBLIM10.779
TFPI0.775
TFPI20.772
KIAA00400.767
SLC43A30.754
IL100.751
CH25H0.751
TNFAIP80.749

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL11A-0.448
FUT9-0.432
OMG-0.431
RS1-0.43
ST6GALNAC5-0.427
ANO3-0.422
CNNM1-0.42
KCNB2-0.42
THY1-0.419
AMER3-0.418

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00013UrokinaseBiotechDrug9039-53-6Approved|Investigational|WithdrawnTarget
DB00594AmilorideSmall Molecule2609-46-3ApprovedTarget
DB017252-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamideSmall MoleculeExperimentalTarget
DB019052-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-CarboxamidineSmall MoleculeExperimentalTarget
DB019776-(N-Phenylcarbamyl)-2-NaphthalenecarboxamidineSmall MoleculeExperimentalTarget
DB022872-(2-Hydroxy-Phenyl)-3h-Benzoimidazole-5-CarboxamidineSmall MoleculeExperimentalTarget
DB023986-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-NaphthalenecarboxamidineSmall Molecule-ExperimentalTarget
DB024736-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-NaphthalenecarboxamidineSmall MoleculeExperimentalTarget
DB02526CRA_10655Small MoleculeExperimentalTarget
DB025516-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-NaphthalenecarboxamidineSmall MoleculeExperimentalTarget
DB027056-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-NaphthalenecarboxamidineSmall MoleculeExperimentalTarget
DB030467-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-CarboximidamideSmall MoleculeExperimentalTarget
DB030826-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-NaphthamideSmall MoleculeExperimentalTarget
DB03127BenzamidineSmall Molecule618-39-3ExperimentalTarget
DB031364-Iodobenzo[B]Thiophene-2-CarboxamidineSmall MoleculeExperimentalTarget
DB03159CRA_8696Small MoleculeExperimentalTarget
DB03476Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-CarboxamidineSmall MoleculeExperimentalTarget
DB037292-Amino-5-Hydroxy-BenzimidazoleSmall MoleculeExperimentalTarget
DB03782N-(1-Adamantyl)-N'-(4-Guanidinobenzyl)UreaSmall MoleculeExperimentalTarget
DB038656-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineSmall MoleculeExperimentalTarget
DB03876Thieno[2,3-B]Pyridine-2-CarboxamidineSmall Molecule-ExperimentalTarget
DB040598-(Pyrimidin-2-Ylamino)Naphthalene-2-CarboximidamideSmall MoleculeExperimentalTarget
DB04172[2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-AlanineSmall MoleculeExperimentalTarget
DB05254FibrinolysinBiotechDrug9004-09-5InvestigationalTarget
DB068556-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidineSmall MoleculeExperimentalTarget
DB068566-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINESmall MoleculeExperimentalTarget
DB06857N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDESmall MoleculeExperimentalTarget
DB070766-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDESmall MoleculeExperimentalTarget
DB071221-[4-(2-oxo-2-phenylethyl)phenyl]guanidineSmall MoleculeExperimentalTarget
DB07129(2R)-1-(2,6-dimethylphenoxy)propan-2-amineSmall MoleculeExperimentalTarget
DB076254-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamideSmall MoleculeExperimentalTarget
DB076264-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamideSmall MoleculeExperimentalTarget
DB080724-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDESmall MoleculeExperimentalTarget
DB086974-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamideSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline inhibits the reaction [PLAU protein results in increased activity of MMP9 protein]"20177776
C5815721-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of PLAU mRNA25827057
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased expression of PLAU mRNA]9442043
C4338262-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine binds to and results in decreased activity of PLAU protein11495587
C4338262-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine analog results in decreased activity of PLAU protein11689072
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PLAU mRNA"19114083
C0787652,3,5-(triglutathion-S-yl)hydroquinone"2,3,5-(triglutathion-S-yl)hydroquinone results in increased expression of PLAU mRNA"14587099
C4338252-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine binds to and results in decreased activity of PLAU protein11495587
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of PLAU mRNA"25710175
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [hispolon results in decreased expression of and results in decreased activity of PLAU protein]27037602
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of PLAU mRNA]"26644586
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of PLAU mRNA"26644586
C0163923,3'-diindolylmethane"3,3'-diindolylmethane results in increased expression of PLAU mRNA"18025290
C1065923,9-bis((ethylthio)methyl)-K-252a"3,9-bis((ethylthio)methyl)-K-252a results in decreased expression of PLAU mRNA"15294995
C0414773-hydroxyflavone3-hydroxyflavone results in decreased expression of PLAU protein27600294
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PLAU mRNA"25380136
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased expression of PLAU mRNA]15557793
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased expression of PLAU protein]15557793
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of PLAU mRNA"25670856
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C0065004-aminobenzamidine4-aminobenzamidine results in decreased activity of PLAU protein16430655
