Gene info: ID 5329

Gene: PLAUR

GENE ID: 5329

Synonyms: CD87|U-PAR|UPAR|URKR

Description: plasminogen activator, urokinase receptor

Gene type: protein-coding

Location: 19q13.31

dbXrefs: Ensembl:ENSG00000011422 MIM:173391 Vega:OTTHUMG00000182778 UniprotKB:Q03405

RefSeq: NG_032898.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.238e-2 (AD) 8.856e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NFKB2	0.895
ICAM1	0.89
IL15RA	0.883
STX11	0.877
PNP	0.875
TNFRSF10B	0.874
SBNO2	0.867
HMOX1	0.865
PPP1R18	0.856
SLC16A3	0.856

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MARCH4	-0.471
KIT	-0.469
SLC7A4	-0.454
NEUROD6	-0.451
HAPLN1	-0.451
BFSP1	-0.448
EDN3	-0.443
CASC15	-0.439
GAD2	-0.43
CHRNB2	-0.429

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00009	Alteplase	BiotechDrug	105857-23-6	Approved	Target
DB00013	Urokinase	BiotechDrug	9039-53-6	Approved\|Investigational\|Withdrawn	Target
DB00015	Reteplase	BiotechDrug	133652-38-7	Approved\|Investigational	Target
DB00029	Anistreplase	BiotechDrug	81669-57-0	Approved	Target
DB00031	Tenecteplase	BiotechDrug	191588-94-0	Approved	Target
DB05476	WX-UK1	Small Molecule		Investigational	Target
DB06245	Lanoteplase	BiotechDrug	171870-23-8	Investigational	Target

