Gene info: ID 53335

Gene: BCL11A

GENE ID: 53335

Description: B cell CLL/lymphoma 11A

Gene type: protein-coding

Location: 2p16.1

dbXrefs: Ensembl:ENSG00000119866 MIM:606557 Vega:OTTHUMG00000129420 UniprotKB:Q9H165

RefSeq: NG_011968.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.528e-1 (AD) 5.088e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg24361098	chr2:60748951	BCL11A		5.000e-9	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CDK5R2	0.939
UBE2QL1	0.937
SYT3	0.935
SYNGR3	0.934
SEZ6L2	0.931
STX1A	0.93
ARHGAP44	0.928
ANKRD34A	0.925
ACTL6B	0.924
STX1B	0.923

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
WWTR1	-0.66
REST	-0.638
TFPI2	-0.628
WEE1	-0.618
YES1	-0.605
RNF135	-0.605
CARD8	-0.597
RBPMS	-0.594
CNN2	-0.589
PRKD3	-0.588

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C017906	3-dinitrobenzene	3-dinitrobenzene results in decreased expression of BCL11A mRNA	21983209
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of BCL11A mRNA"	25912373
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of BCL11A mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of BCL11A mRNA	17562736
D000447	Aldehydes	Aldehydes results in increased expression of BCL11A mRNA	25014914
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of BCL11A mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of BCL11A gene	25304211
C487081	belinostat	belinostat results in increased expression of BCL11A mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of BCL11A mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of BCL11A mRNA	21569818
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of BCL11A mRNA	20660070
C044887	beta-methylcholine	beta-methylcholine affects the expression of BCL11A mRNA	21179406
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of BCL11A mRNA	25912373
C006780	bisphenol A	bisphenol A results in decreased expression of BCL11A mRNA	22576693
C006780	bisphenol A	bisphenol A results in decreased expression of BCL11A mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of BCL11A gene	28505145
C005961	bis(tri-n-butyltin)oxide	bis(tri-n-butyltin)oxide results in increased expression of BCL11A mRNA	18958704
C018475	butyraldehyde	butyraldehyde results in increased expression of BCL11A mRNA	26079696
C054133	casticin	casticin results in decreased expression of BCL11A mRNA	28444820
D002737	Chloroprene	Chloroprene results in decreased expression of BCL11A mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCL11A gene	20938992
C031180	chrysene	chrysene results in increased expression of BCL11A mRNA	26377693
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of BCL11A mRNA	21139344
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of BCL11A mRNA	20971185
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of BCL11A mRNA	28962523
D004041	Dietary Fats	Dietary Fats results in increased expression of BCL11A mRNA	25016146
D004237	Diuron	Diuron results in decreased expression of BCL11A mRNA	21551480
C118739	entinostat	entinostat results in increased expression of BCL11A mRNA	26272509
C118739	entinostat	"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BCL11A mRNA	17942748
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCL11A gene	20938992
D005557	Formaldehyde	Formaldehyde results in decreased expression of BCL11A mRNA	20655997\|2766457
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BCL11A mRNA	25613284
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of BCL11A mRNA	22802445
C042720	mercuric bromide	mercuric bromide results in increased expression of BCL11A mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of BCL11A gene	20938992
C005219	methyl cellosolve	methyl cellosolve results in decreased expression of BCL11A mRNA	21061450
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of BCL11A mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of BCL11A mRNA	21664453
D008767	Methylmercury Compounds	Methylmercury Compounds affects the expression of BCL11A mRNA	21664453
C020771	methylmercury hydroxide	methylmercury hydroxide results in decreased expression of BCL11A mRNA	20493249
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of BCL11A mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of BCL11A promoter"	26251327
C523799	MRK 003	BCL11A results in decreased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of BCL11A mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of BCL11A mRNA	24768652
C029938	nickel sulfate	nickel sulfate results in decreased expression of BCL11A mRNA	18651567
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of BCL11A mRNA	20971185
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in decreased expression of BCL11A mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in decreased expression of BCL11A mRNA	25729387
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of BCL11A mRNA	26272509
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of BCL11A mRNA	26705709
C046012	pentanal	pentanal results in increased expression of BCL11A mRNA	26079696
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of BCL11A mRNA	26272509
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of BCL11A mRNA	21061450
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of BCL11A mRNA	20660070
C005556	propionaldehyde	propionaldehyde results in increased expression of BCL11A mRNA	26079696
D012643	Selenium	Selenium results in decreased expression of BCL11A mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of BCL11A mRNA	25351596
D053260	Soot	Soot results in decreased expression of BCL11A mRNA	26551751
C061133	tamibarotene	tamibarotene results in decreased expression of BCL11A mRNA	15498508
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BCL11A mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of BCL11A mRNA	15652763
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BCL11A mRNA	25613284
C009495	titanium dioxide	titanium dioxide results in increased expression of BCL11A mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of BCL11A mRNA	20133372
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in decreased expression of BCL11A mRNA	25729387
D019772	Topotecan	Topotecan results in decreased expression of BCL11A mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of BCL11A mRNA	15498508
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of BCL11A mRNA	24935251\|2627250
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of BCL11A mRNA	19042947
D014415	Tunicamycin	Tunicamycin results in increased expression of BCL11A mRNA	17127020
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of BCL11A mRNA	24935251
D014635	Valproic Acid	Valproic Acid results in increased expression of BCL11A mRNA	19101580\|2317975
D014810	Vitamin E	Vitamin E results in decreased expression of BCL11A mRNA	19244175
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of BCL11A mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of BCL11A mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	19153051
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IBA	21873635
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	19153051
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0043565	sequence-specific DNA binding	-	IBA	21873635
GO:0044212	transcription regulatory region DNA binding	-	IBA	21873635
GO:0046872	metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	19153051
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006355	regulation of transcription, DNA-templated	-	IBA	21873635
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0016925	protein sumoylation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005654	nucleoplasm	-	IDA	-
GO:0005737	cytoplasm	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28981154	Variation in SWI/SNF Chromatin Remodeling Complex Proteins is Associated with Alcohol Dependence and Antisocial Behavior in Human Populations. (2017 Dec)	Mathies LD	Alcohol Clin Exp Res