C0973984-iodine-benzo(b)thiophene-2-carboxamidine4-iodine-benzo(b)thiophene-2-carboxamidine results in decreased activity of PLAU protein16430655
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of PLAU mRNA21167638
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of PLAU mRNA21167638
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C4399526-chloro-2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine6-chloro-2-(2-hydroxybiphenyl-3-yl)-1H-indole-5-carboxamidine results in decreased activity of PLAU protein11689072
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] results in decreased expression of PLAU protein"25790727
D000079AcetaldehydeAcetaldehyde affects the activity of PLAU protein10513995
D000079AcetaldehydeAcetaldehyde results in increased expression of PLAU mRNA10513995
D000079AcetaldehydeAcetaldehyde results in increased expression of PLAU protein15452360
D000079AcetaldehydeTGFB1 protein inhibits the reaction [Acetaldehyde results in increased expression of PLAU protein]15452360
D000111AcetylcysteineAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased secretion of PLAU protein]15962302
D000111AcetylcysteineAcetylcysteine results in decreased expression of PLAU mRNA16084531
D000255Adenosine TriphosphateAdenosine Triphosphate results in increased secretion of PLAU protein20177776
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PLAU protein21527772
D000393Air PollutantsAir Pollutants analog results in increased expression of PLAU mRNA21757418
C109682alpha-benzoylamino-1,4-naphthoquinone"alpha-benzoylamino-1,4-naphthoquinone results in decreased secretion of PLAU protein"15962302
D000584AmilorideAmiloride inhibits the reaction [PLAU protein results in increased degradation of PLG protein]14644129
D000584AmilorideAmiloride results in decreased activity of PLAU protein11454671|1464412
D000584AmilorideAmiloride results in decreased activity of PLAU protein14511379|1643065
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PLAU mRNA16483693
C006578anetholeanethole results in decreased expression of PLAU mRNA21212515
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of PLAU mRNA24449571
D001151ArsenicArsenic affects the expression of PLAU mRNA28793237
D001151Arsenic[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of PLAU mRNA28793237
C006632arsenic trioxideAcetylcysteine inhibits the reaction [arsenic trioxide results in decreased secretion of PLAU protein]15962302
C006632arsenic trioxidearsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of PLAU protein]15962302
C006632arsenic trioxidearsenic trioxide promotes the reaction [silybin results in decreased expression of PLAU mRNA]21969006
C006632arsenic trioxidearsenic trioxide results in decreased expression of and results in decreased secretion of PLAU protein15962302
C006632arsenic trioxidearsenic trioxide results in decreased expression of PLAU mRNA15962302|2196900
C006632arsenic trioxidearsenic trioxide results in increased expression of PLAU mRNA20458559
C006632arsenic trioxideGH1 protein promotes the reaction [arsenic trioxide results in decreased expression of PLAU mRNA]23851143
C006632arsenic trioxide[silybin co-treated with arsenic trioxide] results in decreased expression of PLAU mRNA21969006
C006632arsenic trioxidesilybin promotes the reaction [arsenic trioxide results in decreased expression of PLAU mRNA]21969006
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of PLAU mRNA"23634900
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of PLAU mRNA"18687144|2535159
D000069059Atorvastatin CalciumAtorvastatin Calcium results in decreased expression of PLAU protein16410222
C010038azelaic acidazelaic acid results in decreased expression of and results in decreased secretion of PLAU protein8635147
C010038azelaic acidazelaic acid results in decreased expression of PLAU mRNA8635147
C547126AZM551248AZM551248 results in increased expression of PLAU mRNA22323515
C006680baicaleinbaicalein results in decreased activity of PLAU protein21803068
C487081belinostatbelinostat results in increased expression of PLAU mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C044946benazeprilbenazepril inhibits the reaction [Streptozocin results in increased expression of PLAU mRNA]15322501
D001542BenomylBenomyl results in decreased expression of PLAU mRNA25530041
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PLAU mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLAU mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of PLAU mRNA22342234
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLAU mRNA22228805|2261060
C038328BEP protocolBEP protocol results in increased expression of PLAU mRNA18987330
D004958EstradiolEstradiol affects the expression of PLAU mRNA14699072
D004958Estradiol[Estradiol binds to ESR2 protein] which results in decreased expression of PLAU mRNA20404318
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of PLAU mRNA20660070
D004958EstradiolEstradiol results in decreased expression of PLAU mRNA23019147|2532141
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of PLAU mRNA17404688
C034786bis(4-hydroxycinnamoyl)methanebis(4-hydroxycinnamoyl)methane results in decreased secretion of PLAU protein18495463
C006780bisphenol Abisphenol A results in decreased expression of PLAU mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PLAU mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PLAU mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PLAU mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PLAU mRNA28628672