ID	Drug Name	Action	PubMed
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of PLAUR mRNA	28329830
C051246	1-methylanthracene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PLAUR mRNA]	28329830
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PLAUR mRNA"	27291303
C501339	2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione	"2-(2,6-diisopropylphenyl)-5-hydroxy-1H-isoindole-1,3-dione results in increased expression of PLAUR"	21788198
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of PLAUR mRNA]	25069788
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of PLAUR mRNA"	25710175
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of PLAUR mRNA"	24172598
C106572	3-iodo-2-propynylbutylcarbamate	3-iodo-2-propynylbutylcarbamate affects the expression of PLAUR	21788198
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of PLAUR mRNA"	18648102
C048324	abamectin	abamectin affects the expression of PLAUR	21788198
C496492	abrine	abrine results in increased expression of PLAUR mRNA	22595364
D000082	Acetaminophen	Acetaminophen affects the expression of PLAUR mRNA	25458485
D000082	Acetaminophen	Acetaminophen affects the expression of PLAUR mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of PLAUR gene	28458013
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PLAUR mRNA	19770486
C000188	alachlor	alachlor affects the expression of PLAUR	21788198
D000447	Aldehydes	Aldehydes results in increased expression of PLAUR mRNA	25014914
D000584	Amiloride	Amiloride inhibits the reaction [IFNA2 protein results in increased expression of PLAUR mRNA]	12070711
D000584	Amiloride	Amiloride inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA]	12070711
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PLAUR mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of PLAUR mRNA"	22863853
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PLAUR mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of PLAUR mRNA	19654921
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PLAUR mRNA	15761015\|1912883
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PLAUR protein	15962302\|1964235
C006632	arsenic trioxide	GH1 protein promotes the reaction [arsenic trioxide results in decreased expression of PLAUR mRNA]	23851143
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of PLAUR mRNA"	18687144\|2535159
D001241	Aspirin	Aspirin promotes the reaction [FOSL1 protein binds to PLAUR promoter]	16893520
D001241	Aspirin	Aspirin promotes the reaction [HIST4H4 protein modified form binds to PLAUR promoter]	16893520
D001241	Aspirin	Aspirin promotes the reaction [JUN protein binds to PLAUR promoter]	16893520
D001241	Aspirin	Aspirin results in increased expression of PLAUR mRNA	16893520
D001241	Aspirin	Aspirin results in increased expression of PLAUR protein	16893520
D001241	Aspirin	Aspirin affects the expression of PLAUR mRNA	12800193
C072763	azamethiphos	azamethiphos affects the expression of PLAUR	21788198
C547126	AZM551248	AZM551248 results in increased expression of PLAUR mRNA	22323515
C044946	benazepril	benazepril inhibits the reaction [Streptozocin results in increased expression of PLAUR mRNA]	15322501
D001554	Benzene	Benzene affects the expression of PLAUR mRNA	21147609
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of PLAUR mRNA	26377693
D001564	Benzo(a)pyrene	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PLAUR mRNA]	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PLAUR mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PLAUR mRNA	21569818\|2222880
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of PLAUR mRNA"	20382639
D004958	Estradiol	Estradiol affects the expression of PLAUR mRNA	22574217
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of PLAUR mRNA	20660070
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAUR mRNA	19619570
D004958	Estradiol	Estradiol inhibits the reaction [EGF protein results in increased expression of PLAUR protein]	19395996
D004958	Estradiol	Estradiol results in increased expression of PLAUR mRNA	19619570\|2686566
C095105	bexarotene	bexarotene results in decreased expression of PLAUR mRNA	17178900
C018465	bioallethrin	bioallethrin affects the expression of PLAUR	21788198
C004541	biochanin A	biochanin A results in decreased expression of PLAUR protein	16598420
C006780	bisphenol A	bisphenol A results in decreased expression of PLAUR mRNA	29275510
C006780	bisphenol A	bisphenol A affects the methylation of PLAUR promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of PLAUR mRNA	28079927
C006780	bisphenol A	bisphenol A affects the expression of PLAUR mRNA	25181051
C006780	bisphenol A	bisphenol A affects the expression of PLAUR	21788198
C487162	butafenacil	butafenacil affects the expression of PLAUR	21788198
C006852	butralin	butralin affects the expression of PLAUR	21788198
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of PLAUR mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in increased expression of PLAUR mRNA	26079696
D002087	Butyrates	Butyrates inhibits the reaction [IFNA2 protein results in increased expression of PLAUR mRNA]	12070711
D002087	Butyrates	Butyrates inhibits the reaction [IFNG protein results in increased expression of PLAUR mRNA]	12070711
D020148	Butyric Acid	Butyric Acid affects the expression of PLAUR mRNA	12800193
C584509	C646 compound	C646 compound results in increased expression of PLAUR mRNA	26191083
D002104	Cadmium	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of PLAUR mRNA]	25069788
D002104	Cadmium	Cadmium results in increased expression of PLAUR mRNA	21120746\|2506978
D002104	Cadmium	MAP2K1 protein affects the reaction [Cadmium results in increased expression of PLAUR mRNA]	25069788
D002104	Cadmium	Cadmium results in increased expression of PLAUR mRNA	22666406
D002211	Capsaicin	Capsaicin results in increased expression of PLAUR mRNA	21310942
D002251	Carbon Tetrachloride	PLAUR protein affects the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]	18279442
D002251	Carbon Tetrachloride	PLAUR protein affects the reaction [Carbon Tetrachloride results in increased expression of IL10 protein]	18279442
D002251	Carbon Tetrachloride	PLAUR protein affects the reaction [Carbon Tetrachloride results in increased expression of IL4 protein]	18279442
D002392	Catechin	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PLAUR mRNA	24763279
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid results in increased expression of PLAUR mRNA	21224055
D002737	Chloroprene	Chloroprene results in increased expression of PLAUR mRNA	23125180
D002794	Choline	Choline affects the expression of PLAUR mRNA	17616785
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAUR mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion promotes the reaction [[CTNNB1 protein co-treated with TCF4 protein] binds to PLAUR promoter]	27323401
C074702	chromium hexavalent ion	chromium hexavalent ion results in increased expression of PLAUR protein	27323401
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of PLAUR mRNA	28472532
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PLAUR mRNA	19376846
D003078	Colchicine	Colchicine results in increased expression of PLAUR mRNA	20624997
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PLAUR mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of PLAUR mRNA	26577399
D003474	Curcumin	Curcumin results in increased expression of PLAUR mRNA	15713895
C465366	cyazofamid	cyazofamid affects the expression of PLAUR	21788198
D003513	Cycloheximide	[Cycloheximide co-treated with IFNA2 protein] results in increased expression of PLAUR mRNA	12070711
D003513	Cycloheximide	[Cycloheximide co-treated with IFNG protein] results in increased expression of PLAUR mRNA	12070711
D003513	Cycloheximide	Cycloheximide results in increased expression of PLAUR mRNA	12070711
D016572	Cyclosporine	Cyclosporine results in increased expression of PLAUR mRNA	21632981\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of PLAUR mRNA	19770486
C004742	daidzein	daidzein inhibits the reaction [Flutamide results in increased expression of PLAUR mRNA]	23135684
C012864	dazomet	dazomet affects the expression of PLAUR	21788198
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of PLAUR mRNA	23640034
D003840	Deoxycholic Acid	Deoxycholic Acid results in increased expression of PLAUR mRNA	21224055
D003907	Dexamethasone	Dexamethasone results in decreased expression of PLAUR mRNA	12732289\|2504701
C042577	diallyl trisulfide	diallyl trisulfide affects the expression of PLAUR protein	27129776
