Gene: PLCD1

5333
NDNC3|PLC-III
phospholipase C delta 1
protein-coding
3p22.2
Ensembl:ENSG00000187091 MIM:602142 Vega:OTTHUMG00000130813 UniprotKB:P51178
NG_031922.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.072e-2 (AD)  6.618e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ALDH1L10.908
LRP100.894
WLS0.891
DDR10.886
ITPKB0.886
MRVI10.885
RFX40.885
ABHD40.88
LRIG10.879
AHCYL10.876

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF860-0.494
TYRP1-0.488
ABCC12-0.474
PPEF1-0.471
GABRG3-0.469
AGMAT-0.469
MYOZ3-0.452
IL12RB2-0.45
SAMD5-0.448
CALHM1-0.447

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB034011D-myo-inositol 1,4,5-trisphosphateSmall Molecule85166-31-0ExperimentalTarget
DB03956Inositol 2,4,5-trisphosphateSmall Molecule91840-07-2ExperimentalTarget
ID Drug Name Action PubMed
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione results in decreased activity of PLCD1 protein"16618758
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]"16714034
C0602291-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]"16714034
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]16714034
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]16714034
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to PLCD1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PLCD1 protein]26598702
D000082AcetaminophenAcetaminophen affects the expression of PLCD1 mRNA17562736
D000181AcrylonitrileAcrylonitrile results in increased expression of and affects the localization of PLCD1 protein12850505
D000535AluminumAluminum results in increased expression of PLCD1 protein10814511
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PLCD1 mRNA21298039
D001151ArsenicArsenic affects the methylation of PLCD1 gene25304211
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PLCD1 protein]26598702
D001194AsbestosAsbestos results in decreased expression of PLCD1 mRNA22398240
D001280AtrazineAtrazine results in increased expression of PLCD1 mRNA22378314
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PLCD1 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLCD1 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PLCD1 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PLCD1 mRNA22228805
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]16714034
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]16714034
C006780bisphenol Abisphenol A results in increased expression of PLCD1 mRNA29275510
C013418bromfenacoumbromfenacoum results in increased expression of PLCD1 protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PLCD1 mRNA15003993
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PLCD1 mRNA17484886
C026690cerous chloridecerous chloride results in increased expression of PLCD1 mRNA23573234
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PLCD120938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PLCD1 gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCD1 mRNA20938992
C031180chrysenechrysene results in increased expression of PLCD1 mRNA26377693
D003471CuprizoneCuprizone results in increased expression of PLCD1 mRNA26577399
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PLCD1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of PLCD1 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PLCD1 mRNA18164116
D004317DoxorubicinPLCD1 protein affects the susceptibility to Doxorubicin16618758
D004317DoxorubicinTNFRSF1A protein affects the reaction [Doxorubicin affects the expression of PLCD1 mRNA]16618758
D004317DoxorubicinTNFRSF1A protein affects the reaction [Doxorubicin affects the expression of PLCD1 protein]16618758
D004317DoxorubicinTNFRSF1B protein affects the reaction [Doxorubicin affects the expression of PLCD1 mRNA]16618758
D004317DoxorubicinTNFRSF1B protein affects the reaction [Doxorubicin affects the expression of PLCD1 protein]16618758
D000431EthanolEthanol results in increased expression of PLCD1 mRNA20655511
D005419FlavonoidsFlavonoids results in decreased expression of PLCD1 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PLCD120938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PLCD1 gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCD1 mRNA20938992
C039281furanfuran results in decreased methylation of PLCD1 gene27387713
C039281furanfuran results in increased expression of PLCD1 mRNA27387713
D019833GenisteinGenistein results in increased expression of PLCD1 mRNA21782745
D017313FenretinideFenretinide results in decreased expression of PLCD1 mRNA28973697
D007295Inositol Phosphates[PLCD1 protein co-treated with AVP protein] results in increased abundance of Inositol Phosphates11377826
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of PLCD1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of PLCD1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PLCD1 mRNA26752646
D007657Ketone BodiesKetone Bodies results in decreased expression of PLCD1 mRNA15469884
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of PLCD1 mRNA"11578593
D008694MethamphetamineMethamphetamine results in decreased methylation of PLCD1 promoter26307267
D008694MethamphetamineMethamphetamine results in increased expression of PLCD1 mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PLCD120938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PLCD1 gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PLCD1 mRNA20938992
D009020MorphineMorphine deficiency inhibits the reaction [Morphine results in increased expression of PLCD1 protein]23056601
D009020MorphineMorphine results in increased expression of PLCD1 protein23056601
C028007nickel monoxidenickel monoxide results in increased expression of PLCD1 mRNA19167457
D009638Norepinephrine"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]"16714034
D009638Norepinephrine"1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]"16714034
D009638Norepinephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]16714034
D009638Norepinephrine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]16714034
D009638Norepinephrinebisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]16714034
D009638Norepinephrinebisindolylmaleimide I inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]16714034
D009638NorepinephrineNorepinephrine results in increased activity of PLCD1 protein16714034
D009638NorepinephrineNorepinephrine results in increased expression of and results in increased activity of PLCD1 protein19225867
D009638NorepinephrineNorepinephrine results in increased expression of PLCD1 mRNA16714034|1922586
D009638NorepinephrineNorepinephrine results in increased expression of PLCD1 protein16714034
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]19225867
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]16714034|1922586
D009638NorepinephrinePrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]16714034
D009638Norepinephrinepyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]19225867
D010100OxygenOxygen affects the localization of PLCD1 protein12850505
D010126OzoneOzone results in decreased expression of PLCD1 mRNA16330353
D010656PhenylephrinePhenylephrine results in increased expression of PLCD1 mRNA16714034
C016658phorbolol myristate acetatephorbolol myristate acetate results in increased expression of PLCD1 mRNA16714034
C016658phorbolol myristate acetatephorbolol myristate acetate results in increased expression of PLCD1 protein16714034
D010936Plant ExtractsPlant Extracts results in increased expression of PLCD1 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PLCD1 mRNA22714537
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]19225867
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]16714034|1922586
D011224PrazosinPrazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein]16714034
D015237DinoprostDinoprost results in increased expression of PLCD1 mRNA11517196
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]19225867
C059514resveratrolresveratrol results in increased expression of PLCD1 protein18089832
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PLCD1 mRNA25895662
D012999SomanSoman results in increased expression of PLCD1 mRNA19281266
D053260SootSoot results in decreased expression of PLCD1 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the reaction [AHR protein binds to PLCD1 promoter]19654925
D014635Valproic AcidValproic Acid affects the expression of PLCD1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PLCD1 mRNA19101580
D014635Valproic AcidValproic Acid results in increased methylation of PLCD1 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PLCD1 mRNA19136453

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001786phosphatidylserine binding-IEA-  
GO:0004435phosphatidylinositol phospholipase C activity-TAS-  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI16115628  
GO:0005546phosphatidylinositol-4,5-bisphosphate binding-IDA11001876  
GO:0032794GTPase activating protein binding-IPI18434237  
GO:0070300phosphatidic acid binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0006644phospholipid metabolic process-TAS9588182  
GO:0016042lipid catabolic process-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0043647inositol phosphate metabolic process-TAS-  
GO:0060716labyrinthine layer blood vessel development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA15702972  
GO:0005829cytosol-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1483249Inositol phosphate metabolismTAS
R-HSA-1855204Synthesis of IP3 and IP4 in the cytosolTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28968711Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients. (2017 Oct 26)Couto PPCarcinogenesis