D001761BleomycinBleomycin results in decreased expression of PLAU protein25648892
D001761BleomycinBleomycin results in increased expression of PLAU mRNA25648892
D001761BleomycinBleomycin results in increased expression of PLAU protein25648892
C584509C646 compoundC646 compound results in increased expression of PLAU mRNA26191083
D002101Cacodylic Acid[Arsenic results in increased abundance of Cacodylic Acid] which affects the expression of PLAU mRNA28793237
D002104CadmiumCadmium results in increased expression of PLAU mRNA17327699
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PLAU mRNA17327699
D000074262Canola OilCanola Oil metabolite results in decreased expression of PLAU mRNA27363782
D002211CapsaicinCapsaicin results in increased expression of PLAU mRNA21310942
D002220CarbamazepineCarbamazepine affects the expression of PLAU mRNA25979313
C006698carbendazimcarbendazim results in decreased expression of PLAU mRNA25530041
D002235CarbofuranCarbofuran results in increased expression of PLAU mRNA20211217
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of PLAU mRNA25827057
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PLAU mRNA24639359|2582705
D002251Carbon TetrachlorideHIF1A protein affects the reaction [Carbon Tetrachloride results in increased expression of PLAU mRNA]24639359
D002251Carbon TetrachloridePLAU protein affects the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]18279442
D002251Carbon TetrachloridePLAU protein affects the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]18279442
D002251Carbon TetrachloridePLAU protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]18279442
D002251Carbon TetrachloridePLAU protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]18481824
D002251Carbon TetrachloridePLAU protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]18481824
D002251Carbon TetrachloridePLAU protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 mRNA]18481824
D002251Carbon TetrachloridePLAU protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]18481824
D002251Carbon TetrachloridePLAU protein promotes the reaction [Carbon Tetrachloride results in increased expression of HGF mRNA]18481824
D002251Carbon TetrachloridePLAU protein promotes the reaction [Carbon Tetrachloride results in increased expression of MMP2 mRNA]18481824
D002251Carbon TetrachloridePLAU protein promotes the reaction [Carbon Tetrachloride results in increased expression of MMP3 mRNA]18481824
D002251Carbon TetrachloridePLAU protein promotes the reaction [Carbon Tetrachloride results in increased expression of MMP9 mRNA]18481824
D002251Carbon TetrachloridePLAU protein promotes the reaction [Carbon Tetrachloride results in increased expression of PCNA protein]18481824
C054133casticincasticin results in decreased expression of PLAU protein28444820
D002392CatechinCatechin results in increased expression of PLAU mRNA11236827
D002392CatechinCatechin results in increased expression of PLAU protein11236827
D002392CatechinDactinomycin inhibits the reaction [Catechin results in increased expression of PLAU mRNA]11236827
D002392CatechinCatechin results in increased expression of PLAU mRNA17478321
C469298CEP-11004CEP-11004 results in decreased expression of PLAU mRNA15294995
C100187chloropicrinchloropicrin affects the expression of PLAU mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAU mRNA20938992
D002995Clofibric AcidClofibric Acid affects the expression of PLAU mRNA17602206
C018021cobaltous chloridecobaltous chloride results in decreased expression of PLAU mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of PLAU mRNA19549813
D003474CurcuminCurcumin results in decreased expression of PLAU protein18226269
D003474CurcuminCurcumin results in decreased secretion of PLAU protein18495463
D003474CurcuminCurcumin results in increased expression of PLAU mRNA18025290
D003474CurcuminTNFSF10 protein promotes the reaction [Curcumin results in decreased expression of PLAU protein]18226269
D003474CurcuminCurcumin results in decreased expression of PLAU18462866
D003520CyclophosphamideCyclophosphamide results in increased expression of PLAU mRNA21527772
D003609DactinomycinDactinomycin inhibits the reaction [Catechin results in increased expression of PLAU mRNA]11236827
D003609DactinomycinDactinomycin inhibits the reaction [Quercetin results in increased expression of PLAU mRNA]11236827
D003609DactinomycinDactinomycin inhibits the reaction [resveratrol results in increased expression of PLAU mRNA]11236827
D003609DactinomycinDactinomycin results in increased expression of PLAU mRNA21527772
D000069439DasatinibDasatinib results in decreased expression of PLAU mRNA20579391
C014347decitabinedecitabine affects the expression of PLAU mRNA23300844
C014347decitabine[decitabine affects the methylation of PLAU promoter] which affects the expression of PLAU mRNA18320071|1832007
C014347decitabinedecitabine inhibits the reaction [sodium arsenite results in increased expression of PLAU mRNA]21167264
C014347decitabinedecitabine inhibits the reaction [sodium arsenite results in increased expression of PLAU protein]21167264
C014347decitabinedecitabine results in increased expression of PLAU mRNA16367923|1802529
D003676DeferoxamineDeferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased activity of PLAU mRNA]17571974