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PLAUR mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of PLAUR mRNA	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of PLAUR mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of PLAUR mRNA	27594783
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of PLAUR mRNA	26865669
C031394	difenzoquat	difenzoquat affects the expression of PLAUR	21788198
D002117	Calcitriol	Calcitriol results in decreased expression of PLAUR mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of PLAUR mRNA	21592394
C076154	dimethomorph	dimethomorph affects the expression of PLAUR	21788198
C049346	diniconazole	diniconazole affects the expression of PLAUR	21788198
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of PLAUR mRNA	28939011
D004237	Diuron	Diuron metabolite results in increased expression of PLAUR mRNA	24172598
D004391	Dust	Dust results in increased expression of PLAUR mRNA	17805423
C108024	emamectin benzoate	emamectin benzoate affects the expression of PLAUR	21788198
C017435	enilconazole	enilconazole affects the expression of PLAUR	21788198
C118739	entinostat	entinostat results in increased expression of PLAUR mRNA	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of PLAUR mRNA	17555576
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLAUR mRNA	17942748
D008656	Mestranol	Mestranol results in increased expression of PLAUR mRNA	26865669
C508136	etoxazole	etoxazole affects the expression of PLAUR	21788198
C052034	fenoxycarb	fenoxycarb affects the expression of PLAUR	21788198
C415144	fenpyroximate	fenpyroximate affects the expression of PLAUR	21788198
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of PLAUR mRNA	28329830
C007738	fluoranthene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PLAUR mRNA]	28329830
C550006	fluoxastrobin	fluoxastrobin affects the expression of PLAUR	21788198
D005485	Flutamide	daidzein inhibits the reaction [Flutamide results in increased expression of PLAUR mRNA]	23135684
D005485	Flutamide	Flutamide results in increased expression of PLAUR mRNA	23135684
D005492	Folic Acid	Folic Acid affects the expression of PLAUR mRNA	16361273
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAUR mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of PLAUR mRNA	18499655\|2088468
C070081	fulvestrant	fulvestrant inhibits the reaction [EGF protein results in increased expression of PLAUR protein]	19395996
C070081	fulvestrant	fulvestrant results in decreased expression of PLAUR mRNA	26865669
C039281	furan	furan results in increased expression of PLAUR mRNA	27387713
D019833	Genistein	Genistein results in increased expression of PLAUR mRNA	26865669
C424943	glutamyl-Se-methylselenocysteine	glutamyl-Se-methylselenocysteine results in decreased expression of PLAUR mRNA	11306469
C511402	Grape Seed Proanthocyanidins	[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PLAUR mRNA	24763279
D006589	Hexestrol	Hexestrol results in increased expression of PLAUR mRNA	26865669
D017313	Fenretinide	Fenretinide results in increased expression of PLAUR mRNA	28973697
D006820	Hyaluronic Acid	[Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAUR mRNA	12402308
D006820	Hyaluronic Acid	[Hyaluronic Acid analog binds to and results in increased activity of CD44 protein] which results in increased expression of PLAUR protein	12402308
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of PLAUR mRNA	22261521
C492448	ICG 001	ICG 001 results in increased expression of PLAUR mRNA	26191083
D007069	Ifosfamide	Ifosfamide affects the expression of PLAUR protein	15659795
D007069	Ifosfamide	[Ifosfamide co-treated with IFNA2] results in decreased expression of PLAUR protein	15659795
D007069	Ifosfamide	[Ifosfamide co-treated with IFNB1] results in decreased expression of PLAUR protein	15659795
C401104	indoxacarb	indoxacarb affects the expression of PLAUR	21788198
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PLAUR mRNA	25613284
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of PLAUR mRNA	27392435
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of PLAUR mRNA	15476862
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of PLAUR mRNA	17085751
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of PLAUR protein	17337753
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PLAUR mRNA	25961927
C561695	(+)-JQ1 compound	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PLAUR mRNA	25119042
C055370	lactofen	lactofen affects the expression of PLAUR	21788198
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased activity of PLAUR mRNA	22103977
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PLAUR mRNA	11739494
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PLAUR mRNA	10975854
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PLAUR mRNA	11779202
D008095	Lithocholic Acid	[Lithocholic Acid results in increased activity of MAPK1 protein] which results in increased expression of PLAUR mRNA	19782465
D008095	Lithocholic Acid	[Lithocholic Acid results in increased activity of MAPK3 protein] which results in increased expression of PLAUR mRNA	19782465
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of PLAUR mRNA	19782465
D008095	Lithocholic Acid	MAP2K1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA]	19782465
D008095	Lithocholic Acid	MAPK1 protein promotes the reaction [Lithocholic Acid results in increased expression of PLAUR mRNA]	19782465
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PLAUR mRNA	21641980
C013099	mancozeb	mancozeb affects the expression of PLAUR	21788198
D008344	Maneb	Maneb affects the expression of PLAUR	21788198
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLAUR mRNA	20938992
C028912	methylene bis(thiocyanate)	methylene bis(thiocyanate) affects the expression of PLAUR	21788198
C060893	MK-886	MK-886 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]	20061081
D009151	Mustard Gas	Mustard Gas results in increased expression of PLAUR mRNA	18988085
D009267	Naled	Naled affects the expression of PLAUR	21788198
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PLAUR mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PLAUR mRNA"	25554681
C000621033	napabucasin	napabucasin results in decreased expression of PLAUR mRNA	25605917
C031721	naphthalene	naphthalene results in increased expression of PLAUR mRNA	18978301
D009281	Naphthalenes	Naphthalenes results in increased expression of PLAUR protein	17337753
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of PLAUR mRNA	20551477
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of PLAUR mRNA	19812364
D009532	Nickel	Nickel results in increased expression of PLAUR mRNA	25583101
C028007	nickel monoxide	nickel monoxide results in increased expression of PLAUR mRNA	19167457
C029938	nickel sulfate	nickel sulfate results in decreased expression of PLAUR mRNA	16780908\|2271453
D009534	Niclosamide	Niclosamide affects the expression of PLAUR	21788198
D009538	Nicotine	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
D009538	Nicotine	Acetylcysteine inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
D009538	Nicotine	MK-886 inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]	20061081
D009538	Nicotine	Nicotine results in increased expression of PLAUR mRNA	20061081\|2226152
D009538	Nicotine	Nicotine results in increased expression of PLAUR protein	22261521
D009538	Nicotine	pyrazolanthrone inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
D009538	Nicotine	JUN protein affects the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
D009538	Nicotine	MAP2K1 protein affects the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
D009538	Nicotine	NFKBIA protein affects the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
D009538	Nicotine	NFKBIB protein affects the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
D005996	Nitroglycerin	Nitroglycerin results in increased expression of PLAUR mRNA	12102619
C025589	ochratoxin A	ochratoxin A results in increased expression of PLAUR mRNA	22124623
C025589	ochratoxin A	ochratoxin A results in increased expression of PLAUR mRNA	22124623
D015242	Ofloxacin	Ofloxacin results in increased expression of PLAUR mRNA	20688128
C002771	Omite	Omite affects the expression of PLAUR	21788198
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of PLAUR mRNA	24888373
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of PLAUR mRNA	25729387
D010100	Oxygen	Oxygen deficiency promotes the reaction [SORL1 protein binds to PLAUR protein]	23486467
