Gene info: ID 5334

Gene: PLCL1

GENE ID: 5334

Synonyms: PLCE|PLCL|PLDL1|PPP1R127|PRIP

Description: phospholipase C like 1 (inactive)

Gene type: protein-coding

Location: 2q33.1

dbXrefs: Ensembl:ENSG00000115896 MIM:600597 Vega:OTTHUMG00000132750 UniprotKB:Q15111

RefSeq: NC_000002.12

Retrived from: PubMed|SNP Mapped

SNPs: 38 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.492e-1 (AD) 1.668e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs10180112	chr2:198118134 (GRCh38.p7)	C>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs9973400	chr2:198076854 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs1866666	chr2:198075883 (GRCh38.p7)	T>C / T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs11690205	chr2:198069224 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs11690149	chr2:198069080 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs7587251	chr2:198065473 (GRCh38.p7)	T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs7572733	chr2:198065082 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs35062652	chr2:198063203 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs2117339	chr2:198051010 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10497813	chr2:198049348 (GRCh38.p7)	G>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs6732340	chr2:198048228 (GRCh38.p7)	C>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs67031482	chr2:198046442 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs745899	chr2:198043316 (GRCh38.p7)	A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs9712275	chr2:198042419 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10206714	chr2:198041757 (GRCh38.p7)	C>A / C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs12329164	chr2:198040500 (GRCh38.p7)	C>A / C>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs2196174	chr2:198040448 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs2196175	chr2:198040349 (GRCh38.p7)	T>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs1371664	chr2:198039741 (GRCh38.p7)	T>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs10497811	chr2:198038185 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs962210	chr2:198037506 (GRCh38.p7)	A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs1579695	chr2:198035639 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs1583792	chr2:198035564 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs11889326	chr2:198034551 (GRCh38.p7)	A>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs1541953	chr2:198033620 (GRCh38.p7)	A>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs6738825	chr2:198032171 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs10166845	chr2:198031347 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs10184227	chr2:198029581 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs10196612	chr2:198029415 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs1595823	chr2:198027075 (GRCh38.p7)	C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs2196172	chr2:198025169 (GRCh38.p7)	T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs2196171	chr2:198025083 (GRCh38.p7)	T>A / T>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs1978888	chr2:198024521 (GRCh38.p7)	T>C	alcohol dependence	SNV(Single Nucleotide Variation)
rs2139049	chr2:198022936 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs11683222	chr2:198019304 (GRCh38.p7)	C>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs34692727	chr2:198018789 (GRCh38.p7)	C>G / C>T	alcohol dependence	SNV(Single Nucleotide Variation)
rs11681663	chr2:198018228 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)
rs1025549	chr2:198016459 (GRCh38.p7)	G>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SECISBP2L	0.882
SPOCK3	0.877
MAP7	0.876
CCP110	0.876
DIP2B	0.873
NIPAL3	0.872
ENOX2	0.865
KLHL4	0.863
PRRG1	0.86
KIAA1324L	0.859

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F29	-0.364
RNF43	-0.363
SLC13A5	-0.359
WNT7B	-0.356
SLC29A4	-0.345
SLC7A10	-0.332
PPP1R3G	-0.326
TNNT1	-0.325
EYA2	-0.316
GPR143	-0.308

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01103	Quinacrine	Small Molecule	83-89-6	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PLCL1 mRNA	19933214
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PLCL1 mRNA"	19114083
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PLCL1 mRNA"	23196670
D000082	Acetaminophen	Acetaminophen affects the expression of PLCL1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of PLCL1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PLCL1 mRNA	22100608
C006632	arsenic trioxide	arsenic trioxide results in increased expression of PLCL1 mRNA	24356939
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in decreased expression of PLCL1 mRNA"	20831825
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in decreased expression of PLCL1 mRNA"	20831825
D001280	Atrazine	Atrazine results in decreased expression of PLCL1 mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PLCL1 mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PLCL1 mRNA	27195522
C006780	bisphenol A	bisphenol A results in increased expression of PLCL1 mRNA	27685785
C006780	bisphenol A	bisphenol A results in decreased expression of PLCL1 mRNA	25181051
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PLCL1 mRNA	23650126
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PLCL1 mRNA	19320972
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PLCL1 mRNA	24386269
D016572	Cyclosporine	Cyclosporine results in decreased expression of PLCL1 mRNA	20106945
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PLCL1 mRNA	21266533
D004041	Dietary Fats	Dietary Fats results in decreased expression of PLCL1 mRNA	25016146
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PLCL1 mRNA"	22485181
D000431	Ethanol	Ethanol results in decreased expression of PLCL1 mRNA	20655511
D000431	Ethanol	"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of PLCL1 mRNA]"	20655511
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of PLCL1 mRNA	29097150
D005473	Fluoxetine	Fluoxetine results in increased expression of PLCL1 mRNA	24356939
D007649	Ketamine	Ketamine results in decreased expression of PLCL1 mRNA	20080153
D001556	Lindane	Lindane results in increased expression of PLCL1 mRNA	24356939
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of PLCL1 mRNA	26011545
D015735	Mifepristone	Mifepristone results in decreased expression of PLCL1 mRNA	25972201
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PLCL1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PLCL1 mRNA"	25554681
C520612	N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid	"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of PLCL1 mRNA]"	20655511
D017239	Paclitaxel	Paclitaxel analog results in increased expression of PLCL1 mRNA	15585946
D017239	Paclitaxel	Paclitaxel results in increased expression of PLCL1 mRNA	15585946
D010672	Phenytoin	Phenytoin results in increased expression of PLCL1 mRNA	20345932
C006253	pirinixic acid	pirinixic acid results in decreased expression of PLCL1 mRNA	23811191
D011239	Prednisolone	Prednisolone results in increased expression of PLCL1 mRNA	24356939
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of PLCL1 mRNA	24780913
D020123	Sirolimus	Sirolimus results in increased expression of PLCL1 mRNA	24356939
C017947	sodium arsenite	sodium arsenite results in decreased expression of PLCL1 mRNA	25879800
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PLCL1 mRNA	19933214
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of PLCL1 mRNA	19042947
D014520	Urethane	Urethane results in increased expression of PLCL1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of PLCL1 mRNA	23179753
C025643	vinclozolin	vinclozolin results in increased expression of PLCL1 mRNA	23555832
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of PLCL1 mRNA	26682919

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004435	phosphatidylinositol phospholipase C activity	-	IEA	-
GO:0004629	phospholipase C activity	-	TAS	7633416
GO:0050811	GABA receptor binding	-	IEA	-
GO:0070679	inositol 1,4,5 trisphosphate binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006629	lipid metabolic process	-	IEA	-
GO:0007214	gamma-aminobutyric acid signaling pathway	-	IEA	-
GO:0032228	regulation of synaptic transmission, GABAergic	-	IEA	-
GO:0033135	regulation of peptidyl-serine phosphorylation	-	IEA	-
GO:0035556	intracellular signal transduction	-	IEA	-
GO:1900122	positive regulation of receptor binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IEA	-
GO:0005886	plasma membrane	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
23743675	A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. (2013 Oct)	Kapoor M	Hum Genet