D003676DeferoxamineDeferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased expression of PLAU mRNA]17571974
C050229demethoxycurcumindemethoxycurcumin results in decreased secretion of PLAU protein18495463
D003907DexamethasoneDexamethasone results in decreased activity of PLAU protein10455257
D003907DexamethasoneDexamethasone results in decreased expression of PLAU mRNA25047013
D003907DexamethasoneDexamethasone results in decreased expression of PLAU protein10467400
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PLAU mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PLAU mRNA28628672
D003907DexamethasoneDexamethasone inhibits the reaction [Mustard Gas results in increased activity of PLAU protein]9101041
D003907DexamethasoneDexamethasone inhibits the reaction [Mustard Gas results in increased expression of PLAU mRNA]9101041
D003907DexamethasoneDexamethasone results in increased expression of PLAU mRNA21041162
D003907DexamethasoneDexamethasone affects the expression of PLAU protein10485340
D002945CisplatinCisplatin affects the expression of PLAU mRNA23300844
D002945CisplatinCisplatin results in increased expression of PLAU mRNA27594783
D002945CisplatinCisplatin results in decreased expression of PLAU mRNA22023808
D004008DiclofenacDiclofenac results in increased expression of PLAU protein23506792
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PLAU mRNA21527772
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PLAU mRNA"21527772
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PLAU mRNA25380136
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of PLAU mRNA28939011
D004237DiuronDiuron results in decreased expression of PLAU mRNA25152437
C521792DMU-212DMU-212 affects the expression of PLAU mRNA26428916
D004317Doxorubicin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased expression of PLAU mRNA]15557793
D004317Doxorubicin4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Doxorubicin results in increased expression of PLAU protein]15557793
D004317DoxorubicinDoxorubicin results in increased expression of and results in increased secretion of PLAU protein12908082
D004317DoxorubicinDoxorubicin results in increased expression of PLAU mRNA15557793
D004317DoxorubicinDoxorubicin results in increased expression of PLAU protein15557793
D004317DoxorubicinPLAU promoter modified form results in decreased susceptibility to Doxorubicin16356834
D004317DoxorubicinPLAU protein affects the susceptibility to Doxorubicin16217747
D004317DoxorubicinU 0126 inhibits the reaction [Doxorubicin results in increased expression of PLAU mRNA]15557793
D004317DoxorubicinU 0126 inhibits the reaction [Doxorubicin results in increased expression of PLAU protein]15557793
D004317DoxorubicinDoxorubicin results in increased expression of PLAU mRNA20211217
D004391DustDust results in decreased expression of PLAU mRNA17805423
D004391DustDust results in increased expression of PLAU mRNA17805423
C118739entinostatentinostat results in increased expression of PLAU mRNA27188386
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of PLAU mRNA16084531
D000431EthanolEthanol results in decreased expression of PLAU mRNA15353170
D000431EthanolEthanol results in increased expression of PLAU mRNA17478321
D005047EtoposideEtoposide results in increased expression of PLAU mRNA21527772
D005227Fatty AcidsFatty Acids results in decreased activity of PLAU protein14724836
C540355fenamidonefenamidone results in increased expression of PLAU mRNA27029645
C020326ferric nitrilotriacetateDeferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased activity of PLAU mRNA]17571974
C020326ferric nitrilotriacetateDeferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased expression of PLAU mRNA]17571974
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased activity of PLAU mRNA17571974
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of PLAU mRNA17571974
D005472FluorouracilFluorouracil affects the expression of PLAU mRNA16584549
D005485FlutamideFlutamide results in increased expression of PLAU mRNA24793618
D005492Folic AcidFolic Acid affects the expression of PLAU mRNA16361273
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAU mRNA20938992
C039281furanfuran results in increased expression of PLAU mRNA27387713
C039281furanfuran results in increased methylation of PLAU gene22079235
C419708gefitinibgefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]23127547
C419708gefitinibgefitinib promotes the reaction [resveratrol inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]]23127547
C419708gefitinibgefitinib promotes the reaction [resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]]23127547
C419708gefitinibresveratrol promotes the reaction [gefitinib inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]]23127547
C419708gefitinibresveratrol promotes the reaction [gefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]]23127547
C001277geldanamycin[geldanamycin co-treated with PTHLH protein modified form] results in decreased expression of PLAU mRNA12724357
C056507gemcitabinegemcitabine results in increased expression of PLAU mRNA17039268
D019833GenisteinGenistein results in decreased expression of PLAU mRNA23019147
D019833GenisteinGenistein results in increased expression of PLAU mRNA18025290
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of PLAU mRNA21782745
D019833GenisteinGenistein results in increased expression of PLAU protein17823541