D010118	Oxytetracycline	Oxytetracycline affects the expression of PLAUR	21788198
D010126	Ozone	Ozone results in increased expression of PLAUR mRNA	16330353\|1671689
D052638	Particulate Matter	Particulate Matter results in increased expression of PLAUR mRNA	21703343
D052638	Particulate Matter	Particulate Matter results in increased expression of PLAUR protein	27295300
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of PLAUR mRNA	18593933
C506614	PD 0325901	[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of PLAUR mRNA	25119042
C506614	PD 0325901	PD 0325901 results in decreased expression of PLAUR mRNA	25119042
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of PLAUR mRNA	26705709
C046012	pentanal	pentanal results in increased expression of PLAUR mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of PLAUR	21788198
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of PLAUR	21788198
D010672	Phenytoin	Phenytoin results in decreased expression of PLAUR mRNA	14741686
D010705	Phosgene	Phosgene affects the expression of PLAUR mRNA	16300373
D010894	Piroxicam	Piroxicam results in decreased expression of PLAUR mRNA	21858171
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of PLAUR mRNA	24888373
C008971	polymarcine	polymarcine affects the expression of PLAUR	21788198
C113831	poly-N-acetyl glucosamine	poly-N-acetyl glucosamine results in increased expression of PLAUR mRNA	19638916
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of PLAUR protein	23718831
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of PLAUR mRNA	22698814
C045362	prochloraz	prochloraz affects the expression of PLAUR	21788198
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of PLAUR mRNA	20660070
D011374	Progesterone	Progesterone results in increased expression of PLAUR mRNA	17170212
D011374	Progesterone	Progesterone results in increased expression of PLAUR protein	17170212
C005556	propionaldehyde	propionaldehyde results in increased expression of PLAUR mRNA	26079696
C513428	pyrachlostrobin	pyrachlostrobin affects the expression of PLAUR	21788198
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Nicotine results in increased expression of PLAUR mRNA]	22261521
C428725	pyridaben	pyridaben affects the expression of PLAUR	21788198
D011791	Quartz	Quartz affects the expression of PLAUR mRNA	19836432
D011794	Quercetin	Quercetin inhibits the reaction [PLAUR protein results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]	22511755
D011794	Quercetin	Quercetin inhibits the reaction [PLAUR protein results in increased expression of LEF1 protein]	22511755
D011794	Quercetin	Quercetin inhibits the reaction [PLAUR protein results in increased expression of TCF7 protein]	22511755
D011794	Quercetin	Quercetin results in decreased expression of PLAUR mRNA	21308698
C470613	quinoxyfen	quinoxyfen affects the expression of PLAUR	21788198
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of PLAUR mRNA	26865669
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of PLAUR protein	16277677
C100036	resmethrin	resmethrin affects the expression of PLAUR	21788198
C059514	resveratrol	resveratrol results in decreased expression of PLAUR mRNA	22199285\|2653719
C059514	resveratrol	resveratrol results in decreased expression of PLAUR protein	26537190
D012402	Rotenone	Rotenone affects the expression of PLAUR	21788198
C093642	SB 203580	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of PLAUR mRNA]	28329830
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of PLAUR mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of PLAUR mRNA	22300531\|2535159
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of PLAUR mRNA	19073995\|2322117
D012834	Silver	Silver results in increased expression of PLAUR mRNA	27131904
C017947	sodium arsenite	sodium arsenite results in decreased expression of and affects the splicing of PLAUR mRNA	25879800
C017947	sodium arsenite	sodium arsenite results in decreased expression of PLAUR mRNA	20371982
C016104	sodium bichromate	sodium bichromate results in decreased expression of PLAUR mRNA	12760830
C016104	sodium bichromate	sodium bichromate results in increased expression of and results in increased stability of PLAUR mRNA	10438662
C016104	sodium bichromate	sodium bichromate results in increased expression of PLAUR protein	10438662
D012965	Sodium Chloride	Sodium Chloride results in increased expression of PLAUR mRNA	16115654
D012999	Soman	Soman results in increased expression of PLAUR mRNA	19281266
D053260	Soot	Soot results in increased expression of PLAUR mRNA	26551751
D013311	Streptozocin	benazepril inhibits the reaction [Streptozocin results in increased expression of PLAUR mRNA]	15322501
D013311	Streptozocin	Streptozocin results in increased expression of PLAUR mRNA	15322501
D013311	Streptozocin	Streptozocin results in increased expression of PLAUR protein	15322501
D010042	Ouabain	Ouabain results in decreased expression of PLAUR mRNA	28795476
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PLAUR mRNA	21641980
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of PLAUR mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of PLAUR mRNA	21592394
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of PLAUR mRNA	25172293
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAUR mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PLAUR mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PLAUR mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PLAUR mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PLAUR mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PLAUR mRNA	19684285\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PLAUR mRNA	22666406
C005806	tetrachloroisophthalonitrile	tetrachloroisophthalonitrile affects the expression of PLAUR	21788198
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PLAUR mRNA	25613284
C009424	tetramethrin	tetramethrin affects the expression of PLAUR	21788198
D013792	Thalidomide	Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]	16288038
D013792	Thalidomide	Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]	16288038
D013792	Thalidomide	Thalidomide results in decreased expression of PLAUR protein	16288038
D013792	Thalidomide	Thalidomide results in increased expression of PLAUR	21788198
D013853	Thioacetamide	Thioacetamide results in increased expression of PLAUR mRNA	23411599
C027971	thiodicarb	thiodicarb affects the expression of PLAUR	21788198
D013893	Thiram	Thiram affects the expression of PLAUR	21788198
C009495	titanium dioxide	titanium dioxide results in increased expression of PLAUR mRNA	23409001\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of PLAUR mRNA	27404394\|2786577
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of PLAUR mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of PLAUR mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of PLAUR mRNA"	19682533
D014212	Tretinoin	Tretinoin results in decreased expression of PLAUR mRNA	19642359
D014212	Tretinoin	Tretinoin results in decreased expression of PLAUR protein	19642359
C467051	trifloxystrobin	trifloxystrobin affects the expression of PLAUR	21788198
C053549	triflumizol	triflumizol affects the expression of PLAUR	21788198
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of PLAUR mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PLAUR mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of PLAUR mRNA	29024780
C022884	undecane	undecane results in increased expression of PLAUR protein	17337753
D014635	Valproic Acid	Valproic Acid affects the expression of PLAUR mRNA	25979313
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA]	19225232
C034028	vanadyl sulfate	vanadyl sulfate results in increased expression of PLAUR mRNA	16330358
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of PLAUR protein	27295300
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of PLAUR mRNA	15541757
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of PLAUR mRNA	19465080
D014747	Vinblastine	Vinblastine results in increased expression of PLAUR mRNA	20624997
D014750	Vincristine	Vincristine results in increased expression of PLAUR mRNA	20624997
C521292	YSNSG cyclopeptide	YSNSG cyclopeptide results in decreased expression of PLAUR	19551865
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of PLAUR mRNA	18593933
C451427	zoxamide	zoxamide affects the expression of PLAUR	21788198
D015054	Zymosan	Zymosan results in increased expression of PLAUR mRNA	11739494

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005102	signaling receptor binding	-	IPI	12665524
GO:0005515	protein binding	-	IPI	11290596 14764453 15922359 18718938 24457100
GO:0019899	enzyme binding	-	IPI	14688365 15922359
GO:0019904	protein domain specific binding	-	IPI	12665524
GO:0030377	urokinase plasminogen activator receptor activity	-	IBA	21873635
GO:0030377	urokinase plasminogen activator receptor activity	-	NAS	1689240 8392005
GO:0038023	signaling receptor activity	-	NAS	1689240 8392005

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001934	positive regulation of protein phosphorylation	-	IMP	22984561
GO:0006935	chemotaxis	-	TAS	10749881
GO:0007165	signal transduction	-	TAS	10749881
GO:0007596	blood coagulation	-	NAS	8392005
GO:0030162	regulation of proteolysis	-	NAS	1689240
GO:0042730	fibrinolysis	-	TAS	-
GO:0043066	negative regulation of apoptotic process	-	IMP	22984561
GO:0043312	neutrophil degranulation	-	TAS	-
GO:0043388	positive regulation of DNA binding	-	IDA	22984561
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	-	IMP	22984561
GO:0090200	positive regulation of release of cytochrome c from mitochondria	-	IMP	22984561
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	-	IMP	22984561
GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	-	IMP	22984561