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of PLAU mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of PLAU mRNA26644586
D006493HeparinHeparin analog results in decreased expression of PLAU mRNA26476401
C103442hispolon2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [hispolon results in decreased expression of and results in decreased activity of PLAU protein]27037602
C103442hispolonhispolon results in decreased expression of and results in decreased activity of PLAU protein27037602
D006820Hyaluronic Acid[Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAU mRNA12402308
D006820Hyaluronic Acid[Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAU protein12402308
D007052IbuprofenIbuprofen inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]16340751
C492448ICG 001ICG 001 results in increased expression of PLAU mRNA26191083
C016517indole-3-carbinolindole-3-carbinol results in increased expression of PLAU mRNA18025290
D007213IndomethacinIndomethacin results in increased expression of PLAU mRNA16984733
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PLAU mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PLAU mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PLAU mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PLAU mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PLAU mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of PLAU mRNA20211217
C544151jinfukangjinfukang results in increased expression of PLAU mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of PLAU mRNA15476862
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of PLAU mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PLAU mRNA24796395|2664458
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PLAU mRNA25119042
C572783kuguacin Jkuguacin J results in decreased secretion of PLAU protein alternative form22266361
D007840LatexLatex analog results in increased expression of PLAU mRNA24768652
C045463leflunomideleflunomide results in increased expression of PLAU mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of PLAU mRNA22103977
D008070LipopolysaccharidesLipopolysaccharides results in increased activity of PLAU protein22103977
D008070LipopolysaccharidesLipopolysaccharides affects the expression of PLAU mRNA28070326
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLAU mRNA18192897
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of PLAU mRNA]28070326
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PLAU protein27098997
D008070LipopolysaccharidesPlant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of PLAU protein]27098997
D018021Lithium ChlorideLithium Chloride results in decreased expression of PLAU mRNA15711924
D018021Lithium ChlorideLithium Chloride results in increased expression of PLAU mRNA23527032
C032881lysophosphatidic acidgefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]23127547
C032881lysophosphatidic acidgefitinib promotes the reaction [resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]]23127547
C032881lysophosphatidic acidlysophosphatidic acid results in increased expression of PLAU mRNA23127547
C032881lysophosphatidic acidresveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]23127547
C032881lysophosphatidic acidresveratrol promotes the reaction [gefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]]23127547
C106335macrophage stimulatory lipopeptide 2[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of PLAU mRNA18832182
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PLAU mRNA26378955
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PLAU mRNA21641980
C013592mangiferinmangiferin inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]19706694
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in decreased expression of PLAU mRNA20843944
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAU mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of PLAU mRNA24449571
D008727MethotrexateMethotrexate results in increased expression of PLAU mRNA21678067
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of PLAU mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of PLAU mRNA21782745
D008748MethylcholanthreneMethylcholanthrene results in increased expression of PLAU mRNA16619036
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PLAU mRNA28001369
D016685MitomycinPLAU protein affects the susceptibility to Mitomycin16217747
C060893MK-886MK-886 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA]20061081
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of PLAU mRNA22108045
D009151Mustard GasDexamethasone inhibits the reaction [Mustard Gas results in increased activity of PLAU protein]9101041
D009151Mustard GasDexamethasone inhibits the reaction [Mustard Gas results in increased expression of PLAU mRNA]9101041
D009151Mustard GasMustard Gas results in increased expression of and results in increased activity of PLAU protein9101041
D009151Mustard GasMustard Gas results in increased expression of PLAU mRNA9101041
D009151Mustard GasRyanodine promotes the reaction [Mustard Gas results in increased activity of PLAU protein]9101041
D009151Mustard GasVanadates inhibits the reaction [Mustard Gas results in increased activity of PLAU protein]9101041
D009151Mustard GasMustard Gas results in increased expression of PLAU mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PLAU mRNA"25790727
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] results in decreased expression of PLAU protein"25790727
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PLAU mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PLAU protein"25790727
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PLAU mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PLAU mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PLAU mRNA25380136
D009532NickelNickel results in increased expression of PLAU mRNA25583101
C029938nickel sulfate[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in decreased expression of PLAU mRNA18832182
C029938nickel sulfatenickel sulfate results in decreased expression of PLAU mRNA18832182
D009538NicotineMK-886 inhibits the reaction [Nicotine results in increased expression of PLAU mRNA]20061081
D009538NicotineNicotine results in increased expression of PLAU mRNA20061081|2382564
D009538NicotinePLAU inhibits the reaction [Nicotine binds to CHRNA1 protein]19690163
C072936notoginsenoside R1notoginsenoside R1 results in increased expression of PLAU mRNA9220151
C072936notoginsenoside R1notoginsenoside R1 results in increased expression of PLAU protein9220151
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of PLAU mRNA24888373
D009950OrnidazoleOrnidazole results in decreased expression of PLAU mRNA18998460
D009950OrnidazoleOrnidazole results in decreased expression of PLAU protein18998460
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PLAU mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PLAU mRNA25729387
D010100OxygenOxygen deficiency promotes the reaction [PLAU protein results in increased activity of PLG protein]12485432
D010100OxygenOxygen deficiency results in increased activity of PLAU protein12485432
D010100OxygenOxygen deficiency results in increased expression of PLAU mRNA12485432
D010126OzoneOzone results in increased expression of PLAU mRNA16716893
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PLAU mRNA26272509
D010269ParaquatParaquat results in increased expression of PLAU mRNA18198484
D052638Particulate MatterParticulate Matter results in decreased expression of PLAU mRNA22369193
D052638Particulate MatterParticulate Matter results in increased expression of PLAU mRNA21703343
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PLAU mRNA18593933
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PLAU mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of PLAU mRNA25119042
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PLAU mRNA26272509
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of PLAU mRNA]28070326
D010936Plant ExtractsPlant Extracts inhibits the reaction [SP1 protein binds to PLAU promoter]23201449
D010936Plant ExtractsPlant Extracts results in decreased activity of PLAU protein22144737
D010936Plant ExtractsPlant Extracts results in decreased expression of and results in decreased activity of PLAU protein23201449
D010936Plant ExtractsPlant Extracts results in decreased expression of PLAU mRNA22144737|2320144
D010936Plant ExtractsPlant Extracts results in decreased activity of PLAU protein22144737
D010936Plant ExtractsPlant Extracts inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]19706694
D010936Plant ExtractsPlant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of PLAU protein]27098997
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of PLAU mRNA24888373
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PLAU mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of PLAU mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of PLAU mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of PLAU mRNA17404688|1807036
D011374ProgesteroneProgesterone results in increased expression of PLAU mRNA23103014
C005556propionaldehydepropionaldehyde results in increased expression of PLAU mRNA26079696
C573121ProstaCaidProstaCaid results in decreased expression of PLAU mRNA21468543
C573121ProstaCaidProstaCaid results in decreased secretion of PLAU protein21468543
D011509ProteoglycansProteoglycans affects the secretion of PLAU protein14511379
C513428pyrachlostrobinpyrachlostrobin results in increased expression of PLAU mRNA27029645
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [TNF protein results in increased activity of PLAU protein]19874453
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [TNF protein results in increased expression of PLAU protein]19874453
C432165pyrazolanthronepyrazolanthrone promotes the reaction [resveratrol results in decreased expression of PLAU protein]23437203
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]16340751
D011794QuercetinDactinomycin inhibits the reaction [Quercetin results in increased expression of PLAU mRNA]11236827
D011794QuercetinQuercetin results in decreased expression of PLAU mRNA21308698
D011794QuercetinQuercetin results in decreased expression of PLAU protein23645742
D011794QuercetinQuercetin results in increased expression of PLAU mRNA11236827|1272435
D011794QuercetinQuercetin results in increased expression of PLAU protein11236827
D011794QuercetinQuercetin results in increased expression of PLAU mRNA17478321
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of PLAU mRNA19059307
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of PLAU protein16277677
C059514resveratrolDactinomycin inhibits the reaction [resveratrol results in increased expression of PLAU mRNA]11236827
C059514resveratrolgefitinib promotes the reaction [resveratrol inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]]23127547
C059514resveratrolgefitinib promotes the reaction [resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]]23127547