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	IEA	-
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005789	endoplasmic reticulum membrane	-	TAS	-
GO:0005886	plasma membrane	-	IBA	21873635
GO:0005886	plasma membrane	-	IDA	12665524
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IEA	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0009986	cell surface	-	IDA	15922359
GO:0016021	integral component of membrane	-	NAS	1689240
GO:0019898	extrinsic component of membrane	-	TAS	8049431
GO:0031225	anchored component of membrane	-	IEA	-
GO:0035579	specific granule membrane	-	TAS	-
GO:0071438	invadopodium membrane	-	IEA	-

KEGG ID	KEGG Term
hsa04610	Complement and coagulation cascades

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-162791	Attachment of GPI anchor to uPAR	TAS
R-HSA-163125	Post-translational modification: synthesis of GPI-anchored proteins	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-6798695	Neutrophil degranulation	TAS
R-HSA-75205	Dissolution of Fibrin Clot	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19878584	PLAUR polymorphisms and lung function in UK smokers. (2009 Oct 31)	Stewart CE	BMC Med Genet
25490122	Cigarette Smoke and the Induction of Urokinase Plasminogen Activator Receptor In Vivo: Selective Contribution of Isoforms to Bronchial Epithelial Phenotype. (2015 Aug)	Portelli MA	Am J Respir Cell Mol Biol
26586467	The prototoxin LYPD6B modulates heteromeric alpha3beta4-containing nicotinic acetylcholine receptors, but not alpha7 homomers. (2016 Mar)	Ochoa V	FASEB J
27143927	Integrin and gene network analysis reveals that ITGA5 and ITGB1 are prognostic in non-small-cell lung cancer. (2016)	Zheng W	Onco Targets Ther