C059514resveratrolpyrazolanthrone promotes the reaction [resveratrol results in decreased expression of PLAU protein]23437203
C059514resveratrolresveratrol inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]23127547
C059514resveratrolresveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]23127547
C059514resveratrolresveratrol inhibits the reaction [SP1 protein binds to PLAU promoter]23437203
C059514resveratrolresveratrol promotes the reaction [gefitinib inhibits the reaction [EGF protein results in increased expression of PLAU mRNA]]23127547
C059514resveratrolresveratrol promotes the reaction [gefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]]23127547
C059514resveratrolresveratrol results in decreased activity of PLAU protein25605016
C059514resveratrolresveratrol results in decreased expression of and results in decreased activity of PLAU protein23437203
C059514resveratrolresveratrol results in decreased expression of PLAU mRNA22199285|2343720
C059514resveratrolresveratrol results in decreased expression of PLAU protein26537190
C059514resveratrolresveratrol results in increased expression of PLAU mRNA11236827
C059514resveratrolresveratrol results in increased expression of PLAU protein11236827
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of PLAU mRNA25905778
D012433RyanodineRyanodine promotes the reaction [Mustard Gas results in increased activity of PLAU protein]9101041
C429533SB 3CT compoundSB 3CT compound inhibits the reaction [PLAU protein results in increased activity of MMP9 protein]20177776
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of PLAU mRNA"23917077
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PLAU mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of PLAU mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of PLAU mRNA19073995
D012834SilverSilver results in increased expression of PLAU mRNA27131904
C440975silybinarsenic trioxide promotes the reaction [silybin results in decreased expression of PLAU mRNA]21969006
C440975silybin[silybin co-treated with arsenic trioxide] results in decreased expression of PLAU mRNA21969006
C440975silybinsilybin promotes the reaction [arsenic trioxide results in decreased expression of PLAU mRNA]21969006
C440975silybinsilybin results in decreased expression of PLAU mRNA21969006
D019821SimvastatinSimvastatin results in decreased expression of PLAU mRNA10412775
D012906SmokeSmoke affects the expression of PLAU mRNA23693141
C118258SN50 peptideSN50 peptide results in decreased secretion of PLAU protein15962302
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite results in increased expression of PLAU mRNA]21167264
C017947sodium arsenitedecitabine inhibits the reaction [sodium arsenite results in increased expression of PLAU protein]21167264
C017947sodium arsenitesodium arsenite results in decreased expression of PLAU mRNA12016162|2549360
C017947sodium arsenitesodium arsenite results in increased expression of PLAU mRNA21167264
C017947sodium arsenitesodium arsenite results in increased expression of PLAU protein21167264
C017947sodium arseniteU 0126 inhibits the reaction [sodium arsenite results in increased expression of PLAU mRNA]21167264
C017947sodium arseniteU 0126 inhibits the reaction [sodium arsenite results in increased expression of PLAU protein]21167264
C017947sodium arsenitesodium arsenite results in increased expression of PLAU protein21167264
C016104sodium bichromatesodium bichromate results in decreased expression of PLAU mRNA17685462
C016104sodium bichromatesodium bichromate results in decreased expression of PLAU protein10438662
D012972Sodium HydroxidePLAU SNP affects the susceptibility to Sodium Hydroxide27206134
D013311Streptozocinbenazepril inhibits the reaction [Streptozocin results in increased expression of PLAU mRNA]15322501
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of PLAU mRNA25905778
D013311StreptozocinStreptozocin results in increased expression of PLAU mRNA15322501
D013311StreptozocinStreptozocin results in increased expression of PLAU protein15322501
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PLAU mRNA26378955
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PLAU mRNA21641980
C025462sulindac sulfidesulindac sulfide results in decreased expression of PLAU mRNA15767558
C446685systhanesysthane results in increased expression of PLAU mRNA25461557
C112689TAC 101TAC 101 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PLAU protein]9848099
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in decreased expression of PLAU mRNA19059307
C087114tebuconazoletebuconazole results in decreased expression of PLAU mRNA26852204
C084178telmisartantelmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]19706694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLAU mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PLAU mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of PLAU mRNA21167638
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLAU mRNA21041162|2756255
D013749TetrachlorodibenzodioxinCGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLAU protein]12128104
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PLAU mRNA15644576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PLAU protein12128104
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased stability of PLAU mRNA10833433
D013755Tetradecanoylphorbol Acetatearsenic trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of PLAU protein]15962302
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of PLAU protein15962302
D013755Tetradecanoylphorbol AcetateTAC 101 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PLAU protein]9848099
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PLAU protein9848099
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of PLAU mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of PLAU protein16288038
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PLAU mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PLAU mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PLAU mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of PLAU24706507
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PLAU mRNA25729387
D014108Tosylphenylalanyl Chloromethyl KetoneTosylphenylalanyl Chloromethyl Ketone results in decreased expression of PLAU protein10467400
C528105trans-3,4'-dimethyl-3-hydroxyflavanone"trans-3,4'-dimethyl-3-hydroxyflavanone results in decreased activity of PLAU protein"18310908
D014212TretinoinTretinoin results in decreased expression of PLAU mRNA23724009
D014212TretinoinTretinoin results in increased expression of PLAU mRNA23830798
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PLAU mRNA24935251|2627250
D014260TriclosanTriclosan inhibits the reaction [TNF protein results in increased activity of PLAU protein]19874453
D014260TriclosanTriclosan inhibits the reaction [TNF protein results in increased expression of PLAU mRNA]19874453
D014260TriclosanTriclosan inhibits the reaction [TNF protein results in increased expression of PLAU protein]19874453
C009954trilostanetrilostane promotes the reaction [GNRH1 protein results in increased expression of PLAU mRNA]17332517
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PLAU mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of PLAU mRNA19140230
D014403TubocurarineTubocurarine inhibits the reaction [CHRNA1 protein binds to PLAU protein]19690163
C113580U 0126U 0126 inhibits the reaction [Doxorubicin results in increased expression of PLAU mRNA]15557793
C113580U 0126U 0126 inhibits the reaction [Doxorubicin results in increased expression of PLAU protein]15557793
C113580U 0126U 0126 inhibits the reaction [sodium arsenite results in increased expression of PLAU mRNA]21167264
C113580U 0126U 0126 inhibits the reaction [sodium arsenite results in increased expression of PLAU protein]21167264
D017974Uranium CompoundsUranium Compounds results in decreased expression of PLAU mRNA19654044
D014635Valproic AcidValproic Acid affects the expression of PLAU mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PLAU mRNA24383497|2800136
D014635Valproic AcidValproic Acid results in increased methylation of PLAU gene29154799
D014638VanadatesVanadates inhibits the reaction [Mustard Gas results in increased activity of PLAU protein]9101041
D014639VanadiumVanadium results in increased expression of PLAU mRNA19000753
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of PLAU mRNA22369193
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PLAU gene25560391
D014747VinblastinePLAU protein affects the susceptibility to Vinblastine16217747
C029297vinylidene chloridevinylidene chloride results in decreased expression of PLAU mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PLAU mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PLAU mRNA26272509
C010807xylosidesxylosides results in decreased activity of and results in decreased secretion of PLAU protein14511379
C521292YSNSG cyclopeptideYSNSG cyclopeptide results in decreased expression of PLAU19551865
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PLAU mRNA18593933
C088658zoledronic acidzoledronic acid results in increased expression of PLAU mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IBA21873635  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI3501295  7904248  10340997  14696115  18376415  
GO ID GO Term Qualifier Evidence PubMed
GO:0001666response to hypoxia-IEA-  
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-TAS6589620  
GO:0006935chemotaxis-TAS10749881  
GO:0007165signal transduction-TAS10749881  
GO:0007596blood coagulation-IEA-  
GO:0010469regulation of signaling receptor activity-IDA8837777  
GO:0014909smooth muscle cell migration-IEA-  
GO:0014910regulation of smooth muscle cell migration-IDA8837777  
GO:0030335positive regulation of cell migration-IDA25168896  
GO:0031639plasminogen activation-IBA21873635  
GO:0031639plasminogen activation-IDA25978044  
GO:0033628regulation of cell adhesion mediated by integrin-IBA21873635  
GO:0033628regulation of cell adhesion mediated by integrin-IDA8837777  
GO:0042127regulation of cell proliferation-IEA-  
GO:0042730fibrinolysis-IBA21873635  
GO:0042730fibrinolysis-TAS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0061041regulation of wound healing-IC8837777  
GO:2000097regulation of smooth muscle cell-matrix adhesion-IDA8837777  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA18835034  
GO:0005886plasma membrane-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-IDA18835034  
GO:0035579specific granule membrane-TAS-  
GO:0070062extracellular exosome-HDA23533145  
GO:0070821tertiary granule membrane-TAS-  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-75205Dissolution of Fibrin ClotTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19147396Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure. (2009 Aug)Cheong SCOral Oncol